The American Journal of Pathology

01/06/2025

97. Expression of Hypoxia-Inducible Cell-Surface Transmembrane Carbonic Anhydrases in Human Cancer

Published March 2001. Cited 601 times.

Full text: https://ajp.amjpathol.org/article/S0002-9440(10)64038-2/fulltext

01/06/2025

: Chronic Peroxisome Proliferator-Activated Receptor α/γ and Cannabinoid Receptor 2 Agonist Treatments Attenuated Visceral Adipose Tissue (VAT)–Derived Extracellular Vesicle–Related VAT and Intestinal Abnormalities in Nonalcoholic Steatohepatitis Mice

Full text:

This study explores the mechanisms and combined effects of chronic peroxisome proliferator-activated receptor (PPAR)α/γ and cannabinoid receptor 2 (CB2R) agonists on visceral adipose tissue (VAT)–derived extracellular vesicle (EV) release and associated systemic/VAT inflammation, decreased VAT c...

01/03/2025

A Novel and Efficient Digital Pathology Classifier for Predicting Cancer Biomarkers Using Sequencer Architecture
Authors from Clinical Pharmacology and Quantitative Science, Genmab Inc., Princeton, New Jersey
Read full text: https://loom.ly/u-PYpn8

In digital pathology tasks, transformers have achieved state-of-the-art results, surpassing convolutional neural networks (CNNs). However, transformers are usually complex and resource intensive. This study developed a novel and efficient digital pathology classifier called DPSeq to predict cancer b...

01/03/2025

98. Vascular Endothelial Growth Factor (VEGF)-Mediated Angiogenesis Is Associated with Enhanced Endothelial Cell Survival and Induction of Bcl-2 Expression

Published February 1999. Cited 600 times.

Full text: https://ajp.amjpathol.org/article/S0002-9440(10)65284-4/fulltext

01/02/2025

: Phenotypic and Functional Diversity of Neutrophils in Gut Inflammation and Cancer. Dr. Ronen Sumagin (Northwestern University Feinberg School of Medicine) was the 2023 recipient of the American Society for Investigative Pathology Cotran Early Career Investigator Award Lecture and presented his work at the annual meeting in Salt Lake City.

Read the full lecture review online for free:

Neutrophils [polymorphonuclear leukocytes (PMNs)] execute important effector functions protecting the host against invading pathogens. However, their activity in tissue can exacerbate inflammation and inflammation-associated tissue injury and tumorigenesis. Until recently, PMNs were considered to be...

01/02/2025

99. Interferon-γ and Tumor Necrosis Factor-α Synergize to Induce Intestinal Epithelial Barrier Dysfunction by Up-Regulating Myosin Light Chain Kinase Expression.

Published February 2005. Cited 595 times.

Full text:

Numerous intestinal diseases are characterized by immune cell activation and compromised epithelial barrier function. We have shown that cytokine treatment of epithelial monolayers increases myosin II regulatory light chain (MLC) phosphorylation and decreases barrier function and that these are both...

01/01/2025

100. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.

https://loom.ly/cs-4EWc

Published in September 1995. Cited 597 times.

01/01/2025

The opening piece in the celebration is an editorial from current Editor-in-Chief of The American Journal of Pathology, Dr. Martha Furie, and ASIP Executive Officer Emeritus, Dr. Mark Sobel entitled "Celebrating the First 100 Years of Publishing Significant Scientific Discoveries in The American Journal of Pathology".

Full text: https://ajp.amjpathol.org/article/S0002-9440(24)00404-8/fulltext

01/01/2025

This January The American Journal of Pathology celebrates its 100th anniversary! Through the course of 2025 we will be posting special content both in the journal and on social media. We thank all the authors, reviewers, and volunteers who have helped produce AJP and look forward to working together in the next 100 years.

12/31/2024

Elucidating the Morphogenic and Signaling Roles of Defined Growth Factors Controlling Human Endothelial Cell Lumen Formation Versus Sprouting Behavior
Read full text: https://loom.ly/Gl_K6H8

12/31/2024

Tumor Mutation Burden–Related Histopathologic Features for Predicting Overall Survival in Gliomas Using Graph Deep Learning
Authors from School of Engineering Medicine, Beihang University, China
Read full text: https://loom.ly/ZCOivIc

Tumor mutation burden (TMB) is a potential biomarker for evaluating the prognosis and response to immune checkpoint inhibitors, but its costly and time-consuming method of measurement limits its widespread application. This study aimed to identify the TMB-related histopathologic features from hemato...

12/30/2024

The January issue of The American Journal of Pathology is live and includes both the introduction to our celebration and the latest group of theme Reviews and associated research articles.

Full issue: https://ajp.amjpathol.org/issue/S0002-9440(23)X0014-5

On the cover: Progression of the cover presentation of The American Journal of Pathology

12/30/2024

Tumor-Infiltrating Lymphocyte Recognition in Primary Melanoma by Deep Learning Convolutional Neural Network
Authors from Institute of Clinical Physiology, National Research Council, Pisa, Italy
Read full text: https://loom.ly/9JekCqU

12/29/2024

Standardized Classification of Lung Adenocarcinoma Subtypes and Improvement of Grading Assessment Through Deep Learning
Authors from Department of Pathology, Kameda Medical Center, Kamogawa, Japan
Read full text: https://loom.ly/jXSu-8k

12/28/2024

Spermidine Suppresses Oral Carcinogenesis through Autophagy Induction, DNA Damage Repair, and Oxidative Stress Reduction
Authors from School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte
Read full text: https://loom.ly/24MHQf8

12/27/2024

Domain and Histopathology Adaptations–Based Classification for Malignancy Grading System
Authors from Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology
Read full text: https://loom.ly/YfpJXiA

Accurate proliferation rate quantification can be used to devise an appropriate treatment for breast cancer. Pathologists use breast tissue biopsy glass slides stained with hematoxylin and eosin to obtain grading information. However, this manual evaluation may lead to high costs and be ineffective....

12/27/2024

Tumor-Derived Immunoglobulin-Like Transcript 4 Promotes Postoperative Relapse via Inducing Vasculogenic Mimicry through MAPK/ERK Signaling in Hepatocellular Carcinoma
Read full text: https://loom.ly/G037xXw