The Lancet

The Lancet The Lancet Group is a collection of 24 medical & health journals united by a shared vision – publishing the best science for better lives,

The Lancet began as an independent, weekly general medical journal founded in 1823 by Thomas Wakley. Since its first issue, the journal has addressed urgent medical and health-related topics, initiated debate, and influenced decision-makers around the world. In 2023, we celebrated The Lancet’s 200th year and its evolution into a Group of 24 journals spanning a wide range of fields and world region

s. After two centuries, The Lancet Group retains, at its core, the belief that medicine must serve society, that knowledge must transform society, and that the best science must lead to better lives. To find out more about, visit www.thelancet.com. The Lancet is a trade mark of RELX Intellectual Properties SA, used under license.

What are the possible effects of spaceflight on brain structure and function? A new Review explores evidence from the pa...
30/06/2024

What are the possible effects of spaceflight on brain structure and function?

A new Review explores evidence from the past five years, and highlights how space travel may impact the brain such as:

🔹microgravity may cause movement of fluids, grey, and white matter in the brain
🔹microgravity may also impact the brain’s sensory processing ability leading to issues with mobility and balance
🔹multiples stressers on the brain during spaceflight – microgravity, radiation, confinement, disrupted sleep, etc – may have a combined effect on the astronaut

Explore the Review in full: https://hubs.li/Q02DHNt80

👇 Figure: Intracranial fluid changes after long-duration spaceflight.

Approximately 1.8 billion people worldwide did not meet the recommended levels of physical activity in 2022, suggests a ...
29/06/2024

Approximately 1.8 billion people worldwide did not meet the recommended levels of physical activity in 2022, suggests a new study in The Lancet Global Health.

Authors discuss how many countries need to strengthen their policy implementation to promote and enable physical activity through community sport, active recreation and transport such as walking and cycling.

Explore the data 👉 https://hubs.li/Q02DHq2G0

A 61-year-old woman presented hemodynamic instability associated with myocarditis, colitis, hepatitis, hypothyroidism, p...
28/06/2024

A 61-year-old woman presented hemodynamic instability associated with myocarditis, colitis, hepatitis, hypothyroidism, polyradiculoneuropathy and these cutaneous lesions. The patient had been receiving treatment for clear cell renal cell carcinoma and had completed the third infusion of pembrolizumab; she was also prescribed axitinib.

What is most likely diagnosis? Write your answer in the comments below 👇

1️⃣ Disseminated petechia associated with sepsis
2️⃣ Thrombosing vasculopathy due to disseminated intravascular coagulopathy
3️⃣ Catastrophic antiphospholipid syndrome
4️⃣ Immune-related adverse event

Sleep problems are common in those with Parkinson's disease, which can occur due to changes in the brain structures that...
27/06/2024

Sleep problems are common in those with Parkinson's disease, which can occur due to changes in the brain structures that control sleep, side effects of medications, movement difficulties, and other health issues that affect sleep.

A new Review discusses how common these issues are in people with Parkinson's disease, the impact on patients, and how they are diagnosed and treated: https://hubs.li/Q02DznS70

👇 Panel: Common features that can be detected in people with isolated REM sleep behaviour disorder.

Did you know Lung cancer is the most commonly diagnosed form of cancer and one of the leading causes of cancer mortality...
27/06/2024

Did you know Lung cancer is the most commonly diagnosed form of cancer and one of the leading causes of cancer mortality in Asia?

Join our upcoming Lancet Webinar to learn more about this epidemic from our Series authors. Our authors will explore the trends and challenges of lung cancer in Asia, including insight into drug development, the impact of climate change on lung cancer incidence, and the unique characteristics shaping the healthcare landscape for Asian populations.

Register now: https://hubs.li/Q02DnQyq0
🗓️ Jul 9, 2024
🕘 09:30 BST / 16:30 CST

Gestational diabetes affects 1 in 7 pregnancies and is the most common medical pregnancy complication worldwide.Without ...
26/06/2024

Gestational diabetes affects 1 in 7 pregnancies and is the most common medical pregnancy complication worldwide.

Without treatment, gestational diabetes can lead to increased risk of high blood pressure, caesarean sections, health complications later in life, such as type 2 diabetes and cardiovascular disease and complications for the baby at delivery.

A new Lancet Series calls for a greater focus on early gestational diabetes and a shift to a holistic life-course approach in how we manage the disease. Explore the Series in full 👉 https://hubs.li/Q02D9f-N0

A 19-year-old man attended a rheumatology clinic with a 7-year history of finger swelling. The patient referred to arthr...
25/06/2024

A 19-year-old man attended a rheumatology clinic with a 7-year history of finger swelling. The patient referred to arthralgia without weakness, limitations of activity, or morning stiffness and habitual knuckle cracking of the affected hand.

Physical examination revealed swelling around the first, second, third, and fourth proximal interphalangeal joints of the left hand with hyperkeratosis. An x-ray of both hands showed soft-tissue swelling without joint alterations.

What is the most likely cause of the swelling? Put your knowledge to the test with our Clinical Picture quiz 👉 https://hubs.li/Q02D8XBZ0

There's still time to register!Join The Lancet Planetary Health's editorial team as they share the journal’s aims and sc...
25/06/2024

There's still time to register!

Join The Lancet Planetary Health's editorial team as they share the journal’s aims and scope, what they are looking for in a research paper, and best practices to prepare your manuscript for publication in their journal.

Can't join us live? Register to receive the link to the on-demand version when it becomes available, to watch at your convenience.

Register now: https://hubs.li/Q02zcXb_0
🗓️ Thurs, Jun 27, 2024
🕘 16:00 BST / 11:00 EDT

Colorectal cancer is the third most diagnosed cancer in the world.In a new Seminar, authors provide a global multidiscip...
24/06/2024

Colorectal cancer is the third most diagnosed cancer in the world.

In a new Seminar, authors provide a global multidisciplinary perspective of clinical advances in colorectal cancer: https://hubs.li/Q02C_Jyl0

👇 Figure: CMS of colorectal cancer.

Lung cancer remains the leading cause of cancer-related mortality in Asia, with nearly 5.8 million total cancer deaths i...
22/06/2024

Lung cancer remains the leading cause of cancer-related mortality in Asia, with nearly 5.8 million total cancer deaths in the region in 2020.

Join our expert panel during our upcoming Lancet Webinar. As part of this cross-journal Review Series between eClinicalMedicine, The Lancet Regional Health – Southeast Asia, and The Lancet Regional Health – Western Pacific, our authors will explore the trends and challenges of the lung cancer epidemic in Asia.

Register now: https://hubs.li/Q02CC4Lt0
🗓️ Jul 9, 2024
🕘 09:30 BST / 16:30 CST

A 37-year-old woman presented with a 1-month history of fatigue, weight loss, palpitations, and dyspnoea. On examination...
21/06/2024

A 37-year-old woman presented with a 1-month history of fatigue, weight loss, palpitations, and dyspnoea. On examination, a firm, hard moderate-sized goitre was found. Laboratory investigations showed severe hyperthyroidism. 12 months earlier, she had pelvic varicose veins treated with embolisation with glue and lipiodised oil.

Looking at the unenhanced CT scan of the thyroid, which showed the gland to be very hyperdense (circle shows unenhanced density of 147 Hounsfield units compared to surrounding muscles).

What is the most likely diagnosis? Try our latest Clinical Picture quiz 👉https://hubs.li/Q02CN1QJ0

Persistent physical symptoms (PPS) is an umbrella term for distressing somatic symptoms that last several months or more...
20/06/2024

Persistent physical symptoms (PPS) is an umbrella term for distressing somatic symptoms that last several months or more, and represent a major burden for patients, health-care professionals, and society.

In a new Review, authors provide a comprehensive overview of the emerging understanding of PPS and explore future research directions: https://hubs.li/Q02CD_fV0

👇 Figure: Illustration of the predictive coding model in symptom perception.

Liver cyst infection is one of the most challenging complications of cystic liver disease which is difficult to diagnose...
19/06/2024

Liver cyst infection is one of the most challenging complications of cystic liver disease which is difficult to diagnose, and can often require long-term hospital admission.

In a new Review, authors discuss management of liver cyst infections in the context of both isolated liver cysts and polycystic liver disease, and develop a clinical decision framework: https://hubs.li/Q02Cthv90

👇 Figure: Liver cyst infection subclassification.

Peptic ulcer disease refers to ulcerations in the stomach and duodenum, involving breaks in the full thickness of the ga...
17/06/2024

Peptic ulcer disease refers to ulcerations in the stomach and duodenum, involving breaks in the full thickness of the gastrointestinal mucosa.

It is usually attributable to Helicobacter pylori infection, intake of some medications, or being critically ill (stress-related).

Find out more in a new Seminar: https://hubs.li/Q02C0Y1H0

⬇️ Figure: Main pathophysiological mechanisms of peptic ulcer disease

📢 We're now inviting submissions for our annual essay competition, The Lancet's Wakley Prize.Put pen to paper and share ...
16/06/2024

📢 We're now inviting submissions for our annual essay competition, The Lancet's Wakley Prize.

Put pen to paper and share your thought provoking and original ideas about centring care in medicine.

Find out more about this year’s theme: https://hubs.li/Q02BTGgN0

A 37-year-old man with no history of hypertension presented to a clinic with acutely elevated blood pressure without sym...
15/06/2024

A 37-year-old man with no history of hypertension presented to a clinic with acutely elevated blood pressure without symptoms. Fundoscopy showed grade IV hypertensive retinopathy. His blood pressure was 230/140 mm Hg and urinalysis showed more than 300 mg/dL of protein.

What combinations of medication would be most helpful and safe to lower the patient’s blood pressure? Try our latest Clinical Picture quiz to find out 👉https://hubs.li/Q02BTVSq0

In the past ten years, avian influenza viruses have become a growing threat worldwide, and have had a significant impact...
14/06/2024

In the past ten years, avian influenza viruses have become a growing threat worldwide, and have had a significant impact on both human and animal health.

Certain strains may pose a risk for future pandemics, highlighting the importance of advanced surveillance, diagnostic technologies, and state-of-the-art analysis methods.

A new Personal View explores how avian influenza viruses have evolved over the last decade, and improved surveillance and analysis methods: https://hubs.li/Q02BVr_p0

👇 Figure: A framework for tracking the emergence of human and animal outbreaks of avian influenza virus infection.

Have you registered yet? Join The Lancet Planetary Health's editorial team as they share their journal's aims and scope ...
13/06/2024

Have you registered yet?

Join The Lancet Planetary Health's editorial team as they share their journal's aims and scope and what they are looking for in a research paper. The session will end with a live Q&A, where Alastair & John will answer your questions.

Register now: https://hubs.li/Q02zcXdS0
🗓️ Thurs, Jun 27, 2024
🕘 16:00 BST / 11:00 EDT

Save time by focusing on what matters most to you with our new In focus Alerts launching this month, bringing you specia...
12/06/2024

Save time by focusing on what matters most to you with our new In focus Alerts launching this month, bringing you specialty focused content, events, and more from across The Lancet Group.

Register today to start receiving your monthly roundup in oncology, obgyn, neurology, or psychiatry: https://hubs.li/Q02BlwKq0 (more specialties to be announced soon!)

Portal hypertension represents the primary non-neoplastic complication of liver cirrhosis. It has life-threatening conse...
11/06/2024

Portal hypertension represents the primary non-neoplastic complication of liver cirrhosis. It has life-threatening consequences, such as oesophageal variceal bleeding, ascites, and hepatic encephalopathy.

The condition occurs due to increased resistance of the cirrhotic liver vasculature to portal blood flow and is further aggravated by the hyperdynamic circulatory syndrome.

In a new Review, authors discuss recent discoveries in the pathophysiology and treatment of cirrhotic portal hypertension - which has few pharmacological treatment options. Read here: https://hubs.li/Q02BdJnf0

👇 Figure: Portal hypertension pathophysiology

What is a diabetes-related foot ulcer (DFU)?DFU has been defined as a break in the skin of the foot of a person with dia...
10/06/2024

What is a diabetes-related foot ulcer (DFU)?

DFU has been defined as a break in the skin of the foot of a person with diabetes, which penetrates as a minimum to the epidermis and part of the dermis. An ulcer might be triggered by trauma, but its cause might not be clear.

Infection complicates the management of DFUs as it might impair wound healing and can lead to tissue loss, sepsis, and osteomyelitis.

A new Review in The Lancet Diabetes & Endocrinology highlights the complexity of the pathological processes that underlie DFUs and draws attention to potential implications for clinical management and outcome ▶️ https://hubs.li/Q02B2X9g0

👇 Figure: Pathogenesis of the onset, persistence, and perpetuation of foot ulcers in diabetes

Children’s health, especially mental health, is not adequately considered in climate adaptation policies, suggests a new...
09/06/2024

Children’s health, especially mental health, is not adequately considered in climate adaptation policies, suggests a new analysis in The Lancet Child & Adolescent Health.

Explore ▶️ https://hubs.li/Q02B1w6V0

👇 Figure: Inductive themes of child-health adaptation and child-related terminology

A 57-year-old man with a two day history of a fever and sudden onset of bilateral hearing loss was admitted to a local i...
07/06/2024

A 57-year-old man with a two day history of a fever and sudden onset of bilateral hearing loss was admitted to a local infectious diseases unit. The patient had rigor nucalis and Kernig’s sign was present. The patient was treated empirically with intravenous ceftriaxone at a dose of 2 g every 12 h. Real-time PCR testing of a sample of CSF was positive for serotype B Neisseria meningitidis.

One month after leaving hospital, the patient attended the unit and had simultaneous bilateral cochlear implantation; his postoperative course was uneventful. At a follow-up appointment 9 months after the operation, the cochlear implants provided the patient with a pure-tone average of 35 dB—indicating mild hearing loss. Speech audiometry found a speech discrimination score of 100% at 50 dB (typically in people with normal hearing the score is 100% at 30 dB).

Why is it appropriate to proceed with an early cochlear implant placement in anacusis due to bacterial meningitis? Try our latest Clinical Picture quiz to find out more 👉 https://hubs.li/Q02zXrxK0

The use of artificial intelligence (AI) in health care has seen remarkable growth in the past 5 years.A recent Review ex...
06/06/2024

The use of artificial intelligence (AI) in health care has seen remarkable growth in the past 5 years.

A recent Review examines the potential of AI to improve care management, clinical decision-making efficiency, and identifies areas for further research:https://hubs.li/Q02zRvRq0

👇 Figure: Randomised controlled trials of artificial intelligence in clinical practice across countries and specialties.

In the UK, there is an ambition to diagnose 75% of cancers at stage 1 or 2 by 2028. Innovations for cancer detection in ...
05/06/2024

In the UK, there is an ambition to diagnose 75% of cancers at stage 1 or 2 by 2028.

Innovations for cancer detection in the last decade have improved diagnosis, but come with various challenges when implementing them into clinical practice.

Explore the four key considerations outlined in a Personal View 👉https://hubs.li/Q02zDtpx0

Table: Common methodological approaches in implementation research.

📣 Upcoming webinar📣Join The Lancet Planetary Health's editorial team as they share the journal’s aims and scope, what th...
05/06/2024

📣 Upcoming webinar📣

Join The Lancet Planetary Health's editorial team as they share the journal’s aims and scope, what they are looking for in a research paper, and best practices to prepare your manuscript for publication in their journal.

The webinar will conclude with a live Q&A, where the editors will be answering your questions.

Register now: https://hubs.li/Q02zcXNv0
📆 Thurs, Jun 27, 2024
🕓 16:00 BST / 11:00 EDT

Cirrhosis is an immune dysfunction that can cause patients to be susceptible to bacterial, fungal, and viral infections....
04/06/2024

Cirrhosis is an immune dysfunction that can cause patients to be susceptible to bacterial, fungal, and viral infections. Prevention and effective treatment can be challenging, coupled with multidrug-resistant organisms that have evolved in recent years.

A recent Review explores current prevention strategies, treatment routes, and future research areas to address infections in those with cirrhosis: https://hubs.li/Q02zr4dx0

👇 Figure: Pathogenesis of infections in cirrhosis and potential treatment targets.

Diabetes-related foot ulcers (DFUs) are defined as a break in the skin of the foot of a person with diabetes, which pene...
03/06/2024

Diabetes-related foot ulcers (DFUs) are defined as a break in the skin of the foot of a person with diabetes, which penetrates the epidermis and part of the dermis.

Cases of DFUs have been decreasing, which may be linked to improved diagnosis and diabetes care, however current studies are not standardised, leading to potenially inaccurate reporting.

A new Review discusses the importance of ongoing practice, review, and further research into the prevention and treatment of DFUs: https://hubs.li/Q02zfnt-0

👇 Figure: Pathogenesis of the onset, persistence, and perpetuation of foot ulcers in diabetes.

Dramatic declines in global fertility rates are set to transform global population patterns by 2100, suggested in the la...
02/06/2024

Dramatic declines in global fertility rates are set to transform global population patterns by 2100, suggested in the latest GBD Capstone study.

The decline in fertility rates will have a significant impact, both economically and socially, and highlights challenges in migration and global aid networks.

Explore the GBD study in full 👉 https://hubs.li/Q02z2XPL0

Figure: A section of the associated infographic that outlines key findings from the GBD study.

A 32-year-old man presented with a 3-week history of fever, cough, and general fatigue along with a 1-month history of n...
01/06/2024

A 32-year-old man presented with a 3-week history of fever, cough, and general fatigue along with a 1-month history of night sweats. On examination he was general unwell looking, his temperature was 38.8C, his blood pressure 82/49 mm Hg & he had a sinus tachycardia of 130 beats p/min.

CT scans of the patient’s chest and abdomen showed multiple pulmonary nodules and bilateral adrenal masses—in the left adrenal gland the lesion was 61 mm×36 mm and in the right 90 mm×63 mm. 18fluorodeoxyglucose PET/CT scan showed an increase in tracer uptake in the multiple pulmonary nodules, the bilateral adrenal masses, and the thyroid gland.

What diagnoses should be considered in this patient? Try our latest Clinical Picture quiz to find out more 👉 https://hubs.li/Q02z2CPK0

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