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Genes MDPI

Genes (ISSN 2073-4425, IF 2.8) is an open access journal of genetics and genomics published monthly
(38)

28/06/2024

We will attend the ASHG Annual Meeting 2024 ( ), held in Denver, Colorado, USA, from 5 to 9 November 2024.

If you plan on attending this conference, stop by our booth #1058 and speak with our delegates!
https://www.mdpi.com/journal/genes/announcements/8743

05/01/2024

We are excited to announce the 2nd International Electronic Conference on Genes (IECGE2024). It will be chaired by Dr. Selvarangan Ponnazhagan on 11–13 Dec 2024.
Choose one session to prepare and submit your abstract by 8th September 2024 at https://bit.ly/48pfjsK
Our session topics are:
A. Non-coding RNAs in Health and Diseases
B. Single-cell RNA Sequencing
C. Genetics and Genomics of Neurodegenerative Diseases
D. Genetic Diagnosis and Targeted Therapy in Cancer
E. Human Genomics and Genetic Diseases
F. Technologies and Resources for Genetics Research
G. Microbial Genetics and Genomics

20/12/2023

syndrome (KS) is a developmental disorder principally comprised of developmental delay, hypotonia and a clearly defined dysmorphism: elongation of the structures surrounding the eyes, a shortened and depressed nose, thinning of the upper lip and thickening of the lower lip, large and prominent ears, hypertrichosis and scoliosis. Other characteristics include poor physical growth, cardiac, gastrointestinal and renal anomalies as well as variable behavioral issues, including autistic features. This paper reviews the current clinical knowledge, provides molecular and scientific links and sheds light on the treatment of Kabuki syndrome individuals.

Please read more details by clicking the link:
bit.ly/4aw3lza

20/12/2023

(GBM) is the most common primary malignant brain tumour in adults. Though literature data suggest that distinct GBM’s subtypes harbour differences in their , its role in treatment response remains obscure. However, an in-depth investigation of GBM’s microenvironment may lead to novel therapeutic opportunities to improve patients’ outcomes. This review will elucidate the GBM’s microenvironment composition, highlighting the current state of the art in approaches. Authors will focus on novel strategies of active and passive immunotherapies, including vaccination, gene therapy, checkpoint blockade, and adoptive T-cell therapies.

Please read more details by clicking the link:
bit.ly/4asiwtc

19/12/2023

currently included in leguminosarum are too diverse to be considered a single species, so they could be referred to this as a species complex ( Rlc). Authors have found 429 publicly available genome sequences that fall within the Rlc and these show that the Rlc is a distinct entity, well separated from other species in the genus. Its sister taxon is R. anhuiense. Authors constructed a phylogeny based on concatenated sequences of 120 universal (core) genes, and calculated pairwise average nucleotide identity (ANI) between all genomes. These analyses show the Rlc includes 18 distinct genospecies, plus 7 unique strains that are not placed in these genospecies.

Please read more details by clicking the link:
bit.ly/3GQpSJs

19/12/2023

is generally expected to have a stronger unfavorable effect on fitness traits than on other traits. Traditionally, the degree of inbreeding depression in has been estimated as the slope of the linear regression of phenotypic values on pedigree-based inbreeding coefficients. Authors performed a meta-analysis of 154 studies, published from 1990 to 2020 on seven livestock species, and compared the degree of inbreeding depression (1) across different trait groups, and (2) across different pedigree-based and SNP-based measures of inbreeding.

Please read more details by clicking the link:
bit.ly/3tydAlU

18/12/2023

The inosine plays an important role in purine biosynthesis, gene translation,and modulation of the fate of RNAs. The editing of adenosine to inosine is a widespread posttranscriptional modification in transfer RNAs ( ) and messenger RNAs ( ). At the wobble position of tRNA anticodons, inosine profoundly modifies codon recognition, while in mRNA, inosines can modify the sequence of the translated polypeptide or modulate the stability, localization, and splicing of transcripts. Inosine is also found in non-coding and exogenous RNAs, where it plays key structural and functional roles. In addition, molecular inosine is an important metabolite in purine metabolism that also acts as a molecular messenger in cell signaling pathways. Authors review the functional roles of in biology and their connections to human health.

Please read more details by clicking the link:
bit.ly/3GNAfxN

18/12/2023

Since phenomena are interdependent, treatment modalities include co-administration of two different epigenetic . In order to sensitize cells to chemotherapy, epigenetic drugs are administered prior to chemotherapy, or both epigenetic drug and chemotherapy are used together to achieve synergistic effects and maximize efficacy. The combinations of epigenetic drug with are being tested, because they have proved to enhance antitumor immune responses. The next approach involves targeting the metabolic causes of epigenetic changes, i.e., enzymes which, when mutated, produce oncometabolites. Finally, editing makes it possible to modify individual chromatin marks at a defined region with unprecedented specificity and efficiency. This review summarizes the above attempts in fulfilling the promise of epigenetic drugs in the effective cancer treatment.

Please read more details by clicking the link:
bit.ly/47YmWXh

14/12/2023

Plants are sessile organisms that need to adapt to constantly changing conditions #. Unpredictable climate change places plants under a variety of stresses #. Studying the regulation of stress-responsive # can help to understand plants’ ability to adapt to fluctuating environmental conditions. Changes in marks # such as modifications # and methylation # are known to regulate gene expression by their dynamic variation in response to stimuli. This can then affect their phenotypic plasticity, which helps with the adaptation of plants to adverse conditions. Epigenetic marks may also provide a mechanistic basis for stress memory, which enables plants to respondmore effectively and efficiently to recurring stress and prepare offspring for potential future stresses. Studying epigenetic changes in addition to genetic factors is important to better understand the molecular mechanisms underlying plant stress responses. This review summarizes the epigenetic mechanisms behind plant responses to some main abiotic stresses.

Please read more details by clicking the link:
bit.ly/3uVs7J0

14/12/2023

# (K+), as a vital element, is involved in regulating important # processes such as activity #, turgor #, and nutrient movement in plant cells, which affects plant growth and production. In the present study, authors find that the repression of #, #, and # in roots wasrelated to tolerance # in rice. These findings provide valuable insights for further structural and functional assays of K+ channel genes in rice.

Please read more details by clicking the link:
bit.ly/3uWjb6b

11/12/2023

acid # (ABA) regulates various aspects of plant physiology, including promoting seed dormancy and adaptive responses to # and stresses #. In addition, # plays an im-portant role in growth and development under non-stressed conditions. This review summarizes phenotypes of ABA biosynthesis and signaling mutants to clarify the roles of basal ABA in growth and development.

Please read more details by clicking the link:
https://bit.ly/3RCdgef

01/12/2023

The genetic landscape of ’s disease # (PD) is characterised by rare high penetrance pathogenic variants causing familial #, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a smallincrease of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. The author summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.

Please read more details by clicking the link:
https://bit.ly/49ZoXnu

21/11/2023

Homeodomain leucine zipper (HD-ZIP) genes family concerned with enlightening plant growth and tolerance to environmental stresses are considered key players for crop improvement. This family containing HD and LZ domain belongs to the superfamily. It is further classified into four subfamilies, namely HD-ZIP I, HD-ZIP II, HD-ZIP III, and HD-ZIP IV. This review summarized the different functions of HD-ZIP genes in plant growth and physiological-related activities from germination to fruit development.

Please check more details by clicking the link:
https://bit.ly/49NnEaW

08/11/2023

The high mobility group protein 2 ( #) regulates gene expression by binding to AT-rich regions of DNA. HMGA2 is re-expressed in nearly all human #, where it promotes # by multiple mechanisms. In this review, authors discuss these oncogenic roles of HMGA2 in different types of cancers and propose that HMGA2 may be used for cancer #, #, and # purposes.

👉Please see more details by clicking the link:
https://bit.ly/40rliu8

31/10/2023

biopsy # is a revolutionary approach with significant potential for the management of cancer. Authors gathered current knowledge regarding the role and potential of liquid biopsies for the # and follow-up of patients #. The presented findings emphasize the strengths of liquid biopsies, revealing their chance of improving the diagnosis and monitoring of several tumor types in the near future.

Please access this paper by this link:
https://bit.ly/3SmwQgm

29/12/2022

Members of the /ERF family play critical roles in plant development, biosynthesis of key metabolites, and stress response. This study of Faraji et.al. was performed to identify
/ERFs in the durum wheat (Triticum turgidum ssp. durum) genome, which resulted in the identification of 271 genes distributed on chromosomes 1A-7B. By carrying 27 genes, chromosome 6A had the highest number of TtAP2s/ERFs.

27/12/2022

conjugation, also referred to as bacterial s*x, is a major gene transfer mechanism through which DNA is transferred from a donor to a recipient bacterium by direct contact. Virolle et.al. review the key steps of plasmid transfer by conjugation in -negative # bacteria, by following the life cycle of the F factor during its transfer from the donor to the recipient cell.

22/12/2022

In contrast to /Cas9 nucleases, CRISPR base editors (BE) and prime editors ( ) enable predefined nucleotide exchanges in genomic sequences without generating DNA double strand breaks. Here, Sürün et. al. employed BE and PE mRNAs in conjunction with chemically synthesized and for ecient editing of human induced pluripotent stem cells ( ).

21/12/2022

acts on the transcriptional regulation of target genes, mainly through Response Factors ( ). Bouzroud et.al. focus on the involvement of in tomato tolerance to salinity and osmotic stress. Using a reverse genetic approach, we found that the antisense down-regulation of SlARF4 promotes root development and density, increases soluble sugars content and maintains chlorophyll content at high levels under stress conditions.

Please access the paper by this link: https://bit.ly/3WdnBOM

15/12/2022

Cytochrome P450 2D6 (CYP2D6) is a critical pharmacogene involved in the metabolism of~20% of commonly used drugs across a broad spectrum of medical disciplines including psychiatry,
pain management, oncology and cardiology. Taylor et.al. review the latest research on CYP2D6 in pharmacogenomics.

Please access the paper by clicking the link: https://bit.ly/3V5wjNw

13/12/2022

Mammalian target of ( ), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 ( ) and . et. al. review recent advances in understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity.

Please access the paper: https://bit.ly/3HxPDjp

08/12/2022

Significant advances in the management of (CF) in recent decades have dramatically changed the epidemiology and prognosis of this serious disease, which is no longer an exclusively pediatric disease. et.al. review the changes in the incidence of and to assess the impact of the discovery of the responsible gene (the gene) on these changes.

Please read this paper by this link: https://bit.ly/3UFhO2U

01/12/2022

Plants are adapted to sense numerous stress stimuli and mount efficient defense responses by directing intricate signaling pathways. et.al. collected the major that are efficient in stress responses through regulating metabolism for the direct cessation of stress factors. LH, bZIP, MYB, and NAC.
Please access this review: https://bit.ly/3uhy92O

25/11/2022

The recent global -19 public health emergency is caused by -CoV-2 infections and can manifest extremely variable clinical symptoms. et.al. investigate the variability of genes coding for these proteins involved in the SARS-CoV-2 entry into the cells.

please access this paper: https://bit.ly/3OA3FCu

24/11/2022

Cells have evolved with several systems that ciently repair spontaneous, isolated with a high degree of accuracy. Please read more content in this review published by et.al:
Clustered DNA Double-Strand Breaks: Biological Effects and Relevance to Cancer Radiotherapy.
Please access this paper: https://bit.ly/3gxqpGS

21/11/2022

In the future, gene therapy could potentially become an option for
patients. et.al. summarized all of the latest and most important research in basic sciences, , and non-operative treatment.

Please access the paper: https://bit.ly/3VdgJ2J

15/11/2022

The introduction of genomics is profoundly changing current . et.al. resent as a model the currently accepted taxonomy of the genus Pseudomonas and how it can be modified when new taxonomic methodologies are applied.

Access the paper :https://bit.ly/3UFKUzM

04/11/2022

Jordá et.al. summarizes the sterol , and systems of . cerevisiae, as well as its adaptive response to sterol depletion, low oxygen, hyperosmotic stress
and iron deficiency. Welcome to read it: https://bit.ly/3fwVlGL

01/11/2022

Giorgio Milazzo et.al. provide here a review on the recent knowledge accrued on the zinc-dependent protein family across different species, tissues, and human pathologies, specifically focusing on the role of inhibitors as anti-cancer agents. Welcome to read this link: https://bit.ly/3fs3iNb

03/06/2020

Special Issue " and Analysis of Fish" guest edited by Dr. Hooman Moghadam is now open for submissions!

Check it out here: https://www.mdpi.com/journal/genes/special_issues/Genomic_Fish

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