14/11/2025
Revealing the ultrastructure of live Candida albicans. C. albicans is a fungus that can cause serious infections. Researchers used a powerful imaging technique called stimulated emission depletion microscopy to study live C. albicans with very fine detail. Traditional dyes used for imaging mammalian cells were ineffective, so the team developed a new method using Nile Red to visualise key structures inside the fungal cells. Their approach achieved much higher resolution than conventional microscopy, allowing them to track dynamic processes inside live cells over many hours. This work opens new possibilities for understanding fungal biology, infection mechanisms, and antifungal resistance.
Read the article in Open Biology:
https://royalsocietypublishing.org/doi/10.1098/rsob.250031