JAMA Internal Medicine

04/29/2025

Initiating SGLT2 inhibitors in individuals with diabetes, heart failure, or chronic kidney disease who were taking renin-angiotensin-aldosterone system inhibitors (RAASi) was associated with a lower risk of hyperkalemia.

This cohort study evaluates the association between sodium-glucose cotransporter 2 inhibitors and hyperkalemia in individuals with diabetes, heart failure, or chronic kidney disease receiving renin-angiotensin-aldosterone system inhibitors.

04/28/2025

A pharmacist-led transition of care program reduced emergency department visits and hospitalizations for the same medication-related events at 6 months compared to usual care.

This randomized clinical trial assesses the efficacy of a pharmacist-led transition of care program in reducing emergency department visits related to the same medication-related event at 6 months compared with usual care.

04/27/2025

Most viewed in the last 7 days from JAMA Internal Medicine: Approximately 103,000 future cancers are projected to result from the 93 million CT examinations performed in the US in 2023, according to this study.

https://ja.ma/4iAvcRU

04/27/2025

This Guide to Statistics and Methods discusses target trial emulation, including why to use it, limitations of the method, and how to interpret target trial emulation findings.

This Guide to Statistics and Methods discusses target trial emulation, including why to use it, limitations of the method, and how to interpret target trial emulation findings.

04/27/2025

Applications are being accepted for the JAMA Internal Medicine Editorial Teachable Moment Editorial Fellowship Program.

🗣 Who? Chief Residents in an accredited Internal Medicine Training program in the US or Canada.

📅 When? Four fellows will be selected for the 2025-2026 academic year, each for a 6-month rotation with 2 fellows serving concurrently.

📖 What? Fellows will work with the editors of the JAMA Internal Medicine Teachable Moment series to solicit, review, edit, and publish manuscripts intended to promote appropriate use of medical care.

Apply by May 16: https://ja.ma/3E5sHJ1

04/26/2025

This cohort study found that large atherosclerotic cardiovascular disease RCTs often use heterogeneous primary end points that are frequently changed from trial initiation to publication.

This cohort study examines heterogeneity in primary end points reported by randomized clinical trials of atherosclerotic cardiovascular disease published in prominent medical journals.

04/26/2025

Most viewed in the last 7 days from JAMA Internal Medicine: Approximately 103,000 future cancers are projected to result from the 93 million CT examinations performed in the US in 2023, according to this study.

https://ja.ma/42Davys

04/25/2025

Implementation of the 2019 Medicare opioid safety policy was associated with shorter duration of initial opioid fills and fewer concurrent multiple prescriber high-dosage episodes among beneficiaries with disabilities.

This interrupted time-series cohort study examines the association of the 2019 Medicare opioid safety edits with changes in opioid use among beneficiaries with disabilities.

04/24/2025

Extreme heat increases the risk of hospitalization for older adults with Alzheimer disease and related dementias (ADRD).

This cohort study evaluates the association between extreme heat and the risk of hospitalization with Alzheimer disease and related dementias in the US.

04/23/2025

Applications for the 2025-2026 academic year Internal Medicine Teachable Moment Editorial Fellowship Program are open.

Chief residents with interest in high value care and medical education or research are encouraged to apply. https://ja.ma/4jbXlzb

04/23/2025

SGLT-2 inhibitors and GLP-1 receptor agonists are linked to a lower risk of COPD exacerbations compared to DPP-4 inhibitors in patients with type 2 diabetes and COPD.

This comparative effectiveness research study examines the outcomes of treatment with sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists, or dipeptidyl peptidase-4 inhibitors for patients with type 2 diabetes and chronic obstructive pulmonary disease.

04/22/2025

Cytisinicline improved smoking cessation rates and reduced ni****ne cravings compared to placebo, demonstrating efficacy and tolerability over 6 and 12 weeks, with benefits extending up to 24 weeks.

This phase 3 replication randomized clinical trial reassesses the efficacy and tolerability of cytisinicline for smoking cessation and reducing ni****ne craving.

04/21/2025

Daily oral and monthly injectable naltrexone given to hospitalized patients with alcohol use disorder did not differ in effectiveness for reducing heavy drinking days.

This randomized clinical trial compares the effectiveness of initiating oral naltrexone vs extended-release injectable naltrexone on reduction in alcohol use and health care utilization among medical inpatients with alcohol use disorder.

04/20/2025

This Teachable Moment describes an 87-year-old man who underwent fatal complications from the use of benzocaine spray for nasopharyngeal anesthesia before the insertion of a nasogastric tube.

This Teachable Moment describes an 87-year-old man who underwent fatal complications from the use of benzocaine spray for nasopharyngeal anesthesia before the insertion of a nasogastric tube.