The American Journal of Pathology

02/07/2025

Evidence and Mechanism of Bile Acid–Mediated Gut-Brain Axis in Anxiety and Depression. From American Society for Investigative Pathology member Dr. Sei Higuchi and colleagues from St. John's University

Free Mini-Review:

Bidirectional communication between the brain and gastrointestinal tract, called the gut-brain axis, is linked with our emotions. Intestinal lipids, hormones, and molecules, such as bile acids (BAs), impact our mood, motivation, and emotions via the gut-brain axis. BAs are synthesized from cholester...

02/07/2025

73. Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology.

Published March 1988. Cited 648 times.

Full text: https://pmc.ncbi.nlm.nih.gov/articles/PMC1880803/

02/07/2025

The American Journal of Pathology seeks your research into Alcohol Induced Organ Damage for our next theme issue.

Submission is free and can be done online: https://www.editorialmanager.com/ajpa/default2.aspx

Deadline: March 31, 2025

02/06/2025

Chronic Coinfection with Pseudomonas aeruginosa and Normal Colony Staphylococcus aureus Causes Lung Structural Damage in the Cystic Fibrosis Rat. Authors from UAB - The University of Alabama at Birmingham.

Full text:

Cystic fibrosis (CF) respiratory outcomes are heavily influenced by complications of infection. Pseudomonas aeruginosa and Staphylococcus aureus are the most common colonizers of the cystic fibrosis lung, and frequently overlap to cause chronic and persistent coinfections associated with severe dise...

02/06/2025

74. Decreased Collagen Production in Chronologically Aged Skin: Roles of Age-Dependent Alteration in Fibroblast Function and Defective Mechanical Stimulation

Published June 2006. Cited 647 times.

Full text:

Reduced synthesis of collagen types I and III is characteristic of chronologically aged skin. The present report provides evidence that both cellular fibroblast aging and defective mechanical stimulation in the aged tissue contribute to reduced collagen synthesis. The reduction in collagen synthesis...

02/05/2025

: Insight into the Role of Gut Microbiota in : An Age-Related Study in Mdx Mice. Authors from Université de Montpellier and Université Paris-Saclay.

Free in the :

Dystrophin deficiency alters the sarcolemma structure, leading to muscle dystrophy, muscle disuse, and ultimately death. Beyond limb muscle deficits, patients with Duchenne muscular dystrophy have numerous transit disorders. Many studies have highlighted the strong relationship between gut microbio...

02/05/2025

75. Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

Published February 1990. Cited 647 times.

Full text: https://pmc.ncbi.nlm.nih.gov/articles/PMC1877598/

02/04/2025

Highlights of the First 100 Years of Publications on in The American Journal of Pathology.

Read the latest Centennial Editorial from Associate Editor Michael Goligorsky that looks back over the last century of renal advancements published in AJP.

Full text: https://ajp.amjpathol.org/article/S0002-9440(24)00414-0/fulltext

02/04/2025

: The Amyloid Cascade Hypothesis: A Conclusion in Search of Support. Authors from Northwestern University Feinberg School of Medicine and UTSA - The University of Texas at San Antonio

Full text:

The amyloid cascade hypothesis as the etiological underpinning of Alzheimer disease (AD) is supported by a large body of literature, the most influential of which are genetic studies of the 1980s and 1990s. Other evidence includes the neuropathology of Down syndrome, apparent toxicity of oligomeric....

02/04/2025

76. Vasculogenic Mimicry and Tumor Angiogenesis

Published February 2000. Cited 643 times.

Full text: https://ajp.amjpathol.org/article/S0002-9440(10)64739-6/fulltext

02/03/2025

77. Chondrocyte apoptosis induced by nitric oxide.

Published January 1995. Cited 643 times.

Full text: https://pmc.ncbi.nlm.nih.gov/articles/PMC1870754/

02/03/2025

: Vascular Endothelial Growth Factor-C Treatment Enhances Cerebrospinal Fluid Outflow during Brain Infection but Does Not Improve Cerebral Edema. From American Society for Investigative Pathology member Dr. Tajie Harris and colleagues from UVA Center for Brain Immunology and Glia - BIG (University of Virginia).

Free in the :

Cerebral edema frequently develops in the setting of brain infection and can contribute to elevated intracranial pressure, a medical emergency. How excess fluid is cleared from the brain is not well understood. Previous studies have shown that interstitial fluid is transported out of the brain along...

01/31/2025

78. Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.

Published February 1995. Cited 642 times.

Full text: https://pmc.ncbi.nlm.nih.gov/articles/PMC1869820/

01/31/2025

The February issue of The American Journal of Pathology is now live!

Full issue: https://loom.ly/rc5qGuM

On the cover: Visualization heat maps of salivary gland tissues.

01/30/2025

79. PDGF and FGF stimulate wound healing in the genetically diabetic mouse.

Published June 1990. Cited 642 times.

Full text: https://pmc.ncbi.nlm.nih.gov/articles/PMC1877595/