Persistent unfolding of an essential cell-cell adhesion component interferes with cell division. This study from Yuou Wang, Alex Yemelyanov, Cara Gottardi and colleagues (Northwestern Medicine) has implications for woun
Persistent unfolding of an essential cell-cell adhesion component interferes with cell division. This study from Yuou Wang, Alex Yemelyanov, Cara Gottardi and colleagues (Northwestern Medicine) has implications for wound repair and eye disease. https://hubs.la/Q031VsG10
Yamilex Acevedo-Sánchez, Rebecca L. Lamason and colleagues (MIT Department of Biology) characterize a novel interkingdom contact site between the ER and a cytosolic bacterial pathogen. They report that these bacteria
Yamilex Acevedo-Sánchez, Rebecca L. Lamason and colleagues (MIT Department of Biology) characterize a novel interkingdom contact site between the ER and a cytosolic bacterial pathogen. They report that these bacteria–ER contacts (BERCs) require the tethering proteins VAPA and VAPB and that actin-based motility of the pathogen negatively impacts the frequency of their formation. https://hubs.la/Q031sDMm0
The interkinetic envelope is a novel organelle, superficially reminiscent of the nuclear envelope, which progressively assembles at the surface of the segregating chromosomes during interkinesis in oocytes. New study from Layla El Mossadeq, Julien Dumont
The interkinetic envelope is a novel organelle, superficially reminiscent of the nuclear envelope, which progressively assembles at the surface of the segregating chromosomes during interkinesis in oocytes. New study from Layla El Mossadeq, Julien Dumont and colleagues (Université Paris Cité): https://hubs.la/Q030-xPs0
Alia Edington, Jonathan Friedman and colleagues (UT Southwestern Medical Center) determine that Mdm33 and CCDC51 are functionally conserved mitochondrial inner membrane proteins that are required for normal mitochondrial
Alia Edington, Jonathan Friedman and colleagues (UT Southwestern Medical Center) determine that Mdm33 and CCDC51 are functionally conserved mitochondrial inner membrane proteins that are required for normal mitochondrial morphology. The authors show that the proteins spatially demarcate and are required for a subset of mitochondrial division events, suggesting that internal mitochondrial proteins facilitate fission in human cells. https://hubs.la/Q030B2kG0
Duligengaowa Wuergezhen, Hironobu Fujiwara and colleagues (RIKEN) developed a Col4a2 fluorescently tagged mouse model to reveal a spatial gradient in basement membrane (BM) turnover and expansion during hair follicl
Duligengaowa Wuergezhen, Hironobu Fujiwara and colleagues (RIKEN) developed a Col4a2 fluorescently tagged mouse model to reveal a spatial gradient in basement membrane (BM) turnover and expansion during hair follicle development. Inhibition of matrix metalloproteinases alters BM turnover, expansion and epithelial progenitor behavior, ultimately impacting hair follicle morphology. https://hubs.la/Q02_6cvy0
Gayathri Ramakrishnan, Anna Huttenlocher (University of Wisconsin-Madison) and colleagues describe a larval zebrafish model of early melanoma invasion that is amenable to real time imaging of the dynamic interactions bet
Gayathri Ramakrishnan, Anna Huttenlocher (University of Wisconsin-Madison) and colleagues describe a larval zebrafish model of early melanoma invasion that is amenable to real time imaging of the dynamic interactions between macrophages and invading tumor cells. The work highlights a role for Rac2 signaling in macrophages during early melanoma invasion. https://hubs.la/Q02Z3Z0h0
Ryota Orii and Hirokazu Tanimoto (YCU 横浜市立大学) study the structural mechanics of microtubule and actin cytoskeletons using high-force intracellular magnetic tweezers. The measurements directly reveal the integrated na
Ryota Orii and Hirokazu Tanimoto (YCU 横浜市立大学) study the structural mechanics of microtubule and actin cytoskeletons using high-force intracellular magnetic tweezers. The measurements directly reveal the integrated nature of the two cytoskeletons throughout the cytoplasm, which defines their physical behavior as a simple cell-scale continuum. https://hubs.la/Q02Yn3l60
Serhiy Pankiv, Anne Simonsen and colleagues (Universitetet i Oslo (UiO)) identify BEACH domain–containing proteins (BDCPs) as novel sorting adaptors for transmembrane proteins (TMPs) in post-Golgi secretory and recyc
Serhiy Pankiv, Anne Simonsen and colleagues (Universitetet i Oslo (UiO)) identify BEACH domain–containing proteins (BDCPs) as novel sorting adaptors for transmembrane proteins (TMPs) in post-Golgi secretory and recycling endocytic pathways. They demonstrate that BDCPs and clathrin coat adaptors localize to distinct subdomains of secretory/recycling tubules, leading to the sorting of TMPs into distinct transport carriers. https://hubs.la/Q02XxlWf0
Yuhao Han, Kay Grünewald, Marina Mikhaylova (Humboldt-Universität zu Berlin) and colleagues use primary hippocampal cultures to demonstrate that neurons with axon-carrying–dendrite (AcD) morphology can develop independe
Yuhao Han, Kay Grünewald, Marina Mikhaylova (Humboldt-Universität zu Berlin) and colleagues use primary hippocampal cultures to demonstrate that neurons with axon-carrying–dendrite (AcD) morphology can develop independent of an in vivo environment. They found that the axon initial segment (AIS) of AcD neurons maintains cytoskeletal integrity but lacks homeostatic plasticity and receives fewer inhibitory inputs. https://hubs.la/Q02WPzgl0
Joshua Larson, Sue Biggins, Charles Asbury (University of Washington) and colleagues show that kinetochores grip the sides of microtubules much more strongly when they are pulled toward plus ends. This striking mechanical
Joshua Larson, Sue Biggins, Charles Asbury (University of Washington) and colleagues show that kinetochores grip the sides of microtubules much more strongly when they are pulled toward plus ends. This striking mechanical asymmetry correlates with molecular rearrangements inside the kinetochores and might promote biorientation during early mitosis by stabilizing attachments specifically when sister kinetochores have captured opposing microtubules. https://hubs.la/Q02WCHd70
Julie Verhoef, Taco Kooij and colleagues (Radboudumc) used advanced microscopy techniques to visualize cellular processes during the fast replication of malaria parasites in our red blood cells. Verhoef's images provide
Julie Verhoef, Taco Kooij and colleagues (Radboudumc) used advanced microscopy techniques to visualize cellular processes during the fast replication of malaria parasites in our red blood cells. Verhoef's images provide an unprecedented detailed view of what happens inside this bloodthirsty microscopic killer. https://hubs.ly/Q02WCFmB0
