Editors-in-Chief: 
18/12/2024
Rationale and design of the MICE study: exploration of the temporal relation between electrical and mechanical events during myocardial ischemia 📝
This study protocol outlines the rationale and design of the MICE (Myocardial Ischemia Cascade Events) study, which critically evaluates the validity of the established ischemic cascade hypothesis. This concept postulates a predictable sequence of physiological events during myocardial ischemia. The primary aim is to elucidate the temporal interplay between electrical and mechanical dysfunction in the myocardium during acute ischemia, using an innovative method combining intracoronary electrocardiography (icECG) and wall motion analysis via a single PCI wire.
Study Highlights
🔸 Objective: To identify the primary ischemic event (electrical or mechanical) and assess its clinical implications.
🔸 Methodology: A single-center, prospective, observational study including 323 patients with chronic coronary syndrome scheduled for PCI. Ischemia is induced transiently by balloon inflation, allowing simultaneous recording of mechanical and electrical parameters.
🔸 Preliminary Results:
🔹 In 55% of patients, electrical changes (e.g., ST-segment elevation) were the initial manifestation of ischemia.
🔹 Mechanical dysfunction (e.g., reduced wall motion) occurred first in 36% of cases.
🔹 Concurrent onset of both phenomena was observed in 9% of patients.
🔸 Clinical Implications: Findings may inform advancements in diagnostic strategies and therapeutic interventions for coronary artery disease, with the potential to improve patient outcomes and refine clinical guidelines.
Authors: Niya Mileva, Teodora Yaneva-Sirakova, Irina Hristova, Despina Georgieva, Greta Koleva, Dimitra Psalla, Ranko Georgiev, Dobrin Vassilev.
🔗 Access Full Article: https://journals.viamedica.pl/cardiology_journal/article/view/98481
