Inside Precision Medicine

09/10/2025

Brain-on-a-Chip Shows How Inflammation Damages the Blood-Brain Barrier

The new brain-on-a-chip technology, developed by University of Rochester researchers, simulates how the blood-brain barrier (BBB) responds to both systemic inflammation and neurodegenerative conditions, identifying how breakdowns in the BBB can result in cognitive impairment.

Brain-on-a-chip technology simulates how systemic inflammation and neurodegenerative conditions can result in cognitive impairment.

09/10/2025

What if your body could tell you—in real time—when inflammation starts?

In this new episode of Behind the Breakthroughs, host Jonathan D. Grinstein, PhD, speaks with Shana Kelley, PhD, President of the Chan Zuckerberg Biohub Chicago, about how her team is creating “instrumented tissues” that could one day monitor molecular activity inside the body continuously.

Learn how this visionary work could transform how we detect and treat chronic disease.

🎧 Listen: https://hubs.li/Q03MXvHT0

📖 Read more: https://hubs.li/Q03MXD_30

09/10/2025

Engineered Bacterial Therapy Trains Immune System to Fight Solid Tumors

In preclinical studies, ACTM-838 safely targets tumors, reshapes the immune landscape, and synergizes with checkpoint blockade—offering a new frontier for resistant cancers.

Engineered bacterial therapy targets solid tumors to boost immune attack and checkpoint therapy response in mice.

08/10/2025

Bladder Health and Cancer Risk Modulated by Smoking and Biological S*x

Among donors over 55, smokers harbored a high frequency of mutations in the TERT promoter, a region of DNA that reactivates the enzyme telomerase, enabling cells to escape aging and continue dividing indefinitely.

University of Washington
*x

Smoking and s*x drive distinct patterns of mutation expansion in healthy bladder tissue, shaping future cancer risk.

08/10/2025

Gene Promoting High Blood Sugar in Type 2 Diabetes Discovered

Research led by Beckman Research Institute of City of Hope shows that the abnormal expression of the SMOC1 gene promotes high blood sugar and decreased insulin expression and secretion in the body and an abnormal change from beta to alpha cells in the pancreas in people with type 2 diabetes.

Abnormal expression of the SMOC1 gene promotes high blood sugar and decreased insulin expression and secretion in the body in type 2 diabetes.

08/10/2025

Home Cancer Tests Using Breath and Urine Get U.S. Funding Boost

At-home tests for cancer based on urine and breath samples could be a step closer, following major funding awards to key players by a U.S. federal agency specializing in health innovation.

Owlstone Medical

A U.S. federal health agency has awarded millions of dollars aimed at bringing cancer detection into the home.

08/10/2025

FDA Clears First-in-Class Heart Tissue Regeneration Drug for In-Human Trials

The first-in-class therapeutic targets ENPP1, a protein that was identified by UCLA researcher Arjun Deb, MD, as a key regulator of impaired tissue repair following heart attack and other acute organ damage.

National Institutes of Health (NIH), U.S department of defense, California Institute for Regenerative Medicine

The first-in-class therapeutic targets ENPP1, a key regulator of impaired tissue repair following heart attack and other acute organ damage.

07/10/2025

Beneficial Gut Bacteria Boost Chance of Pregnancy Success

Results from a mouse study suggest the beneficial gut bacteria Bifidobacterium breve could help women to maintain a healthy pregnancy.

University of Cambridge University of Birmingham

Results from a mouse study suggest the beneficial gut bacteria Bifidobacterium breve could help women to maintain a healthy pregnancy.

07/10/2025

Cutting-Edge Technologies Could Trigger Personalized CVD Drug Revolution

AI, omics, and systems biology could create new treatments for previously “undruggable” CVD, experts believe, but global health partnership will be crucial.

Harvard Medical School, Harvard University

AI, omics, and systems biology could create new treatments for previously “undruggable” CVD, experts believe, but global health partnership will be crucial.

07/10/2025

Mitochondrial Switch Identified as Drug Target for Parkinson’s Disease

Modulating the activity of PP2A-B55α in a model of Parkinson’s disease reduced the disease’s motor symptoms.

Università Roma Tre

Modulating the activity of PP2A-B55α in a model of Parkinson’s disease reduced the disease’s motor symptoms.

06/10/2025

BCIs Near Clinic with Minimally Invasive, High-Density Electrode Arrays

These thin-film cortical arrays, created by Precision Neuroscience Corporation’s research team, may form the basis for next-generation BCIs that can be implanted during a routine neurosurgical procedure and restore lost abilities without piercing the brain.

The implants can be removed without visible cortical damage, making them a safer, reversible alternative to penetrating arrays.

06/10/2025

Aggressive Endometrial Cancer Linked to Metabolic Activity in Visceral Fat

High levels of metabolic activity in visceral fat are associated with more advanced stages of endometrial cancer and the presence of lymph node metastases. This discovery could enable the use of routine clinical imaging techniques to help physicians identify high-risk patients and make more personalized treatment decisions.

Universitetet i Bergen, Haukeland universitetssjukehus

High levels of metabolic activity in visceral fat are linked to more advanced stages of endometrial cancer and lymph node metastases.