
09/08/2025
⚠️ Long COVID is real — and scientists may have just found the proof.
A groundbreaking study has identified viral fragments lingering in the blood of patients months after their initial SARS-CoV-2 infection. These “ghost proteins,” tucked inside microscopic packages called extracellular vesicles (EVs), were discovered in individuals experiencing persistent symptoms such as fatigue, brain fog, and shortness of breath.
Researchers detected 65 unique viral fragments—all tied to a replication protein called Pp1ab, which is absent in healthy human cells. This makes it the first potential measurable biomarker for long COVID.
The findings strengthen the idea that long COVID may be driven by hidden viral reservoirs or leftover debris disrupting normal body function long after acute infection. Interestingly, the viral proteins did not show up in every blood sample, suggesting their presence may be intermittent and influenced by factors like physical exertion.
If confirmed by larger trials, this discovery could lead to the world’s first reliable blood test for long COVID—a breakthrough that would not only help in diagnosis but also guide the development of more targeted treatments for millions still struggling with the condition.
📖 Source: Abbasi, Asghar et al. Possible long COVID biomarker: identification of SARS-CoV-2 related protein(s) in Serum Extracellular Vesicles. Infection, July 21, 2025.