Nature Medicine

01/14/2025

A cohort study of over 15k U.S. adults found that 42% developed dementia by age 95, with the highest risk in APOE 𝜀4 carriers, women, and Black adults, and projected that around 1 million U.S. adults will develop dementia annually by 2060.

Understanding the lifetime risk of dementia can inform public health planning and improve patient engagement in prevention. Using data from a...

01/14/2025

An individual-based mathematical model to evaluate the public health benefits of RSVpreF vaccination uncovered that vaccinating older adults and pregnant women can substantially reduce RSV-related hospitalizations and deaths, averting significant inpatient costs with the impact varying across countries and influenced by both uptake rates and the local epidemiological characteristics of RSV seasons.

Respiratory syncytial virus (RSV) causes a substantial health burden among infants and older adults. Prefusion F protein-based vaccines have shown...

01/14/2025

National modelling estimates reported that 3 million children experience orphanhood and caregiver loss in the United States with drug overdose surpassing as the leading cause of parental death by 2021.

Deaths of parents and grandparent caregivers threaten child well-being owing to losses of care, financial support, safety and family stability, but...

01/14/2025

An individual with multidrug-resistant HIV and Kaposi sarcoma achieved viral sustained suppression after treatment with an anti-domain 1 CD4 antibody and the injectable long-acting capsid inhibitor, lenacapvir.

The clinical management of people with multidrug-resistant (MDR) human immunodeficiency virus (HIV) remains challenging despite continued...

01/14/2025

CANAIRI: the Collaboration for Translational Artificial Intelligence Trials in healthcare.

Correspondence from Melissa D. McCradden and colleagues

01/13/2025

How citizen scientists and community engagement boost the impact of health research.

Q&A with the winners of the Inclusive Health Research Awards and Kelsey Chapman.

With the Declaration of Helsinki now mandating community engagement, Nature Medicine asks three winners of the Nature Awards for Inclusive Health...

01/13/2025

Can quantum computing crack the biggest challenges in health?

News feature by

Quantum computing can model molecular interactions for drug discovery and analyze complex health datasets, but better hardware is needed.

01/13/2025

Resurgence of malaria and artemisinin resistance in Africa requires a concerted response.

Correspondence from and colleagues

https://www.nature.com/articles/s41591-024-03439-z

01/13/2025

In the second case in which a genetically-modified pig heart was transplanted into a living person, the xenografted heart functioned well initially, but antibody-mediated rejection occurred thereafter, pointing to the need for improved strategies to avoid this complication.

Following our previous experience with cardiac xenotransplantation of a genetically modified porcine heart into a live human, we sought to achieve...

01/13/2025

Using a s*x- and gender-informed lens to enhance care in Parkinson’s disease.

Comment from and colleagues

S*x and gender differences in Parkinson’s disease should be a priority for researchers and clinicians, to ensure appropriate care is provided to...

01/13/2025

The oral drug obeldesivir confers 80% survival when given after lethal Marburg virus exposure in cynomolgus macaques and also delays viral replication and disease onset, suggesting a potential treatment option for an infection with no approved therapies.

The oral drug obeldesivir confers 80% survival when given after lethal Marburg virus exposure in cynomolgus macaques and also delays viral...

01/13/2025

Prioritizing infant mental health: a research-driven pathway for action.

Comment from Anusha Lachman and colleagues

A comprehensive research agenda is needed to identify gaps and actionable steps to prioritize infant and early life mental health care globally.

01/13/2025

Liver transplant is the only available treatment for end-stage liver disease. This study reports the safety and efficacy of autologous monocyte-derived macrophage therapy for liver cirrhosis in a phase 2 randomized controlled clinical trial

Cirrhosis is a major cause of morbidity and mortality; however, there are no approved therapies except orthotopic liver transplantation....

01/13/2025

An ultra-sensitive and specific ctDNA assay provides novel pre-operative disease stratification in early-stage lung adenocarcinoma.

Circulating tumor DNA (ctDNA) detection can predict clinical risk in early-stage tumors. However, clinical applications are constrained by the sensitivity of clinically validated ctDNA detection approaches. NeXT Personal is a whole-genome-based, tumor-informed platform that has been analytically val...

01/13/2025

RNA gene therapies offer hope for millions with high cholesterol.

Read the latest Clinical Pipeline, by

Base editing, antisense oligonucleotides and siRNA therapies that target low-density lipoprotein and the genes encoding molecules that regulate it are being tested in several clinical trials.

01/13/2025

Gene therapy targets the retina to treat eye disease.

Read the latest Clinical Pipeline, by

Several gene therapies are hoped to cure blindness and other eye diseases.

01/13/2025

Structured programs to train the next generation of clinician scientists.

Comment from Anette Melk and colleagues

Structured programs for training clinician scientists have been implemented in several European countries, but these must include adequate...

01/10/2025

As part of the SWEETSTONE trial, authors report the ability of the SGLT2 inhibitor empagliflozin to reduce the likelihood of kidney stone formation in individuals without diabetes.

Efficacy of sodium-glucose cotransporter 2 inhibitors for kidney stone prevention in nondiabetic patients is unknown. In a double-blind,...