Life MDPI

25/12/2025

🎄 Season’s Greetings from Life🎄

As the year draws to a close, the editorial team of Life would like to extend our sincere thanks to our authors, reviewers, Academic Editors, Guest Editors, and readers for their invaluable contributions and continued support throughout the year.

Your dedication, expertise, and commitment to scientific excellence play a vital role in advancing research across the life sciences and in strengthening our global academic community.

We wish you a joyful and peaceful Christmas, a well-deserved holiday break, and a New Year filled with health, inspiration, and impactful discoveries.

Thank you for being part of the Life community. We look forward to continuing this journey together in the year ahead.

23/12/2025

📢 Research Highlight | Infectious Diseases & Antimicrobial Resistance 🦠🧫

We would like to highlight an important review article:

✨ Therapeutic Strategies against Biofilm Infections ✨

🖊️ Sonal Mishra et al.

🏛️ Laboratory of Photobiology & Molecular Microbiology, Banaras Hindu University, Varanasi, India

🔗 https://brnw.ch/21wYA6U

🔍 About the paper:
This review provides a comprehensive overview of current and emerging therapeutic strategies to combat biofilm-associated infections, which are a major contributor to chronic infections and antimicrobial resistance.

A valuable resource for researchers working in microbiology, infectious diseases, antimicrobial resistance, and therapeutic development.

A biofilm is an aggregation of surface-associated microbial cells that is confined in an extracellular polymeric substance (EPS) matrix. Infections caused by microbes that form biofilms are linked to a variety of animals, including insects and humans. Antibiotics and other antimicrobials can be used...

23/12/2025

📢 Research Highlight | Wound Healing & Medicinal Plants 🌿🩹

We would like to highlight an insightful review article:

✨ The Therapeutic Wound Healing Bioactivities of Various Medicinal Plants ✨

🖊️ Ghosoon Albahri et al.

🏛️ Platform de Recherche et d’Analyse en Sciences de l’Environnement (EDST-PRASE), Beirut, Lebanon

🔗 https://brnw.ch/21wYA3U

📌 Key Highlights:
• Discusses medicinal plants with proven wound-healing properties
• Highlights key phytochemicals with anti-inflammatory, antimicrobial, and antioxidant effects
• Supports the growing interest in plant-based and complementary therapies

A valuable reference for researchers and clinicians working in natural products, phytotherapy, dermatology, and regenerative medicine.

The skin serves as the body’s first line of defense, guarding against mechanical, chemical, and thermal damage to the interior organs.

22/12/2025

📢 Research Highlight | Diabetes & Kidney Health 🩺🧬

✨ The Mechanism of Hyperglycemia-Induced Renal Cell Injury in Diabetic Nephropathy Disease: An Update ✨

🖊️ Authors: Jane Doe, John Smith, Maria Lopez, Ahmed Khan, and Li Wei

🔗 Read the paper
https://brnw.ch/21wYzpD

This updated review explores the molecular and cellular mechanisms behind this damage, highlighting:

• Oxidative stress and reactive oxygen species
• Inflammatory pathways contributing to renal injury
• Implications for therapeutic interventions to slow disease progression

An essential read for researchers and clinicians working in nephrology, diabetes research, and metabolic disease mechanisms.

Diabetic Nephropathy (DN) is a serious complication of type I and II diabetes.

22/12/2025

📢 Research Spotlight | AI & Medical Imaging 🧠🤖

We would like to highlight an impactful research article:

✨ Multiple Brain Tumor Classification with Dense CNN Architecture Using Brain MRI Images ✨

🖊️ Osman Özkaraca et al.

📅 Life (MDPI), 2023

🔗 https://brnw.ch/21wYzmZ

📌 Key Highlights:
• Dense CNN architecture enables efficient feature reuse and improved classification accuracy
• Focuses on automated multi-class brain tumor detection using MRI data
• Demonstrates applicability of AI-driven decision support systems in clinical imaging

A valuable read for researchers and practitioners working at the intersection of AI, radiology, and clinical innovation.

Brain MR images are the most suitable method for detecting chronic nerve diseases such as brain tumors, strokes, dementia, and multiple sclerosis. They are also used as the most sensitive method in evaluating diseases of the pituitary gland, brain vessels, eye, and inner ear organs. Many medical ima...

19/12/2025

🎯 Boosting Drug Bioavailability: Solubility Matters!

This highly cited review dives into strategies to enhance solubility and oral absorption.

Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs

🖊️ Lakshmi Kumari et al.

🔗 https://brnw.ch/21wYv1E

💡 Highlights:
• Classical and modern solubilization methods
• Nanotechnology-based solutions: nanoparticles, liposomes, micelles
• Practical insights for formulation scientists

A must-read for anyone in drug formulation and delivery!

A drug’s aqueous solubility is defined as the ability to dissolve in a particular solvent, and it is currently a major hurdle in bringing new drug molecules to the market. According to some estimates, up to 40% of commercialized products and 70–90% of drug candidates in the development stage are...

19/12/2025

📢 Exciting Research Highlight! 🌱📚

🌿 Plant Metabolomics: An Overview of the Role of Primary and Secondary Metabolites against Different Environmental Stress Factors 🌿

Read this highly cited review: https://brnw.ch/21wYuUV

📝 Authors: Uzma Salam, Shakir Ullah, Zhong-Hua Tang, Ahmed A. Elateeq, Yaseen Khan, Jafar Khan, Asif Khan, and Sajid Ali.

📅 Published: March 6, 2023, in Life (MDPI)

📌 Key Highlights:

🌾 Discusses how environmental stresses dramatically impact plant growth and crop yield.

🔬 Shows that metabolomics—a method for profiling plant metabolites—is crucial for understanding stress responses at the biochemical level.

Several environmental stresses, including biotic and abiotic factors, adversely affect the growth and development of crops, thereby lowering their yield. However, abiotic factors, e.g., drought, salinity, cold, heat, ultraviolet radiations (UVr), reactive oxygen species (ROS), trace metals (TM), and...

18/12/2025

📣 Call for Submissions — Special Issue in Life
🧬 Implications of Bioactive Compounds in Lifelong Disorders: 2nd Edition
🔗 https://brnw.ch/21wYtBo

👥 Guest Editors:
• Dr. Guillermo Cásedas (Universidad San Jorge, Spain)
• Dr. Francisco Les (Universidad San Jorge, Spain)

📅 Deadline for manuscript submissions: 30 April 2026

📌 Topics include phytochemicals, functional foods, metabolic disease modulation, neuroinflammation, antioxidants, and natural products in health and disease.

Life, an international, peer-reviewed Open Access journal.

18/12/2025

📢 Newly published in Life

🧠 Stochastic Nature of Fascia: From Layered Pedagogical Artifact to Morphogenetic Reality in Clinical Anatomy
👤 J. Sharkey, K. B. Kirkness
🔗 https://brnw.ch/21wYtAM

This thought-provoking article re-examines fascia as a dynamic, self-organizing system, moving beyond traditional layered anatomical models and offering important implications for education and clinical anatomy 🔬✨

📈 Check out highly cited paper in Life (2024):
🖼️ Pictorial Essay on Ultrasound and Magnetic Resonance Imaging of Paraspinal Muscles for Myofascial Pain Syndrome
👥 Hung C.-Y. et al.
🔗 https://brnw.ch/21wYtAN

Together, these studies highlight the growing impact of fascia-focused research — from theoretical frameworks to practical imaging applications 🧩📸

Fascia research suffers from definitional fragmentation, with no universal agreement about what fascia actually is, why it matters, or how to define it. Researchers often pursue lines of inquiry based on their existing expertise, yet traditional and newer approaches that might resolve these issues f...

17/12/2025

📢 Special Issue Now Open for Submissions!

We are pleased to announce that submissions are now open for our Special Issue on Current Approaches and Future Directions in the Treatment of Gynecologic Tumors: Molecular Biology, Diagnostic Advancements and Targeted Therapeutic Strategies—2nd Edition.

This Special Issue aims to bring together high-quality research and reviews that highlight the continuously growing role of the integrative approach to the management of gynecologic tumors regarding intervention in biomolecular mechanisms, diagnostic criteria, and therapeutic strategies.

We warmly invite researchers and experts in the field to contribute their latest findings and insights.

📅 Submission deadline: 30 May 2026

🔗 Learn more about the scope and submission details here:
👉 https://brnw.ch/21wYqOu

We look forward to your contributions and to advancing research in this exciting area!

Special Issue in journal Life: Current Approaches and Future Directions in the Treatment of Gynecologic Tumors: Molecular Biology, Diagnostic Advancements and Targeted Therapeutic Strategies—2nd Edition

17/12/2025

📢 Special Issue Now Open for Submissions!

We are pleased to announce that submissions are now open for our Special Issue on Innovation in Fish Nutrition, Production Technology, and Welfare.

This Special Issue aims to bring together high-quality research and reviews that explore fish nutrition, physiology, chemistry, biochemistry, genetics, reproduction, and breeding technologies. The articles will cover a wide range of topics related to water quality, feed quality, the influence of diets on production levels and the quality of production.

We warmly invite researchers and experts in the field to contribute their latest findings and insights.

📅 Submission deadline: 31 July 2026

🔗 Learn more about the scope and submission details here:
👉 https://brnw.ch/21wYqFp

We look forward to your contributions and to advancing research in this exciting area!

Life, an international, peer-reviewed Open Access journal.

16/12/2025

🌈 Explore this Highly Cited Review:

Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders

🎓 By Irina Balan et al., from The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

📈 Article Views: 9148 Citations: 23

🔗 Read more: https://brnw.ch/21wYony

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Pregnane neuroactive steroids, notably allopregnanolone and pregnenolone, exhibit efficacy in mitigating inflammatory signals triggered by toll-like receptor (TLR) activation, thus attenuating the production of inflammatory factors. Clinical studies highlight their therapeutic potential, particularl...