The Lancet

The Lancet The Lancet Group is a collection of 24 medical & health journals united by a shared vision – publishing the best science for better lives,

The Lancet began as an independent, weekly general medical journal founded in 1823 by Thomas Wakley. Since its first issue, the journal has addressed urgent medical and health-related topics, initiated debate, and influenced decision-makers around the world. In 2023, we celebrated The Lancet’s 200th year and its evolution into a Group of 24 journals spanning a wide range of fields and world region

s. After two centuries, The Lancet Group retains, at its core, the belief that medicine must serve society, that knowledge must transform society, and that the best science must lead to better lives. To find out more about, visit www.thelancet.com. The Lancet is a trade mark of RELX Intellectual Properties SA, used under license.

In 2019, an estimated 16.75 million people aged 55 years and older had a hip fracture, which is an increase of more than...
25/01/2025

In 2019, an estimated 16.75 million people aged 55 years and older had a hip fracture, which is an increase of more than 60% since 1990.

With these trends projected to continue due to an ageing global population, what is the potential role for AI in fracture risk prediction?

Find out in a recent Viewpoint ➡️ https://hubs.li/Q033Wxzf0

👇 Figure showing involvement of AI–ML in key strategies to prevent osteoporotic fractures

Hidradenitis Suppurativa is a chronic inflammatory disease that has a profound impact on patients' quality of life.Disco...
24/01/2025

Hidradenitis Suppurativa is a chronic inflammatory disease that has a profound impact on patients' quality of life.

Discover the latest advances, treatment options, and the complex pathogenesis of Hidradenitis Suppurativa in a new Seminar: https://hubs.li/Q033VD_n0

👇 Figure: The structural changes and underlying immune pathways in the skin in hidradenitis suppurativa.

The blood-brain barrier is a protective wall that separates the brain from the blood, keeping harmful substances out.How...
23/01/2025

The blood-brain barrier is a protective wall that separates the brain from the blood, keeping harmful substances out.

However, this barrier makes it hard to deliver medications to the brain for treating brain disorders.

A new Personal View discusses the difficulties surrounding therapeutic delivery to the brain & challenges of developing new drugs for brain tumours and neurodegenerative diseases: https://hubs.ly/Q033HBCw0

👇 Figure: Structure of the blood–brain barrier neurovascular unit.

A recent consensus report concluded that the “review of the literature did not support the conclusion that social media ...
22/01/2025

A recent consensus report concluded that the “review of the literature did not support the conclusion that social media causes changes in adolescent health at the population level”.

Yet, numerous governments have issued guidelines & passed laws that limit adolescents’ social media use to protect their mental health.

A new Personal View discusses how we must improve research on digital harms in youth ▶️ https://hubs.li/Q033lwwl0

👇 Figure: Proposed order and division of research activities for an effective cycle of technological innovation, research, policy making, and industry regulation outlining key responsibilities for stakeholders.

Bipolar disorders are chronic psychiatric conditions characterized by recurrent episodes of mania and depression,  affec...
21/01/2025

Bipolar disorders are chronic psychiatric conditions characterized by recurrent episodes of mania and depression, affecting over 1% of the global population.

A new Review offers a comprehensive update on bipolar disorders to guide further research in addressing the ongoing challenges: https://hubs.li/Q0336W1L0

👇 Figure: Lifechart showing progression of bipolar disorders and recommended pharmacological treatments.

For over a century, radiotherapy has revolutionised cancer treatment. However, long-term toxic effects on healthy tissue...
20/01/2025

For over a century, radiotherapy has revolutionised cancer treatment. However, long-term toxic effects on healthy tissues remain a great clinical challenge.

New Review—Radiotherapy toxicities: mechanisms, management, and future directions:
https://hubs.li/Q03375CT0

👇 Figure: Toxic effects of radiotherapy by site.

Multidrug-resistant Gram-negative bacterial infections cause significant morbidity & mortality globally.However, new dia...
19/01/2025

Multidrug-resistant Gram-negative bacterial infections cause significant morbidity & mortality globally.

However, new diagnostic & antibiotic treatments provide hope that we can better address this important global health issue.

Find out more in our latest Review 👉 https://hubs.li/Q032-lFx0

Figure: Mechanisms of action of key antibiotics for the treatment of multidrug-resistant Gram-negative bacterial infections.

Road traffic crashes are the leading cause of death of children and young adults aged 5–29 years, according to a recent ...
18/01/2025

Road traffic crashes are the leading cause of death of children and young adults aged 5–29 years, according to a recent WHO report.

A new clinical picture quiz follows the treatment of a 4-year-old boy involved in a collision with a speeding motorcycle: https://hubs.li/Q032ZXt50

Acute kidney injury (AKI) is a serious condition that over time, can raise the risk of chronic kidney disease and heart ...
17/01/2025

Acute kidney injury (AKI) is a serious condition that over time, can raise the risk of chronic kidney disease and heart problems.

While there are ways to prevent and treat AKI, care often focuses on managing complications. However, effective long-term care for those recovering from AKI are still limited.

Discover more in the latest Seminar ▶️ https://hubs.li/Q032-nl40

👇 Figure: AKI pathophysiology.

By 2050, diabetes is anticipated to affect over 1.3 billion people, ranking among the primary contributors to global mor...
17/01/2025

By 2050, diabetes is anticipated to affect over 1.3 billion people, ranking among the primary contributors to global mortality and disability.

A new Review explores type 2 diabetes from a genetic standpoint, and highlights the pathophysiological and precision medicine insights derived from genetic studies: https://hubs.li/Q032Yk5V0

👇 Figure: Frequency and risk effect of variants involved in type 2 diabetes.

Over 1 billion people live with obesity. There is an urgent need for a universal definition and diagnosis.🆕 A Lancet Dia...
15/01/2025

Over 1 billion people live with obesity. There is an urgent need for a universal definition and diagnosis.

🆕 A Lancet Diabetes & Endocrinology Commission introduces a new model with categories: clinical obesity (an illness) and pre-clinical obesity. This reframing identifies medically meaningful targets for prevention and treatment.

Joe Nadglowski, patient advocate and Commissioner, adds: “Studies show that the way obesity is usually talked about adds to weight stigma, making it harder to prevent, manage and treat. The approach proposed by this Commission can help clear up misconceptions.”

Read in The Lancet Diabetes & Endocrinology ➡️ https://hubs.li/Q032Bd2_0

Alt: An infographic panel for the Lancet Diabetes & Endocrinology Commission on clinical obesity.

Borna disease is a serious brain infection primarily affecting horses and sheep, which can cause an often fatal brain in...
14/01/2025

Borna disease is a serious brain infection primarily affecting horses and sheep, which can cause an often fatal brain infection in people.

Current knowledge on how the virus spreads and infects the body is limited, prompting the authors of a new Review to discuss the current understanding of Borna disease, and call for further research: https://hubs.li/Q032rjRy0

👇 Figure: Possible Borna disease virus 1 infection cycle in reservoir and dead-end hosts.

Axial spondyloarthritis is a long-lasting inflammatory disease that affects the sacroiliac joints (where the spine meets...
13/01/2025

Axial spondyloarthritis is a long-lasting inflammatory disease that affects the sacroiliac joints (where the spine meets the pelvis) and the spine, often resulting in chronic back pain and stiffness.

A new Seminar reviews the current research for treatment options and future directions to improve early diagnosis care:https://hubs.li/Q0321Pj00

👇 Figure: Pathogenesis of axial spondyloarthritis.

Chronic lymphocytic leukaemia (CLL) is a haematological malignancy of B cells.In the past decade, remarkable progress ha...
12/01/2025

Chronic lymphocytic leukaemia (CLL) is a haematological malignancy of B cells.

In the past decade, remarkable progress has been made in our understanding of disease biology of CLL & the development of novel targeted therapies.

Read more in a Seminar: https://hubs.li/Q0321R8C0

👇 Figure: Approved targeted therapies for patients with CLL and corresponding mechanism of action.

Despite the diverse nature of obesity, there is compelling evidence to suggest brain circuits play an important role.Rea...
11/01/2025

Despite the diverse nature of obesity, there is compelling evidence to suggest brain circuits play an important role.

Read a Review on hypothalamic obesity, from basic mechanisms to clinical perspectives: https://hubs.li/Q030Yp0y0

👇 Figure: Overview of the main hypothalamic nuclei involved in bodyweight and metabolic control

🆕 Clinical Picture quiz: a 62-year-old man with a parastomal hernia at the site of a urinary conduit and symptoms of uri...
10/01/2025

🆕 Clinical Picture quiz: a 62-year-old man with a parastomal hernia at the site of a urinary conduit and symptoms of urinary obstruction lasting several months, attended hospital.

He had a radical cysto-prostatectomy with formation of an ileal conduit ileostomy—involving the interposition of a segment of small bowel between the distal end of the ureters and the skin resulting in urine being collected in a stoma bag—because of a high grade transitional cell carcinoma of the bladder seven years earlier.

On examination, some deformity and asymmetry were seen on inspection of his abdomen: a bulge was visible inferior and lateral to the conduit; overall the abdomen was soft with some mild tenderness noted at the stoma site. Bowel sounds were normal. The conduit ileostomy was pink and warm. The patient reported that only a minimal of urine had been collected in the past few days and we noted little urine output. Regarding the hernia, we found that it was partially reducible with some incarceration, and we concluded that the ileal conduit had obstructed acutely secondary to a parastomal hernia.

Discover more on this case 👉https://hubs.li/Q0321Pjs0

Paediatric acute liver failure is challenging to manage, particularly for clinically unstable patients who may require l...
09/01/2025

Paediatric acute liver failure is challenging to manage, particularly for clinically unstable patients who may require liver transplantation, but may be too critically unwell to receive one.

A recent Review provides a multidisciplinary perspective: https://hubs.li/Q031VLtz0

👇 Figure: Multidisciplinary considerations in managing a child with paediatric acute liver failure in deteriorating condition.

🆕 Experts have developed recommendations to increase transparency and tackle potential AI bias in scientific research. A...
08/01/2025

🆕 Experts have developed recommendations to increase transparency and tackle potential AI bias in scientific research.

AI technologies are increasingly used in healthcare, for example in diagnosing diseases or suggesting appropriate treatments. However, the data used to train AI systems can be a source of algorithmic bias, and this comes with a risk of worsening health inequalities.

In response, the STANdards for data Diversity, Inclusivity and Generalisability (STANDING Together) programme conducted an extensive study and has produced 29 consensus-driven recommendations.

The Lancet Group is pleased to endorse the STANDING Together recommendations. Find out more ➡️ https://hubs.li/Q031J87p0

Figure 2: Datasets, data origins, and source datasets

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