Life MDPI

03/09/2026

🧠 Can the gut influence our mood?

The microbiota–gut–brain axis is emerging as an important area of research in understanding mood disorders. This review explores the complex connections between gut microbiota, brain function, and mood, as well as potential microbiota-targeted approaches.

🦠 Gut Microbiota and Mood Disorders Gut Microbiota: A New Challenge in Mood Disorder Research
Examines the microbiota–gut–brain axis and its potential role in mood disorders.
Highlights immune, metabolic, neuroendocrine, and neurotransmitter pathways linking gut dysbiosis with mood.
Discusses microbiota-targeted approaches such as diet, prebiotics, probiotics, and f***l microbiota transplantation, while emphasizing the need for further clinical research.

👏 Congratulations to the authors Giuseppe Marano, Sara Rossi, Greta Sfratta, Gianandrea Traversi, Francesco Maria Lisci, Maria Benedetta Anesini, Roberto Pola, Antonio Gasbarrini, Eleonora Gaetani and Marianna Mazza on this valuable contribution to the field!

📖 Read the full article and discover the latest insights into the relationship between gut microbiota and mood disorders: https://brnw.ch/21x5oJZ

03/09/2026

🎉 Welcoming Our New Editorial Board Members!

We are delighted to welcome 10 distinguished researchers and experts who have recently joined the Editorial Board of Life!

🌍 Bringing together diverse expertise and international perspectives, our newly appointed Editorial Board Members will play an important role in supporting the journal’s continued growth and contributing to our scientific community.

Please join us in welcoming:
🔬 Prof. Dr. Stefano Palomba — Unit of Gynecology, Sant’Andrea Hospital of Rome, University Sapienza of Rome, Italy
🔬 Prof. Dr. Pierluigi Caboni — Department of Life and Environmental Sciences, University of Cagliari, Italy
🔬 Dr. Massimo Di Giulio — Institute of Biosciences and Bioresources, National Research Council, Naples, Italy
🔬 Dr. Ana Faustino — Department of Zootechnics, School of Sciences and Technology, University of Évora, Évora, Portugal
🔬 Prof. Dr. Alin Laurentiu Tatu — Clinical Department, Dermatology, Faculty of Medicine and Pharmacy, Dunarea de Jos University, Galati, Romania
🔬 Prof. Dr. Young Ah Goo — Mass Spectrometry Technology Access Center at McDonnell Genome Institute, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA
🔬 Prof. Dr. Gheorghe Solcan — Internal Medicine Unit, Clinics Department, Faculty of Veterinary Medicine, Iași University of Life Sciences Ion Ionescu de la Brad, Iasi, Romania
🔬 Prof. Lefteris Koumakis — Department of Electrical and Computer Engineering, Hellenic Mediterranean University, Heraklion, Greece
🔬 Dr. Jun Wan — Department of Medical and Molecular Genetics, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, USA
🔬 Dr. Giuseppe Grande — Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy

We sincerely appreciate their willingness to support Life and look forward to their valuable contributions to the journal and the wider research community.

👏 Welcome to the Editorial Board!

You can check our complete Editorial Board here: https://brnw.ch/21x5oHB

Life, an international, peer-reviewed Open Access journal.

02/09/2026

🦵 Advances in Knee Biomechanics—2nd Edition

Following the success of the first edition, which resulted in 10 published papers, we are pleased to announce the continuation of this Special Issue in Life! 🧬

This Special Issue welcomes research exploring the latest advances in knee biomechanics, including biomechanical analysis, joint function, injury mechanisms, rehabilitation, computational approaches, and innovative methods for understanding and improving knee health and performance.

📅 Submission Deadline: 15 February 2027

We warmly invite researchers in biomechanics, orthopedics, sports medicine, rehabilitation, engineering, and related fields to contribute their latest research.

A special thank you to our Guest Editor, Dr. Jason Shearn, for continuing to lead this exciting Special Issue!

👉 We look forward to receiving your contributions and building on the success of the first edition: https://brnw.ch/21x5mNt

Life, an international, peer-reviewed Open Access journal.

01/09/2026

🧪 Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy
A classic treatment strategy, revisited. 🔬

This review explores the current knowledge surrounding the combination of H1 and H2 histamine receptor antagonists, examining the pharmacological rationale, therapeutic applications, and perspectives of this established treatment approach.

📌 Key highlights:
🔹 Reviews the pharmacological basis of H1 and H2 histamine receptor antagonism
🔹 Discusses the rationale and potential benefits of combination therapy
🔹 Examines current evidence and clinical perspectives
🔹 Highlights areas where further research may clarify the role of combined histamine receptor blockade

📖 Read the full review:
👉 https://brnw.ch/21x5kYi

👥 Congratulations to the authors:
Erwen Kou | Xiaobei Zhang | Baiping D**g | Bo Wang | Yuanjie Zhu

Histamine receptor antagonists, which can bind to specific histamine receptors on target cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated disorders. Notably, histamine H1 and H2 receptor antagonists have been extensively investigated and universally acknowl...

01/09/2026

🧠 Resveratrol-Enhanced Neural Stem Cell-Derived Exosomes

Can engineered exosomes offer a new strategy for protecting neurons from oxidative and inflammatory damage? 🔬

A recent study published in Life investigates the neuroprotective potential of resveratrol-enhanced human neural stem cell-derived exosomes against MPP⁺-induced neurotoxicity.

🔹 Demonstrates that engineered exosomes can protect against MPP⁺-induced neurotoxicity.
🔹 Identifies the AMPK–Nrf2 antioxidant pathway and suppression of NLRP3 inflammasome signaling as key mechanisms.
🔹 Highlights the potential of resveratrol preconditioning to improve exosome-based therapeutic strategies for neurodegenerative disorders.

📖 Read the full article:

👉 https://brnw.ch/21x5kWF

👥 Authors: Ming-Chang Chiang, Yu-Ping Yang, Christopher Nicol, Tairui Chiang and Chiahui Yen

Parkinson’s disease (PD) is a progressive neurodegenerative disorder primarily characterized by the loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction, oxidative stress, and neuroinflammation are recognized as critical pathological mechanisms driving neurodegeneration ...

01/09/2026

🦠 Special Issue | Animal Infectious Diseases and Gut Microbiota

The gut microbiota plays a crucial role in animal health, immunity, and susceptibility to infectious diseases. Understanding the complex interactions between pathogens, the host, and the gut microbial community may provide new insights into disease prevention and treatment.

📢 We are pleased to invite researchers to contribute to the Special Issue “Animal Infectious Diseases and Gut Microbiota.”

We welcome research and review articles exploring:
🔬 Host–pathogen–microbiota interactions
🦠 Infectious diseases in animals
🧬 Gut microbiome composition and function
💊 Microbiota-based strategies for disease prevention and treatment
🐄🐖🐔 Microbiota, immunity, nutrition, and animal health

If your research aligns with these topics, we would be delighted to consider your contribution.

Guest Editors: Dr. Qinglong Gong, Dr. Wentao Yang and Dr. Chao Xu

👉 Learn more and submit your manuscript: https://brnw.ch/21x5kVA

Life, an international, peer-reviewed Open Access journal.

26/08/2026

🌱 Antioxidant Defense Systems in Plants: Mechanisms, Regulation, and Biotechnological Strategies for Enhanced Oxidative Stress Tolerance

We are pleased to highlight this insightful review exploring how plants respond to oxidative stress and how emerging technologies can help enhance their resilience.

🔬 The review:
• Explores how enzymatic and non-enzymatic antioxidant networks regulate redox homeostasis and plant stress resilience.
• Highlights emerging tools including multi-omics, CRISPR/Cas, synthetic biology, and AI.
• Discusses opportunities to develop climate-resilient crops and more sustainable agriculture.

This review provides a timely overview of the mechanisms underlying plant stress tolerance and the biotechnological strategies that may contribute to more resilient and sustainable agriculture.

👏 We would like to thank the authors Dr. Faustina Barbara Cannea and Dr. Alessandra Padiglia for their valuable contribution to this important area of plant research.

📖 We invite you to explore the full review and discover the latest advances in plant antioxidant defense systems: https://brnw.ch/21x5esq

Plants must contend with oxidative stress, a paradoxical phenomenon in which reactive oxygen species (ROS) can cause cellular damage while also serving as key signaling molecules. Environmental stressors, such as drought, salinity, and temperature extremes, promote ROS accumulation, affecting plant ...

26/08/2026

❤️🩻 Advances in Cardiovascular Imaging for Heart Failure and Ischemic Heart Disease

We are pleased to highlight this Special Issue, bringing together the latest advances in cardiovascular imaging and their applications in the diagnosis, assessment, and management of heart failure and ischemic heart disease.

The Special Issue welcomes research exploring innovative imaging techniques, emerging imaging biomarkers, multimodal approaches, and new strategies for improving cardiovascular patient care.

A special thank you to our Guest Editor Dr. Maria Lo Monaco, for their valuable contribution in bringing together this collection of research.

🔎 We invite researchers and clinicians working in cardiovascular medicine and imaging to share their latest findings and contribute: https://brnw.ch/21x5epZ

Life, an international, peer-reviewed Open Access journal.

26/08/2026

🧬🤖 Artificial Intelligence in Molecular Biomedicine: From Multi-Omics Integration to Therapeutic Innovation

How is AI transforming molecular biomedicine? From multi-omics integration and computational biology to drug discovery and therapeutic innovation, artificial intelligence is opening new opportunities to better understand disease mechanisms and accelerate biomedical research.

We are pleased to invite researchers to contribute to this Special Issue and share their latest findings, methodologies, and perspectives at the intersection of AI and molecular biomedicine.

📅 Deadline: 28 February 2027
📚 Submit your research and join the discussion: https://brnw.ch/21x5epP

A special thank you to our Guest Editors Prof. yudong cai and Dr. Lin Lu for leading this exciting Special Issue and bringing together researchers from these rapidly evolving fields.

Life, an international, peer-reviewed Open Access journal.

21/08/2026

🏋️ Effects of Exercise Training on Muscle Function—2nd Edition

We are excited to highlight the continued success of our Special Issue, “Effects of Exercise Training on Muscle Function—2nd Edition”! 💪🔬

The 1st Edition successfully published 10 papers, and the 2nd Edition is already off to a great start, with 3 papers published so far. 🎉

A sincere thank you to our Guest Editors: Dr. Marco Duca, PhD and Dr. Athos Trecroci for their expertise and dedication in bringing together this collection, and to all reviewers who have generously contributed their time and valuable expertise to ensuring the quality of the published research. 🙏

📢 Submissions are open until 31 December 2026!

We welcome new contributions: https://brnw.ch/21x57mH

We look forward to building on the success of the first edition and making the 2nd Edition an equally valuable collection of research! 🏃‍♀️🏋️‍♂️

Life, an international, peer-reviewed Open Access journal.