STEM CELLS Journal

19/11/2024

High-throughput solutions in tumor organoids: from culture to drug screening
https://doi.org/10.1093/stmcls/sxae070

12/11/2024

Read the November issue of Stem Cells online at https://academic.oup.com/stmcls/issue/42/11

11/11/2024

This study reveals different licensing strategies for enhancing mesenchymal stromal cell immunomodulation. The information may be useful for improving the standardization and immune regulation mechanism of MSCs.

Abstract. Cytokine(s) pre-activation/licensing is an effective way to enhance the immunomodulatory potency of mesenchymal stromal cells (MSCs). Currently,

04/11/2024

This study investigated the mechanism by which metformin protects against osteoporosis, particularly in the elderly.

Abstract. A general decline in the osteogenic differentiation capacity of human bone marrow mesenchymal stem cells (hBMSCs) in the elderly is a clinical co

29/10/2024

Using an innovative reporter line, this study sheds light on the complex interplay between genome editing components, vector choices, and cellular stress responses, offering insights for optimizing gene therapy protocols.

Sun et al. develop a p21-mNeonGreen reporter iPSC line to dynamically monitor TP53-p21 pathway activation post-CRISPR-Cas9 editing. Their findings reveal h

28/10/2024

Deadline to apply is fast approaching!

Early Career Investigator Award: Call for Applications

For more information:
https://bit.ly/3BMGhPT

21/10/2024

This interesting article reports the use of human umbilical cord-derived MSCs to combat ischemia-induced loss of muscle mass and function.

Abstract. Peripheral arterial disease (PAD) is associated with lower-extremity muscle wasting. Hallmark features of PAD-associated skeletal muscle patholog

17/10/2024

Early Career Investigator Award: Call for Applications

The annual Stem Cells Early Career Investigator Award is open for applications.

For more information:
https://bit.ly/3BMGhPT

17/10/2024

This Virtual Issue explores mesenchymal stromal cells and the conversation around them. https://bit.ly/4eNLR32

15/10/2024

This study investigated the problem of lack of efficient migration of transplanted MSCs to the affected site in spinal cord injuries. https://doi.org/10.1093/stmcls/sxae055

08/10/2024

This review explores the epigenetic landscape of intestinal cells, from intestinal stem cells to differentiated progenies (eg, enterocytes) and addresses how the intestinal epigenome is deregulated in colorectal cancer.

Abstract. Epigenetic mechanisms play a pivotal role in controlling gene expression and cellular plasticity in both normal physiology and pathophysiological

01/10/2024

This review summarizes the progress made on using patient-derived organoids in personalized medicine context. Examples of organoid applications, such as diagnostics, treatment outcome prediction, and organoid transplantation, and the challenges associated with their implementation are discussed.

Abstract. Inter-individual variation largely influences disease susceptibility, as well as response to therapy. In a clinical context, the optimal treatmen

24/09/2024

Silencing endomucin in bone marrow sinusoids improves hematopoietic stem and progenitor cell homing during transplantation
Yue Li, Miao Ren, Hu Li, Zuo Zhang, Ke Yuan, Yujin Huang, Shengnan Yuan, Wen Ju, Yuan He, Kailin Xu, Lingyu Zeng
https://doi.org/10.1093/stmcls/sxae046

16/09/2024

Human umbilical cord MSCs (UC-MSCs) & their derived exosomes have potential for treatment of skeletal muscle atrophy. This study investigated the molecular mechanism by which UC-MSCs and their derived exosomes delay muscle atrophy following nerve injury.

Abstract. Cell therapy based on mesenchymal stem cells (MSCs) alleviate muscle atrophy caused by diabetes and aging; however, the impact of human umbilical

11/09/2024

Read the September issue of Stem Cells online at https://academic.oup.com/stmcls/issue/42/9

06/09/2024

This research identified a novel role of regulating pluripotency by ubiquitin E3 ligase FBXO9 through ubiquitination of pluripotency associated protein DPPA5.

Abstract. Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have unique characteristics where they can both contribute to all three ge

03/09/2024

Division-Independent Differentiation of Muscle Stem Cells During a Growth Stimulus
Ahmed Ismaeel, Jensen Goh, C. Brooks Mobley, Kevin A. Murach, Jamie O. Brett, Antoine de Morrée, Thomas A. Rando, Charlotte A. Peterson, Yuan Wen, John J. McCarthy
https://doi.org/10.1093/stmcls/sxad091