Advances in Clinical and Experimental Medicine

Advances in Clinical and Experimental Medicine 5-Year IF 2.0, IF 1.9, JCI (2024) 0.43, Scopus CiteScore 4.3, H-index 49 (SJR)
Initial editorial assessment and first decision within 24 h

📢New call for submissions 📢📢 Innovations in Therapeutic Interventions: Advancing Clinical and Experimental Medicine 📢Han...
13/12/2025

📢New call for submissions 📢

📢 Innovations in Therapeutic Interventions: Advancing Clinical and Experimental Medicine 📢

Handling Editors

Dr. Masaru Tanaka (ELKH-SZTE Neuroscience Research Group, Eötvös Loránd Research Network, University of Szeged (ELKH-SZTE), Hungary)
Dr. Simone Battaglia (Center for Studies and Research in Cognitive Neuroscience, Department of Psychology, University of Bologna, Italy
Dr. Francesco Di Gregorio (AUSL Bologna; Department of Psychology, University of Bologna, Italy)
Prof. Izabella Uchmanowicz (Wroclaw Medical University, Poland)
Prof. Donata Kurpas (Wroclaw Medical University, Poland)

We welcome reviews as well as original research articles and research letters in various clinical and experimental medicine areas. We encourage submissions on the following topics:

Precision Medicine and Personalized Therapies: Explore novel approaches in tailoring medical treatments based on an individual's genetic makeup, environmental factors, and disease characteristics. Highlight the potential of precision medicine in improving patient outcomes and overcoming treatment challenges. This topic includes but is not limited to:

a) Immunotherapy and Immunomodulation: Investigate the role of immunotherapy and immunomodulation in treating various diseases, including cancer, autoimmune disorders, and infectious diseases. Focus on cutting-edge techniques, therapeutic targets and potential synergies with other treatment modalities.
b) Gene and Cell Therapies: Present innovative research on gene and cell-based therapies, such as stem cell transplantation, gene editing and regenerative medicine. Explore their applications across different diseases and discuss their clinical implications and prospects.

The paper can also encompass:
Artificial Intelligence and Big Data Analytics in Medicine: Examine the integration of artificial intelligence (AI) and big data analytics in medical research, diagnostics, treatment optimization, and patient care. Highlight the potential of AI algorithms, machine learning and data-driven approaches in revolutionizing healthcare practices.
Digital Health Technologies and Wearables: Discuss the advancements in digital health technologies (including telemedicine), wearable devices and remote monitoring systems. Explore their impact on healthcare delivery, patient engagement, disease management, and prevention strategies.

All papers should focus on:
Translational Research and Bench-to-Bedside Innovations: Showcase translational research efforts that bridge the gap between laboratory discoveries and clinical applications. Present successful examples of bench-to-bedside innovations that have improved patient care and outcomes.

Keywords
therapeutic interventions; personalized therapies; immunotherapy; immunomodulation; gene and cell therapies; artificial intelligence; Big Data analytics; digital health technologies

By submitting your research to Adv Clin Exp Med, you will become an integral part of a dynamic and vibrant community of dedicated researchers committed to advancing the fields of clinical and experimental medicine. By undergoing our rigorous peer-review process, you can be assured that only high-quality and impactful studies are published, enhancing your professional reputation and contributing to advancing medical knowledge.

We look forward to receiving your submissions and collaborating to make a lasting impact on the field of clinical and experimental medicine.

MORE INFORMATION
https://advances.umw.edu.pl/en/innovations

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

🚀Ahead of print 🚀Comparative study of the protective effects of adenosine triphosphate and resveratrol against amiodaron...
12/12/2025

🚀Ahead of print 🚀

Comparative study of the protective effects of adenosine triphosphate and resveratrol against amiodarone-induced potential liver damage and dysfunction in rats

Highlights

➡️Amiodarone as a leading class III antiarrhythmic agent combines antiarrhythmic and vasodilator effects but carries a risk of hepatotoxicity.
➡️Amiodarone induces severe oxidative liver damage in rats, confirmed by biochemical, histopathological, and immunohistochemical analyses.
➡️Mitochondrial dysfunction underlies hepatocyte injury, with reduced ATP content and elevated ROS levels driving oxidative stress.
➡️Exogenous ATP and resveratrol supplementation mitigate liver damage, with resveratrol enhancing intracellular ATP production.
➡️Optimizing ATP dosing or combining ATP with resveratrol may offer a protective strategy against amiodaroneinduced hepatic injury.

https://advances.umw.edu.pl/en/ahead-of-print/202011/

🚀Ahead of print🚀🚀Preliminary exploration of the potential role of salvianolic acid F in regulating ovarian cancer cell p...
12/12/2025

🚀Ahead of print🚀

🚀Preliminary exploration of the potential role of salvianolic acid F in regulating ovarian cancer cell proliferation, migration, invasion, and apoptosis and its association with the EP300/PI3K/AKT pathway🚀

✔️SAF Inhibits Ovarian Cancer Cell Growth, Migration, and Invasion: This study is the first to demonstrate that Salvianolic acid F (SAF) significantly inhibits the growth, migration, and invasion of ovarian cancer cell lines SKOV-3 and OVCAR-3, while inducing apoptosis, providing experimental evidence for its anti-tumor effects.

✔️Network Pharmacology Reveals Core Targets: Through network pharmacology analysis and protein-protein interaction (PPI) network analysis using the String database, core targets such as TP53, EP300, STAT3, MMP9, NFKB1, HIF1A, and PTGS2 were identified, offering important insights into the mechanisms of SAF.

✔️Key Role of the EP300/PI3K/AKT Pathway: Mechanistic research indicates that SAF promotes ovarian cancer cell apoptosis by regulating the EP300-mediated PI3K/AKT signaling pathway, revealing its potential molecular mechanisms.

✔️SAF as a Novel Candidate Drug for Ovarian Cancer Treatment: The results demonstrate that SAF exhibits significant anti-ovarian cancer activity, making it a potential candidate drug for ovarian cancer treatment and providing new directions for clinical research.

✔️Multidisciplinary Approach to Validate Mechanisms: This study combines in vitro cell experiments and network pharmacology analysis to systematically explore the anti-tumor effects and mechanisms of SAF, offering a scientific methodological reference for research on active components of natural medicines.

https://advances.umw.edu.pl/en/ahead-of-print/195334/

🚀Ahead of print🚀🚀Combined CB1 antagonist AM6545 and NOP agonist SCH221510 worsen DSS-induced colitis in mice🚀Highlights➡...
11/12/2025

🚀Ahead of print🚀

🚀Combined CB1 antagonist AM6545 and NOP agonist SCH221510 worsen DSS-induced colitis in mice🚀

Highlights

➡️The study explores interactions between the endocannabinoid system (ECS) and nociceptin receptors (NOP) in dextran sulfate sodium-induced colitis.
➡️Co-administration of a CB1 antagonist (AM6545) and a NOP agonist (SCH221510) exacerbates colitis severity in mice.
➡️The treatment combination alters key signaling pathways, reducing ERK1/2 while increasing β-arrestin and phospho-AKT levels.
➡️CB1 receptor expression is upregulated in inflamed colonic tissue following NOP agonist treatment.
➡️Findings suggest a complex interplay between endogenous cannabinoid system and NOP, providing insights for future colitis therapies.

https://advances.umw.edu.pl/en/ahead-of-print/203426/

📢Meet the author of our latest editorial!📢Prof. Oleksii Korzh✔️ READ THE EDITORIALFrom consensus to action: Implementing...
11/12/2025

📢Meet the author of our latest editorial!📢

Prof. Oleksii Korzh

✔️ READ THE EDITORIAL

From consensus to action: Implementing cardiovascular prevention guidelines in primary healthcare

https://advances.umw.edu.pl/en/ahead-of-print/213742/

✔️SHORT BIO
https://ojs.umw.edu.pl/files/acem/O.Korzh_2025.pdf

✔️MINI-INTERVIEW

1. Could you explain how barriers in implementing cardiovascular guidelines look in practice on the example of rural primary care in Europe, and specifically in countries you know first-hand?

In daily rural primary care in Europe, cardiovascular guidelines are most often “partially implemented”: core elements like BP measurement and basic pharmacotherapy are present, but systematic risk‑based prevention, full use of recommendations, and structured follow‑up are fragmentary or absent, especially in countries with constrained resources such as Ukraine.

In Ukraine, especially in remote regions, family doctors historically relied on non‑evidence‑based state screening programs and personal routines rather than international guidelines; efforts to retrain them in ESC‑style risk‑based prevention showed improved knowledge but highlighted persistent barriers. Family doctors mentioned a lack of time for motivational interviews, low patient motivation to modify their lifestyle, restricted access to basic equipment and laboratory tests in remote ambulatories, and a lack of clarity regarding the duties of nurses in preventing chronic diseases. More recently, primary care has been overburdened by war-related disruption, population displacement, and the growing prevalence of mental health issues and cardiovascular disease, which has left even less room for the organized application of prevention recommendations.

2. What are currently the most prominent challenges for cardiovascular prevention in Ukraine, particularly in the context of ongoing Russian invasion?

The most prominent challenges are a surge in cardiovascular risk in a population already highly burdened with CVD, combined with severely disrupted continuity of care, damaged infrastructure, workforce strain, and growing financial and psychosocial barriers that directly undermine primary and secondary prevention.

The war has shifted attention and resources away from preventive care towards trauma, emergencies, and acute infectious threats, interrupting routine follow‑up for hypertension, dyslipidaemia, heart failure, and atrial fibrillation. Many people report reduced access to primary care, and unavailability of services and high cost of medicines are now the leading barriers for those with chronic NCDs, including CVD. For prevention, this means more missed visits, delayed titration of therapies, interrupted prescriptions, and loss of structured counselling or rehabilitation.

Front‑line and newly liberated regions face the most severe disruptions, with damaged facilities, shortages of staff and supplies, and high rates of care refusal or postponement among residents with chronic conditions.

3. How is low health literacy hindering cardiovascular prevention?

Low health literacy undermines cardiovascular prevention at every step: people are less likely to recognise risk, engage in screening, understand diagnoses and targets, adhere to treatment, or sustain lifestyle changes, leading to poorer risk factor control and more events.

Patients with low health literacy may feel intimidated in clinical encounters, ask fewer questions, and rarely disclose non‑adherence or confusion, which reduces the effectiveness of counselling and shared decision‑making. Because low health literacy is more common in disadvantaged groups, it amplifies existing social gradients in cardiovascular risk, making it a key upstream driver of inequalities in prevention outcomes.

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu


🚀Ahead of print🚀🚀Association between proinflammatory cytokines and pain intensity in patients with postherpetic neuralgi...
10/12/2025

🚀Ahead of print🚀

🚀Association between proinflammatory cytokines and pain intensity in patients with postherpetic neuralgia🚀

Highlights

➡️Proinflammatory cytokine surge in acute herpes zoster: Cytokine levels peak within 72 h post-rash onset and steadily decline over a 90-day follow-up.
➡️Higher cytokine burden predicts postherpetic neuralgia (PHN): Patients who develop PHN exhibit significantly elevated proinflammatory cytokines compared to non-PHN cases.
➡️Cytokine intensity mirrors PHN pain severity: Individuals with severe PHN pain have greater cytokine elevations than those reporting mild-to-moderate pain.
➡️Blunted cytokine decline in severe PHN: The reduction of proinflammatory cytokines over time is markedly lower in severe-pain patients compared to those with milder symptoms.

https://advances.umw.edu.pl/en/ahead-of-print/200267/

📢New call for submissions📢Call for Submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection o...
10/12/2025

📢New call for submissions📢

Call for Submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on Advances in Hand Surgery and Hand Therapy

The hand is a remarkably complex organ, and even minor injury or disease can severely impair its function, making precise assessment essential for accurate diagnosis, effective treatment, and successful rehabilitation.

Hand surgery combines orthopedics, plastic and reconstructive surgery, microsurgery, and traumatology. Advances in techniques, biomaterials, and regenerative medicine continue to improve outcomes and quality of life. Hand therapy – encompassing physiotherapy, occupational therapy, splinting, pain management, and patient education – plays an equally vital role in restoring fine motor skills after delicate surgical repair.

Effective management of hand conditions depends on close interdisciplinary collaboration among surgeons, therapists, and other professionals. Despite progress, challenges remain in achieving long-term functional recovery, improving patient-reported outcomes, and ensuring equitable access to care. Evidence-based healthcare (EBHC) provides the foundation for modern practice, integrating clinical expertise, research evidence, and patient values.

In recognition of these ongoing developments and collaborative efforts, this Call for Submissions accompanies the 13th Congress of the Polish Society for Surgery of the Hand and the 3rd Congress of the Polish Society for Hand Therapy, to be held in Wroclaw, Poland, on October 9–11, 2025, organized by the Polish Society for Surgery of the Hand, the Polish Society for Hand Therapy, and the Clinical Department and Department of Orthopedics, Traumatology and Hand Surgery, Faculty of Medicine, Wroclaw Medical University.

Articles submitted should address the broad field of hand surgery and hand therapy. Contributions may focus on fundamental principles of hand function, such as anatomy and biomechanics, clinical examination, functional assessment, imaging, electrodiagnostic studies, and patient-reported outcome measures, as well as modern diagnostic approaches, surgical techniques, therapeutic strategies, and interdisciplinary care.

Suggested topics include, but are not limited to, hand surgery and hand therapy in the following conditions:

Traumatic injuries: fractures, dislocations, flexor and extensor tendon injuries, nerve and vascular injuries, amputations and replantations, and complex post-traumatic reconstructions.
Degenerative and inflammatory diseases: osteoarthritis, rheumatoid arthritis, scleroderma, and other connective tissue diseases.
Neurological conditions: stroke, tetraplegia, peripheral and central neurologic diseases, and nerve compression syndromes.
Congenital and developmental disorders: congenital anomalies and deformities in children, including malformations requiring surgical correction and long-term therapy.
Metabolic and systemic disorders: diabetes-related hand conditions and other systemic metabolic diseases affecting the hand.
Burns of the hand: acute surgical treatment, reconstructive procedures, and long-term rehabilitation, including scar management, splinting, and functional recovery.
Tumors of the hand and wrist: benign and malignant tumors.
Infections: acute and chronic infections.
Vascular disorders: Raynaud’s phenomenon, ischemic conditions, and vascular insufficiency of the hand.
Iatrogenic and secondary conditions: complications after surgery, contractures, scarring, stiffness, and chronic pain syndromes.
Other common hand problems: Dupuytren’s contracture, trigger finger, ganglion cysts, and other frequently encountered conditions

MORE INFORMATION
https://advances.umw.edu.pl/en/hand-surgery-therapy



Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

🚀Ahead of print 🚀Novel therapies in SLE treatment: A literature review➡️Advances in Systemic Lupus Erythematosus Treatme...
09/12/2025

🚀Ahead of print 🚀

Novel therapies in SLE treatment: A literature review

➡️Advances in Systemic Lupus Erythematosus Treatment Improve Patient Outcomes. Corticosteroids and immunosuppressive agents have significantly enhanced prognosis and life expectancy in SLE patients, despite notable side effects.

➡️New EULAR Guidelines Introduce Anifrolumab and Voclosporin for SLE Management. In 2023, EULAR expanded recommendations to include anifrolumab (IFN receptor inhibitor) and voclosporin (calcineurin inhibitor), marking a major therapeutic update.

➡️Emerging Biologics Target Cytokines and Immune Cells in SLE Therapy. Multiple biological agents are in phase II and III clinical trials, offering innovative approaches to reduce inflammation and organ damage in lupus.

➡️Experimental Therapies Show Promise for Severe Lupus Cases. Cutting-edge strategies such as plasma cell targeting, CAR-T cell therapy, and stem cell transplantation may revolutionize treatment of refractory SLE.

https://advances.umw.edu.pl/en/ahead-of-print/193892/


Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

🚀Ahead of print 🚀Effectiveness of gua sha with Masanggoubang oil in rats with chronic soft tissue injuryHighlights➡️Gua ...
09/12/2025

🚀Ahead of print 🚀

Effectiveness of gua sha with Masanggoubang oil in rats with chronic soft tissue injury

Highlights

➡️Gua Sha with Masanggoubang Oil Reduces Inflammation in Chronic Soft Tissue Injury GSMO therapy downregulated pro-inflammatory markers (TNF-α, IL-1β, IL-6, iNOS) in skin, muscle, and serum, demonstrating strong anti-inflammatory effects.
➡️Synergistic Effect of Gua Sha and Masanggoubang Oil for Pain Relief Combined treatment alleviated muscle fiber necrosis, reduced scar tissue formation, and increased β-endorphin levels, enhancing analgesic outcomes.
➡️Mechanism of GSMO Linked to M1 Macrophage Polarization Reduction Findings suggest GSMO improves inflammatory response by modulating immune activity, offering a novel therapeutic pathway for chronic soft tissue injuries.
➡️Masanggoubang Oil Therapy Outperforms Tea Oil in Gua Sha Treatment Compared to gua sha with tea oil, GSMO showed superior healing benefits, highlighting its potential as an effective natural intervention.



https://advances.umw.edu.pl/en/ahead-of-print/186865/

🚀Ahead of print 🚀Quality of life assessment after minimally invasive operative treatment in children with pectus excavat...
08/12/2025

🚀Ahead of print 🚀

Quality of life assessment after minimally invasive operative treatment in children with pectus excavatum: A single-center study and literature review

➡️Minimally invasive repair of pectus excavatum (MIRPE) significantly improves psychological wellbeing and physical activity in pediatric patients within 12 months post-surgery.
➡️Quality-of-life scores measured by KIDSCREEN-52 and EQ-5D-Y showed notable postoperative gains, including easier daily functioning (p = 0.048) and enhanced psychological health (p = 0.013).
➡️Peer relationships improved after MIRPE, highlighting the procedure’s positive impact on social integration and adolescent development.
➡️Strong agreement between parent and patient reports confirms the reliability of perceived QoL improvements following MIRPE in children with chest wall deformities.

https://advances.umw.edu.pl/en/ahead-of-print/194483/

🚀Ahead of print🚀🚀Vestibular rehabilitation: Proven benefits in enhancing balance and reducing dizziness🚀Highlights➡️Vest...
08/12/2025

🚀Ahead of print🚀

🚀Vestibular rehabilitation: Proven benefits in enhancing balance and reducing dizziness🚀

Highlights

➡️Vestibular rehabilitation therapy (VRT) significantly reduces dizziness symptoms, showing a mean improvement of 7.63 points on the Dizziness Handicap Inventory (DHI).
➡️VRT enhances balance and mobility, with substantial gains observed on the Berg Balance Scale (BBS) across multiple clinical studies.
➡️Meta-analysis using advanced statistical tools confirms VRT’s effectiveness, despite high heterogeneity among included trials.
➡️VRT is a proven treatment for vestibular disorders, but further research is needed to standardize protocols and improve patient outcomes.

https://advances.umw.edu.pl/en/ahead-of-print/193242/

📢Out in Health: Health Equity and Innovations in LGBT+ Care📢Call for submissions of an Expression of Interest for an Adv...
07/12/2025

📢Out in Health: Health Equity and Innovations in LGBT+ Care📢

Call for submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on LGBT+ Health Equity and Innovation

Handling Editors

Assoc. Prof. Michał Czapla (Division of Scientific Research and Innovation in Emergency Medical Service, Department of Emergency Medical Service, Faculty of Nursing and Midwifery, Wroclaw Medical University, Wrocław, Poland; Group of Research in Care (GRUPAC), Faculty of Health Sciences, University of La Rioja, Logroño, Spain; ORCID 0000-0002-4245-5420) [email protected]

Dr. Anthony Dissen (Stockton University, Galloway, USA; ORCID 0000-0003-0828-387X) [email protected]

This Call for Submissions invites Expressions of Interest for a Special Collection of Advances in Clinical and Experimental Medicine, focusing on LGBT+ health equity and innovation.

LGBT+ individuals around the world face unique and persistent health disparities driven by stigma, discrimination, and systemic exclusion from healthcare systems. These inequities result in significantly worse physical and mental health outcomes and limit access to inclusive, culturally competent care.

This Special Collection will offer researchers and clinicians an opportunity to publish original research, meta-analyses, and review articles that address these disparities and propose inclusive, personalized, and innovative solutions to improve health outcomes for LGBT+ populations.

This Call welcomes submissions on (but not limited to):

* Mental Health & Well-being
* Sexual & Reproductive Health
* Transgender & Gender-Diverse Health
* Equity in Healthcare Access
* Social Determinants of Health
* Stigma & Healthcare Avoidance
* Community & Public Health Initiatives
* Intersectionality in Health

MORE INFORMATION
https://advances.umw.edu.pl/en/lgbt


Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu
Dr hab. Michał Czapla

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