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https://www.mdpi.com/journal/vaccines

Vaccines MDPI, Basel (2024)

18/12/2024

The first paper in this special issue has been published! 🎉

Titled "Challenges of Multidrug-Resistant Tuberculosis Meningitis: Current Treatments and the Role of Glutathione as Adjunct Therapy," by Mohammad J. Nasiri, Kabir Lutfy and Vishwanath Venketaraman.

You can enjoy reading it here: https://brnw.ch/21wPuid 📖

We warmly invite everyone to contribute! 🤝

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Multidrug-resistant tuberculosis (MDR-TB) poses a significant global health threat, especially when it involves the central nervous system (CNS). Tuberculous meningitis (TBM), a severe manifestation of TB, is linked to high mortality rates and long-term neurological complications, further exacerbate...

18/12/2024

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"Aspects of Phage-Based Vaccines for Protein and Epitope Immunization" by Marco Palma.

Because vaccine development is a difficult process, this study reviews aspects of phages as vaccine delivery vehicles through a literature search. The results demonstrated that because phages have adjuvant properties and are safe for humans and animals, they are an excellent vaccine tool for protein and epitope immunization.

To read the full paper, click here: https://brnw.ch/21wPudO 📖✨

Because vaccine development is a difficult process, this study reviews aspects of phages as vaccine delivery vehicles through a literature search. The results demonstrated that because phages have adjuvant properties and are safe for humans and animals, they are an excellent vaccine tool for protein...

18/12/2024

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"A Comprehensive Review on Cancer Vaccines and Vaccine Strategies in Hepatocellular Carcinoma" by Alireza Tojjari, Ahmed Saeed, Meghana Singh, Ludimila Cavalcante, Ibrahim Halil Sahin and Anwaar Saeed.

This review explores the potential of cancer vaccines as a promising therapeutic strategy for hepatocellular carcinoma (HCC), a prevalent and deadly liver cancer. The authors discuss various types of cancer vaccines, their challenges, and their role in modulating the immune response within HCC. They also highlight clinical trials and future perspectives, emphasizing the importance of personalized therapies, novel antigen delivery platforms, and predictive biomarkers. The findings from this research could significantly impact the research community by providing a comprehensive understanding of the current state of cancer vaccines for HCC, thereby guiding future research and potentially transforming HCC treatment strategies.

To read the full paper, click here: https://brnw.ch/21wPudH 📖✨

HCC, the most prevalent form of primary liver cancer, presents a substantial global health challenge due to its high mortality and limited therapeutic options. This review delves into the potential of cancer vaccines as a novel therapeutic avenue for HCC. We examine the various categories of cancer ...

18/12/2024

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"Perspectives of Next-Generation Live-Attenuated Rift Valley Fever Vaccines for Animal and Human Use" by Paul J. Wichgers Schreur, Brian H. Bird, Tetsuro Ikegami, Erick Bermúdez-Méndez and Jeroen Kortekaas.

Facilitated by an increased understanding of the RVFV infection and replication cycle and availability of reverse genetics systems, novel rationally-designed live-attenuated candidate RVF vaccines with improved safety profiles have been developed. Several of these experimental vaccines are currently advancing beyond the proof-of-concept phase and are being evaluated for application in both animals and humans. We here provide perspectives on some of these next-generation live-attenuated RVF vaccines and highlight the opportunities and challenges of these approaches to improve global health.

To read the full paper, click here: https://brnw.ch/21wPudo 📖✨

Live-attenuated Rift Valley fever (RVF) vaccines transiently replicate in the vaccinated host, thereby effectively initiating an innate and adaptive immune response. Rift Valley fever virus (RVFV)-specific neutralizing antibodies are considered the main correlate of protection. Vaccination with clas...

18/12/2024

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"Tilapia Lake Virus Vaccine Development: A Review on the Recent Advances" by Japhette E. Kembou-Ringert, Dieter Steinhagen, John Readman, Janet M. Daly and Mikolaj Adamek.

We here present these approaches in relation with previously developed fish vaccines and discuss their efficacy, vaccine administration routes, and the various factors that can impact vaccine efficacy. The overall recent advances in TiLV vaccine development show different but promising levels of protection. The field is however hampered by the lack of knowledge of the biology of TiLV, notably the function of its genes. Further research and the incorporation of several approaches including prime–boost vaccine regimens, codon optimization, or reverse vaccinology would be beneficial to increase the effectiveness of vaccines targeting TiLV and are further discussed in this review.

To read the full paper, click here: https://brnw.ch/21wPu9r 📖✨

Tilapia tilapinevirus (or tilapia lake virus, TiLV) is a recently emerging virus associated with a novel disease affecting and decimating tilapia populations around the world. Since its initial identification, TiLV has been reported in 17 countries, often causing mortalities as high as 90% in the af...

18/12/2024

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"Carriers and Antigens: New Developments in Glycoconjugate Vaccines" by Robert M.F. van der Put, Bernard Metz and Roland J. Pieters.

This review evaluates the advances of glycoconjugate vaccines in the last five years. We focus on developments regarding both new carriers and antigens. Innovative developments regarding carriers are outer membrane vesicles, glycoengineered proteins, new carrier proteins, virus-like particles, protein nanocages and peptides. With regard to conjugated antigens, we describe recent developments in the field of antimicrobial resistance (AMR) and ESKAPE pathogens.

To read the full paper, click here: https://brnw.ch/21wPu8M 📖✨

Glycoconjugate vaccines have proven their worth in the protection and prevention of infectious diseases. The introduction of the Haemophilus influenzae type b vaccine is the prime example, followed by other glycoconjugate vaccines. Glycoconjugate vaccines consist of two components: the carrier prote...

18/12/2024

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"Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines" by Brankica Filipić, Ivana Pantelić, Ines Nikolić, Dragomira Majhen, Zorica Stojić-Vukanić, Snežana Savić and Danina Krajišnik.

In this review, we present an overview of the most promising nanoadjuvants and nanoparticulate delivery systems and discuss their benefits from tehchnological and immunological standpoints as well as their objective drawbacks and possible side effects. The presented nano alums, silica and clay nanoparticles, nanoemulsions, adenoviral-vectored systems, adeno-associated viral vectors, vesicular stomatitis viral vectors, lentiviral vectors, virus-like particles (including bacteriophage-based ones) and virosomes indicate that vaccine developers can now choose different adjuvants and/or delivery systems as per the requirement, specific to combatting different infectious diseases.

To read the full paper, click here: https://brnw.ch/21wPu8y 📖✨

Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines and develop new vaccination strategies and vaccine platforms t...

18/12/2024

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"Mitigating Vaccine Hesitancy and Building Trust to Prevent Future Measles Outbreaks in England" by Sarah Thompson, Johanna C. Meyer, Rosemary J. Burnett and Stephen M. Campbell.

Official administrative 2012–2021 data on measles incidence and measles, mumps and rubella vaccine (MMR) coverage in England were reviewed alongside a scoping literature review on factors associated with MMR uptake in England. Increasing MMR uptake by reducing vaccine hesitancy requires allocated funding for area-based and targeted domiciliary and community-specific immunisation services and interventions, public health catch-up campaigns and web-based decision aid tools.

To read the full paper, click here: https://brnw.ch/21wPu6q 📖✨

Measles, a highly infectious respiratory viral infection associated with severe morbidity and mortality, is preventable when coverage with the highly effective measles, mumps and rubella vaccine (MMR) is ≥95%. Vaccine hesitancy is responsible for measles outbreaks in countries where measles had pr...

18/12/2024

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"Engineered Phage-Based Cancer Vaccines: Current Advances and Future Directions" by Murali Ragothaman and So Young Yoo.

In this review, we explored the role of bacteriophages and bacteriophage engineering in targeted cancer therapy. The question of how the engineered bacteriophages can interact with the biological and immunological systems is emphasized to comprehend the underlying mechanism of phage use in cancer immunotherapy. The effectiveness of phage display technology in identifying high-affinity ligands for substrates, such as cancer cells and tumor-associated molecules, and the emerging field of phage engineering and its potential in the development of effective cancer treatments are discussed. We also highlight phage usage in clinical trials as well as the related patents. This review provides a new insight into engineered phage-based cancer vaccines.

To read the full paper, click here: https://brnw.ch/21wPu6f 📖✨

Bacteriophages have emerged as versatile tools in the field of bioengineering, with enormous potential in tissue engineering, vaccine development, and immunotherapy. The genetic makeup of phages can be harnessed for the development of novel DNA vaccines and antigen display systems, as they can provi...

18/12/2024

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"Yeast-Based Virus-like Particles as an Emerging Platform for Vaccine Development and Delivery" by Vartika Srivastava, Kripa N. Nand, Aijaz Ahmad and Ravinder Kumar.

The present review will discuss VLPs produced using different yeasts as fermentation hosts. We also compile a list of studies highlighting the expression and purification of VLPs using a yeast-based platform. We also discuss the advantages of using yeast to generate VLPs over other available systems. Further, the issues or limitations of yeasts for producing VLPs are also summarized. The review also compiles a list of yeast-derived VLP-based vaccines that are presently in public use or in different phases of clinical trials.

To read the full paper, click here: https://brnw.ch/21wPu63 📖✨

Virus-like particles (VLPs) are empty, nanoscale structures morphologically resembling viruses. Internal cavity, noninfectious, and particulate nature with a high density of repeating epitopes, make them an ideal platform for vaccine development and drug delivery. Commercial use of Gardasil-9 and Ce...

17/12/2024

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"Monkeypox (MPOX)-Related Knowledge and Vaccination Hesitancy in Non-Endemic Countries: Concise Literature Review" by Mohamed Lounis and Abanoub Riad.

This review could help understand the MPOX-related knowledge and awareness and vaccine hesitancy in the first months of the emergence of the MPOX by comparing their evolution in recent studies.

To read the full paper, click here:
https://www.mdpi.com/2076-393X/11/2/229?utm_campaign=journnews_ccbj_vaccines&utm_medium=social_journ&utm_source=facebook 📖✨

In May 2022, the world witnessed the emergence of human monkeypox (MPOX), a new zoonotic viral disease in multiple non-endemic countries. This health threat has been associated with increased anxiety, especially after the COVID-19 catastrophe. In addition, people are exposed to an unprecedented amou...

17/12/2024

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"The Potential Role of Vaccines in Preventing Antimicrobial Resistance (AMR): An Update and Future Perspectives" by Vincenzo Costanzo and Giovanni N. Roviello.

In this review, we describe not only the main causes of AMR and the role of vaccines in reducing the burden of infectious diseases, but we also report on specific prophylactic advancements against some of the main pathogens, focusing on new strategies that aim at improving vaccine efficiency.

To read the full paper, click here: https://brnw.ch/21wPsOa 📖✨

In the modern era, the consumption of antibiotics represents a revolutionary weapon against several infectious diseases, contributing to the saving of millions of lives worldwide. However, the misuse of antibiotics for human and animal purposes has fueled the process of antimicrobial resistance (AMR...

17/12/2024

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"Improved DNA Vaccine Delivery with Needle-Free Injection Systems" by Carmen Ledesma-Feliciano et al.

In this review, we discuss physical delivery methods for DNA vaccines with an emphasis on commercially available NFIS and their resulting safety, immunogenic effectiveness, and protective efficacy. As is discussed, prophylactic DNA vaccines delivered by NFIS tend to induce non-inferior immunogenicity to electroporation and enhanced responses compared to needle and syringe.

To read the full paper, click here:
https://brnw.ch/21wPsNV 📖✨

DNA vaccines have inherent advantages compared to other vaccine types, including safety, rapid design and construction, ease and speed to manufacture, and thermostability. However, a major drawback of candidate DNA vaccines delivered by needle and syringe is the poor immunogenicity associated with i...

17/12/2024

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"Outcomes of High-Grade Cervical Dysplasia with Positive Margins and HPV Persistence after Cervical Conization" by Andrea Giannini et al.

The objective of this work is to assess the 5-year outcomes of patients undergoing conization for high-grade cervical lesions that simultaneously present as risk factors in the persistence of HPV infection and the positivity of surgical resection margins.

To read the full paper, click here:
https://brnw.ch/21wPsNK 📖✨

The objective of this work is to assess the 5-year outcomes of patients undergoing conization for high-grade cervical lesions that simultaneously present as risk factors in the persistence of HPV infection and the positivity of surgical resection margins. This is a retrospective study evaluating pat...

17/12/2024

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"An RNA-Based Vaccine Platform for Targeting Mycobacterium tuberculosis" by Sasha E. Larsen et al.

This research presents the first evidence that repRNA platforms represent a promising approach for developing vaccines against tuberculosis (TB). The authors emphasize the importance of prioritizing M.tb antigens that encompass both CD4+ and CD8+ T-cell epitopes.

To read the full paper, click here:
https://brnw.ch/21wPsNo 📖✨

Mycobacterium tuberculosis (M.tb), a bacterial pathogen that causes tuberculosis disease (TB), exerts an extensive burden on global health. The complex nature of M.tb, coupled with different TB disease stages, has made identifying immune correlates of protection challenging and subsequently slowing ...

12/12/2024

📢 The submission deadline for the following special issue has been extended!

🧬"Vaccines and Vaccinations in the Pandemic Period," guest-edited by Dr. Dimitrios Papagiannis and Dr. Georgios Rachiotis.

This issue has garnered significant interest with 19,981 views and 8 articles already published!

💡The research areas may include:

-Public health and policy issues linked to vaccination coverage, vaccine research, communication strategies for encouraging vaccine uptake, and vaccine hesitancy.
- Efficacy of COVID-19 vaccines in the context of new variants, novel vaccine platforms, safety, and booster doses.
- Routine vaccinations in workplaces, infants, and adults during the pandemic.
📅 New Submission Deadline: June 15, 2025

🔗 For more information, visit:

Vaccines, an international, peer-reviewed Open Access journal.

11/12/2024

🌟 New Special Issue Launched! 🌟

"Vaccination Against Vector-Borne Diseases: Bridging Public Health and Epidemiology" guest edited by Dr. Angela Stufano and Dr. Claudia Maria Trombetta.

This Special Issue aims to address factors that influence vector-borne diseases requiring adaptive vaccination strategies. 🌍✨ Overall, it showcases how vaccines, when integrated with robust public health and epidemiological frameworks, offer a powerful tool to reduce the burden of diseases worldwide. 🦠💪

🗓️ Submissions Deadline: 31 August 2025
🔗 Read more about the special issue: https://t.ly/c1m_a

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Vaccines, an international, peer-reviewed Open Access journal.

11/12/2024

🔓"Molecular Evolution of Dengue Virus 3 in Senegal between 2009 and 2022: Dispersal Patterns and Implications for Prevention and Therapeutic Countermeasures" by Idrissa Dieng et al.

we studied the molecular evolution of DENV−3 in Senegal between 2009 and 2022. We then assessed the impact of the observed genetic diversity on the efficacy of preventive countermeasures and vaccination by mapping amino acid changes against vaccine strains. The results showed that the DENV−3 strains circulating in Senegal belong to genotype III, similarly to strains from other West African countries, while belonging to different clades. Phylogeographic analysis based on nearly complete genomes revealed three independent introduction events from Asia and Burkina Faso.

💡Read the full text: https://t.ly/UMSwx

Dengue fever is the most prevalent arboviral disease worldwide. Dengue virus (DENV), the etiological agent, is known to have been circulating in Senegal since 1970, though for a long time, virus epidemiology was restricted to the circulation of sylvatic DENV−2 in south-eastern Senegal (the Kedougo...

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