
02/18/2025
THIS VICTORIAN-ERA PREDECESSOR TO ADVIL/PEPTO WAS LEADING TO DEATHS AND AMERICANS ARE STILL INGESTING ONE OF THE INGREDIENTS IN OUR FOOD IN 2025?!?! (READ ON TO FIND OUT) (Long but honestly way wilder/more scandalous than I would have ever thought and took me hours to research and put this together haha)
When compared to other Victorian medicines of the time, Hick's Capudine was actually NOT "snake oil" but it was still VERY dangerous and actually responsible for deaths. It was promoted to cure headaches, colds, la grippe, neuralgia, sick headache, nervous headache, hangover headache, acidity, flatulency, indigestion and pains. It contained Salicylates: a group of drugs that includes Aspirin and salicylic acid (which is still used in Pepto-Bismol). It also contained caffeine... so it was actually effective!
BUT... it also contained these 2 ingredients (Antipyrine, Bromide), which have been largely discontinued in medicines due to the potential for VERY SERIOUS SIDE EFFECTS and until 2024 the latter was STILL ALLOWED IN USA FOOD AND IS ONLY BEING PHASED OUT AUGUST THIS YEAR 🤦🏼♂️ :
Antipyrine (analgesic and antipyretic):
According to Synapse by Petsnap, "is effective for pain and inflammation, [but] it is not without potential side effects. Local irritation, allergic reactions, gastrointestinal disturbances, central nervous system impacts, blood disorders, and liver dysfunction represent the spectrum of possible adverse effects." The NIH notes that it is non-narcotic but also an "enviornmental contaminant", and historical documents from the time Capudine was popular described it as having fatal consequences due to its "heart depressing" effects.
Bromide (an anticonvulsent):
According to the CDC it was "historically used in medicine as a sedative and is naturally found in the earth's crust and seawater".. and is a "bromine" that can cause Bromism: "once a very common disorder, being responsible for 5 to 10% of psychiatric hospital admissions" (CDC) Also, bromine is chemically added to vegetable oil, making Brominated Vegetable Oil" (BVO), and despite being banned in multiple countries for decades and all of EU in 2008 is only being phased out of American food now. "The final rule banning BVO took effect August 2, 2024, and beverage companies have one year to reformulate their products to comply with the final rule... One case reported that a man who consumed two to four liters of a soda containing BVO on a daily basis experienced memory loss, tremors, fatigue, loss of muscle coordination, headache, and ptosis of the right eyelid, as well as elevated serum chloride." (Wikipedia: Brominated Vegetable Oil)
Baffles me how behind the USA STILL is sometimes on the chemical things they put in our food. But here's where early 1900s corporate America put profit over people. 😢 (Weird how some themes seem to be timeless). They purposefully ran ads that hid one of its dangerous ingredients by marketing that their product didn't contain a completely other drug. Here's the background and how:
From the September 15, 1908 edition of the "Atlanta Constitution":
"FUNERAL OF MRS WINBURN
Her Death Was Due to Overdose of Capudine
The sudden death of Mrs. Joe Winburn at Mansfield yesterday, was due to an overdose of capudine for periodic headaches. She was the wife of Rev. Joe Winburn, Baptist pastor at Mansfield, and leaves five small children. the oldest being 9.
One month later the American Medical Association published in their journal, "This puts the nostrum in the dangerous class of “patent medicines,” increasingly common of late, in which a heart depressing drug is present but one, unfortunately, which the Food and Drug Act does not require to be specifically named on the label." This heart depressing hidden drug it mentions was Antipyrine.
The Hick's company at this point did something really shady. "In response, the Capudine Chemical Company dug in, running advertisements promoting the fact that Capudine did not contain Acetanilid with no mention of the fact that it did contain its cousin and equally dangerous heart depressant, antipyrine. One such advertisement appeared in the December, 1919 edition of “The American Druggist.”" (baybottles.com) (Picture included in post)
Despite how shady this was, at the end of the day, as James Little of Hatch, Little & Bunn (the present day law firm who owned the inventor's home for their law office) says , this drug was a "predecessor to the over the counter pain and fever relievers of today." (James Little, "Drug Crimes. 2017.) And in this way it serves as an important step in our evolution in modern medicine and in finding effective and safe medicines.
In-depth history and images not of my bottle: https://baybottles.com/tag/henry-t-hicks-company/
https://synapse.patsnap.com/article/what-are-the-side-effects-of-antipyrine
https://www.cdc.gov/chemical-emergencies/chemical-fact-sheets/bromine.html
https://pubchem.ncbi.nlm.nih.gov/compound/Antipyrine
https://en.m.wikipedia.org/wiki/Brominated_vegetable_oil