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Advances in Clinical and Experimental Medicine

Strona główna
Polska
Wroclaw
Advances in Clinical and Experimental Medicine

5-Year IF 2.0, IF 1.9, JCI (2024) 0.43, Scopus CiteScore 4.3, H-index 49 (SJR)
Initial editorial assessment and first decision within 24 h

31/10/2025

🚀Ahead of print 🚀

Comparison of phonemic awareness in children with auditory processing disorder and children without auditory processing disorder using an objective test for assessing phonemic hearing: A preliminary study

Highlights

• Phonemic hearing deficits in auditory processing disorder (APD): Children with APD exhibit significant impairments in phoneme discrimination, underscoring core processing challenges.
• 62.9% higher phonemic error rate vs peers: Quantitative analysis reveals that APD diagnoses correspond with a marked increase in phonemic mistakes compared to non-APD children.
• Early phonemic assessment and intervention boost outcomes: Timely diagnosis and targeted therapy for phonemic disorders enhance both academic performance and emotional well-being in APD-affected children.
• Specialized phonemic rehabilitation needed for APD: Results highlight the importance of developing and implementing tailored therapeutic protocols to address phonemic hearing issues in pediatric APD.

https://advances.umw.edu.pl/en/ahead-of-print/204557/

30/10/2025

🚀Ahead of print 🚀

The role of urinary biomarkers in the diagnosis, prognosis and pathophysiology of heart failure with preserved ejection fraction

Highlights

• Heart failure with preserved ejection fraction (HFpEF) is often misdiagnosed or inadequately diagnosed, as many diagnostic parameters lack clear cutoffs. Additionally, its pathophysiology remains incompletely understood.
• Studies have demonstrated a strong correlation between albuminuria and HFpEF, identifying it as a prognostic factor for HFpEF development. Albuminuria is associated with poor outcomes and echocardiographic parameters related to diastolic dysfunction.
• Urinary biomarkers N-acetyl-d-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) are correlated with HFpEF. Patients with HFpEF exhibit higher levels of tubular kidney injury biomarkers in their urinary profile compared to those with HFrEF.
• Urinary oxidative stress markers, such as F2-isoprostanes, 8-hydroxy-2’-deoxyguanosine (8-OHdG) and biopyrrins, are potential biomarkers for HFpEF; however, further research is needed.
• In HFpEF, urinary proteome analysis has shown correlations with collagen metabolism proteins and pathways involved in immune system regulation.

https://advances.umw.edu.pl/en/ahead-of-print/200268/

29/10/2025

📢 New Issue Alert – Advances in Clinical and Experimental Medicine (October 2025)📢

We are pleased to announce that the October 2025 issue of Advances in Clinical and Experimental Medicine has been officially published on our website. This latest edition features high-impact research and novel findings in the field of clinical and experimental medicine, contributing to the advancement of medical science.

🔗 https://advances.umw.edu.pl/en/issue/2025/34/10/

The issue will also be distributed via our mailing list. However, we encourage you to help us maximize its reach by sharing it through professional networks, email lists, and social media. Your support in promoting open-access medical research is greatly appreciated.

📖 Stay informed, stay engaged, and help us advance medical knowledge!

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

28/10/2025

🚀Ahead of print🚀

🚀Mapping the evolution of mitochondrial dynamics research: A bibliometric analysis of global trends and collaborations🚀

Highlights

➡️Global bibliometric analysis (2000–2023) revealed China and the USA as the leading contributors to mitochondrial dynamics research.
➡️Research focus has shifted from basic mitochondrial function to disease mechanisms, including Alzheimer’s and cardiovascular disease.
➡️Collaboration networks identified Chiang Mai University and Caltech as key institutions driving advances in mitochondrial dynamics.
➡️Visualization with VOSviewer and CiteSpace highlighted emerging trends linking mitochondrial fission–fusion balance to oxidative stress, inflammation, and apoptosis.

https://advances.umw.edu.pl/en/ahead-of-print/196720/

27/10/2025

🚀Ahead of print🚀

🚀MALAT1 modulates granulosa cells ferroptosis and apoptosis through PAK2 upregulation in polycystic ovary syndrome🚀

Highlights

• MALAT1 controls ferroptosis in KGN granulosa cells, uncovering a novel lncRNA-driven cell-death pathway in ovarian physiology.
• Reduced MALAT1 expression links to polycystic ovary syndrome (PCOS)-associated ovarian dysfunction, highlighting its potential as a biomarker and therapeutic target in PCOS.
• MALAT1 sponges miR-155-5p to upregulate PAK2 in KGN cells, defining a MALAT1/miR-155-5p/PAK2 ceRNA network critical for granulosa-cell function.

https://advances.umw.edu.pl/en/ahead-of-print/202385/

26/10/2025

💥We work with the best!💥

Experts from Stanford University, under the supervision of Prof. John Ioannidis, in cooperation with Elsevier, prepared the 8th version of a publicly available database of top-cited scientists that provides standardized information on citations, h-index, co-authorship-adjusted hm-index, citations to papers in different authorship positions, and a composite indicator (c-score). This database includes a list of the top 2% most widely cited scientists in various disciplines. Separate data are shown for career-long and, separately, for single recent year impact. Metrics with and without self-citations and the ratio of citations to citing papers are given. The selection is based on the top 100,000 scientists by c-score (with and without self-citations) or a percentile rank of 2% or above in the sub-field. Career-long data are updated to end-of-2024 and single recent year data pertain to citations received during calendar year 2024. The selection is based on the top 100,000 scientists by c-score (with and without self-citations) or a percentile rank of 2% or above in the sub-field. This version is based on the August 1, 2025 snapshot from Scopus, updated to end of citation year 2024.

This list shows how many top researchers are in our Scientific Committee and among our section editors – 20! It’s clear proof that experienced and renowned specialists want to work with us and contribute to the development of Advances in Clinical and Experimental Medicine!

The congratulations go to: Sandra Maria Barbalho, Maria Magdalena Bujnowska-Fedak, Antonio Cano, Chong Chen, Breno Diniz, Chris Fox, Kinga Grzech-Leśniak, Donata Kurpas, Christopher S. Lee, Jerzy Leszek, Christos Lionis, Adam Matkowski, Monika Sawhney, James Sharman, Jamil Awad Shibli, Jacek Szepietowski, Robert Śmigiel, Masaru Tanaka, Izabella Uchmanowicz, and Ming Yi.

The database is available here:

https://elsevier.digitalcommonsdata.com/datasets/btchxktzyw/8

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

25/10/2025

📢Call for submissions of an Expression of Interest for an Adv Clin Exp Med Special Collection on

Application of stem cells in human medicine – from basic science research to clinical trials 📢

Medicine in the twenty-first century is closely associated with stem cell research, based on advanced in vitro analyzes, the use of model animals, and their application in clinical trials. Experimental research requires understanding the physiological and morphological properties of stem cells and analyzing their ability to divide and differentiate into other cell types. The best-known stem cells are those derived from bone marrow and umbilical cord blood. However, in recent years, stem cells have been discovered in, for example, adipose tissue and Wharton jelly. Stem cells isolated from these tissues, once properly differentiated, are increasingly used for the treatment of bone and neurodegenerative diseases. In recent years, the number of therapies using stem cells has increased significantly. The ability of stem cells to differentiate makes them an increasingly common therapeutic tool in regenerative and reconstructive medicine.

Key words:

mesenchymal stem cells, embryonic stem cells, iPSCs, cancer stem cells, cell proliferation and differentiation, small extracellular vesicles, exosomes, omics, animal models, preclinical and clinical trials, regenerative medicine, reconstructive medicine

Articles submitted should be related to the topic of stem cells and their use in basic and clinical research. Topics may include:

• molecular research involving advanced genomic methods
• tissue and cell research
• studies on the morphological and physiological properties of stem cells
• studies on the proliferative and multidirectional differentiation capacity of stem cells
• studies on model animals
• use of stem cells in preclinical and clinical research
• therapies with stem cell
• stem cells in regenerative and reconstructive medicine
• stem cells in translational medicine

Review articles describing recent achievements in stem cell medicine, as well as original articles will be accepted.

MORE INFORMATION:

https://advances.umw.edu.pl/en/application-stem

24/10/2025

🚀Ahead of print🚀

Next-generation sequencing study of inflammatory spindle cell lesions focused on receptor tyrosine kinase gene rearrangements most frequently occurring in inflammatory myofibroblastic tumor

Highlights

💡Inflammatory spindle cell lesions (ISCLs) feature spindle cells mixed with inflammatory infiltrates – hallmark morphology for this rare entity.
💡ISCL spectrum ranges from neoplastic inflammatory myofibroblastic tumors (IMTs) to reactive inflammatory pseudotumors (IPTs).
💡Neoplastic and reactive ISCLs alike can exhibit aggressive histology, oncogenic mutations and clonal genetic changes.
💡 Tyrosine receptor kinase gene rearrangement testing (ALK, ROS1, NTRK) is mandatory for a definitive IMT diagnosis.
💡 Pathology reports should list prognostic and diagnostic markers – ganglion-like cells, cytologic atypia, mitotic index, necrosis, and gene rearrangements.

https://advances.umw.edu.pl/en/ahead-of-print/203097/

23/10/2025

🚀Ahead of print🚀

🚀Reconstruction of outer glycolipid synthesis pathways from Porphyromonas gingivalis in Escherichia coli for production of a vaccine candidate🚀

Highlights

• A novel P. gingivalis vaccine candidate was engineered by glycosylating gingipain with the O-antigen of P. gingivalis LPS in a modified E. coli strain.
• The antigen was successfully expressed in E. coli and purified to over 99% purity using advanced chromatography techniques.
• Western blot analysis confirmed efficient glycosylation, with the antigen recognized by both anti-gingipain and anti-LPS antibodies.
• This innovative strategy eliminates the need for chemical conjugation, enabling precise, recombinant LPS glycosylation for vaccine development.
• If proven effective in animal models, this approach could accelerate the development of vaccines for periodontitis and other bacterial infections.

https://advances.umw.edu.pl/en/ahead-of-print/200882/

22/10/2025

🚀Ahead of print 🚀

Association between stress-induced hyperglycemia ratio and sepsis risk in patients admitted to ICU

❗Highlights❗

➡️Elevated stress hyperglycemia ratio (SHR) is significantly associated with increased sepsis risk in ICU patients.
➡️SHR, rather than baseline blood glucose, serves as an independent predictor of sepsis during critical care admission.
➡️The association between high SHR and sepsis is particularly strong in elderly, male, and non-diabetic patients.
➡️Routine SHR monitoring could help clinicians identify high-risk patients and enable earlier sepsis intervention in the ICU.

https://advances.umw.edu.pl/en/ahead-of-print/194503/

21/10/2025

📢1st Rare Disease Congress – Rare Diseases for Pediatricians and Family Physicians📢

We cordially invite you to participate in the 1st Rare Disease Congress - Rare Diseases for Pediatricians and Family Physicians, which will take place on November 21–22, 2025, at the Mercure Hotel in Wroclaw.

This is not a motto that has been defined: There is no disease whose incidence is so rare that it does not require our special attention.

Rare diseases pose a challenge to modern medicine, the healthcare system, and society as a whole. Although they are indeed rare, patients with rare diseases are numerous – in Poland, they may affect over 2.5–3 million people.

To date, nearly 8,000 conditions have been described that meet the definition of a rare disease (one person in 2,000 inhabitants). These diseases have a variety of symptoms, a progressive course, and often a poor prognosis. They encompass every field of medicine, so every doctor, nurse, physiotherapist, therapist, or other medical specialist undoubtedly encounters them in their practice. Early diagnosis and initiation of appropriate treatment are crucial.

Rare diseases, like all chronic diseases, require comprehensive and coordinated care. However, in medicine, pediatricians and family medicine physicians are closest to the patient with a rare disease. Therefore, to address the need to systematize and deepen knowledge about rare diseases, we invite you to the two-day First Congress of Rare Diseases, is organized by the Polish Society of Pediatric Endocrinology and Diabetology and the Polish Society of Congenital Metabolism, in cooperation with: the Polish Society of Human Genetics, the Polish Society of Pediatric Neurologists and the Polish Society of Family Medicine. The Congress will be a unique platform for exchanging knowledge, experiences, and the latest advancements in the field. The program includes thematic workshops and panel discussions. We believe that the opportunity for shared debate broadens diagnostic and therapeutic perspectives, building the potential and value of every physician.

This will also be an opportunity for our integration, which often creates new opportunities and opens doors in difficult clinical situations, improving the quality of life of patients suffering from rare diseases.

WE WARMLY INVITE YOU TO WROCLAW

MORE INFORMATION [IN POLISH]:

https://ptmr.info.pl/wydarzenia/i-kongres-chorob-rzadkich/

https://grupamedica.pl/wydarzenia/i-kongres-chorob-rzadkich-choroby-rzadkie-dla-pediatrow-i-lekarzy-rodzinnych-21-22-11-2025-hotel-mercure-wroclaw/

20/10/2025

🚀Ahead of print🚀

🚀Effects of echinacoside on the regulation of mitochondrial fission induced by TBK1/Drp1 in rheumatoid arthritis🚀

Highlights

• TBK1 is highly expressed in rheumatoid arthritis (RA) synovial tissue and may promote inflammation through Drp1-mediated mitochondrial fission.
• Echinacoside reduces inflammation and oxidative stress in RA-derived MH7A synoviocytes, highlighting its potential as a natural anti-inflammatory compound.
• Echinacoside alleviates mitochondrial dysfunction by inhibiting mitochondrial fission in MH7A cells.
• The anti-inflammatory effects of echinacoside in rheumatoid arthritis are linked to its regulation of the TBK1/Drp1 signaling pathway.

https://advances.umw.edu.pl/en/ahead-of-print/199920/

Adres

Karola Marcinkowskiego 2-6
Wroclaw
50-368

Godziny Otwarcia

Poniedziałek	08:00 - 16:00
Wtorek	08:00 - 16:00
Środa	08:00 - 16:00
Czwartek	08:00 - 16:00
Piątek	08:00 - 16:00

Telefon

+48607983232

Strona Internetowa

https://advances.umw.edu.pl/en/home/

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