Psychoactives MDPI

28/11/2024

🗣️Psychedelic states offer therapeutic potential beyond substances. Exploring non-pharmacological methods and integrating psychological with pharmacological approaches could revolutionize mental health by focusing on transformative subjective experiences. 🌌

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This narrative review explores the utilization of psychedelic states in therapeutic contexts, deliberately shifting the focus from psychedelic substances back to the experiential phenomena which they induce, in alignment with the original meaning of the term “mind-manifesting”. This review provi...

19/11/2024

🖐New research: Evidence-based policies aimed at protecting users, supporting public health, and educating clinicians should be prioritized when making decisions about how alkyl nitrites are regulated in the future.
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Alkyl nitrites (“poppers”) are a diverse class of volatile chemical compounds with a varied legal and medical history. Though once commonly prescribed to treat angina, popper use is now almost exclusively recreational. Currently, poppers are widely available and sold legally under labels like .....

18/11/2024

👉Psychedelic approaches can be an innovative and transformative method for group facilitators. An overview depicting what a PAG with an interdisciplinary team could entail, including recruitment, screening, selection, therapeutic processes, and termination.
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Psychedelics, combined with talk therapy, indicate promise with challenging clients, such as those struggling with PTSD. Furthermore, groupwork, with the emphasis on social connections, can be an effective modality. There appears, however, little movement with integrating psychedelics with professio...

12/11/2024

👉 In the present narrative review, the relationship between suicidal behavior (SB) and the use and abuse of common recreational drugs, such as alcohol, cannabis, co***ne, methamphetamine, he**in, ni****ne, ketamine, psilocybin, M**A, and L*D, has been explored.

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Substance use/abuse and su***de are two closely related phenomena, mostly due to neurobiological, psychological, and social impairments. In the present narrative review, the relationship between suicidal behavior (SB) and the use and abuse of common recreational drugs, such as alcohol, cannabis, coc...

28/08/2024

New research: Cessation from repeated M**H exposure alters gut microbiota and induces anxiety and depressive behaviors in rats. A probiotics combo mitigates depressive effects and supports gut health, highlighting the gut–brain axis's role in treating substance use disorders.

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Methamphetamine use disorder (MuD) is a global health problem, with no FDA-approved medications. Our prior work demonstrated that repeated methamphetamine exposure alters the gut microbiota in male rats and results in depressive-like behaviors. In this study, we extend our findings to females and de...

24/07/2024

👍 Good News! Psychoactives has been accepted into the DOAJ. The journal's webpage has been updated to reflect this new status:

https://www.mdpi.com/journal/psychoactives/indexing

🙌 Welcome to contribute and collaborate with us!

Psychoactives, an international, peer-reviewed Open Access journal.

15/07/2024

🖱️New Study: Ayahuasca reduces stigma in distressed men, DMT in women. M**A and psilocybin increase stigma in distressed individuals, especially women. Psychedelics may not reduce distress-linked stigma overall.
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Because psychedelics have been found to increase psychological traits like openness, mental flexibility, and interpersonal perceptiveness, some researchers believe that psychedelics could help individuals cope with the psychological effects of discrimination. However, it is still unclear whether psy...

24/06/2024

🙌Drug abuse is rising with new psychoactive substances (NPS) mimicking traditional drugs to bypass regulations. This review explores NPS trends, legal challenges, and health risks, offering insights for future research.
👉https://www.mdpi.com/2813-1851/3/2/18

19/06/2024

✍️The study used computational methods to analyze new psychoactive substances (NPS) via spectroscopy. NPS groups were effectively distinguished, showcasing the power of quantum chemistry in forensic analysis.
🙌https://www.mdpi.com/2813-1851/3/2/17

17/06/2024

🗣Our review highlights key factors for college students' drinking and driving: heavy drinking, polysubstance use, peer pressure, Greek life, and family alcohol use. Effective strategies: education, targeted interventions, and responsible campus policies.
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College students are a primary population for risky alcohol use behaviors, with one of every eleven students grappling with severe alcohol-related issues. The objective of this scoping review was to synthesize the existing literature to identify factors influencing the prevalence of drinking and dri...

23/05/2024

👋Meldonium, originally for cardiovascular use, is now noted for potential performance enhancement. This review explores its pharmacological roles, including neuroprotection, cognitive benefits, and treatment of neurodegenerative & psychiatric disorders. Athlete use has led to WADA banning it, sparking ethical debates.
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Meldonium, a promising pharmacological agent initially developed for cardiovascular indications, has sparked considerable interest in recent years due to its potential performance-enhancing effects. This review manuscript delves into the multifaceted roles of meldonium, examining its pharmacological...

14/05/2024

🙌Depression causes immense suffering worldwide, and new treatments are needed. Compared to other mood disorder treatments, psychedelics have favorable risks and benefits, but larger, rigorous trials are needed. Current data suggest cautious optimism and further exploration of their therapeutic potential.
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Rationale: Psychedelic research re-emerged from a period of suppression into the so-called psychedelic renaissance. In parallel, most media reporting has shifted from the overstatement of the risks of psychedelics to overly positive hype. As the empirical evidence is more equivocal than frequently p...

11/05/2024

📖Exciting findings on OlAla: OlAla shows promise in easing opioid withdrawal in rats via oral admin, enhancing the potential for human medicines.

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(1) Background: Intraperitoneal injections of the endogenous N-acyl amino acid N-Oleoyl alanine (OlAla) effectively reduces both the affective and somatic responses produced by opioid withdrawal in preclinical models. To increase the translational appeal of OlAla in clinical drug applications, the c...

02/05/2024

👏 Exciting findings from a study comparing ayahuasca and breathwork: Both enhance well-being, resilience, and self-compassion. This suggests promise for treating conditions like depression and anxiety.



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Background: In recent years, there has been a growing interest in the therapeutic potential of classical psychedelics like ayahuasca for mental health improvement. Naturalistic studies at ayahuasca retreats have shown (short-term) improvements in mental well-being but understanding the psychological...

23/04/2024

The study provides a comprehensive overview of how various psychoactive substances, including , , , and , impact addiction vulnerability.
👉https://www.mdpi.com/2813-1851/3/2/13

30/03/2024

Something New! 👏
"Authors identify key research gaps in the role of ASC interventions in addiction and outline a set of promising future research directions."
📖https://www.mdpi.com/2813-1851/3/2/10

28/03/2024

👀The findings highlight the critical value of prevention efforts directed to increase education and awareness about ho**ah smoking use and known health effects.
👉https://www.mdpi.com/2813-1851/3/1/8

27/03/2024

👋New insight by EiC: Psychoactive landscape evolves, presenting clinical & forensic challenges. Join us in shaping the future of psychoactives. Submit impactful research!
👉https://www.mdpi.com/2813-1851/3/1/9