JAMA Ophthalmology

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JAMA Ophthalmology JAMA Ophthalmology is a member of the JAMA Network, a consortium of peer-reviewed publications.

In this cohort study of repeat long-duration spaceflight missions, previous SANS diagnosis and optic disc edema severity...
29/11/2025

In this cohort study of repeat long-duration spaceflight missions, previous SANS diagnosis and optic disc edema severity reliably predicted recurrence in individual astronauts, enabling tailored preflight planning and in-flight treatment to enhance astronaut care.

https://ja.ma/4pvDjTx

On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a ...
28/11/2025

On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new World Health Organization (WHO) guideline concerning -1 therapy and adults with .

Register for the webinar: https://ja.ma/4p3nRhu

Descemet membrane endothelial keratoplasty ( ) demonstrated superior contrast sensitivity compared with ultra-thin Desce...
28/11/2025

Descemet membrane endothelial keratoplasty ( ) demonstrated superior contrast sensitivity compared with ultra-thin Descemet stripping automated endothelial keratoplasty ( ).

https://ja.ma/4rdjqCi

The 23-item Vitreous Floaters Functional Questionnaire had high test-retest reliability and correlated with vitreous str...
28/11/2025

The 23-item Vitreous Floaters Functional Questionnaire had high test-retest reliability and correlated with vitreous structure and visual function.

https://ja.ma/4826NT9

In patients with molecularly confirmed USH1C-associated retinopathy, longitudinal assessment demonstrates slow progressi...
27/11/2025

In patients with molecularly confirmed USH1C-associated retinopathy, longitudinal assessment demonstrates slow progression of vision loss and structural change into middle adulthood, with preservation of central vision in some cases.

Depression and unemployment were frequent, signaling substantial social impact.

https://ja.ma/3XiXsQE

Up to 82% of UK patients with geographic atrophy found intravitreal complement inhibitor therapy acceptable if it provid...
27/11/2025

Up to 82% of UK patients with geographic atrophy found intravitreal complement inhibitor therapy acceptable if it provided vision benefits, with acceptability closely tied to perceived treatment effectiveness and confidence in attending regular clinic visits.

https://ja.ma/4p3neVt

On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a ...
26/11/2025

On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new WHO guideline concerning -1 therapy and adults with .

Register for the webinar: https://ja.ma/4ohyxYM

A case series study at a tertiary referral center evaluated compounded imiquimod 5% ointment as a treatment for diffuse ...
26/11/2025

A case series study at a tertiary referral center evaluated compounded imiquimod 5% ointment as a treatment for diffuse conjunctival melanoma in situ (MIS) and ocular surface squamous neoplasia (OSSN).

All five adult patients showed either complete or partial clinical and histological responses after 12-15 weeks of treatment, with no concerning safety events—ocular side effects resolved quickly after drug holidays or treatment completion.

https://ja.ma/49C7aFf

An 11-day-old boy was referred for evaluation of right eye leukocoria and was diagnosed with persistent fetal vasculatur...
26/11/2025

An 11-day-old boy was referred for evaluation of right eye leukocoria and was diagnosed with persistent fetal vasculature.

Fundus photographs revealed perfluoro-n-octane bubbles in the inferior retina, and optical coherence tomography showed good foveal contour, no macular edema or epiretinal membrane, and final best-corrected visual acuity of 20/300 in the right eye.

What would you do next?

https://ja.ma/4836fMW

Use of atropine for cycloplegia in preschool children was associated with less myopic refraction compared with cyclopent...
25/11/2025

Use of atropine for cycloplegia in preschool children was associated with less myopic refraction compared with cyclopentolate and may potentially avoid overestimation of premyopia prevalence. https://ja.ma/4acgcJ8

Among patients with newly diagnosed , lower wealth was associated with decreased odds of achieving the minimum reductio...
24/11/2025

Among patients with newly diagnosed , lower wealth was associated with decreased odds of achieving the minimum reduction in intraocular pressure recommended by national guidelines on quality of care. https://ja.ma/48xaqRa

The incidence of acute angle closure following pharmacologic pupillary dilation in a large teleretinal diabetic retinopa...
23/11/2025

The incidence of acute angle closure following pharmacologic pupillary dilation in a large teleretinal diabetic retinopathy screening program was low, supporting the safety of dilation in such settings and validating the use of ICD codes for identifying AAC cases. https://ja.ma/4ppuk6k

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