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Diseases MDPI

Diseases (2079-9721) is an international, open access journal on human diseases and conditions.

30/12/2025

🌿 “Impacts of Forest Bathing (Shinrin-Yoku) in Female Participants with Depression/Depressive Tendencies”
published in Diseases (2025, 13(4), 100).
Authored by Qing Li, Norimasa Takayama, Masao Katsumata, Hiroshi Takayama, Yukako Kimura, Shigeyoshi Kumeda, Takashi Miura, Tetsuya Ichimiya, Ruei Tan, Haruka Shimomura, Amane Tateno, Tsunemi Kitagawa, Yoichiro Aoyagi, and Michiko Imai.

🔬 Study Overview:
This randomized crossover study investigated the effects of forest bathing (Shinrin-Yoku) on female participants with depression or depressive tendencies. Thirty-one women participated in both forest bathing and city walking trips, each involving structured walking sessions. Psychological assessments (SDS, POMS), subjective fatigue and sleep questionnaires, and blood biomarkers (serotonin, oxytocin, IGF-1, and lactic acid) were measured before and after each condition. Environmental factors were also recorded. The study found that forest bathing significantly reduced depressive symptoms, improved mood, increased positive neurohormonal markers, reduced fatigue, and enhanced sleep quality compared to city walking, with some benefits lasting up to one week.

🔗 Full study: https://www.mdpi.com/2079-9721/13/4/100

24/12/2025

✨ Research Highlight
📌 Study: Healthcare Resource Utilization and Economic Outcomes of RSV-Hospitalized Patients Aged ≥ 60 Years: A Retrospective Cohort Study
🖋️Authors: Anna Puggina, Melania Dovizio, Alexander Domnich, Alen Marijam, Chiara Veronesi, Caterina Rizzo, Marta Vicentini, Luca Degli Esposti, Giovanna Elisa Calabrò, Maria João Fonseca
🔗View the full study: https://www.mdpi.com/2079-9721/13/3/68 #

24/12/2025

🔬✨ Study Spotlight
📌 Title: Evaluation of Binding and Neutralizing Antibodies for Inactivated SARS-CoV-2 Vaccine Immunization
👩‍⚕️👨‍⚕️ Authors: Heng Zhao et al.
📖 Check the full study: https://www.mdpi.com/2079-9721/12/4/67

24/12/2025

🦠💉 Safety and Efficacy of Convalescent Plasma Combined with Other Therapies in COVID-19

🩸 Convalescent plasma (CCP), collected from individuals recovered from COVID-19, was the first antibody-based therapy used during the pandemic. In clinical practice, CCP was frequently administered alongside other treatments, including the antiviral remdesivir and glucocorticoids, but the effects of these combinations had not been systematically evaluated.

📚 This systematic review and meta-analysis assessed the safety and efficacy of CCP combined with other pharmaceutical agents in hospitalized COVID-19 patients. A comprehensive literature search was conducted across PubMed, EMBASE, Cochrane Central, medRxiv, and bioRxiv, following Cochrane methodology, with mortality and safety as the main outcomes. Treatment effects were reported as risk ratios (RRs) with 95% confidence intervals.

✅ Overall, the evidence suggests a potential mortality benefit of combining CCP with remdesivir compared to CCP alone in hospitalized COVID-19 patients, while no significant clinical interaction was observed between CCP and steroids.

👩‍⚕️👨‍⚕️ Authors: Massimo Franchini, Daniele Focosi, Mario Cruciani, Michael J. Joyner, Liise-anne Pirofski, Jonathon W. Senefeld, Shmuel Shoham, David J. Sullivan, Arturo Casadevall

🎓 Affiliations: Carlo Poma Hospital; Pisa University Hospital; Mayo Clinic; Albert Einstein College of Medicine; University of Illinois; Johns Hopkins University and Bloomberg School of Public Health

Read the full article: https://www.mdpi.com/2079-9721/12/3/41

24/12/2025

🫀The Association between Diagnosis-to-Ablation Time and Atrial Fibrillation Recurrence

💓 Catheter ablation (CA) is superior to antiarrhythmic drug therapy in maintaining sinus rhythm in patients with atrial fibrillation (AF). This retrospective cohort study investigates whether the time between the first AF diagnosis and catheter ablation, referred to as diagnosis-to-ablation time (DAT), is associated with AF recurrence after a first ablation procedure.

✅ The findings indicate that a shorter interval between AF diagnosis and catheter ablation is associated with a higher likelihood of procedural success following the first AF ablation.

👩‍⚕️👨‍⚕️ Authors: Alexandrina Nastasă, Mohamad Hussam Sahloul, Corneliu Iorgulescu, Ștefan Bogdan, Alina Scărlătescu, Steliana Paja, Adelina Pupaza, Raluca Mitran, Viviana Gondos, Radu Gabriel Vătășescu
🏥🎓 Affiliations: Elias University Emergency Hospital; “Carol Davila” University of Medicine and Pharmacy;

Website: https://www.mdpi.com/2079-9721/12/2/38

23/12/2025

👁️ “Long Vax in the Eye: Long Post-COVID Vaccination Syndrome Presenting with Frosted Branch Angiitis”
Published in Diseases (2024, 12(2), 36)
Authored by Koju Kamoi* and Kyoko Ohno-Matsui

🩺 Study Overview:
A 51-year-old woman developed fever 🌡️ and blurry vision 👀 within 24 hours of her second Pfizer-BioNTech COVID-19 vaccine. Exams showed frosted branch angiitis ❄️🌿 and eye inflammation that lasted 18 months despite treatment. This case highlights a potential long post-COVID vaccination syndrome (“long vax”) and the need for more research on vaccine-related immune effects 🧬.

🔗 Full study: https://www.mdpi.com/2079-9721/12/2/36

23/12/2025

Proud to share our publication! 📄✨

Title: Automated Atrial Fibrillation Diagnosis by Echocardiography without ECG: Accuracy and Applications of a New Deep Learning Approach 💡🫀

Authors: Nelson Lu, Hooman Vaseli, Mobina Mahdavi, Fatemah Taheri Dezaki, Christina Luong, Darwin Yeung, Ken Gin, Michael Tsang, Parvathy Nair, John Jue, Marion Barnes, Delaram Behnami, Purang Abolmaesumi, Teresa S. M. Tsang, from the Division of Cardiology, Department of Medicine, and the Department of Electrical and Computer Engineering at the University of British Columbia, Vancouver, Canada

Read the full paper in Diseases (2024) 📘: https://www.mdpi.com/2079-9721/12/2/35

19/12/2025

🫁 Study Spotlight
Title: A Scoping Review of Eosinophilic Pneumonia and Antidepressants: An Association Not to Be Overlooked
👩‍⚕️👨‍⚕️ Authors: Jaron Steiner, Leonie Steuernagel, Fotios Drakopanagiotakis, Konstantinos Bonelis & Paschalis Steiropoulos
🔗 Read more: https://www.mdpi.com/2079-9721/13/1/13

19/12/2025

💊 “Prevalence of Vitamin K2 Deficiency and Its Association with Coronary Artery Disease: A Case–Control Study”
Published in Diseases (2025, 13(1), 12)

🫀 Key Insights:

Vitamin K2 deficiency is more common in patients with coronary artery disease (CAD) compared to healthy controls
Serum levels of menaquinone-4 (MK-4) and menaquinone-7 (MK-7) were significantly lower in acute coronary syndrome patients (MK-4: 1.61 ± 0.66 ng/mL; MK-7: 1.64 ± 0.59 ng/mL) versus controls (MK-4: 2.29 ± 0.54 ng/mL; MK-7: 2.16 ± 0.46 ng/mL)
Unstable angina patients had the lowest K2 levels among CAD subtypes
Strong links were found between low vitamin K2 analog levels and CAD risk indicators

Highlights the need to include metabolic, lipid, and vitamin K2 pathways in CAD risk assessment and management

🔗 Full study: https://www.mdpi.com/2079-9721/13/1/12

19/12/2025

🧪 “Knowledge, Attitudes and Practices of Albanian Medical Students toward Occupational Exposure to Biological Agents”
Published in Diseases (2025, 13(1), 11)

🩺 Key Insights:

64% of medical students reported awareness of occupational exposure risks
High recognition of HIV (93%) and HBV (87%) as blood-borne pathogens, but limited awareness of Treponema pallidum (44%)
85% were aware of HIV post-exposure prophylaxis
Although 75% received training, only 45% considered it adequate

Better knowledge of infection control was significantly associated with awareness of pathogen transmission and the importance of vaccination

🔗 Full study: https://www.mdpi.com/2079-9721/13/1/11

17/12/2025

🎗️ Study Spotlight
📄 Title: Clinical Impact of Olaparib for Platinum-Sensitive Recurrent Ovarian Cancer
👥 Authors: Hiroaki Ishida, Megumi Manrai, Akiko Takashima, Hiroki Egashira, Mizuki Nonaka & Hideaki Shimada
🔗 Read more: https://www.mdpi.com/2079-9721/13/2/51

17/12/2025

🦴 “Sagittal Parameters and Clinical Outcomes in Cervical Spondylitis: The Cohort Analysis”
Published in Diseases (2025, 13(2), 49).
Authored by Denis Naumov, Sergey Tkach, Natalia Linkova, Dmitrii Medvedev, Alexander Krasichkov, Olga Sokolova, Victoria Polyakova, Giuseppe Gullo, and Piotr Yablonskiy.

📐 Key Insights:
This monocentric cohort study examined the relationship between cervical sagittal alignment and clinical outcomes in patients with cervical spondylitis undergoing reconstructive spinal surgery. Clinical and radiological data from 59 patients were analyzed before and after surgery, focusing on sagittal parameters such as cervical sagittal vertical axis (CSVA), T1 slope (T1S), and health-related quality of life measured by the Oswestry Disability Index. The results showed significant correlations between therapeutic pause duration and T1S with quality-of-life outcomes, as well as a direct relationship between patient age and CSVA values. A Charlson comorbidity index of 7 or higher emerged as a strong predictor of postoperative complications. The study concludes that anterior cervical spine reconstruction can correct sagittal imbalance in cervical spondylitis, while comorbidity burden and surgical approach are key predictors of treatment-related complications.

🔗 Full study: https://www.mdpi.com/2079-9721/13/2/49

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