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Advances in Clinical and Experimental Medicine, Karola Marcinkowskiego 2-6, Wroclaw (2025)

21/11/2025

🚀Ahead of print🚀

🚀Enhancing Castor stent graft placement: A novel approach using direction-turnover and unwrapping techniques🚀

Discover the groundbreaking Castor single-branch stent graft for treating aortic arch lesions involving the left subclavian artery. This study showcases the effectiveness of innovative procedural methods, such as direction-turnover and unwrapping techniques, which enhance stent graft placement precision while minimizing guidewire entanglement.

Promising outcomes include exceptional safety and efficacy, with zero complications—no stent migration or endoleaks—reported during the procedure. Postoperative imaging further confirms the long-term stability and minimal complications of the stent placement over a 12-month follow-up. These advancements represent significant improvements in clinical outcomes for complex aortic arch interventions.

https://advances.umw.edu.pl/en/ahead-of-print/197313/

21/11/2025

📢1st Rare Disease Congress – Rare Diseases for Pediatricians and Family Physicians📢

We cordially invite you to participate in the 1st Rare Disease Congress - Rare Diseases for Pediatricians and Family Physicians, which will take place on November 21–22, 2025, at the Mercure Hotel in Wroclaw.

This is not a motto that has been defined: There is no disease whose incidence is so rare that it does not require our special attention.

Rare diseases pose a challenge to modern medicine, the healthcare system, and society as a whole. Although they are indeed rare, patients with rare diseases are numerous – in Poland, they may affect over 2.5–3 million people.

To date, nearly 8,000 conditions have been described that meet the definition of a rare disease (one person in 2,000 inhabitants). These diseases have a variety of symptoms, a progressive course, and often a poor prognosis. They encompass every field of medicine, so every doctor, nurse, physiotherapist, therapist, or other medical specialist undoubtedly encounters them in their practice. Early diagnosis and initiation of appropriate treatment are crucial.

Rare diseases, like all chronic diseases, require comprehensive and coordinated care. However, in medicine, pediatricians and family medicine physicians are closest to the patient with a rare disease. Therefore, to address the need to systematize and deepen knowledge about rare diseases, we invite you to the two-day First Congress of Rare Diseases, is organized by the Polish Society of Pediatric Endocrinology and Diabetology and the Polish Society of Congenital Metabolism, in cooperation with: the Polish Society of Human Genetics, the Polish Society of Pediatric Neurologists and the Polish Society of Family Medicine. The Congress will be a unique platform for exchanging knowledge, experiences, and the latest advancements in the field. The program includes thematic workshops and panel discussions. We believe that the opportunity for shared debate broadens diagnostic and therapeutic perspectives, building the potential and value of every physician.

This will also be an opportunity for our integration, which often creates new opportunities and opens doors in difficult clinical situations, improving the quality of life of patients suffering from rare diseases.

WE WARMLY INVITE YOU TO WROCLAW

MORE INFORMATION [IN POLISH]:

https://ptmr.info.pl/wydarzenia/i-kongres-chorob-rzadkich/

https://grupamedica.pl/wydarzenia/i-kongres-chorob-rzadkich-choroby-rzadkie-dla-pediatrow-i-lekarzy-rodzinnych-21-22-11-2025-hotel-mercure-wroclaw/

20/11/2025

🚀 Ahead of print🚀

Immune reprogramming of cold tumors using TGF-β/PD-L1 bispecific antibody and armed oncolytic virus therapy

Highlights

➡TGF-β/PD-L1 bispecific antibody (YM101/BiTP) effectively reprograms the tumor microenvironment, overcomes immune exclusion and enhances antitumor immune activation, highlighting its potential for clinical translation in cancer immunotherapy.
➡VG161, a multi-cytokine-armed oncolytic virus, exhibits synergistic effects by activating innate immunity and enhancing antitumor immune responses, providing a promising therapeutic strategy for immunologically “cold” tumors.

https://advances.umw.edu.pl/en/ahead-of-print/210993/

19/11/2025

🚀 Ahead of print 🚀

Electrical impedance tomography confirmed the impact of the method of delivery of term neonates on early lung aeration

Highlights

🔹 Cesarean-section newborns showed significantly poorer early lung aeration in gravity-dependent regions compared with vaginally delivered infants, as measured by electrical impedance tomography (EIT).
🔹 Neonates born via NVD demonstrated greater changes in lung stretch and more efficient lung tissue expansion during the first hours after birth.
🔹 EIT revealed distinct tidal-volume distribution patterns between delivery modes, with CS infants showing more central right-lung ventilation and NVD infants showing enhanced central-ventral expansion.
🔹 Findings highlight that mode of delivery influences early postnatal respiratory adaptation, supporting EIT as a valuable tool for monitoring neonatal lung function.

https://advances.umw.edu.pl/en/ahead-of-print/190742/

18/11/2025

🚀Ahead of print 🚀

Access to services. Mental health in catastrophes and emergencies: Aspects

Highlights

➡️Disasters, wars, and public health emergencies have a profound impact on mental health, with up to 1/3 of affected individuals developing PTSD, depression, anxiety, or related disorders.
➡️Limited access to mental health and psychosocial support (MHPSS) – due to stigma, resource shortages, and disrupted health systems – worsens outcomes among vulnerable populations.
➡️Integrating mental health care into disaster preparedness and emergency response frameworks is essential to improve resilience and recovery in crisis-affected communities.

https://advances.umw.edu.pl/en/ahead-of-print/211237/

17/11/2025

📚Publish in Advances in Clinical and Experimental Medicine! 📚

💪 WHY?
– We have a broad scope and publish papers from all fields of medicine and related sciences;
– Our Impact Factor is 1.9 and steadily rising [see below];
– Our Scopus CiteScore is 4.3 and also steadily rising;
– We publish papers ahead of print [with active DOI] as soon as they are ready – no unnecessary waiting;
– We are indexed in all important databases;
– We offer professional linguistic editing and DTP;
– If you become our reviewer, article processing charge can be waivered.

🔎 HOW?
Create an account here:
https://www.editorialsystem.com/acem/preRegister/?email=
Check our instructions for authors here:
https://advances.umw.edu.pl/en/instructions-for-authors/
and submit your paper!

🔥 EDITORIALS
We invite experts to submit an editorial to our journal. Editorials published in our journal are meant to promote current and crucial directions of research in experimental and clinical medicine. Such article is published free of charge.
https://advances.umw.edu.pl/source/Flyer_ACEM_popr_2025-editorial.pdf

🔥 CALLS FOR SUBMISSION
Current calls for submissions in ACEM are listed below. Please share them with the members of your professional networks.
https://advances.umw.edu.pl/en/calls-for-submissions/

16/11/2025

If you experience problems in choosing a checklist, use this :-)

To improve the success rate of publishing articles, authors can consider these checklists which will be considered as a checklist by the Reviewers in the review process.

Using a checklist can help you get published faster and maximize the impact of your work. The below checklists are copied from a tool was made by the EQUATOR Network in collaboration with Penelope.ai.

https://humangeneticsgenomics.ir/page/169/Checklists

16/11/2025

📢From Bench to Bedside: Advances in Neuroinflammation and CNS Disorder Research 📢

📢 Call for submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on Neuroinflammation in CNS Disorders 📢

The editors of this special collection invite submissions exploring the latest advances in clinical and experimental research on neuroinflammation in the central nervous system (CNS). Neuroinflammation is at the forefront of neuroscience, shaping our understanding of CNS disorders such as neurodegenerative disease, psychiatric disorders, and traumatic brain injuries. This collection aims to unite diverse perspectives, fostering insights into the complex cellular and molecular mechanisms driving neuroinflammatory processes. We encourage the submission of original research, meta-analyses, and comprehensive review articles that shed light on diagnostic, therapeutic, and mechanistic aspects of CNS inflammation.
We are particularly interested in manuscripts that explore the interplay between immune cells, neurons, and glia, with a focus on translational research. Contributions detailing innovative diagnostic approaches, therapeutic targets, or computational models are highly welcome. Join this effort to advance the boundaries of neuroinflammation research and contribute to groundbreaking findings that bridge laboratory and clinical neuroscience.

Topic and format
Advances in Clinical and Experimental Medicine is therefore seeking original papers for a Special Collection focused on the following themes:
• Neuroimmune Interactions in Health and Disease
• Cellular and Molecular Pathways of Neuroinflammation
• Neuroinflammation and Neurodegeneration: Cause or Consequence?
• Innovative Imaging and Biomarkers for CNS Inflammation
• Therapeutic Interventions Targeting Neuroinflammation
• Role of Microglia and Astrocytes in Neuroinflammatory Diseases

MORE INFORMATION
https://advances.umw.edu.pl/en/neuroinflammation-in-cns-disorders

Masaru Tanaka

15/11/2025

📢New call for submissions 📢

📢 Innovations in Therapeutic Interventions: Advancing Clinical and Experimental Medicine 📢

Handling Editors

Dr. Masaru Tanaka (ELKH-SZTE Neuroscience Research Group, Eötvös Loránd Research Network, University of Szeged (ELKH-SZTE), Hungary)
Dr. Simone Battaglia (Center for Studies and Research in Cognitive Neuroscience, Department of Psychology, University of Bologna, Italy
Dr. Francesco Di Gregorio (AUSL Bologna; Department of Psychology, University of Bologna, Italy)
Prof. Izabella Uchmanowicz (Wroclaw Medical University, Poland)
Prof. Donata Kurpas (Wroclaw Medical University, Poland)

We welcome reviews as well as original research articles and research letters in various clinical and experimental medicine areas. We encourage submissions on the following topics:

Precision Medicine and Personalized Therapies: Explore novel approaches in tailoring medical treatments based on an individual's genetic makeup, environmental factors, and disease characteristics. Highlight the potential of precision medicine in improving patient outcomes and overcoming treatment challenges. This topic includes but is not limited to:

a) Immunotherapy and Immunomodulation: Investigate the role of immunotherapy and immunomodulation in treating various diseases, including cancer, autoimmune disorders, and infectious diseases. Focus on cutting-edge techniques, therapeutic targets and potential synergies with other treatment modalities.
b) Gene and Cell Therapies: Present innovative research on gene and cell-based therapies, such as stem cell transplantation, gene editing and regenerative medicine. Explore their applications across different diseases and discuss their clinical implications and prospects.

The paper can also encompass:
Artificial Intelligence and Big Data Analytics in Medicine: Examine the integration of artificial intelligence (AI) and big data analytics in medical research, diagnostics, treatment optimization, and patient care. Highlight the potential of AI algorithms, machine learning and data-driven approaches in revolutionizing healthcare practices.
Digital Health Technologies and Wearables: Discuss the advancements in digital health technologies (including telemedicine), wearable devices and remote monitoring systems. Explore their impact on healthcare delivery, patient engagement, disease management, and prevention strategies.

All papers should focus on:
Translational Research and Bench-to-Bedside Innovations: Showcase translational research efforts that bridge the gap between laboratory discoveries and clinical applications. Present successful examples of bench-to-bedside innovations that have improved patient care and outcomes.

Keywords
therapeutic interventions; personalized therapies; immunotherapy; immunomodulation; gene and cell therapies; artificial intelligence; Big Data analytics; digital health technologies

By submitting your research to Adv Clin Exp Med, you will become an integral part of a dynamic and vibrant community of dedicated researchers committed to advancing the fields of clinical and experimental medicine. By undergoing our rigorous peer-review process, you can be assured that only high-quality and impactful studies are published, enhancing your professional reputation and contributing to advancing medical knowledge.

We look forward to receiving your submissions and collaborating to make a lasting impact on the field of clinical and experimental medicine.

MORE INFORMATION
https://advances.umw.edu.pl/en/innovations

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

14/11/2025

🚀 Ahead of print🚀

Personalized medicine for patients with chronic diseases in Europe: From concept to clinical practice

Highlights

➡Personalized medicine advances chronic disease management through patient-specific strategies, improving treatment precision, response and long-term outcomes.
➡Cross-border data sharing, real-world evidence (RWE) integration and sustainable funding models are vital for the successful implementation of personalized medicine in Europe.
➡Coordinated health policies, clinician education and active patient engagement are essential to translate personalized medicine into clinical practice and enhance healthcare quality.

https://advances.umw.edu.pl/en/ahead-of-print/213758/

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

13/11/2025

📢Meet the author of our latest editorial!📢

Prof. Timothy Daly

✔️ READ THE EDITORIAL

Blood biomarkers of Alzheimer’s disease: Balancing clinical relevance with improved accessibility and sustainability
https://advances.umw.edu.pl/en/ahead-of-print/208917/

✔️SHORT BIO and PUBLICATIONS

https://ojs.umw.edu.pl/files/acem/CV%20Timothy%20Daly%20%282%29.pdf
https://www.researchgate.net/profile/Timothy-Daly-2

✔️MINI-INTERVIEW

1. Is the perspective of the influence of diagnostic techniques on anthropogenic climate change frequently taken into consideration in medical research?

There is an increasing recognition of the carbon footprint of medicine in general. But the idea that there are trade-offs being made is rarely made explicit. In neurology, given the high burden of disease and the lack of therapeutic progress made, while there is an increasing recognition of the impact of climate change on the brain, the major value driving diagnosis in neurology is understandably clinical precision, not environmental sustainability. Until these blood tests came along, diagnosis of Alzheimer's disease required either post-mortem confirmation, a "PET" brain scan, or a spinal tap. Blood tests are more "low-tech," more accessible and less invasive, and have a reduced carbon footprint compared to the other techniques.

2. Why is important in a therapeutic context to discern Alzheimer's disease from other cognitive disorders?

Dementia is a neurocognitive syndrome with many different causes that are generally diseases or traumatic injuries. Of the over 57 million cases worldwide, there is a general consensus that approximately 40 million of those are caused by Alzheimer's disease, leading to progressive neurocognitive disorder associated with the accumulation of signature brain proteins beta-amyloid and tau. These new blood tests can reliably predict the accumulation of amyloid in someone's brain. Discerning Alzheimer's from other causes of someone's dementia is important for immediate practical reasons, to make sure the right care and treatment gets to the right people. Long-term, it's important for researchers to know the prevalence of different causes of dementia in the population.

3. A blood test on its own without knowing someone's cognitive status will not provide clinically meaningful information to those who need it – this sounds like a large group of AD specialists are pushing the idea of "one simple test" which would detect present or future AD, similar to basic blood tests for several other diseases. Why is this idea dangerous?

Since the 1990s, the dominant theory of the cause of Alzheimer's disease has been that signature proteins (amyloid and tau) accumulate and trigger a downstream cascade of neurodegeneration later on. This, combined with the historical failures of amyloid-lowering drugs (despite more hopeful results from recent antibodies) to improve cognition in people with Alzheimer's dementia, led the US Alzheimer's Association's working group in 2024 to propose a biological definition of Alzheimer's disease in which amyloid accumulation is theoretically sufficient to diagnose Alzheimer's disease, without cognitive symptoms. But in the ageing brain, amyloid accumulation without dementia is actually the rule rather than the exception. There are thought to be over 400 million "amyloid-positive" people in the world, but only approximately 100 million of them have associated cognitive decline. This led another major expert group, known as the International Working Group (IWG) which is mostly made up of neurologists from memory clinics in Europe, to argue that Alzheimer's should be understood as a "clinical-biological entity" (dementia with Alzheimer's biomarkers). Otherwise, the IWG argues that amyloid-positive people without symptoms and no known genetic risk factors profiles are only at risk of Alzheimer's disease. In the era of blood tests, it's important to know who will develop dementia and who won't, to make sure that these blood tests are clinically meaningful to patients. For that reason, they are not recommended for use in people without cognitive symptoms. If that criterion of clinical relevance is satisfied, then they should make confirmation of diagnosis of Alzheimer's more accessible and environmentally sustainable.

12/11/2025

🚀Ahead of print🚀

Recent advances in the study of perinatal mental health: Epidemiology, psychopathology and intervention

Highlights

➡️Perinatal mental health conditions affect up to 1 in 5 women and are more common than major obstetric complications.
➡️Suicidal ideation is 16 times more likely in women with postpartum depression, especially when social support is lacking.
➡️Mother-infant bonding difficulties and perinatal depression share risk factors and can hinder child development if untreated.
➡️Integrative therapies combining psychotherapy, lifestyle, and family support offer promising outcomes for maternal recovery.

https://advances.umw.edu.pl/en/ahead-of-print/212646/

Advances in Clinical and Experimental Medicine

21/11/2025

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