Nature Medicine

12/03/2024

can help challenge taboos around , amplify underrepresented voices & prioritize women's involvement in health research. Our latest Perspective considers the key challenges & ingredients for success.

12/02/2024

New study in Nature Medicine reveals a novel deep brain stimulation target which improves walking recovery following spinal cord injury in preclinical models and in a first-in-human pilot study.

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after incomplete SCI and that could be targeted to ...

12/02/2024

New study in Nature Medicine reveals a novel deep brain stimulation target which improves walking recovery following spinal cord injury in preclinical models and in a first-in-human pilot study.
https://www.nature.com/articles/s41591-024-03306-xtudy.

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after incomplete SCI and that could be targeted to ...

12/02/2024

Even with new drugs available, interventions targeting lifestyle behaviours remain crucial for preventing & managing cardiometabolic diseases – and should be reinforced by supportive environments & policies.
Review from Joline Beulens et al.

Unhealthy lifestyle behaviors such as poor diets and physical inactivity account for most of the cardiometabolic disease (CMD) burden, including...

11/30/2024

In a cohort of 51,170 South Asian individuals, partitioned polygenic risk scores helped identify genetic susceptibility to insulin deficiency and unfavorable fat distribution as key drivers of young onset T2D diagnosis and faster progression to diabetes-related complications.

South Asians develop type 2 diabetes (T2D) early in life and often with normal body mass index (BMI). However, reasons for this are poorly...

11/29/2024

The spatial single-cell multiomic atlas of the first trimester human placenta at molecular resolution provides a blueprint for future studies on early placental development and pregnancy.

Successful pregnancy relies directly on the placenta’s complex, dynamic, gene-regulatory networks. Disruption of this vast collection of...

11/29/2024

In a mechanistic analysis of the SUMMIT trial that tested tirzepatide in patients with heart failure with preserved ejection fraction and obesity, treatment with this dual GLP-1 receptor and GIP agonist, as compared to placebo, reduced blood pressure and estimated circulatory volume-pressure overload, reduced systemic inflammation, and mitigated cardiovascular and kidney injury.

Patients with obesity-related heart failure with preserved ejection fraction (HFpEF) display circulatory volume expansion and pressure overload...

11/29/2024

A vascular cell atlas integrating single-cell data of 19 organs and tissues from 62 donors identifies angiotypic and organotypic characteristics of endothelial and mural cells.

The human vascular system, comprising endothelial (EC) and mural cells, covers a vast surface area in the body, providing a critical interface...

11/28/2024

⭐Research highlight: Interim results from the GUARDIAN study shows that genomic identifies treatable conditions that would be missed by standard tests.

Interim results from a large, ongoing study shows that genomic newborn screening identifies treatable conditions that would be missed by standard...

11/27/2024

⭐Research highlight: Internet use among adults over 50 years of age correlates with reduced depressive symptoms, increased life satisfaction and improved self-reported health.

According to a large international study, Internet use among adults 50 or more years of age correlates with reduced depressive symptoms, increased...

11/27/2024

⭐Research highlight: A large-scale genomic analysis reveals associations between and specific driver mutations, such as mutations in lung adenocarcinoma.

A large-scale genomic analysis reveals associations between body mass index and certain driver mutations in various cancer types, particularly lung...

11/26/2024

In a cohort of 51,170 South Asian individuals, partitioned polygenic risk scores helped identify genetic susceptibility to insulin deficiency and unfavorable fat distribution as key drivers of young onset T2D diagnosis and faster progression to diabetes-related complications.

South Asians develop type 2 diabetes (T2D) early in life and often with normal body mass index (BMI). However, reasons for this are poorly understood because genetic research is largely focused on European ancestry groups. We used recently derived multi-ancestry partitioned polygenic scores (pPSs) t...

11/25/2024

Are GLP-1 drugs really for everybody?
As evidence for their benefits beyond diabetes and obesity accumulates, it becomes critical to understand how genetic, clinical and sociodemographic differences impact their effects on weight loss.
Read our latest editorial here: https://www.nature.com/articles/s41591-024-03382-z

11/25/2024

can help challenge taboos around women's health, amplify underrepresented voices & prioritize women's involvement in health research. Our latest Perspective considers the key challenges & ingredients for success.

Women’s health research is receiving increasing attention globally, but considerable knowledge gaps remain. Across many fields of research, active...

11/22/2024

By generating synthetic image samples specific to underrepresented groups, diffusion models help medical image classifiers to achieve greater fairness metrics across a variety of medical disciplines and demographic attributes.

Automated radiology report generation has the potential to improve patient care and reduce the workload of radiologists. However, the path toward...

11/22/2024

⭐Research highlight: Post-war rationing in the UK in 1953 facilitated a natural experiment that now reveals that restricting sugar intake in early life reduces the risk of and .

Post-war rationing in the UK in 1953 facilitated a natural experiment that now reveals that restricting sugar intake in early life reduces the risk...

11/22/2024

A single-cell study integrating data from lung tissues from patients with fatal Covid 19 from Malawi, US and Europe identifies shared and distinct immune and inflammatory mechanisms of response

Postmortem single-cell studies have transformed understanding of lower respiratory tract diseases (LRTDs), including coronavirus disease 2019...

11/22/2024

In the dose escalation phase of the ongoing LIBRA4 trial, patients with relapsed/refractory peripheral T cell lymphoma were treated with TRBC1-targeted CAR T cell therapy, showing limited toxicity and promising early clinical responses.

Relapsed/refractory peripheral T cell lymphomas (PTCLs) are aggressive tumors with a poor prognosis. Unlike B cell lymphomas, treatment of PTCL has...