The American Journal of Pathology

07/01/2024

: A -based assessment pipeline for intraepithelial and stromal tumor-infiltrating lymphocytes in high-grade serous ovarian carcinoma. Authors from Kyoto University Graduate School of Medicine, Kindai University,

https://ajp.amjpathol.org/article/S0002-9440(24)00110-X/abstract

06/28/2024

Isolation and Characterization of a Novel Mammary Adenocarcinoma, MCa-P1362, with Hormone Receptor Expression, Human Epidermal Growth Factor Receptor 2 Positivity, and Enrichment in Cancer and Mesenchymal Stem Cells
From American Society for Investigative Pathology member author Dr. Dan Jones and colleagues from Boston University Chobanian & Avedisian School of Medicine, Massachusetts General Hospital and Harvard Medical School.

Read full text: https://loom.ly/ncJMAdg

06/28/2024

: Identification of Spatial Proteomic Signatures of Colon Tumor Metastasis: A Digital Spatial Profiling Approach. From American Society for Investigative Pathology member authors at Dartmouth Health, Geisel School of Medicine at Dartmouth, Dartmouth Cancer Center and Harvard Medical School.

Free in the :

Over 150,000 Americans are diagnosed with colorectal cancer (CRC) every year, and annually >50,000 individuals are estimated to die of CRC, necessitating improvements in screening, prognostication, disease management, and therapeutic options. CRC tumors are removed en bloc with surrounding vasculatu...

06/28/2024

Send in your original research on the of neurological disorders for consideration in this upcoming theme issue dedicated to Neuropathology. Submission is free!

https://www.editorialmanager.com/ajpa/default2.aspx

06/27/2024

Protein Kinase D2 and D3 Promote Prostate Cancer Cell Bone Metastasis by Positively Regulating Runx2 in a MEK/ERK1/2–Dependent Manner
Authors from Pitt School of Medicine and Amity University

Read full text: https://loom.ly/Ssq9sCY

06/27/2024

Tumor Necrosis Factor α–Induced Protein 8–Like 1 Binds to Protein Arginine Methyltransferase 1 to Suppress the Methylation of Signal Transducer and Activator of Transcription 3 and Cell Growth in Oral Squamous Cell Carcinoma
Authors from Chinese PLA General Hospital
Read full text: https://loom.ly/_Sj8GZw

06/27/2024

The Transcriptional Landscape of Coding and Noncoding RNAs in Recurrent and Nonrecurrent Colon Cancer.
Authors from Aarhus Universitetshospital.

text: https://ajp.amjpathol.org/article/S0002-9440(24)00163-9/fulltext

06/26/2024

Tumor-Derived Oxidative Stress Triggers Ovarian Follicle Loss in Breast Cancer
Authors from Department of Pathology, Jinan University School of Medicine
Read full text: https://loom.ly/fiqmkL8

06/26/2024

Rat Model of Type 2 Diabetes Mellitus Recapitulates Human Disease in the Anterior Segment of the Eye

Authors from Carver College of Medicine, University of Iowa, University of Wisconsin School of Veterinary Medicine, and Iowa City VA Health Care System.
Read full text: https://loom.ly/-akIhYg

06/26/2024

Suppression of N-Glycosylation of Zinc Finger Protein 471 Affects Proliferation, Invasion, and Docetaxel Sensitivity of Tongue Squamous Cell Carcinoma via Regulation of c-Myc
Authors from Xiangya School of Medicine, Central South University
Read full text: https://loom.ly/kDQxBW4

06/25/2024

Announcing the newest call for papers from The American Journal of Pathology! Our next theme issue will focus on and we seek your original research into the pathogenesis of neurologic conditions. Deadline is September 30, 2024.

Submission to AJP is free and can be done online here: https://www.editorialmanager.com/ajpa/default2.aspx

06/25/2024

Communication has been restored at The American Journal of Pathology Editorial Office! We are working our way through the backup of emails from the weekend outage and will get back to you as soon as possible.

06/25/2024

Dysregulation of the Long Noncoding RNA X-Inactive–Specific Transcript Expression in Male Patients with Pulmonary Arterial Hypertension https://loom.ly/VQ2o1MI

06/24/2024

Tensor Decomposition of Largest Convolutional Eigenvalues Reveals Pathologic Predictive Power of RhoB in Re**al Cancer Biopsy
Read full text: https://loom.ly/c2LABUk

06/24/2024

The servers in the Editorial Office for The American Journal of Pathology are currently offline. We will reply to any emails as soon as possible once they have been brought back online.

The online manuscript processing system is still open and functional- please send in your work or your manuscript reviews as normal. Submissions and reviews can be completed at https://www.editorialmanager.com/ajpa/default2.aspx

06/24/2024

Protein Kinase CK2 Promotes Proliferation, Abnormal Differentiation, and Proinflammatory Cytokine Production of Keratinocytes via Regulation of STAT3 and Akt Pathways in Psoriasis
Read full text: https://loom.ly/sXNTsbA

06/24/2024

Ferroptosis Contributes to Microvascular Dysfunction in Diabetic Retinopathy

Authors from Jinan University
Read full text: https://loom.ly/R31Bdw4

Ferroptosis is a new form of cell death characterized by iron-dependent lipid peroxidation. Whether ferroptosis is involved in retinal microvascular dysfunction under diabetic condition is not known. Herein, the expression of ferroptosis-related genes in patients with proliferative diabetic retinopa...

06/21/2024

A Spatial Atlas of Wnt Receptors in Adult Mouse Liver

Work from University of Pittsburgh Liver Research Center and Dr. Paul Monga
Read full text: https://loom.ly/_SMt41c

06/21/2024

Prediction of MET Overexpression in Lung Adenocarcinoma from Hematoxylin and Eosin Images

Authors from Tempus AI
Read full text: https://loom.ly/USAJ0VY

06/21/2024

Adipose Triglyceride Lipase–Mediated Adipocyte Lipolysis Exacerbates Acute Pancreatitis Severity in Mouse Models and Patients https://ajp.amjpathol.org/article/S0002-9440(24)00165-2/abstract

06/20/2024

TRPV1 Dysfunction Impairs Gastric Nitrergic Neuromuscular Relaxation in High-Fat Diet–Induced Diabetic Gastroparesis Mice

Read full text: https://loom.ly/8_cSJog

06/20/2024

Developmental Dopaminergic Signaling Modulates Neural Circuit Formation and Contributes to Autism Spectrum Disorder–Related Phenotypes
Authors from Nantong University
Read full text: https://loom.ly/SnMKKAY

06/20/2024

Deletion of MyD88 in T Cells Improves Antitumor Activity in Melanoma

Work by American Society for Investigative Pathology trainee member Abe Bayer in Pilar Alcaide's lab at Tufts University School of Medicine
Read full text: https://loom.ly/cueKDVE

06/19/2024

Transcriptional Profiling Supports the Notochordal Origin of Chordoma and Its Dependence on a TGFB1-TBXT Network

Authors from Harvard Medical School, Massachusetts General Hospital
Read full text: https://loom.ly/u-w_q_Y

06/19/2024

Ficolin-A/2 Aggravates Severe Lung Injury through Neutrophil Extracellular Traps Mediated by Gasdermin D–Induced Pyroptosis

Authors from First Affiliated Hospital of Hunan Normal University
Read full text: https://loom.ly/uN3DdYc

06/19/2024

The Role of Pericytes in Lipopolysaccharide-Induced Murine Acute Respiratory Distress Syndrome https://ajp.amjpathol.org/article/S0002-9440(24)00164-0/fulltext

06/18/2024

The Parkinson-Associated Toxin Paraquat Shifts Physiological α-Synuclein Tetramers toward Monomers That Can Be Calpain-Truncated and Form Oligomers
Authors from Mass General Brigham and Harvard Medical School.
Read full text: https://loom.ly/VCcUgBw

06/18/2024

The Role of Hyaluronan/Receptor for Hyaluronan-Mediated Motility Interactions in the Modulation of Macrophage Polarization and Cartilage Repair
From American Society for Investigative Pathology member, and The American Journal of Pathology Associate Editor Dr. Thorsten Kirsch and colleagues from NYU Tandon School of Engineering and NYU Grossman School of Medicine.
Read full text: https://loom.ly/qhcxZN4

06/18/2024

REGγ Mitigates Radiation-Induced Enteritis by Preserving Mucin Secretion and Sustaining Microbiome Homeostasis


Read full text: https://loom.ly/ff6-oLg

06/17/2024

: Latent-Transforming Growth Factor β-Binding Protein 1/Transforming Growth Factor β1 Complex Drives Antitumoral Effects upon ERK5 Targeting in Melanoma. Authors from Università degli Studi di Firenze

: https://ajp.amjpathol.org/article/S0002-9440(24)00167-6/fulltext