Practical Neurology

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Practical Neurology

A monthly publication that strives to enhance quality of care and improve the daily operation of neur

Each month, our experts explain the real-world significance of recent advances in neurologic science and offer step-by-step advice on how to overcome the clinical and business challenges neurologists face. Our straightforward, how-to articles give neurologists tools they can put into practice right away.

01/07/2025

Cognitive decline is increasingly recognized as a substantial contributor to .

Read about cognitive impairment and in an article by Neelum Aggarwal, MD and Dixon Yang, MD.

https://practicalneurology.com/articles/2024-dec/poststroke-cognitive-impairment-and-dementia

Rush University American Stroke Association Alzheimer's Association American Academy of Neurology (AAN) American College of Physicians (ACP)

A summary of the classification, epidemiology, evaluation, diagnosis, and management of poststroke cognitive impairment and dementia.

01/01/2025

Finally, our most read article of 2024: Clinic-Based Assessment and Treatment Strategies for Functional Neurologic Disorders by Drs. Cicio, Hershberg, Richardson, and Pugh, edited by Dr. Fu at David Geffen School of Medicine at UCLA.

https://practicalneurology.com/articles/2024-sept-oct/clinic-based-assessment-and-treatment-strategies-for-functional-neurologic-disorders

ReActive Physiotherapy USC Division of Biokinesiology and Physical Therapy American Academy of Neurology (AAN) International Parkinson and Movement Disorder Society American College of Physicians (ACP)

Practical strategies can be used in the clinic for management of functional neurologic disorders.

12/31/2024

Our 2nd most read article of 2024: Diagnosis of by Drs. Gonzalez Caldito and Habib, edited by Dr. Distad at University of Washington.

https://practicalneurology.com/articles/2024-apr/diagnosis-of-chronic-inflammatory-demyelinating-polyneuropathy

University of California, Irvine GBS-CIDP Foundation International American Association of Neuromuscular & Electrodiagnostic Medicine - AANEM National Multiple Sclerosis Society

Due to the heterogeneous presentation of this complex disease, diagnosis is not always straightforward, and proper interpretation of clinical and diagnostic data is crucial to avoid misdiagnosis.

12/30/2024

Our 3rd most read article of 2024: Diagnosis and Treatment of Vasculitic by Drs. Witt, Kodal, and Dysgaard, edited by Dr. Distad at University of Washington.

https://practicalneurology.com/articles/2024-apr/diagnosis-and-treatment-of-vasculitic-neuropathy

American Association of Neuromuscular & Electrodiagnostic Medicine - AANEM

Despite its heterogeneous clinical presentation, vasculitic neuropathy requires rapid identification and treatment to prevent diagnostic delay or lack of diagnosis.

12/29/2024

Our 4th most read article of 2024: Management of Poststroke Mobility and Spasticity by Drs. Baskar, Jadoon, and Naqvi, edited by Dr. Cherian at Rush University Medical Center.

https://practicalneurology.com/articles/2024-dec/management-of-poststroke-mobility-and-spasticity

Columbia University Irving Medical Center Columbia University American Stroke Association American Academy of Neurology (AAN) American College of Physicians (ACP) Endovascular Today

Mobility and spasticity management tailored appropriately to the individual’s needs and abilities, as well as early rehabilitation, result in reduced disability levels and optimized outcomes after stroke.

12/28/2024

Our 5th most read article of 2024: Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease by Drs. Valencia-Sanchez and Wingerchuk, edited by Dr. Samkoff at University of Rochester and Dr. Giesser at the Pacific Neuroscience Institute.

https://practicalneurology.com/articles/2024-nov/ms-minute-myelin-oligodendrocyte-glycoprotein-antibody-associated-disease

Brain & Life Magazine Mayo Clinic Mayo Clinic Neurology and Neurosurgery National Multiple Sclerosis Society The Consortium of Multiple Sclerosis Centers European Committee for Treatment & Research in Multiple Sclerosis ACTRIMS American Academy of Neurology (AAN) American College of Physicians (ACP)

MOGAD, an inflammatory demyelinating disease of the central nervous system, has some overlapping clinical features with NMOSD and MS but is a distinct entity with unique pathologic, clinical, and imaging features.

12/27/2024

New podcast episode: Sarena Ho discusses the Centers for Medicare and Medicaid Services GUIDE Model, which helps physicians support patients with dementia and their .

https://theneurologyhub.com/podcasts/expert-voices-in-dementia/the-cms-guide-model-to-support-patients-with-dementia-and-their-caregivers

Medicare American Academy of Neurology (AAN) American College of Physicians (ACP) Alzheimer's Association

Sarena Ho, Health Insurance Specialist at the CMS Innovation Center, provides an overview on the Guiding an Improved Dementia Experience (GUIDE) Model, which helps physicians provide coordinated care to support patients with dementia and their caregivers.

12/27/2024

Our 6th most read article of 2024: Diagnostic Considerations for New-Onset in Older Adults by Dr. Elder and Harley Mocker, edited by Dr. Mazumder at David Geffen School of Medicine at UCLA.

https://practicalneurology.com/articles/2024-nov/diagnostic-considerations-for-new-onset-epilepsy-in-older-adults

American Epilepsy Society National Institute on Aging - NIH American Academy of Neurology (AAN) American College of Physicians (ACP) NYU Grossman School of Medicine

Early recognition and accurate diagnosis by health care providers are key to the optimal management of the older adult with epilepsy.

12/26/2024

Our 7th most read article of 2024: Adult Inflammatory by Drs. Jammal, Pinal-Fernandez, and Mammen, edited by Dr. Distad at University of Washington.

https://practicalneurology.com/articles/2024-apr/adult-inflammatory-myopathies-updates-on-classification-and-management
Johns Hopkins Neurology American Association of Neuromuscular & Electrodiagnostic Medicine - AANEM National Institute of Arthritis and Musculoskeletal and Skin Diseases

The inflammatory myopathies are classified into homogeneous subtypes on the basis of specific autoantibodies, and management strategies continue to evolve rapidly.

12/24/2024

Our 8th most read article of 2024: Update on Devices for Headache by Drs. Tepper, McAllister, and Monteith, edited by Dr. Yuan at Thomas Jefferson University.

https://practicalneurology.com/articles/2024-may-june/update-on-noninvasive-neuromodulation-devices-for-headache-treatment

University of Miami Miller School of Medicine New England Institute for Neurology and Headache American Headache Society®

Neuromodulation devices are effective in primary headache management, present low risk, and have minimal to no adverse events but require an understanding of how they can be integrated into the therapeutic armamentarium.

12/23/2024

Our 9th most read article of 2024: The Diagnosis and Treatment of Syndrome by Drs. Varon and Dimachkie, edited by Dr. Distad at University of Washington.

https://practicalneurology.com/articles/2024-apr/diagnosis-and-treatment-of-lambert-eaton-myasthenic-syndrome

American Association of Neuromuscular & Electrodiagnostic Medicine - AANEM University of Kansas Medical Center

Recognition of this rare immune-mediated disorder of the neuromuscular junction is critical for treatment, including of potential associated malignancy.

12/22/2024

Our 10th most read article of 2024: Menopause and Multiple Sclerosis by Dr. Bove and Denisse Morales-Rodriguez, edited by Dr. Samkoff at University of Rochester School of Medicine & Dentistry and Dr. Giesser at Pacific Neuroscience Institute.

https://practicalneurology.com/articles/2024-apr/ms-minutebrmenopause-and-multiple-sclerosis

National Multiple Sclerosis Society UCSF School of Medicine American College of Obstetricians and Gynecologists - ACOG

Multiple sclerosis and menopause have overlapping symptoms, complicating evaluation of disease progression and care of this population.

12/21/2024

The 3rd runner up to our Top 10 articles of 2024: Pharmacologic Considerations for Older Adults with Epilepsy by Drs. Nguyen, Bainbridge, & Dergalust, edited by Dr. Mazumder at David Geffen School of Medicine at UCLA.

https://practicalneurology.com/articles/2024-nov/pharmacologic-considerations-in-the-treatment-of-older-adults-with-epilepsy

Chapman University School of Pharmacy - CUSP Harbor-UCLA Medical Center Veterans Health Administration (VHA) - U.S. Department of Veterans Affairs ASHP Research and Education Foundation American Epilepsy Society

Many antiseizure medications are available for treatment of older adults with epilepsy, and choosing the best option requires understanding of their pharmacokinetic and pharmacodynamic properties.

12/21/2024

The 2nd runner up to our Top 10 articles of 2024: Blood-Based in disease by Drs. Pleen, Camerucci, Al-Sabbagh, & K. Cunningham, edited by Dr. Schneider at University of Toronto.

https://practicalneurology.com/articles/2024-mar/blood-based-biomarkers-in-alzheimer-disease-clinical-implementation-and-limitations

University of Kansas Medical Center University of Kansas: School of Medicine The University of Kansas Alzheimer's Association

Although biomarkers for Alzheimer disease have the potential to improve evaluation and care, barriers to implementation remain.

12/20/2024

As we approach the end of 2024, we’d like to highlight this year’s most read articles, starting with the 1st runner up to our Top 10 countdown: Dr. Silvestri’s article on the Diagnosis and Treatment of Gravis, edited by Dr. B. Jane Distad at University of Washington Department of Medicine.

https://practicalneurology.com/articles/2024-apr/myasthenia-gravis-making-progress-for-more-accurate-diagnoses-and-targeted-treatments

Jacobs School of Medicine & Biomedical Sciences - University at Buffalo American Academy of Neurology (AAN) Myasthenia Gravis Foundation of America, Inc. American Association of Neuromuscular & Electrodiagnostic Medicine - AANEM

Advances in testing and treatments for myasthenia gravis are leading to more accurate diagnoses and improvements in symptom control for individuals with this rare chronic autoimmune disease.

12/18/2024

Drs. Beriwal, Misra, Mishra, and Yuki Kawamura, MS, provide an overview on the management of .

Read their article in our December issue: https://practicalneurology.com/articles/2024-dec/management-of-poststroke-epilepsy-an-update
Yale Medicine American Academy of Neurology (AAN) American Epilepsy Society Endovascular Today American College of Physicians (ACP)

Poststroke seizure management is a clinical and research priority to improve prognosis.

12/17/2024

In a new Masters podcast episode, Scott Newsome, DO discusses the use of subcutaneous for the treatment of primary progressive and relapsing .

https://theneurologyhub.com/podcasts/ms-masters/subcutanous-ocrevus-zunovo-as-a-new-treatment-option-for-multiple-sclerosis
Johns Hopkins Neurology Johns Hopkins Medicine National Multiple Sclerosis Society The Consortium of Multiple Sclerosis Centers Roche American Academy of Neurology (AAN)

In this episode, Scott D. Newsome, DO, Professor of Neurology, Johns Hopkins University, Baltimore, MD, discusses how Ocrevus Zunovo can be used to treat primary progressive and relapsing forms of multiple sclerosis, including how the drug is...

12/16/2024

has received Breakthrough Therapy Designation from the U.S. Food and Drug Administration for adults with non-relapsing secondary progressive

https://practicalneurology.com/news/btk-inhibitor-tolebrutinib-receives-breakthrough-therapy-designation-for-nrspms
Sanofi US Sanofi National Multiple Sclerosis Society The Consortium of Multiple Sclerosis Centers

Tolebrutinib (Sanofi, Paris, France), an investigational, oral, bioactive brain-penetrant Bruton tyrosine kinase (BTK) inhibitor, has been granted Bre

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The i-STAT TBI cartridge (Abbott), a portable whole blood test for concussion #mTBIm has been cleared by the U.S. Food and Drug Administration. https://practicalneurology.com/news/abbotts-portable-whole-blood-test-for-tbi-cleared-by-fda #biomarker #TBI National Neurotrauma Society Neurocritical Care Society Brain Injury Association of America Footage of the i-STAT TBI cartridge in use:

Can 3D motion capture help improve Dx and clinical decision-making for #movement_disorders? R. Tripathi, MD, J. L. McKay, PhD, and C. D. Esper, MD. Emory University School of Medicine reveal the benefits and limitations of this new technology. https://practicalneurology.com/articles/2023-dec/movement-disorders-moment-use-of-3d-motion-capture-for-kinematic-analysis-in-movement-disorders

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