01/10/2023
🔔📚"Detail syllabus for SPSC test for Hospital Pharmacist (BPS-17)
1- PHARMACEUTICS:
🔹Pharmaceutical Principles and Drug Dosage Forms;
🔺Solutions; Solvents, Solutes, Electrolytes, Non-electrolytes
🔹Colligative Properties:
🔺Lowering of v***r pressure, Elevation of boiling point, Depression of freezing point, Osmosis and Osmotic pressure
🔹Buffers and buffer capacity:
🔺Buffers, Buffer action, and Buffer capacity
🔹Dispersed Systems
🔹Chemical Kinetics and Drug Stability
🔹Reaction rates and orders of reaction
🔹Modes of pharmaceutical Degradation:
🔺Hydrolysis, Oxidation, Photolysis
2- Pharmaceutical Dosage Forms
🔹Basics of Dosage forms; Modified Release Dosage Forms and Novel Drug Delivery Systems
3- Biopharmaceutics and Pharmacokinetics
🔹Drug Dissolution, Drug Solubility, Particle size and surface area, Partition coefficient and extent of ionization, Salt formation, Polymorphism, Chirality, Hydrates, Complex formation.
🔹Zero order and first order Kinetics, Models and compartments, Drug Absorption, Distribution, Metabolism and Excretion (ADME).
🔹Bioavailability and Bioequivalence; Relative and Absolute bioavailability, AUC, Cmax, Tmax, Half-life
4- Industrial Processes and Techniques
🔹Heat & mass transfer, clarification & filtration, ev***ration, mixing, compression & compaction. Microencapsulation and coating techniques.
5- Micro biology:
🔹Difference b/w Gram negative & positive structure
Atypical Organisms
🔹Acid fast Bacilli
🔹Causative agents of various infective diseases
Virus.structurte, growth, main causative agents
Fungi structurte, growth, main causative agents
Protozaons structurte, growth, main causative agents
🔹Hook worms & flat worms
🔹Sterilization in detail
6- PHARMACEUTICAL CHEMISTRY:
🔹Introduction to organic chemistry
🔹Introduction and application of Carhoxylic acids, Phenols,Alcohols, Aldehyde and Ketones Free Radical studies.
7- Chemistry of Biomolecules
🔹Introduction, Biological and pharmaceutical importance of Carbohydrates, Proteins, Lipids, Vitamins, Enzymes and Hormones
8-Principles of Medicinal Chemistry
🔹Structure Activity Relationship;
🔹Structurally non-specific drugs,
🔹Structurally specific drugs
🔹SAR of NSAIDS drugs
🔹SAR of Beta-Lactam Antibiotics
🔹SAR of local and general anasthetic drugs
🔹Receptor-site theory, Receptor-site Binding
🔹 Stereochemistry (optical isomers, geometric isomers and conformational isomers)
9- Instrumentation
🔹Basic Principle, instrumentation and Pharmaceutical applications of following techniques; HPLC, UV-spectrophotometery, IR, Mass-spectroscopy and NMR column chromatography, TLC and paper chromatography
10- PHARMACOLOGY AND THERAPEUTICS :
🔹General Pharmacology
🔹Pharmacokinetics:
🔺Drug absorption, distribution, metabolism, elimination and factors influencing.
🔺Route of drug administration, merits and demerits.
🔺Biological half life, volume of drug distribution, clearance, area under curve, bioavailability.
🔹Pharmacodynamics:
🔺Mechanism of drug action.
🔺Concept of drug receptors, types and properties.
Agonists, antagonists, partial agonists and inverse agonists.
🔺Antagonisms and types.
🔺Dose and factors affecting dose.
🔺Dose-response relationship and types.
🔺ED:50, LD:50, TD:50 and therapeutic index.
11- Systemic Pharmacology:
🔹Classification, mode of action, pharmacokinetics, organ/system effects, indications and adverse effects of the following classes of drugs:
🔺Drugs acting on autonomic nervous system
🔺Sympathomimetics and sympatholytics.
🔺Parasympathomimetics and parasympatholytics.
🔺Drugs acting on cardiovascular system
🔺Antihypertensive.
🔺Antianginal and antiarrythmics.
🔺Diuretics.
🔺Drugs use in congestive cardiac failure.
🔺Autacoids and antagonists
🔺Analgesics, antipyretics and anti-inflammatory.
🔺Drugs used in central nervous system disorders
Antidepressants.
🔺Sedatives, hypnotics including anxiolytics.
🔺Antiepileptics.
🔺Drugs used in Parkinson’s disease.
🔺Antipsychotics.
🔺Central nervous system stimulants.
🔺Drugs used in respiratory system diseases
🔺Antiasthmatics.
🔺Antitussive.
🔺Anesthetics (local and general)
🔺Hormones and antagonists
🔺Chemotherapeutic agents
🔺Antineoplastics (anticancer)
🔺Antimicrobials.
🔺Drugs used in gastrointestinal diseases
🔺Poisoning and principles of treatment
12- Clinical Pharmacy
🔹General introduction to clinical pharmacy
🔹Clinical trials of drug substances
🔹Clinical therapeutics and disease management
🔹Community Pharmacy
🔹Community Pharmacy practice
🔹Patient education and counseling
🔸Pharmacovigilance
13- Hospital Pharmacy
🔹Rational use of drugs and essential drugs
🔹Safe use of medication in the hospital
🔹Drug utilization evaluation & drug utilization review (DUE/DUR)
🔹Hospital formulary & Pharmacy therapeutic committee.
♦️General knowledge portion-Go through General knowledge book Of Ch Ahmed Najib.
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