JAMA Ophthalmology

19/12/2025

This case report discusses a diagnosis of reticular epithelial corneal edema in a male patient aged 57 years who presented with a sudden decrease in vision in his right eye, which was receiving treatment with netarsudil for neovascular . https://ja.ma/3YyPX8L

18/12/2025

Interview with Tien Y. Wong, MD, PhD, author of Aflibercept 8 mg in Polypoidal Choroidal Vasculopathy: Post Hoc Analysis of the PULSAR Randomized Clinical Trial. Hosted by Neil Bressler, MD. https://ja.ma/3Mxq6ve

18/12/2025

Among adults with polypoidal choroidal vasculopathy, visual and anatomical outcomes at 48 weeks were comparable between aflibercept 8 mg every 12 or 16 weeks and aflibercept 2 mg every 8 weeks.

https://ja.ma/45afFnF

15/12/2025

Multimodal imaging demonstrated an unusual complex inner retinal structure with epiretinal hyperreflective features in a patient with blurred vision after cataract surgery. Genetic testing showed no COL4A1-3 variations; vitrectomy is under consideration to clarify the diagnosis. https://ja.ma/49bswZe

14/12/2025

A case of rapid, severe bilateral vision loss in a patient with metastatic bladder cancer revealed cancer-associated retinopathy potentiated by pembrolizumab immunotherapy. Aggressive immunosuppression and plasmapheresis were associated with partial visual recovery despite profound initial deficits. https://ja.ma/4iVmW0w

13/12/2025

In a national analysis, fluoroquinolones were the most common first-line therapy for bacterial keratitis, most frequently as monotherapy, followed by aminoglycosides and vancomycin. Despite guideline recommendations, cefazolin use was rare, while vancomycin prescribing increased over time. https://ja.ma/48Afgx9

12/12/2025

Home hazards amplify fall risk for older adults with visual impairment, supporting combined vision and environmental risk assessments in prevention protocols.

https://ja.ma/4admKY6

12/12/2025

Subcutaneous pentosan polysulfate sodium was associated with macular toxic effects at doses as low as 45.5 to 96 g over 7 to 10 years. These findings highlight the need for early recognition and regular retinal imaging in patients using this route of administration. https://ja.ma/4rOoPAh

11/12/2025

In this episode of the JAMA Ophthalmology Author Interviews podcast, Neil Bressler, MD, speaks with Joshua Ehrlich, MD, MPH, of the University of Michigan Department of Ophthalmology and Visual Sciences about how home hazards and visual function work together to shape fall risk in older adults.

Listen now:

Interview with Joshua R. Ehrlich, MD, MPH author of The Central Role of Home Hazards in Shaping the Association of Visual Function and Falls in Older Adults. Hosted by Neil Bressler, MD.

11/12/2025

Among US adults aged ≥65 years, the association between impaired visual function and falls was stronger in homes with environmental hazards such as missing grab bars, tripping hazards, or broken flooring.

These findings highlight the potential for targeted home safety interventions to reduce fall risk in older adults with poor vision.

https://ja.ma/48KXUwj

08/12/2025

This case report discusses a diagnosis of Axenfeld-Rieger syndrome in an 8-month-old infant who presented with bilateral abnormal pupils, posterior embryotoxon, and dental abnormalities. https://ja.ma/3XzBFo2

07/12/2025

Pharmacologic inhibition of the Hippo signaling pathway via YAP/TEAD inhibitor therapy was associated with peripapillary chorioretinal atrophy similar to findings in inherited TEAD1-related disease.

This suggests Hippo pathway activity is important for retinal maintenance in adults, and new therapeutic agents targeting this pathway may require increased clinical attention to ocular adverse effects among treated patients. https://ja.ma/3YfsMjy