JAMA Ophthalmology

10/01/2026

Distinctive HR-OCT features in pseudoxanthoma elasticum highlight Bruch membrane calcification and provide a potential early marker for progression and treatment response.

https://ja.ma/49wPwky

10/01/2026

A 66-year-old man had nebulomacular corneal opacities, iris atrophy, and corectopia along with coarse facial skin, resorbed digits, anesthetic patches, and healed trophic skin ulcers.

What would you do next?

https://ja.ma/4pxS6g3

09/01/2026

In the first month of life, preterm infants who developed severe showed distinct longitudinal protein profiles related to metabolic stress, inflammation, and coagulation.

The most pronounced finding was a rapid increase in , which was associated with key neonatal factors including low birth weight and poor nutritional intake.

https://ja.ma/4aLktDP

08/01/2026

A multicenter cohort study of nearly 2 million clinic encounters found that intraocular pressure ( ) remains a central factor in glaucoma management, with treatment initiation rates rising alongside increasing IOP values.

Although clinicians generally appeared to use IOP as a continuous risk factor, the rate of initiating IOP-lowering therapy showed marked acceleration for IOP levels ≥22 mm Hg. https://ja.ma/4svwhQR

08/01/2026

Despite guidelines, vancomycin prescribing for bacterial keratitis has increased, while cefazolin use remains low.

https://ja.ma/4qzGzO2

07/01/2026

This case report describes a large choroidal excavation and outer retinal atrophy in an otherwise healthy man aged 29 years who presented with bilateral gradually worsening vision since childhood.

https://ja.ma/4pnBlnM

05/01/2026

Distinctive HR-OCT features in pseudoxanthoma elasticum highlight Bruch membrane calcification and provide a potential early marker for progression and treatment response.

https://ja.ma/4ptc1wF

04/01/2026

Case report: occlusion of the retinal vessels following intravitreal injection of aflibercept, 8.0 mg, in a woman with neovascular age-related macular degeneration.

https://ja.ma/4jmsH7v

03/01/2026

Children as young as 15 months with biallelic RPE65 pathogenic variants treated with voretigene neparvovec showed measurable improvements in pattern , suggesting retinogeniculostriate pathway recovery. Reliable full-field stimulus testing was limited, and changes in standard visual acuity were not significant for most patients.

https://ja.ma/4aJ2PAI

02/01/2026

💬 Editorial: The “Eye on AI” series by JAMA Ophthalmology aims to translate complex advances—such as vision-language models and autonomous device integration—into practical concepts for clinicians, accelerating adoption of safe, effective AI in ophthalmic care.

In 2025, JAMA Ophthalmology launched a new theme for submissions and publications, JAMA Eye on AI. This theme recognizes the potentially transformative effect that artificial intelligence (AI) in the form of deep learning may have on ophthalmology and all of medicine through quantum leaps in both...

02/01/2026

A case-control study analyzed female carriers of RPGR variants responsible for X-linked cone dystrophy in hemizygous male individuals.

In this cohort, female carriers exhibited mild cone dysfunction with photophobia, myopia, and macular changes—manifested as diffuse, granular hyperautofluorescence limited to the posterior pole and an en face tapetallike sheen detected on multimodal imaging.

https://ja.ma/4pUNDoG

02/01/2026

Home hazards amplify fall risk for older adults with visual impairment, supporting combined vision and environmental risk assessments in prevention protocols.

https://ja.ma/4qs0COu