28/09/2019
Dopamine is made in the eye by sunlight and it can be made in the gut by your microbiome. People forget that bacteria release 5000 times more light than eukaryotic cells and this light is capable of making dopamine from the aromatic amino acids in the gut. This is why serotonin and phenylalanine and tyrosine are stored in the enterochromaffin system there. The more and more I look into it, I feel confident in saying that light is just as...... Joshua a recent mitochondriac convert realizes now that "Light is the most powerful drug for living systems. The light release is more important than the fuel in the diet for our health outcomes because food has light information built into by photosynthesis. This stimulus leads to light release to start the optical signal cascade in the gut using aromatic amino acids as the mover in the GI tract. Joshua said, "When I was blue light toxic I could not repair my gut at all."
I can tell you this. Your gastrointestinal system will never function optimally in a circadian mismatch (melanopsin dysfunction) and that will bypass however good a diet is.
Serotonin synthesis via morning sunlight programs tryptophan which is a cells time crystal. When light between 200-400nm emits the aromatic rings of this amino acid the crystal oscillates and that allows cells to build a peripheral clock in the cell that can be entrained by the SCN in the eye. That is the main clock in the human system. Serotonin, therefore, plays many roles in regulating digestive function and that would seem obvious when you know that most of the bodies serotonin are actually created in the gut by light release from the microbiome that is controlled by the incident light we chose to live under. This is why serotonin in the gut is made in the gut of humans and not in the brain.
Study about serotonin in the gut below:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694720/
For instance, chronic constipation has been correlated with low mucosal levels of serotonin in the large intestine. Tryptophan is programmed by sunlight and it creates serotonin when the light is slowed down. Serotonin is also converted to melatonin, given that we aren't inhibiting it with BLUE light at night at some surface. This causes melanopsin dysfunction which lowers melatonin levels and destroys the two programs that control mtDNA.
Melatonin also plays large roles in the GI tract in this way.
In the gut melatonin plays significant roles in regulating intestinal motility, the immune system, GI secretion, and the release of peptides involved in energy balance and maintenance. Melatonin also protects the colon in different pathophysiological conditions, and these protective effects involve activation of antioxidative mechanisms which combat oxidative stress. This is why blue light causes light stress and this drives melatonin LOWER and diminishes your ability to sleep and regenerate.
Another effect of melatonin is the alteration of gut flora and potential anti-microbiotic actions. So we can deduct from this that lower serotonin, and thus melatonin, can play a role in stages of dysbiosis. Study about melatonin found below:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198018/
Morning sunlight also stimulates dopamine production and we now know that dopamine receptors in the GI tract regulate gastrointestinal motility.
Irritable bowel syndrome and small intestinal bacterial overgrowth, which are becoming pandemic today, are largely motility related disorders. Coincidence? I think not, although there are other dietary, pathogenic, and environmental factors that contribute.
Dopamine in the gastrointestinal tract stimulates exocrine secretions, inhibits gut motility, modulates sodium absorption and mucosal blood flow, and is protective against gastroduodenal ulcer disease. Study about dopamine in the gut below:
https://academic.oup.com/…/Substantial-Production-of-Dopami…
So the message of all this is that everything seems downstream of the appropriate light exposure in our environment due to its influence on these neurotransmitters, mitochondria, and many hormones involved in various processes." WHEN YOU KNOW BETTER YOU DO BETTER!!!!! Few of your food or microbiome gurus do. Realize that now. https://academic.oup.com/jcem/article/82/11/3864/2866142/Substantial-Production-of-Dopamine-in-the-Human