Gayathri Ramakrishnan, Anna Huttenlocher (University of Wisconsin-Madison) and colleagues describe a larval zebrafish model of early melanoma invasion that is amenable to real time imaging of the dynamic interactions bet
Gayathri Ramakrishnan, Anna Huttenlocher (University of Wisconsin-Madison) and colleagues describe a larval zebrafish model of early melanoma invasion that is amenable to real time imaging of the dynamic interactions between macrophages and invading tumor cells. The work highlights a role for Rac2 signaling in macrophages during early melanoma invasion. https://hubs.la/Q02Z3Z0h0
Ryota Orii and Hirokazu Tanimoto (YCU 横浜市立大学) study the structural mechanics of microtubule and actin cytoskeletons using high-force intracellular magnetic tweezers. The measurements directly reveal the integrated na
Ryota Orii and Hirokazu Tanimoto (YCU 横浜市立大学) study the structural mechanics of microtubule and actin cytoskeletons using high-force intracellular magnetic tweezers. The measurements directly reveal the integrated nature of the two cytoskeletons throughout the cytoplasm, which defines their physical behavior as a simple cell-scale continuum. https://hubs.la/Q02Yn3l60
Serhiy Pankiv, Anne Simonsen and colleagues (Universitetet i Oslo (UiO)) identify BEACH domain–containing proteins (BDCPs) as novel sorting adaptors for transmembrane proteins (TMPs) in post-Golgi secretory and recyc
Serhiy Pankiv, Anne Simonsen and colleagues (Universitetet i Oslo (UiO)) identify BEACH domain–containing proteins (BDCPs) as novel sorting adaptors for transmembrane proteins (TMPs) in post-Golgi secretory and recycling endocytic pathways. They demonstrate that BDCPs and clathrin coat adaptors localize to distinct subdomains of secretory/recycling tubules, leading to the sorting of TMPs into distinct transport carriers. https://hubs.la/Q02XxlWf0
Yuhao Han, Kay Grünewald, Marina Mikhaylova (Humboldt-Universität zu Berlin) and colleagues use primary hippocampal cultures to demonstrate that neurons with axon-carrying–dendrite (AcD) morphology can develop independe
Yuhao Han, Kay Grünewald, Marina Mikhaylova (Humboldt-Universität zu Berlin) and colleagues use primary hippocampal cultures to demonstrate that neurons with axon-carrying–dendrite (AcD) morphology can develop independent of an in vivo environment. They found that the axon initial segment (AIS) of AcD neurons maintains cytoskeletal integrity but lacks homeostatic plasticity and receives fewer inhibitory inputs. https://hubs.la/Q02WPzgl0
Joshua Larson, Sue Biggins, Charles Asbury (University of Washington) and colleagues show that kinetochores grip the sides of microtubules much more strongly when they are pulled toward plus ends. This striking mechanical
Joshua Larson, Sue Biggins, Charles Asbury (University of Washington) and colleagues show that kinetochores grip the sides of microtubules much more strongly when they are pulled toward plus ends. This striking mechanical asymmetry correlates with molecular rearrangements inside the kinetochores and might promote biorientation during early mitosis by stabilizing attachments specifically when sister kinetochores have captured opposing microtubules. https://hubs.la/Q02WCHd70
Julie Verhoef, Taco Kooij and colleagues (Radboudumc) used advanced microscopy techniques to visualize cellular processes during the fast replication of malaria parasites in our red blood cells. Verhoef's images provide
Julie Verhoef, Taco Kooij and colleagues (Radboudumc) used advanced microscopy techniques to visualize cellular processes during the fast replication of malaria parasites in our red blood cells. Verhoef's images provide an unprecedented detailed view of what happens inside this bloodthirsty microscopic killer. https://hubs.ly/Q02WCFmB0
Marvin Rötte, Mila Höhne, Sven Bogdan and colleagues (Philipps-Universität Marburg) highlight an important role of CYRI as a molecular brake on the Rac-WRC-Arp2/3 pathway to slow down epidermal wound closure and to l
Marvin Rötte, Mila Höhne, Sven Bogdan and colleagues (Philipps-Universität Marburg) highlight an important role of CYRI as a molecular brake on the Rac-WRC-Arp2/3 pathway to slow down epidermal wound closure and to limit invasive collective epithelial cell migration. https://hubs.la/Q02VSpt10
Amin Khosrozadeh, Benoît Zuber ad colleagues (Universität Bern) developed CryoVesNet, which enables accurate segmentation of synaptic vesicles in cryo-electron tomograms. This automated tool analyzes synaptic ultrast
Amin Khosrozadeh, Benoît Zuber ad colleagues (Universität Bern) developed CryoVesNet, which enables accurate segmentation of synaptic vesicles in cryo-electron tomograms. This automated tool analyzes synaptic ultrastructure and vesicle pools efficiently across diverse synapses, advancing our understanding of synaptic function and synaptic vesicle pool dynamics. https://hubs.la/Q02VJbzY0
Takami Sho, Li Yu and colleagues (Tsinghua University) unveil migratory autolysosome disposal, a response to lysosomal damage where cells expel LAMP1-LC3 positive structures via autolysosome exocytosis, requiring au
Takami Sho, Li Yu and colleagues (Tsinghua University) unveil migratory autolysosome disposal, a response to lysosomal damage where cells expel LAMP1-LC3 positive structures via autolysosome exocytosis, requiring autophagy machinery, SNARE proteins, and cell migration. This novel mechanism highlights the intricate relationship between cell migration, organelle quality control, and extracellular vesicle release. https://hubs.la/Q02RwkPy0
Berrak Ugur, Pietro De Camilli (Yale Medicine) and colleagues characterize the bridge-like lipid transfer protein VPS13B and report its localization between Golgi cisternae and its impact on Golgi complex reformation
Berrak Ugur, Pietro De Camilli (Yale Medicine) and colleagues characterize the bridge-like lipid transfer protein VPS13B and report its localization between Golgi cisternae and its impact on Golgi complex reformation after its BFA-induced dispersion. They also provide evidence for its functional partnership with FAM177A1, a newly identified Golgi complex protein. https://hubs.la/Q02RmkyD0
Noah de Leeuw, Rashmi Budhathoki, Liam Russell, Dinah Loerke, and Todd Blankenship (University of Denver) examine the mechanical limitations that nuclear volumes impose on epithelial remodeling in Drosophila. They identi
Noah de Leeuw, Rashmi Budhathoki, Liam Russell, Dinah Loerke, and Todd Blankenship (University of Denver) examine the mechanical limitations that nuclear volumes impose on epithelial remodeling in Drosophila. They identify two primary mechanisms—nuclear dispersion and nuclear deformation—that permit the resolution of internuclear tensions. Failures in both pathways lead to epithelial extrusion. https://hubs.la/Q02RdLPB0
Mechanisms leading to abnormal distribution of neural progenitors during cortical development in the context of subcortical heterotopia associated with EML1 mutations remain unknown. Using a forebrain-specific mouse model and mutant human cells, Donia Za
Mechanisms leading to abnormal distribution of neural progenitors during cortical development in the context of subcortical heterotopia associated with EML1 mutations remain unknown. Using a forebrain-specific mouse model and mutant human cells, Donia Zaidi, Fiona Francis and colleagues (Inserm, Sorbonne University Paris) innovatively demonstrate that by restoring microtubule function, abnormal progenitor distribution and heterotopic volume are significantly reduced. https://hubs.la/Q02QZygh0
