Cafer's Psychopharmacology

10/01/2024

Newly approved next-generation antipsychotic COBENFY is a 9 out of 10 big deal.

Cobenfy, xanomeline + trospium, the next-generation antipsychotic is 9 out of 10 a big deal. Understand in context of all things muscarinic

07/14/2024

"Allergic to Everything but "– AI-produced Medication Mnemonics Song
https://www.cafermed.com/post/allergic-to-everything-but-oxycodone-ai-produced-medication-mnemonics-song

07/10/2024

cafermed.com/blog
clears beta amyloid, but the clinical benefit is small. This implies that simply clearing amyloid may not be the solution, or that any potential benefits are offset by neurotoxicity, evidenced by accelerated brain volume decline.

07/08/2024

New medication: - monoclonal antibody targeting pyroglutamate-modified amyloid beta, approved for
❖ Mild cognitive impairment with evidence (PET scan) of amyloid beta pathology
❖ Mild Alzheimer’s dementia
Mascot: “Kissin’ LaDonna, maybe”

05/31/2024

New formulation of approved for

A third formulation of the alpha-2 agonist clonidine will soon be available as an ER suspension, branded ONYDA XR. The other 2 are available as generic tabs: IR Catapres and ER Kapvay.

05/28/2024

Medication mascot, interaction avatar, and ballicule for famotidine. This humble acid blocker may improve symptoms of schizophrenia.

05/27/2024

Dr Cafer Interview, sneak peak at Cafer's Psychopharmacology 2nd Edition

Sneak peak of Cafer's Psychopharmacology 2nd Edition: Medication Mascots, Avatars, and Ballicules (2025)

05/26/2024

The herbal supplement R. rosea is an adaptogen with some evidence for generalized anxiety. It's a 4th line option on Osser's GAD algorithm.

05/25/2024

Mouthwash kills bacteria that produce nitric oxide (NO), resulting in adverse HTN and ED. NO has been implicated in many psych conditions.

05/24/2024

Fluoxetine ↑ amitriptyline x2 and nortriptyline metabolite x9. The danger is arrhythmia. 5-HT toxicity Sx would not be life threatening.

05/24/2024

Arachidonic acid (AA), an omega-6 PUFA, may be deficient in bipolar disorder. Bipolar risk is strongly linked to AA-related genes. Lithium ↑

05/22/2024

1-hr of inhaled nitrous oxide is efficacious for depression within 2 hr. NO2 is an NMDA receptor antagonist like (es)ketamine.

05/21/2024

Clozapine's efficacy is from mechanisms other than D2 blocking, e.g., NMDA receptor agonism. The nororcloz metabolite causes salivation.

05/21/2024

Guide to QT-prolonging medication

Among the commonly prescribed antipsychotics, 3 have moderate risk of QT prolongation: haloperidol, quetiapine, and ziprasidone (24 mascots)

05/08/2024

New mascot for

04/25/2024

Blog post on pharmacology of

The closest prescribable comparison to MG may be the atypical opioid tramadol (Ultram). Tramadol is a weak opioid receptor agonist and SNRI.

04/16/2024

Upgraded medication mascots for risperidone/paliperidone and aripiprazole products, with conversion tables for the LAIs.

Equivalent Dose and Drug Conversions: How to convert between doses of risperidone, paliperidone, Uzedy, Perseris, Invega Sustenna, Trinza

04/14/2024

Blog post with mascot for the newest LAI, Risvan.

No oral overlap is needed. No loading dose required. Minimal pain and low incidence of injection site reactions.