De Gruyter Open Medicine

28/12/2022

Researchers have shown for the first time that 𝑷𝒊𝒓𝒇𝒆𝒏𝒊𝒅𝒐𝒏𝒆, a class of anti-fibrotic drugs 💊💊 inhibits the progression of interstitial lung disease (ILD) in people with 𝗿𝗵𝗲𝘂𝗺𝗮𝘁𝗼𝗶𝗱 𝗮𝗿𝘁𝗵𝗿𝗶𝘁𝗶𝘀 (𝗥𝗔):
https://scitechdaily.com/groundbreaking-study-finds-treatment-effective-for-rheumatoid-arthritis-patients/

Researchers have shown for the first time that a class of anti-fibrotic drugs inhibits the progression of interstitial lung disease (ILD) in people with rheumatoid arthritis (RA). Pirfenidone was shown to be safe and effective in these individuals, according to research conducted in part at National

26/12/2022

New paper in 🅾🅿🅴🅽 🅼🅴🅳🅸🅲🅸🅽🅴 ❗
Congenital adrenal hyperplasia (CAH) is a group of rare inherited autosomal recessive disorders characterized by a deficiency of one of the enzymes needed to make specific hormones. CAH effects the adrenal glands located at the top of each kidney.
Here, we present an interesting paper 𝑪𝒐𝒏𝒈𝒆𝒏𝒊𝒕𝒂𝒍 𝒂𝒅𝒓𝒆𝒏𝒂𝒍 𝒉𝒚𝒑𝒆𝒓𝒑𝒍𝒂𝒔𝒊𝒂. 𝑹𝒐𝒍𝒆 𝒐𝒇 𝒅𝒆𝒏𝒕𝒊𝒔𝒕 𝒊𝒏 𝒆𝒂𝒓𝒍𝒚 𝒅𝒊𝒂𝒈𝒏𝒐𝒔𝒊𝒔 that investigates the oral manifestation of CAH:
https://www.degruyter.com/document/doi/10.1515/med-2022-0524/html

22/12/2022

Covid update ☑🩺
Scientists at Karolinska Institutet in Sweden completed a study that indicates that increased levels of the cytokine interleukin-26 (IL-26) in blood is a potential biomarker for severe COVID-19.
To find out more go to the link below 👉
https://scitechdaily.com/a-new-biomarker-for-acute-covid-19-may-have-been-found-in-blood/

Scientists have shown that patients with acute COVID-19 infection have increased levels of the cytokine IL-26 in their blood. Moreover, high IL-26 levels correlate with an exaggerated inflammatory response that signifies severe cases of the disease. The findings, which are presented in the peer-revi

22/12/2022

New article alert ⏰
Preterm infants face a significant risk of brain injury in the perinatal period, as well as potential long-term neurodevelopmental disabilities. However, this condition lacks specific clinical manifestations in the early days. Therefore, an accurate diagnosis of brain injury is of great importance.
Read our newly published paper 𝙍𝙚𝙡𝙖𝙩𝙞𝙤𝙣𝙨𝙝𝙞𝙥 𝙤𝙛 𝙥𝙡𝙖𝙨𝙢𝙖 𝙈𝘽𝙋 𝙖𝙣𝙙 8-𝙤𝙭𝙤-𝙙𝙂 𝙬𝙞𝙩𝙝 𝙗𝙧𝙖𝙞𝙣 𝙙𝙖𝙢𝙖𝙜𝙚 𝙞𝙣 𝙥𝙧𝙚𝙩𝙚𝙧𝙢 to find out more 👉
https://www.degruyter.com/document/doi/10.1515/med-2022-0566/html

19/12/2022

Scientific news alert ❗
A new study found that 𝘁𝘂𝗺𝗼𝗿 𝗻𝗲𝗰𝗿𝗼𝘁𝗶𝗰 𝗳𝗮𝗰𝘁𝗼𝗿 𝗮𝗹𝗽𝗵𝗮 𝘀𝗲𝗻𝗱𝘀 𝗰𝗲𝗹𝗹𝘀 𝗶𝗻𝘁𝗼 𝗮 𝗽𝗮𝗻𝗶𝗰-𝗹𝗶𝗸𝗲 𝘀𝘁𝗮𝘁𝗲, prompting them to rush decisions about when to commit su***de under inflammatory conditions.
Source: https://www.insidescience.org/news/inflammation-may-cause-cells-rush-life-and-death-decisions

(Inside Science) -- A molecule that triggers inflammation may send cells into a panic-like state, prompting them to rush decisions about when to commit su***de, according to new research. This could help quell viral infection by ensuring infected cells die before new viruses are released. But it app...

18/12/2022

Article alert ☑
Antibiotics 💊 are used for the proper fight against bacterial infections. However, they also affect our microbiota. Their irrational use may lead to the emergence of resistant bacteria, aggravation of infection, damage to the whole body, and severe harm to human health.
The study presented in 𝑴𝒆𝒕𝒂-𝒂𝒏𝒂𝒍𝒚𝒔𝒊𝒔 𝒐𝒇 𝒆𝒂𝒓𝒍𝒚-𝒍𝒊𝒇𝒆 𝒂𝒏𝒕𝒊𝒃𝒊𝒐𝒕𝒊𝒄 𝒖𝒔𝒆 𝒂𝒏𝒅 𝒂𝒍𝒍𝒆𝒓𝒈𝒊𝒄 𝒓𝒉𝒊𝒏𝒊𝒕𝒊𝒔 article informs also about the correlation between the use of antibiotics in early life and allergic rhinitis. Read the paper fully here:
https://www.degruyter.com/document/doi/10.1515/med-2022-0459/html

16/12/2022

New interesting read ❗
Healthy and not overworked clinical stuff is one of the most important things for maintaining the high quality of healthcare 👩‍⚕️. Here, we present 𝘀𝘂𝗿𝘃𝗲𝘆-𝗯𝗮𝘀𝗲𝗱 𝘀𝘁𝘂𝗱𝘆 that tests the hypothesis that negative or positive affect mediate 𝘁𝗵𝗲 𝗮𝘀𝘀𝗼𝗰𝗶𝗮𝘁𝗶𝗼𝗻 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗿𝗶𝘀𝗸 𝗽𝗲𝗿𝗰𝗲𝗽𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗳𝗲𝗲𝗹𝗶𝗻𝗴 𝗼𝗳 𝘄𝗼𝗿𝗸 𝗲𝘅𝗵𝗮𝘂𝘀𝘁𝗶𝗼𝗻 among obstetrics healthcare providers during COVID-19 pandemic 🩺 .
To read the paper click on the link below:
https://www.degruyter.com/document/doi/10.1515/med-2022-0571/html

15/12/2022

Article alert ⏰
𝐈𝐦𝐦𝐮𝐧𝐨𝐨𝐧𝐜𝐨𝐥𝐨𝐠𝐲 is now one of the topics with most interest. 𝐓𝐡𝐞 𝐫𝐨𝐥𝐞 𝐨𝐟 𝐢𝐦𝐦𝐮𝐧𝐞 𝐜𝐞𝐥𝐥𝐬, 𝐥𝐢𝐤𝐞 𝐍𝐊-𝐜𝐞𝐥𝐥𝐬 𝐦𝐚𝐲 𝐛𝐞 𝐜𝐫𝐮𝐜𝐢𝐚𝐥 𝐟𝐨𝐫 𝐭𝐚𝐫𝐠𝐞𝐭𝐢𝐧𝐠 𝐧𝐞𝐰 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦𝐬 𝐨𝐟 𝐜𝐚𝐧𝐜𝐞𝐫-𝐢𝐦𝐦𝐮𝐧𝐞 𝐫𝐞𝐬𝐩𝐨𝐧𝐬𝐞 𝐢𝐧𝐭𝐞𝐫𝐚𝐜𝐭𝐢𝐨𝐧.
Herein, we present paper about NK-cell dysfunction in acute myeloid leukemia 👉
https://www.degruyter.com/document/doi/10.1515/med-2022-0551/html

13/12/2022

Scientists have recently created the first model to digitally showcase the heart’s unique network of neurons, called the intracardiac nervous system (ICN) 👀. It helps fine-tune external signals from the body’s autonomic nervous system to keep the heart pumping smoothly. A properly working ICN is essential for good heart health ❗️
To find out more check the link below 👉
https://www.insidescience.org/video/3d-model-hearts-brain
Credit: Achanta et al. - iScience

09/12/2022

Research news ☑️❗️
Recent studies identified 𝗲𝘅𝗽𝗼𝘀𝘂𝗿𝗲 𝘁𝗼 𝗹𝗼𝘂𝗱 𝗻𝗼𝗶𝘀𝗲 𝗮𝘀 𝘁𝗵𝗲 𝗰𝗮𝘂𝘀𝗲 𝗼𝗳 𝘀𝗶𝗴𝗻𝗶𝗳𝗶𝗰𝗮𝗻𝘁 𝗵𝗲𝗮𝗿𝗶𝗻𝗴 𝗹𝗼𝘀𝘀 𝗱𝘂𝗲 𝘁𝗼 𝗱𝗮𝗺𝗮𝗴𝗲 𝘁𝗼 𝗵𝗮𝗶𝗿 𝗰𝗲𝗹𝗹𝘀❗️
To read more visit the page: 👉
https://www.insidescience.org/index.php/news/noise-exposure-may-cause-even-more-hearing-loss-doctors-thought

(Inside Science) -- Researchers have long debated why so many people lose their hearing as they age. Some have argued that the problem lies mainly with the stria vascularis, a sort of battery in the inner ear that powers the transformation of sound energy into nerve impulses. But a new study places....

23/11/2022

Scientific news alert 🔔 ❗️❗️
Probiotic bacteria coated in a layer of biomaterial emerge as a 𝒑𝒓𝒐𝒎𝒊𝒔𝒊𝒏𝒈 𝒕𝒓𝒆𝒂𝒕𝒎𝒆𝒏𝒕 𝒐𝒑𝒕𝒊𝒐𝒏 💊𝒇𝒐𝒓 𝒊𝒏𝒇𝒍𝒂𝒎𝒎𝒂𝒕𝒐𝒓𝒚 𝒃𝒐𝒘𝒆𝒍 𝒅𝒊𝒔𝒆𝒂𝒔𝒆𝒔 𝒍𝒊𝒌𝒆 𝑪𝒓𝒐𝒉𝒏’𝒔 𝒂𝒏𝒅 𝑼𝒍𝒄𝒆𝒓𝒂𝒕𝒊𝒗𝒆 𝒄𝒐𝒍𝒊𝒕𝒊𝒔 ❗️ ✴️

Image credits: Quanyin Hu, SciTechDaily
https://scitechdaily.com/nanoparticle-probiotic-backpacks-show-promise-for-treating-inflammatory-bowel-diseases-like-crohns-and-ulcerative-colitis/

09/11/2022

Researchers from Rutgers University, USA have found that people who are 'night owls' could have greater risk of type 2 diabetes and heart disease than those who are 'early birds'. The research further identified that wake/sleep cycles cause metabolic differences and alter our body's preference for energy sources. The researchers found that those who stay up later have a reduced ability to use fat for energy, meaning fats may build-up in the body and increase risk for metabolic diseases.

Source: The Physiological Society, Sciencedaily.com
Image credit: Karl Tate, LiveScience Infographic Artist

05/09/2022

The new CANTOS analysis provides evidence that "Inflammation" relates to residual risk in patients with chronic kidney disease (CKD), rather than lipids in these CKD patients aggressively treated with statins. (Ridker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG. Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy. Eur Heart J. 2022 Aug 9:ehac444. doi: 10.1093/eurheartj/ehac444. Epub ahead of print. PMID: 35943897.)
https://academic.oup.com/.../eurheartj/ehac444/6659025...
Recently, Open Medicine has published multiple research articles focussing on the role and underlying mechanisms of how these pro-inflammatory cytokines participate in the progression of cardiovascular and metabolic diseases
https://www.degruyter.com/document/doi/10.1515/med-2021-0400/html?fbclid=IwAR3OvGvwaj2pEiJDBNW4Dk5SruvwZ9PLRpns9J_2onOxu23806ffWMBbLy0
https://www.degruyter.com/.../doi/10.1515/med-2022-0487/html

Leptin and proprotein convertase subtilisin kexin 9 (PCSK9) play an important role in regulating blood lipid concentration. Recently, they have been found to show the ability to independently regulate the immune response. Vascular immune response has an important pathological function in the develop...

31/08/2022

Ketamine is primarily used for induction and maintenance of general anesthesia, but it also presents sedative, amnestic, anesthetics, analgesic, antihyperalgesia, neuroprotective, anti-inflammatory, immunomodulant, and antidepressant effects. Here we present the review of the role of ketamine in the pediatric field.

Although ketamine is primarily used for induction and maintenance of general anesthesia, it also presents sedative, amnestic, anesthetics, analgesic, antihyperalgesia, neuroprotective, anti-inflammatory, immunomodulant, and antidepressant effects. Its unique pharmacodynamics and pharmacokinetic prop...

24/08/2022

There is growing evidence of the potential role of calprotectin as a non-invasive diagnostic screening test of inflammation and the influence of stress factors on the digestive tract of the newborns. Here, we present the study that aimed to provide additional information on the influence of perinatal factors on f***l (f)-calprotectin values in preterm infants.

This study aimed to provide additional information on the influence of perinatal factors on f***l (f)-calprotectin values in preterm infants. Calprotectin was determined from the first spontaneous stool (analyzed on the Alegria device by using the enzyme-linked immunosorbent assay [ELISA] method) ob...

17/08/2022

Autophagy is complex process that participates in the regulation of pulmonary arterial hypertension (PAH). However, the role of autophagy-related genes in the pathogenesis of the PAH is still unclear. Here, we present the study that aim to identify autophagy-related genes biomarkers in PAH.

Autophagy participates in the regulation of pulmonary arterial hypertension (PAH). However, the role of autophagy-related genes (ARGs) in the pathogenesis of the PAH is still unclear. This study aimed to identify the ARGs in PAH via bioinformatics analysis. A microarray dataset (GSE113439) was downl...

10/08/2022

Mental health is one of the most important topics these days. Months of lockdown and worldwide pandemic made a great impact on our mental health. Here, we present very interesting study about possible impact of COVID-19 pandemic and lockdown on su***de behavior among patients in Serbia.

Individuals with serious mental illness are more affected by emotional reactions, including suicidal behavior due to COVID‐19 and psychosocial consequences of pandemic. The current cross-sectional study aimed to explore the possible association of COVID-19 and suicidal behavior (su***de ideation a...

09/08/2022

New research links intake of red meat to increased risk of cardiovascular diseases in older adults. Surprise! The risk pathways are not related to blood cholesterol but to glucose and insulin metabolism, inflammation and more importantly to novel gut microbiome-synthesized metabolites – TMAO, gamma-butyrobetaine, and crotonobetaine.

Open Medicine now has an expert editorial board specialized in Cardiometabolic diseases and we are extremely excited to invite you to contribute original research articles in the field.
https://now.tufts.edu/2022/08/01/research-links-red-meat-intake-gut-microbiome-and-cardiovascular-disease-older-adults

Microbiome-related metabolites, blood sugar, and inflammation appear more important than blood cholesterol in mediating heart disease due to meat intake.