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PAI - Pediatric Allergy and Immunology

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PAI - Pediatric Allergy and Immunology

PAI is the world's leading journal in Pediatric Allergy. Edited by Philippe Eigenmann
IF 4.4

06/01/2026

New research in ! 🌟
A recent study suggests that children’s responses before starting may help predict how well they’ll respond later — and who is most at risk for severe exacerbations.

Why it matters 🔬 :
These early could support more personalized and better long-term for children.
Have a gander 🔗 https://doi.org/10.1111/pai.70247

05/01/2026

Fixed Drug Eruption in a Child 💊 Clarithromycin & Paracetamol

A in reports a case of ( ) triggered by and in a pediatric patient.
-> It highlights the importance of considering FDE in differential diagnosis when recur at the same site after .

Here: 📖 https://onlinelibrary.wiley.com/doi/10.1111/pai.70255

04/01/2026

Rethinking Asthma Risk Assessment in Children 🌍

Race has long been included in the Pediatric Asthma Risk Score ( ), but using race as a proxy can perpetuate and . A recent study explored whether ( ) indices could replace race in predicting .

Key findings:
✅ SED performed equally well as race in estimating asthma risk.
✅ 93% of children remained in the same risk category when SED replaced race.
✅ This approach helps move toward reducing in pediatric care.

Why it matters: Replacing race with SED in is a step toward more and better understanding of environmental and socioeconomic influences on .

📖 Read the full article at : 🔗 https://doi.org/10.1111/pai.70263

03/01/2026

Food protein-induced allergic proctocolitis is a frequent and often mismanaged condition in early infancy.
This provides consensus-based recommendations from the SIGENP/SIAIP WG to support a standardized approach for and .
A that aims to improve , reduce , and lessen the on families and .

here 🔗 https://doi.org/10.1111/pai.70264

01/01/2026

Dear Readers! Take a look at the December Issue: 🔗 https://onlinelibrary.wiley.com/toc/13993038/2025/36/12

30/12/2025

Still on , caregivers of younger children may feel greater worry and burden compared to caregivers of teenagers.
Reducing FA-worry and increasing FA-self-efficacy should be prime targets to improve FA-QoL in caregivers.

Take a peek at this 🔗 https://doi.org/10.1111/pai.70248, at

29/12/2025

This paper presents novel data on detectable bos d5 (β-lactoglobulin) and bos d11 (β-casein) in milk .
-> which contribute to our current understanding of milk ladders, a critical aspect in the management of Cow's .

See more about this 🔗 https://doi.org/10.1111/pai.70230

27/12/2025

When a Chromosomal Deletion Rewrites the Immune Script 🧬
New single-cell profiling reveals surprising players in .2 deletion syndrome.

1️⃣ Single-cell RNA-seq shows , , and also carry distinct transcriptional shifts.

2️⃣ Every cell type examined differed from controls - suggesting the deletion reshapes far beyond .

3️⃣ show elevated proliferative ; T cells shift further in children who had .

4️⃣ The syndrome may act through a -dosage ripple, altering the entire .

🔍 This study expands the paradigm - 22q11.2DS isn’t just a T-cell story, but a whole-immune-system rewrite.

🔗 https://doi.org/10.1111/pai.70237

26/12/2025

One more highlight, an article from last issue -> we present Chang Hoon Han & Seok-Jae Heo
the original article: 🔗 https://doi.org/10.1111/pai.70223

22/12/2025

Skin Barrier & Early Allergy 🔬 🔬
* Weak barrier = early trigger for ( ) & ( )
* Filaggrin mutations, changes, type-2 weaken the skin's defenses

🧴 AD : early & environment care (limited but promising)
🍽️ FA Prevention: early introduction of foods to build

Read more of this , here 🔗 https://doi.org/10.1111/pai.70238

20/12/2025

Turning Skin Prick Tests into a Better Experience 🕶️✨

What if testing felt less like a medical procedure… and more like an adventure?
In a new with 108 children, did exactly that.

With Virtual reality:
🎧 Anxiety, fear, and pain dropped significantly
🎧 100% compliance (yes, every single child!)
🎧 Happier staff, smoother testing
🎧 Zero adverse events

Know more at 🩺https://doi.org/10.1111/pai.70235

19/12/2025

Walnut Anaphylaxis on the Rise in Japan 🌰

📈 From 2011 → 2021, walnut-induced jumped from 3% to 26% in children
👶 Mostly first-time reactions in young kids (~4 years old)
🤢 Gastrointestinal symptoms more common than with other foods
⚠️ Prior allergy diagnosis less frequent in walnut cases

📌 is an emerging pediatric risk - and are key.
🔗 https://doi.org/10.1111/pai.70243

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Geneva

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https://onlinelibrary.wiley.com/journal/13993038

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