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Diseases MDPI

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Diseases MDPI

Diseases (2079-9721) is an international, open access journal on human diseases and conditions.

31/10/2025

📢 New Research Alert!
Title: SARS-CoV-2 Variants and Their Impact on Pediatric COVID-19: Clinical Manifestations and Hematological Profiles
Authors: Konstantinos Paris Trempelis, et al.
🔗 Read more here: https://www.mdpi.com/2079-9721/13/2/48

31/10/2025

🧬“Effectiveness of Omega-3 Fatty Acid Supplementation in Improving the Metabolic and Inflammatory Profiles of Mexican Adults Hospitalized with COVID-19”
published in Diseases (2024, 12(1), 28).
Authored by Diana Rodríguez-Vera, Juan Rodrigo Salazar, Marvin A. Soriano-Ursúa, Jessica Guzmán-Pérez, Arely Vergara-Castañeda, Horacio Muñoz-Durán, Gabriela L. Ramírez-Velez, Alonso Vivar-Sierra, Carlos Rogelio Naranjo-Navarro, Patricia A. Meza-Meneses, Marco A. Loza-Mejía, and Rodolfo Pinto-Almazán.

🩺 Study Overview:
Malnutrition and chronic conditions can worsen COVID-19 outcomes. Given the anti-inflammatory properties of omega-3 fatty acids (O3FAs), this randomized, double-blind clinical trial investigated their potential benefits in unvaccinated Mexican adults hospitalized with COVID-19.

🌿 Takeaway:
Omega-3 fatty acids may offer a valuable nutritional strategy to support recovery and reduce complications in COVID-19 patients through their anti-inflammatory and metabolic benefits.

🔗 Read the full study here: https://doi.org/10.3390/diseases12010028

31/10/2025

📢 Research Highlight
📖 Title: Desmoid Fibromatosis of the Anterior Abdominal Wall in Pregnancy: A Case Report and Review of the Literature
👩‍🔬 Authors: Pavol Zubor et al.
🔗 Read more: https://www.mdpi.com/2079-9721/12/1/27

31/10/2025

🌬️ We are excited to share the following study:
“Management of Acute Bronchiolitis in Spoke Hospitals in Northern Italy: Analysis and Outcome”
published in Diseases (2024, 12(1), 25)
by Carla Guidi, Neftj Ragusa, Ilaria Mussinatto, Francesca Parola, Diego Luotti, Giulia Calosso, Eleonora Rotondo, Virginia Deut, Fabio Timeus, Adalberto Brach del Prever, and Massimo Berger.

👶 About the study:
Bronchiolitis is a common acute viral infection of the lower respiratory tract in infants, most frequently caused by RSV. We retrospectively analyzed infants under 12 months hospitalized for acute bronchiolitis across the Pediatric Units of Chivasso, Cirié, and Ivrea Hospitals (Piedmont, Northern Italy) over two bronchiolitis seasons (September 2021–March 2022 and September 2022–March 2023).

🔗 Read more: https://doi.org/10.3390/diseases12010025

28/10/2025

🥗 Mediterranean Diet Linked to Stronger Muscle Health in University Students!

A new study by Paraskevi Detopoulou, Olga Magni, Ioanna Pylarinou, and colleagues from the University of the Peloponnese reveals that adherence to the Mediterranean diet may play a key role in maintaining healthy muscle mass among young adults.

The researchers examined 151 university students using anthropometry and bioimpedance analysis to calculate the appendicular skeletal muscle index (aSMI)—a measure of muscle mass adjusted for height. They then assessed dietary habits through the Mediterranean Diet Score (MedDietScore) and physical activity via the HPAQ questionnaire.

📖 Website: https://www.mdpi.com/2079-9721/13/1/3

28/10/2025

💔 Is Lung Disease a Hidden Risk Factor for Sudden Cardiac Death?

Sudden cardiac death (SCD) accounts for nearly half of all cardiovascular deaths, but could lung disease play a bigger role than we realize? A new study by Ioana Radu, Anca Otilia Farcas, and colleagues explored this question by comparing heart and lung tissue from individuals who died suddenly from cardiac causes with those who died from violent causes.

📖 Full study: https://doi.org/10.3390/diseases13010008

28/10/2025

📢 Recent Findings!
📜 Title: Real-World Efficacy and Safety of Dupilumab Use in Japanese Adult Patients with Atopic Dermatitis: A Single-Center, Retrospective, 104-Week, Observational Study
✍️ Tetsuharu Ikegami and Ken Igawa
📌 Full article: https://www.mdpi.com/2079-9721/13/2/44

28/10/2025

🌿 New Research Alert: Understanding the Combined Effects of Social and Behavioral Factors on Stress and Depression 🌿

Chronic stress can have far-reaching effects on both physical and mental health. A recent study by Emmanuel Obeng-Gyasi and Sonya Parker explored how social factors (like income and education) and behavioral factors (like alcohol consumption and smoking) interact to influence stress and depressive symptoms.

Using data from the CDC’s NHANES, the researchers measured cumulative physiological stress through allostatic load and depressive symptoms via the PHQ-9 questionnaire. They applied Bayesian Kernel Machine Regression (BKMR) to capture complex, non-linear interactions among these factors.

📖 Read more: https://www.mdpi.com/2079-9721/13/2/46

27/10/2025

🧠 “Challenges in the Management of a Calvarial Defect in an NF1-Patient”

Calvarial defects in Neurofibromatosis type 1 (NF1) are rare, and standardized management guidelines are lacking. This case report highlights a five-year-old female with NF1 who developed a spontaneous occipital calvarial defect with an underlying arachnoid cyst.

📖 Read the full article: https://www.mdpi.com/2079-9721/12/12/325

27/10/2025

🦷“Secondary Primary Carcinoma Arising on the Flap Skin in the Oral Cavity—Case Series”

Oral squamous cell carcinoma (OSCC) causes considerable morbidity and mortality. While surgical resection and reconstruction are the gold standard, our case series highlights a rare phenomenon: secondary primary OSCC appearing on the skin of flaps used for reconstruction.

We present three cases in which secondary tumors appeared on radial forearm free flaps and pectoralis major flaps. The underlying mechanism remains unclear, but these findings emphasize the importance of careful physical examination of the flap itself, alongside monitoring for recurrence or metastasis.

📖 Read the full article here: https://www.mdpi.com/2079-9721/12/12/324

24/10/2025

🫘Change in Estimated Glomerular Filtration Rate After Direct-Acting Antiviral Treatment in Chronic Hepatitis C Patients
👨‍⚕️ Authors: Gantogtokh Dashjamts, Amin-Erdene Ganzorig, Yumchinsuren Tsedendorj, Dolgion Daramjav, Enkhmend Khayankhyarvaa, Bolor Ulziitsogt, Otgongerel Nergui, Ganchimeg Dondov, Tegshjargal Badamjav, Tulgaa Lonjid, Chung-Feng Huang, Po-Cheng Liang, Batbold Batsaikhan, and Chia-Yen Dai
🔗 https://doi.org/10.3390/diseases13020026

This large-scale study assessed renal function changes in 4,823 patients with chronic hepatitis C virus (HCV) infection in Taiwan following direct-acting antiviral (DAA) therapy. 🧬 The results showed that while overall eGFR declined slightly after treatment, patients with chronic kidney disease (CKD) and baseline eGFR < 60 mL/min/1.73 m² experienced significant improvement in renal function during therapy. 📈 Liver fibrosis and function tests improved markedly after DAA treatment, suggesting that antiviral therapy not only achieves viral control but may also help stabilize or improve kidney function in patients with pre-existing CKD. 💊

24/10/2025

🧬 Prognostic Implications of Initial Radiological Findings of Pulmonary Fibrosis in Patients with Acute SARS-CoV-2 Infection: A Prospective Multicentric Study
👩‍⚕️ Authors: Roxana-Elena Cîrjaliu, Sri Vidhya Gurrala, Balaji Nallapati, Vamsi Krishna, Cristian Oancea, Emanuela Tudorache, Monica Marc, Felix Bratosin, Iulia Bogdan, Ovidiu Rosca, Paula Irina Barata, Laurentiu Tony Hangan, Sergiu Ioachim Chirilă, and Ariadna-Petronela Fildan
🔗 https://doi.org/10.3390/diseases12110285

This prospective multicentric study explored the prognostic impact of initial high-resolution computed tomography (HRCT) findings of pulmonary fibrosis in hospitalized COVID-19 patients. 🫁 Among 120 participants, those with fibrosis signs on HRCT showed higher severity scores and poorer clinical outcomes. 📈 The HRCT score proved to be a strong predictor of severe COVID-19 (AUC = 0.885), and when integrated with clinical severity indices into Compound Score 1, predictive performance improved further (AUC = 0.947). These findings emphasize the importance of early HRCT evaluation for identifying high-risk patients and optimizing clinical management. 💡

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