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Advances in Clinical and Experimental Medicine

Strona główna
Polska
Wroclaw
Advances in Clinical and Experimental Medicine

5-Year IF 2.0, IF 1.9, JCI (2024) 0.43, Scopus CiteScore 4.3, H-index 49 (SJR)
Initial editorial assessment and first decision within 24 h

30/11/2025

NEW REQUIREMENTS CONCERNING FIGURES IN ADV CLIN EXP MED

We implemented new requirements regarding figures – they stem from stipulations issued by databases and digital archives in which our journal is indexed.

We accept up to 10 figures (2 figures in Research letters). Overtly complex figures will be divided into smaller ones and the number of figures will be counted again. A single figure can have no more than 6 panels (A–F). One panel means one chart – multiple small charts cannot form one panel.

All elements of each figure must be legible when viewed on an A4 page in a PDF file in full-screen mode, without zooming. Overtly complex figures with multiple charts/graphs combined into one panel cannot fulfill this requirement. Figures of low quality cannot be published, and consequently, papers with low-quality figures will not be published, even if accepted by peer reviewers.

Figures should be placed in separate files, not pasted into the main body of the text. Name your figure files with "Fig" and the figure number, e.g., Fig.1.tiff.

References to Figures should be placed according to the sequence of citing them in the manuscript. The text should include references to all figures.

Each figure should have a concise, self-explanatory caption describing accurately what the figure depicts. Captions for the figures should be placed at the end of the main body of the text. Do not embed the legend in the figure file. When applicable, be sure that both the figure captions and the figures themselves contain corresponding labels for multiple parts. Identify all elements found in the figure in the figure caption; and use boxes, circles, etc., as coordinate points in graphs. If any magnification is used in the photographs, indicate this by using scale bars within the figures themselves. All abbreviations used in a given table/figure should be explained below it or in the caption, even if a given abbreviation has already been explained in the text.

If Authors used in the work any figures, photographs, charts, tables, etc. which are not their work, and are protected by the copyright law, they shall be obliged to provide the Publisher with a written authorization to use such materials issued by the author’s economic rights holders. Identify previously published material by giving the original source in the form of a reference citation at the end of the figure caption.

OUR NEW TECHNICAL REQUIREMENTS:

https://advances.umw.edu.pl/source/Adv%20Clin%20Exp%20Med-figures-technical%20requirements.pdf

29/11/2025

📢Call for submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on

Application of stem cells in human medicine – from basic science research to clinical trials 📢

Medicine in the twenty-first century is closely associated with stem cell research, based on advanced in vitro analyzes, the use of model animals, and their application in clinical trials. Experimental research requires understanding the physiological and morphological properties of stem cells and analyzing their ability to divide and differentiate into other cell types. The best-known stem cells are those derived from bone marrow and umbilical cord blood. However, in recent years, stem cells have been discovered in, for example, adipose tissue and Wharton jelly. Stem cells isolated from these tissues, once properly differentiated, are increasingly used for the treatment of bone and neurodegenerative diseases. In recent years, the number of therapies using stem cells has increased significantly. The ability of stem cells to differentiate makes them an increasingly common therapeutic tool in regenerative and reconstructive medicine.

Key words:

mesenchymal stem cells, embryonic stem cells, iPSCs, cancer stem cells, cell proliferation and differentiation, small extracellular vesicles, exosomes, omics, animal models, preclinical and clinical trials, regenerative medicine, reconstructive medicine

Articles submitted should be related to the topic of stem cells and their use in basic and clinical research. Topics may include:

• molecular research involving advanced genomic methods
• tissue and cell research
• studies on the morphological and physiological properties of stem cells
• studies on the proliferative and multidirectional differentiation capacity of stem cells
• studies on model animals
• use of stem cells in preclinical and clinical research
• therapies with stem cell
• stem cells in regenerative and reconstructive medicine
• stem cells in translational medicine

Review articles describing recent achievements in stem cell medicine, as well as original articles will be accepted.

MORE INFORMATION:

https://advances.umw.edu.pl/en/application-stem

28/11/2025

🚀 Ahead of print 🚀

Comorbidity-related risk factors for acute respiratory distress syndrome in sepsis patients: A systematic review and meta-analysis

➡️Meta-analysis of 16,964 sepsis patients identifies chronic obstructive pulmonary disease (COPD) as a significant risk factor for developing ARDS (OR 1.43).
➡️Common comorbidities—including diabetes, hypertension, coronary artery disease, chronic kidney disease, and cancer—showed no significant association with ARDS risk in sepsis.
➡️Findings highlight the need for targeted monitoring and early intervention in septic patients with pre-existing COPD to prevent ARDS progression.
➡️Results underscore substantial heterogeneity across studies and call for further research to clarify mechanisms linking comorbidities with ARDS in sepsis.

https://advances.umw.edu.pl/en/ahead-of-print/191594/

28/11/2025

🚀Ahead of print🚀

🚀The efficacy of carfilzomib and dexamethason (Kd-70) as once-weekly two-drug regimen: The analysis of real-world data from Poland🚀

Highlights

➡️Real-world Kd-70 regimen matches A.R.R.O.W. trial overall response rate (ORR): Achieved a 67.2% ORR, mirroring pivotal clinical data.
➡️Lower deep-response rates vs A.R.R.O.W Complete responses (CR; 5.3%) and very good partial responses (VGPR; 9.6%) fell below trial benchmarks.
➡️Primary resistance limits early efficacy: Patients progressing within 12 months of diagnosis showed significantly reduced Kd-70 effectiveness.
➡️Prior therapy lines don’t impact Kd-70 success: Efficacy remained consistent regardless of the number of previous treatment regimens.

https://advances.umw.edu.pl/en/ahead-of-print/205167/

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

27/11/2025

🚀Ahead of print🚀

🚀Assessment of physical performance and muscle function in hemodialysis patients participating in an exercise regimen: A cluster-randomized, single-center study🚀

Highlights

➡️A 6-month exercise program – aerobic, ressistance and tai chi – was conducted in a cohort of end-stage renal disease patients with significantly lower levels of physical capacity.
➡️After a 6-month exercise program, limited increase in cardiorespiratory function was observed in the aerobic exercise group.
➡️After a 6-month resistance exercise program, changes in strength and speed parameters, were observed.
➡️Resistance training demonstrates superior functional relevance in a group of dialysis patients.
➡️A long-term rehabilitation program can be succesfully implemented in a group of dialysis patients.

https://advances.umw.edu.pl/en/ahead-of-print/202940/

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

27/11/2025

🚀Ahead of print🚀

Insights into brain oscillations and connectivity in neuropsychiatric disorders

Highlights

• EEG connectivity and oscillatory biomarkers reveal rhythm-specific network dysfunctions across neurological and psychiatric disorders.
• Alpha oscillations provide a unifying framework linking local neural activity with large-scale network coordination via thalamocortical circuits.
• Combining cross-frequency coupling, dynamic connectivity and graph-theoretical analyses enhances understanding of brain network dynamics.
• Multimodal and longitudinal EEG approaches enable precision diagnostics and personalized neuromodulation therapies.

https://advances.umw.edu.pl/en/ahead-of-print/213945/

26/11/2025

📢 New Issue Alert – Advances in Clinical and Experimental Medicine (November 2025)📢

We are pleased to announce that the November 2025 issue of Advances in Clinical and Experimental Medicine has been officially published on our website. This latest edition features high-impact research and novel findings in the field of clinical and experimental medicine, contributing to the advancement of medical science.

🔗 https://advances.umw.edu.pl/en/issue/2025/34/11/

The issue will also be distributed via our mailing list. However, we encourage you to help us maximize its reach by sharing it through professional networks, email lists, and social media. Your support in promoting open-access medical research is greatly appreciated.

📖 Stay informed, stay engaged, and help us advance medical knowledge!

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

25/11/2025

🚀Ahead of print 🚀

Mesoderm/mesenchyme homeobox l as a potential target that orchestrates hepatic stellate cell activation

• Meox1 was identified as a key regulator of hepatic stellate cell activation in liver fibrosis.
• TGF-β1 upregulates Meox1 expression in Lx-2 cells, promoting fibrotic gene expression and HSC activation.
• Meox1 overexpression enhances HSC proliferation, migration, and Smad3 phosphorylation, linking it to the TGF-β1/ Smad pathway.
• Knockdown of Meox1 suppresses HSC activation, reducing α-SMA, collagen-I and MMP-2 expression.
• Meox1 induces cell cycle redistribution and upregulates p21CIP1/WAF1 independently of p53, suggesting a novel regulatory mechanism.

https://advances.umw.edu.pl/en/ahead-of-print/197320/

25/11/2025

📢Meet the author of our latest editorial!📢

Prof. Rafał Matkowski

✔️ READ THE EDITORIAL

Stromal cells as a part of tumor microenvironment of melanoma: Their role in cancer progression and drug resistance

https://advances.umw.edu.pl/en/ahead-of-print/211897/

✔️SHORT BIO

https://ojs.umw.edu.pl/files/acem/Rafal%20Matkowski%20CV%20June%20%2025%20ENG.pdf

✔️MINI-INTERVIEW

1. In your opinion, how well understood is the role of the tumor microenvironment in tumor progression and therapy resistance?

Recent studies identify the environment of cancer cells as one of the contributing factors responsible for disease occurrence. The tumor niche is a complex biological system, unique for every type of cancer. It comprises neighboring cells with their secretome and the extracellular matrix, which fills the space between the cells. Physicochemical properties, such as oxygen saturation, may also influence the tumor microenvironment (TME). The interactions between cancer cells and the individual elements that form the TME have not yet been fully understood. They can significantly promote disease progression and the development of treatment resistance, which makes a thorough understanding of the molecular basis of these interactions crucial.

2. Why melanomas were chosen for your research?

Malignant melanoma comprises only 4% of all diagnosed skin cancer cases; however, it is the cause of 80% of deaths caused by these tumors. Such an immense mortality rate is mainly connected with the high invasiveness and heterogeneity of melanoma, which translates to a limited success rate of therapy directed against advanced melanoma. Despite the development of novel targeted therapies, patients’ response to treatment is often weak or short-term due to the rapid acquisition of drug resistance. The tumor microenvironment (TME) may play a significant role in melanoma's progression and resistance to treatment. This is the reason why we decided to focus our research on the interactions between melanoma cells and cells present in its tumor niche.

3. Is it possible that keratinocytes, which play a protective role toward melanocytes in healthy skin, “switch roles” (so to say) when a melanoma develops and become a destructive element in patient’s body?

Keratinocytes change their role in the microenvironment as cancer progresses. Initially, they serve a protective function and later support tumor growth. In physiological conditions, keratinocytes control the proliferation of melanocytes through direct interactions or in a paracrine manner. Moreover, under UV radiation, keratinocytes induce DNA damage repair pathways in pigmented cells, thus protecting melanocytes from transforming into melanoma. During melanoma development, melanocytes escape from the control of keratinocytes. Consequently, melanocytes start to form connections with, e.g., fibroblasts. Moreover, keratinocytes under the influence of melanoma change cytokeratin (CK) expression profiles. They exhibit downregulation of CK10, which is highly expressed in suprabasal keratinocytes that undergo cornification. Simultaneously, they exhibit upregulation of CK14, which, in turn, is characteristic of rapidly proliferating basal keratinocytes. Moreover, melanoma leads to the increased proteolytic activity of keratinocytes and the secretion of higher amounts of galectin 3 by these cells. The increased proteolytic activity of cancer-associated keratinocytes and secretion of galectin 3 might support cancer progression

24/11/2025

🚀Ahead of print 🚀

Peptide pool instability of precancerous lesions in rats with chronic pancreatitis model and/or without type 1 diabetes mellitus

Highlights

➡️Chronic pancreatitis and diabetes-induced metabolic disruption significantly altered pancreatic and plasma peptide pools, correlating with early PanIN precancerous lesions.
➡️Rats with combined chronic pancreatitis and type 1 diabetes showed more advanced PanIN grades and greater reductions in pancreatic protein and peptide levels.
➡️Peptide profiling revealed distinct qualitative and quantitative shifts, including increased high-molecular-weight peptides (>700 Da) in both plasma and pancreatic tissue of pathological groups.
➡️Peptide pool instability in blood and pancreas may serve as a sensitive, minimally invasive early biomarker of pancreatic cancer development.

https://advances.umw.edu.pl/en/ahead-of-print/193243/

24/11/2025

🚀Ahead of print🚀

From consensus to action: Implementing cardiovascular prevention guidelines in primary healthcare

Highlights

• Cardiovascular prevention guidelines remain under-implemented in primary care due to systemic barriers and workload challenges.
• The 2025 European consensus calls for multidisciplinary teamwork and equity-driven approaches in prevention strategies.
• Digital health tools and context-specific adaptation are essential for improving cardiovascular risk management.
• Closing the evidence–practice gap can enhance population-level cardiovascular outcomes across healthcare systems.

https://advances.umw.edu.pl/en/ahead-of-print/213742/

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

23/11/2025

📢¡Únete al movimiento para avanzar en la salud mental y el bienestar!📢

Advances in Clinical and Experimental Medicine te invita a enviar tu investigación y artículos de vanguardia en el campo de la salud mental y el bienestar. Buscamos contribuciones innovadoras que amplíen los límites de la comprensión, el tratamiento y la promoción del bienestar mental.

Editores a cargo

Prof. Dr. Raúl Juárez-Vela (Grupo de Investigación en Cuidados (GRUPAC), Facultad de Ciencias de la Salud, Universidad de La Rioja, Logroño, España; ORCID 0000-0003-3597-2048) [email protected]

Los temas de interés incluyen, pero no se limitan a:

- Intervenciones terapéuticas innovadoras
- Estrategias para la prevención y promoción del bienestar mental
- Impacto de la salud mental en la calidad de vida
- Nuevos enfoques en el tratamiento de trastornos mentales
- Estudios sobre la relación entre la salud mental y las enfermedades físicas

¿Por qué publicar con nosotros?

- Visibilidad global: Alcanza una amplia audiencia internacional con tu trabajo.
- Revisión rigurosa: Benefíciate de nuestro proceso de revisión por pares de alta calidad.
- Impacto académico: Haz una contribución significativa a un campo vital y dinámico.

Proceso de envío

Como primer paso, solicitamos el envío de una Expresión de Interés con un resumen de artículos originales que aborden los temas mencionados al Editor de Sección de Adv Clin Exp Med: [email protected]

El Editor de Sección, junto con el Editor en Jefe, revisará todas las presentaciones y seleccionará aquellas que serán invitadas a enviar un artículo completo. El proceso de envío seguirá el proceso en línea regular de Adv Clin Exp Med. Todos los manuscritos serán enviados a al menos dos revisores independientes.

Fechas y tarifas

- Envío de la Expresión de Interés hasta el 31 de diciembre de 2025 a [email protected]
- Invitación para enviar un artículo completo antes del 31 de enero de 2026;
- Envío del artículo completo antes del 31 de marzo de 2026.

Si se acepta, los autores deberán pagar una tarifa (https://advances.umw.edu.pl/en/article-processing-charges/) para cubrir los costos de publicación;

Para autores seleccionados (expertos destacados), es posible reducir o incluso cancelar la tarifa de publicación.

Envía tu manuscrito hoy y únete a la conversación global sobre el mejoramiento de la salud mental y el bienestar. Para más detalles sobre el proceso de envío, visita nuestro sitio web.

¡Esperamos con ansias tus valiosas contribuciones!

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Wroclaw
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