Cafer's Psychopharmacology

07/14/2024

"Allergic to Everything but "– AI-produced Medication Mnemonics Song
https://www.cafermed.com/post/allergic-to-everything-but-oxycodone-ai-produced-medication-mnemonics-song

07/10/2024

cafermed.com/blog
clears beta amyloid, but the clinical benefit is small. This implies that simply clearing amyloid may not be the solution, or that any potential benefits are offset by neurotoxicity, evidenced by accelerated brain volume decline.

07/08/2024

New medication: - monoclonal antibody targeting pyroglutamate-modified amyloid beta, approved for
❖ Mild cognitive impairment with evidence (PET scan) of amyloid beta pathology
❖ Mild Alzheimer’s dementia
Mascot: “Kissin’ LaDonna, maybe”

05/31/2024

New formulation of approved for

A third formulation of the alpha-2 agonist clonidine will soon be available as an ER suspension, branded ONYDA XR. The other 2 are available as generic tabs: IR Catapres and ER Kapvay.

05/28/2024

Medication mascot, interaction avatar, and ballicule for famotidine. This humble acid blocker may improve symptoms of schizophrenia.

05/27/2024

Dr Cafer Interview, sneak peak at Cafer's Psychopharmacology 2nd Edition

Sneak peak of Cafer's Psychopharmacology 2nd Edition: Medication Mascots, Avatars, and Ballicules (2025)

05/26/2024

The herbal supplement R. rosea is an adaptogen with some evidence for generalized anxiety. It's a 4th line option on Osser's GAD algorithm.

05/25/2024

Mouthwash kills bacteria that produce nitric oxide (NO), resulting in adverse HTN and ED. NO has been implicated in many psych conditions.

05/24/2024

Fluoxetine ↑ amitriptyline x2 and nortriptyline metabolite x9. The danger is arrhythmia. 5-HT toxicity Sx would not be life threatening.

05/24/2024

Arachidonic acid (AA), an omega-6 PUFA, may be deficient in bipolar disorder. Bipolar risk is strongly linked to AA-related genes. Lithium ↑

05/22/2024

1-hr of inhaled nitrous oxide is efficacious for depression within 2 hr. NO2 is an NMDA receptor antagonist like (es)ketamine.

05/21/2024

Clozapine's efficacy is from mechanisms other than D2 blocking, e.g., NMDA receptor agonism. The nororcloz metabolite causes salivation.

05/21/2024

Guide to QT-prolonging medication

Among the commonly prescribed antipsychotics, 3 have moderate risk of QT prolongation: haloperidol, quetiapine, and ziprasidone (24 mascots)

05/08/2024

New mascot for

04/25/2024

Blog post on pharmacology of

The closest prescribable comparison to MG may be the atypical opioid tramadol (Ultram). Tramadol is a weak opioid receptor agonist and SNRI.

04/16/2024

Upgraded medication mascots for risperidone/paliperidone and aripiprazole products, with conversion tables for the LAIs.

Equivalent Dose and Drug Conversions: How to convert between doses of risperidone, paliperidone, Uzedy, Perseris, Invega Sustenna, Trinza

04/14/2024

Blog post with mascot for the newest LAI, Risvan.

No oral overlap is needed. No loading dose required. Minimal pain and low incidence of injection site reactions.

03/09/2024

New blog post on

Phenibut (β-phenyl-GABA) Nickname / Mnemonic phrase: “bacloFEN-a-butt is a GABApentinoid” Pronunciation: Fin i but Street nicknames: pbut, party powder Voltage-gated calcium channel blocker (like gabapentin and pregabalin) GABA-B agonist (like baclofen) Rx drug in Russia, used for treatment of ...

01/18/2024

This is interesting.

Novel adjunctive treatment for chronic pain, not yet evaluated by the FDA.

01/01/2024

New blog post

Mascot for Relexxii and the other methylphenidate products

11/11/2023

https://www.cafermed.com/post/tirzepatide-zepbound

10/23/2023

How to understand and remember 5-HT1a serotonin receptors
https://www.cafermed.com/post/5-ht1a

10/13/2023

Mascot and interaction avatars for pitolisant (Wakix), now approved for idiopathic hypersomnia. https://www.cafermed.com/post/pitolisant

10/02/2023

Let's compare the new antidepressant gepirone (Exxua) to its structural analogue, buspirone

Comparison of gepirone (Exxua) and Buspirone (Buspar) with mnemonic mascots and ballicules explaining mechanism of action - psychopharm book

09/04/2023

https://www.cafermed.com/post/memantine-namenda-looks-like-a-ballcap-with-wings

Am I right?

08/29/2023

Cariprazine (VRAYLAR) is a CYP3A4 substrate (fish)

cafermed.com/cyp3a4

08/28/2023

Pimavanserin (Nuplazid) is a CYP3A4 substrate (fish) cafermed.com/cyp3a4

08/27/2023

Quetiapine (Seroquel) is a CYP3A4 substrate (fish)
cafermed.com/cyp3a4

08/27/2023

The interaction of the week is lamotrigine + valproate (VPA)

VPA doubles serum levels of lamotrigine by inHibiting UGT enzymes. Also, valproate (VPA) may increase risk of lamotrigine-induced Stevens Johnson Syndrome (SJS) by a different mechanism. VPA can inhibit epoxide hydrolase enzymes and/or depletion of glutathione levels leading to SJS (Vazquez et al, 2...

08/26/2023

Mascot for donepezil (Aricept) https://www.cafermed.com/post/donepezil-aricept-mnemonics

Medical mnemonics for donepezil (Aricept) including drug-drug interactions