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American Registry of Pathology Press

Publisher of the AFIP/ARP fascicles
(17)

08/17/2024

From arppress.org/books/book/47:
Spiradenoma is a benign sweat gland tumor with ductal differentiation that typically occurs within the dermis/superficial subcutis. Admixed lymphocytes and aggregates of thickened basement membrane material are typically present.

08/14/2024

More about hidradenoma (arppress.org/books/book/47):
Morphology can be variable; tumor cells are round to polygonal, containing abundant clear cytoplasm with small eccentric nuclei (clear cell hidradenoma) or brightly eosinophilic to oncocytic cytoplasm.

08/12/2024

More from the nonmelanocytic skin tumor fascicle (arppress.org/books/book/47):
Hidradenomas are benign nodular dermal-based sweat gland tumors (most commonly seen on the extremities and the head and neck area of middle-aged adults), and frequently have CRTC1::MAML2.

08/05/2024

Continuing with our nonmelanocytic skin tumor fascicle:
Pilomatricomas are benign tumors with matrical differentiation, most frequently seen in children. Tumors consist of basaloid cells that mature toward the center of lobules and transition to "ghost" cells.

07/29/2024

A good one for the PGY1s out there!
Trichilemmal (pilar) cyst frequently occurs in the scalp of adults and shows outer root sheath/trichilemmal differentiation. The lining lacks a granular cell layer and has an abrupt transition to dense, eosinophilic, pilar keratin.

07/25/2024

More from the nonmelanocytic skin tumor fascicle (arppress.org/books/book/47):
Spindle cell/pleomorphic lipoma often occurs in the subcutis of the upper back of older men, but the dermal variant has a broader anatomic distribution and no gender predilection.

07/18/2024

More from the nonmelanocytic skin tumor fascicle (arppress.org/books/book/47):
Sebaceous hyperplasia, commonly seen on sun-exposed skin of the face, consists of multiple well-formed lobules draining into one common duct, and is frequently associated with a hair follicle.

07/13/2024

More from the non-melanocytic skin tumor fascicle (arppress.org/books/book/47):
Syringomas are small, benign sweat duct neoplasms with a strong predilection for the eyelids, and present as circumscribed tumors in the upper and mid-dermis. Ducts have a “tadpole” appearance

07/08/2024

In July, we're revisiting our series 5 fascicle "Nonmelanocytic Tumors of the Skin" (arppress.org/books/book/47):
Clear cell acanthoma is a sharply demarcated intraepidermal squamous proliferation with pale cytoplasm, typically affecting the lower extremities of adults.

06/28/2024

From arppress.org/books/book/45:
Collecting duct carcinoma is a rare and aggressive renal carcinoma. They often resemble a mixture of both adenocarcinoma and urothelial carcinoma, and a "hobnail" appearance is a useful feature (real hobnails included in the last image)

06/25/2024

Primary sarcomas of the bladder are rare and can include rhabdomyosarcoma, leiomyosarcoma, and angiosarcoma (AS). AS in particular is associated with a history of radiation; they share morphology and immunophenotype with AS of others sites, and have a poor prognosis.

06/22/2024

From the kidney/bladder fascicle (arppress.org/books/book/45):
Primary condyloma acuminatum of the urinary bladder is exceedingly rare (but it happens!). Viral DNA of HPV subtypes 6 and 11, but not 16 and 18, have been demonstrated in these rare lesions.

06/20/2024

From the kidney/bladder fascicle:
Nephrogenic adenoma, an AMACR-positive (C) proliferation of renal tubular epithelial cells, can occur throughout the urinary tract and is associated with chronic irritation. These can recur, and recurrence does not indicate malignancy.

06/17/2024

More from the bladder/kidney fascicle (arppress.org/books/book/45):
Primary adenocarcinoma of the upper urinary tract is rare. A papillary architecture and resemblance to mucinous adenocarcinoma of the colon are common; metastatic origin must be excluded clinically.

06/07/2024

From arppress.org/books/book/45:
Some normal anatomy/histology - Cowper glands (bulbourethral glands) are a pair of exocrine glands that empty into the bulbous urethra, and are composed of voluminous mucous glands with a lobular arrangement.

06/05/2024

From the bladder/kidney fascicle:
Clear cell sarcoma of the kidney (separate from clear cell sarcoma of soft tissue) is a rare pediatric tumor with variable morphology, but often has nests of undifferentiated cells separated by arborizing fibrovascular septa.

05/30/2024

More the the bladder/kidney fascicle (arppress.org/books/book/45):
Nephroblastoma (Wilms tumor) is a malignant embryonal neoplasm and the most common pediatric renal neoplasm, classically composed of blastemal, stromal, and epithelial elements.

05/22/2024

More from the kidney/bladder tumor fascicle (arppress.org/books/book/45):
Paragangliomas of the bladder (

05/16/2024

More from the kidney/bladder fascicle (arppress.org/books/book/45):
Renal mucinous tubular and spindle cell carcinoma is composed of cuboidal cells in tubule-like structures and spindle cells that grow in sheets with stroma containing basophilic mucin.

05/13/2024

More on renal oncocytomas from the GU tumor fascicle (arppress.org/books/book/45):
The predominant pattern is sheets of tumors cells (with moderate to abundant, intensely finely granular eosinophilic cytoplasm) divided into groups by small blood vessels.

05/07/2024

In June, we're revisiting the series 5 "Tumors of the Kidney, Bladder, and Related Urinary Structures" fascicle (arppress.org/books/book/45):
Renal oncocytomas are variably sized, often well-circumscribed, have a classic brown/"mahogany" color, and can have a central scar.

04/30/2024

To wrap up our posts from the melanocytic tumor fascicle (arppress.org/books/book/64):
Melanoma metastases to the skin are often circumscribed and most often situated in the dermis and/or subcutis (1st image), but can be superficial and colonize the epidermis (2nd image).

04/24/2024

From arppress.org/books/book/64:
"Nodular melanoma" can represent either 1) a primary dermal invasive melanoma without associated in situ melanoma; or 2) a primary invasive melanoma accompanied by in situ melanoma that does not extend beyond the invasive tumor.

04/18/2024

Combined melanocytic nevi display 2+ nevus phenotypes within the same clinical lesion. Examples include combined deep penetrating nevus in which a wedge-shaped growth of pigmented spindle and epithelioid melanocytes is juxtaposed to a conventional nevus remnant.

04/16/2024

From the melanocytic fascicle (arppress.org/books/book/64):
Superficial spreading melanoma usually occurs in intermittently sun-exposed skin with an intraepidermal growth pattern with junctional nests and individual melanocytes in a pagetoid and/or lentiginous pattern.

04/10/2024

More on pigmented epithelioid melanocytoma (PEM) from the melanocytic fascicle (arppress.org/books/book/64):
By IHC, PEMs express S-100, HMB-45, Melan-A, and SOX10, and some show loss of PRKAR1A (C) or express BRAFV600E, related to underlying molecular alterations.

04/05/2024

More from the melanocytic tumor fascicle (arppress.org/books/book/64):
Pigmented epithelioid melanocytoma (PEM) is a heavily pigmented melanocytic tumor composed of large epithelioid melanocytes admixed with macrophages, and is most common in children/young adults.

03/22/2024

Acral melanoma happens in a broad age range but mean age at diagnosis is between 60-70. Most occur in the foot with the heel being the most common. When subungual, it predominantly affects the great toe (or thumb if in the hand).

03/20/2024

More from the melanocytic tumor fascicle (arppress.org/books/book/64):
Lentigo maligna melanoma (LMM) is a variant of melanoma that occurs on chronically sun-damaged skin, and is characterized by a junctional proliferation of predominantly solitary units of melanocytes.

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