Clinical news for nephrologists and urologists.
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The BUN to serum albumin ratio could be a simple and useful prognostic tool to gauge survival odds in ICU patients with diabetes and chronic disease.
The blood urea nitrogen (BUN) to albumin ratio could be a useful tool to gauge prognosis of patients with type 2 diabetes and CKD.
Darolutamide appears to have greater efficacy and tolerability compared with enzalutamide and apalutamide in the treatment of nonmetastatic castration-resistant , a real-world study suggests.
Clinical experience may inform expectations with use of ARIs such as darolutamide, enzalutamide, and apalutamide for castration-resistant prostate cancer (CRPC).
Findings confirm a substantial risk of cardiovascular and all-cause mortality as well as graft failure in transplant recipients who develop post-transplant diabetes, but meds might help.
According to a study based on 30 years of data from 164,593 living donors in the Scientific Registry of Transplant Recipients, perioperative mortality after living donation has declined substantially to fewer than 1 event per 10,000 donations.
Risk factors for sustained eGFR decline included lower eGFR and hypertension before donation or de novo diabetes after donation. Studies have characterized the health risks associated with living kidney donor health as well as persistent racial disparities.
Regional anticoagulation using calcium-free dialysate can reduce early termination of the dialysis session compared with using a heparin-coated dialysis filter, according to preliminary trial results. https://brnw.ch/21wMevi
For cancer patients, cognitive behavioral therapy (CBT) improves mental health and quality-of-life outcomes.
Moderate improvement seen in mental health, QoL in meta-analysis; efficacy of CBT can be influenced by age and delivery format
The presence of anatomical and functional genitourinary disorders at baseline were predictive of reduced likelihood of successful response to antibiotic therapy among patients with complicated urinary tract infection or acute pyelonephritis.
Anatomical and functional genitourinary disorders were associated with reduced likelihood of successful response to antibiotic therapy in patients with complicated UTI.
A 12-week pelvic floor yoga program is not superior to a physical conditioning program for women with daily urinary incontinence.
For adults with stones, increasing thiazide dose is associated with greater reductions in calcium, which are negatively associated with symptomatic stone events.
New data suggest that olaparib without ADT could be a reasonable treatment strategy in selected patients with high-risk prostate cancer that recurs after radical prostatectomy. https://brnw.ch/21wMdhi
Repleting vitamin D levels is a low-risk intervention to support multiple biochemical pathways that impact chronic disease outcomes.
Potassium-competitive acid blockers are safe and efficacious compared with proton pump inhibitors (PPIs) for erosive esophagitis, especially in the early stage of treatment.
Potassium-competitive acid blockers compared with proton pump inhibitors are safe and efficacious for treating erosive esophagitis.
Neighborhoods in highest quartile of structural racism had elevated cancer risk from traffic-related air pollutants.
Neighborhoods in highest quartile of structural racism had elevated cancer risk from traffic-related air pollutants
The use of GLP-1RAs was linked to better cardiorenal outcomes than insulin among patients with type 2 diabetes on acute dialysis.
GLP-1RA vs insulin use was associated with improved cardiovascular and kidney outcomes among patients with type 2 diabetes on dialysis.
Combination treatment with nivolumab and ipilimumab provides lasting benefits over sunitinib in patients with advanced renal cell carcinoma.
Nivolumab plus ipilimumab provides lasting benefits over sunitinib in patients with advanced RCC, according to an 8-year update of the CheckMate 214 trial.
Investigators identified 9 cytokines that can distinguish between disease relapse and remission in ANCA-associated vasculitis. https://brnw.ch/21wMbo7
A study has documented a group of cytokines involved in the pathogenesis of ANCA-associated vasculitis which could be of value as predictive biomarkers.
Patients with autosomal dominant polycystic disease (ADPKD) have an excess burden of chronic obstructive pulmonary disease (COPD) as well as kidney-related comorbidities, according to studies.
ADPKD is a leading inheritable cause of kidney failure and is commonly associated with other complications.
The FDA has approved the Insulet Omnipod 5 insulin delivery system for patients with type 2 diabetes.
Omnipod 5 works in concert with a continuous glucose monitor to manage blood glucose with no daily injections and no finger pricks
African American patients are at higher risk for a more severe form of diabetes, which may contribute to health outcome disparities within the population.
Black patients were more likely to have severe insulin-deficient diabetes and less likely to have mild age-related diabetes than White patients.
For older patients with diabetes, prolonged time out of target range hemoglobin A1c is associated with increased risk for Alzheimer disease and related dementias.
Poor glycemic control, specifically less time in range and more time below range, was associated with an increased risk for Alzheimer disease.
A third of post-surgery patients are interested in trying a patient-controlled liquid opioid dispenser device for post-surgical pain management.
Survey shows nurses and post-surgical patients interested in trying patient-controlled opioid dispenser for post-surgical pain management. A survey showed 33% of patients and 57% of nurses were in favor of trying a device that allows controlled self-administration of liquid opioids in post-surgery p...
Findings confirm a substantial risk of cardiovascular and all-cause mortality as well as graft failure in transplant recipients who develop post-transplant diabetes, but meds might help.
Post-transplant diabetes frequently occurs among kidney transplant recipients and has serious and even life-threatening consequences.
Prophylaxis with valganciclovir does not prevent breakthrough episodes of cytomegalovirus (CMV) DNA in the blood (DNAemia) among pediatric solid organ transplant recipients.
Breakthrough CMV infection was observed among pediatric SOT recipients who received valganciclovir prophylaxis within the first year following transplantation.
A single session of 20-minute mindful breathing is beneficial for reducing cancer pain.
Single 20-minute session had significant efficacy for reducing pain intensity, pain unpleasantness, anxiety
Women with postoperative atrial fibrillation after cardiac surgery have increased mortality risk.
Men and women with poAF have higher risk for death than those without poAF, with higher risk seen for women than men
Belzutifan outperformed everolimus in patients with previously treated, advanced clear-cell renal cell carcinoma (RCC). https://brnw.ch/21wM979
Belzutifan outperformed everolimus in patients with previously treated, advanced clear-cell RCC in the phase 3 LITESPARK-005 trial.
Cancer patients may fare better if they receive lower corticosteroid doses to treat immune-related adverse events caused by immune checkpoint inhibitor therapy.
Cancer patients may fare better if they receive lower corticosteroid doses to treat irAEs, according to researchers.
Plasmapheresis was used in nearly 15% of adults hospitalized for newly diagnosed ANCA-associated vasculitis (AAV) with severe acute kidney involvement from 2016 to 2020 in the US. https://brnw.ch/21wM7LB
Plasmapheresis is recommended in cases of ANCA-associated vasculitis involving severe kidney and/or lung involvement.
Patients with moderate to severe atopic dermatitis (AD) had continuous improvement in pruritus and sleep disturbance with lebrikizumab monotherapy through 52 weeks of treatment.
Patients with atopic dermatitis taking lebrikizumab had stable and continued improvements in pruritus and sleep symptoms through week 52 of treatment.
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