Inside Precision Medicine

21/12/2024

Mutated Cilia Implicated in Pathology of ALS

This could open a potential new avenue for therapeutic development.

KU Leuven VIB KU Leuven Center for Brain & Disease Research

Researchers have looked at the role of specific mutations in primary cilia in ALS.

20/12/2024

Genetic Importance for Flu Vaccine Protection Could Broaden Pandemic Preparedness

Genes are more important than previous flu infection in determining the protection a person receives from the seasonal vaccination. This greater potential for flexibility has led researchers to design a more effective vaccine that can trick the body into responding to multiple subtypes of a virus

Stanford University

Genes are more important than previous flu infection in determining the protection a person receives from the seasonal vaccination, in findings that have opened new avenues against future viral pandemics.

20/12/2024

New SMART Software Revolutionizes Cell Signaling Simulations

The UC San Diego cutting-edge technology provides unprecedented accuracy and flexibility, addressing the challenges of modeling molecular interactions within the intricate, three-dimensional environments of cells.

SMART, a groundbreaking software tool, models complex cell-signaling networks, advancing biological research and treatment development.

20/12/2024

Season’s Greetings from Inside Precision Medicine!

As this year comes to a close, we extend our gratitude to the vibrant precision medicine community for your continued dedication to innovation and patient care.

May your holidays be filled with joy, peace, and moments of celebration. Here’s to another year of progress, collaboration, and meaningful impact in precision medicine!

From all of us at Inside Precision Medicine, happy holidays and best wishes for a successful New Year!

20/12/2024

Study Suggests Cytomegalovirus Could Contribute to Alzheimer's Pathology in Certain Individuals

While HCMV typically remains dormant, in some people, the virus may linger in an active state in the gut and travel to the brain via the vagus nerve.

Arizona State University Banner Health

HCMV typically remains dormant, however, in some people, it may linger in an active state in the gut and travel to the brain via the vagus nerve.

19/12/2024

U.S. Food and Drug Administration Clears Sangamo’s ST-503 for Chronic Neuropathic Pain Clinical Trials

The clearance marks a major milestone as Sangamo Therapeutics prepares to launch a Phase I/II clinical trial in mid-2025 to evaluate the safety and efficacy of this novel treatment.

ST-503, an epigenetic regulator targeting intractable neuropathic pain, receives FDA clearance for clinical trials.

19/12/2024

How the Body's Clock Manages Inflammation

New findings from the Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences reveal how macrophages behave differently depending on the time of day, highlighting a potential for time-specific treatments for inflammatory diseases.

19/12/2024

Brain Structure Linked with Dyslexia Predisposition

A genetic predisposition to dyslexia may be associated with brain structure, research in over 30,000 adults suggests, with the potential involvement of brain networks involving motor coordination, vision, and language

UK Biobank 23andMe

A genetic predisposition to dyslexia may be associated with brain structure, research in over 30,000 adults suggests, with the potential involvement of brain networks involving motor coordination, vision and language.

19/12/2024

First Synovial Fluid Biomarker Test Accurately Diagnoses Primary Osteoarthritis

Read More: https://hubs.li/Q0302WRx0

“This study addresses an unmet need for objective diagnosis of OA to improve clinical decision-making and patient outcomes,” said corresponding author Daniel Keter, a research senior scientist at CD Diagnostics, a division of U.S. medtech company Zimmer Biomet.

19/12/2024

🎧Not All Precision Medicine Heroes Wear Lab Coats

In this episode of Behind the Breakthroughs Tom Whitehead shares his journey with his daughter Emily, the first pediatric CAR T-cell therapy recipient. He discusses her treatment, highlighting challenges in research-as-care and the role of persistence and luck.

Emily Whitehead Foundation

Tom Whitehead shares his journey with Emily’s CAR T treatment, highlighting challenges in research-as-care and the role of persistence and luck.

18/12/2024

Potential Action: SiteOne’s $100M Series C to Advance Non-Opioid Pain Drugs

The funding will enable clinical proof of concept for selective, small-molecule ion channel modulators for pain, cough, and other related conditions.

The funding will enable clinical proof of concept for selective, small-molecule ion channel modulators for pain, cough, and other conditions.

18/12/2024

Genetic Testing Improves Diagnosis of Children with Neurodevelopmental Disorders

Lead author Aaron D. Besterman, MD, from UC San Diego Department of Psychiatry, and team found that of 246 patients who underwent genetic testing, 42% had or likely had a diagnosis of a rare genetic condition.

Adding genetic testing to evaluate pediatric patients with neurodevelopmental disorders resulted in more individualized care.

18/12/2024

Blood Test Identifies Early Brain Changes Linked to Dementia Risk

Researchers at UCLA have identified that elevated levels of placental growth factor in the blood may serve as an early indicator of vascular brain injury, potentially providing a cost-effective tool for screening patients at risk before significant cognitive decline occurs.

Researchers uncover PIGF as a novel blood-based biomarker for detecting early brain changes leading to cognitive decline and dementia.

17/12/2024

When It Comes to Space Precision Medicine, the Sky Is the Limit—Literally

Spaceflight alters drug integrity and how the human body reacts to it—even in the case of precision medicine.

“There are many genes that are related to pharmacogenomics that change during spaceflight, and so this is an area of medical research that will be key for upcoming long-duration missions,” said Christopher Mason, PhD, a professor of genomics and computational biomedicine at Weill Cornell Medicine in New York.

Spaceflight alters drug integrity and how the humanbody reacts to it—even in the case of precision medicine.

17/12/2024

Breakthrough Nanoscale Microchip Technology Could Revolutionize Disease Diagnosis

Researchers at the NYU Tandon School of Engineering have developed of a microchip that can detect, at nanoscale, multiple diseases from a single air sample, bringing the promise of portable, at-home diagnostics closer to reality. The new advance in field-effect transistors (FETs), described in the journal Nanoscale, could eventually be integrated into devices such as a smartwatches to detect miniscule concentrations of viruses or bacteria in the air.

The field-effect transistors (FET) could be integrated into smartwatches to detect miniscule concentrations of viruses or bacteria.

17/12/2024

First Baby Born Using Technology That Matures Eggs Outside the Body

Gameto has announced the world’s first live human birth using Fertilo, an ovarian support cell (OSC) technology that matures eggs outside the body. The delivery was conducted at Santa Isabel Clinic, in Lima, Peru. This could represent a huge step forward in fertility management.

The world’s first baby has been born using Gameto's Fertilo, an ovarian support cell technology, that matures eggs outside the body.

16/12/2024

The Importance of Increasing Diversity in Clinical Trials

Before reaching the market, new drugs are tested in people who voluntarily participate in clinical trials. However, for a new medicine to work in as many people as possible, these drugs should be tested in a patient population that is as diverse as possible.

Before reaching the market, new drugs are tested in people who voluntarily participate in clinical trials. However, for a new medicine to work in as many people as possible, these drugs should be tested in a patient population that is as diverse as possible.

16/12/2024

New Combination of Anti-CXCR4 and Anti-PD1 Therapy Shows Promise for Liver Cancer Treatment

An international study, led by researchers at the Massachusetts General Hospital has found that a combination of anti-CXCR4 and anti-PD1 therapies can improve treatment outcomes for hepatocellular carcinoma (HCC), the most common form of liver cancer. While immunotherapy has shown significant improvements in treating certain cancers, its effectiveness against HCC has remained limited due to the development of treatment resistance often from the lack of dendritic cells. This new approach, published in the journal Cancer Immunology Research, details a method to address this obstacle by increasing the activity of dendritic cells to significantly improve immune response.

An international study found that a combination of anti-CXCR4 and anti-PD1 therapies can improve treatment outcomes for HCC.