Retina

OPEN ACCESS Article DYNAMIC VIRAL LOAD MONITORING AND METAGENOMIC SEQUENCING IN ACUTE RETINAL NECROSIS CAUSED BY VARICELLA-ZOSTER VIRUS Gu, Junxiang MD; Lei, Boya MD; Wang, Zhujian MS; Zhang, Ting PhD; Jiang, Tingting PhD; Zhang, Peijun MD; Chen, Wenwen PhD; Zhang, Yanqiong PhD; Jiang, Rui MD, PhD; Xu, Gezhi MPhil; Chang, Qing MD, PhD; Zhou, Min PhD Retina 44(11):p 1966-1975, November 2024 In this study, intensive viral load monitoring and metagenomic sequencing were performed to acute retinal necrosis cases during antiviral treatment. The plateau phase of viral load curve correlated well with the remission of active necrotizing lesions. Loss-of-function variations in viral ribonucleotide reductase gene led to impaired virulence of the virus. https://journals.lww.com/retinajournal/fulltext/2024/11000/dynamic_viral_load_monitoring_and_metagenomic.16.aspx #retina

SHORT-TERM REACTIVATION OF RETINOPATHY OF PREMATURITY AFTER PRIMARY RANIBIZUMAB TREATMENT Strawbridge, Jason MD; Cheng, John Y. MD; Gundlach, Bradley S. MD; Gillespie, Tessa BS; Karmouta, Reem BS; Khitri, Monica MD; Chu, Alison MD; Tsui, Irena MD Retina 44(11):p 1945-1951, November 2024 Short-term reactivation of retinopathy of prematurity after primary intravitreal ranibizumab (IVR) occurred in 26.8% of patients at a range of 38.0 to 45.6 weeks postmenstrual age and 7.2 weeks ± 1.7 weeks after treatment. Risk factors included zone I disease, earlier treatment, and lower gestational age. Repeat IVR injections were effective and well tolerated. https://journals.lww.com/retinajournal/abstract/2024/11000/short_term_reactivation_of_retinopathy_of.13.aspx #retina

GUNN DOTS IN CHILDREN AGED 11–12 YEARS FROM THE GENERAL COMMUNITY SAMPLE COPENHAGEN CHILD COHORT 2000 STUDY Boberg-Ans, Lars Christian MD; Munch, Inger Christine PhD; Olsen, Else Marie PhD; Skovgaard, Anne Mette MD; Larsen, Michael MD Retina 44(11):p 1961-1965, November 2024 This study investigates Gunn dots in healthy children aged 11 to 12 years, finding their prevalence, distribution, and associations with age and retinal nerve fiber layer thickness. The clinical significance of Gunn dots remains uncertain, but their location suggests potential relevance in the study of age-related eye conditions. https://journals.lww.com/retinajournal/abstract/2024/11000/gunn_dots_in_children_aged_11_12_years_from_the.15.aspx #retina

OPTICAL COHERENCE TOMOGRAPHY FEATURES ASSOCIATED WITH VITREOMACULAR TRACTION RELEASE AND MACULAR HOLE SIZE PROGRESSION FOLLOWING TREATMENT WITH OCRIPLASMIN Johannigmann-Malek, Navid MD; Iannetta, Danilo MD, PhD; Zheng, Yalin PhD; Kaye, Stephen B. BSc, MBBCh, FRCS, FRCOphth, MD; Groselli, Sofia MD; Kirchmair, Katharina MD; Dervenis, Nikolaos MD, PhD, FEBO; Issa, Peter Charbel MD, DPhil, FEBO; Baumann, Carmen MD, PhD, FEBO Retina 44(11):p 1923-1930, November 2024 In patients with VMT-associated MHs, the risk of MH enlargement following ocriplasmin injection is negatively correlated with the nasal PVC angle size and is increased if the ratio of the temporal to nasal PVC angle is greater than 1. https://journals.lww.com/retinajournal/abstract/2024/11000/optical_coherence_tomography_features_associated.10.aspx #retina

OPEN ACCESS Article COMPLEX MACULAR HOLE CLOSURE BY TEMPORAL INTERNAL LIMITING MEMBRANE FLAP WITHOUT ENDOTAMPONADE Szeto, Simon K. H. FCOphth(HK); Yu, Amy H. Y. MBChB; Tsang, Chi Wai FCOphth(HK); Mohamed, Shaheeda FCOphth(HK); Chen, Li Jia PhD; Lai, Timothy Y. Y. MD Retina 44(11):p 1915-1922, November 2024 Temporal internal limiting membrane flap without gas endotamponade is effective in closing complex macular hole (MH), including large MH and MH associated with high myopia. Retinal surgeons may consider using this technique for complex MH, particularly in patients with only-seeing eye, preexisting glaucoma, or noncompliant to posturing. https://journals.lww.com/retinajournal/fulltext/2024/11000/complex_macular_hole_closure_by_temporal_internal.9.aspx #retina @simonkhszeto

OPEN ACCESS Article SURGICAL OUTCOMES AND INTRAOPERATIVE PARAMETERS OF THREE-DIMENSIONAL VISUALIZATION SYSTEM VERSUS CONVENTIONAL MICROSCOPES FOR MACULAR SURGERY IN HIGHLY MYOPIC EYES A Prospective Randomized Clinical Trial Tsui, Mei-Chi MD; Hsieh, Yi-Ting PhD; Lai, Tso-Ting MD; Lee, Cheng-Yung MD; Hsia, Yun MD; Wang, Shih-Wen MD; Ma, I-Hsin MD; Hung, Kuo-Chi MD; Lin, Chang-Pin MD; Yang, Chang-Hao PhD; Yang, Chung-May MD; Ho, Tzyy-Chang MD Retina 44(11):p 1906-1914, November 2024 The 3D visualization system reduced the number of indocyanine green injections and shortened membrane peeling times, potentially decreasing indocyanine green exposure and toxicity; therefore, it may offer advantages for macular surgery in highly myopic eyes. https://journals.lww.com/retinajournal/fulltext/2024/11000/surgical_outcomes_and_intraoperative_parameters_of.8.aspx #retina @meichitsui #NTUH #Taiwan

FIVE-YEAR CHANGES IN METAMORPHOPSIA AND THE ASSOCIATION OF OUTER RETINAL LAYERS AFTER VITRECTOMY FOR RHEGMATOGENOUS RETINAL DETACHMENT INVOLVING THE MACULA Okuda, Tetsuhiko MD, PhD; Higashide, Tomomi MD, PhD; Sugiyama, Kazuhisa MD, PhD Retina 44(11):p 1884-1890, November 2024 The authors evaluated the 5-year changes in metamorphopsia after vitrectomy for macula-off rhegmatogenous retinal detachment. Metamorphopsia presented more than 50% of the patients at 5 years postoperatively, and early metamorphopsia was a poor prognostic marker for long-term functional deficits. https://journals.lww.com/retinajournal/abstract/2024/11000/five_year_changes_in_metamorphopsia_and_the.5.aspx #retina #Kanazawa University

THE MINI-STEAMROLL An Abbreviated Variation of the Steamroller Maneuver After Pneumatic Retinopexy for Rhegmatogenous Retinal Detachment Pecaku, Aurora MD; El-Sehemy, Ahmed PhD; Melo, Isabela Martins MD; Demian, Sue Ellen MD; Andreoli, Michael T. MD; Ramachandran, Arun PhD; Muni, Rajeev H. MD, MSc, FRCSC Retina 44(11):p 1876-1883, November 2024 Mini-steamroll is an alternative positioning regimen after pneumatic retinopexy, offering a potential blend of advantages of direct-to-break positioning and the full steamroller maneuver. https://journals.lww.com/retinajournal/abstract/2024/11000/the_mini_steamroll__an_abbreviated_variation_of.4.aspx #retina

EXPLORING THE CHALLENGES OF DISTINGUISHING PUNCTATE INNER CHOROIDOPATHY FROM MULTIFOCAL CHOROIDITIS AND PANUVEITIS Park, Hyo Song MD; Kang, Hyun Goo MD; Kim, Yong Joon MD; Choi, Eun Young MD; Lee, Junwon MD; Byeon, Suk Ho MD; Kim, Sung Soo MD; Lee, Christopher Seungkyu MD Retina 44(11):p 1869-1875, November 2024 It is difficult to clearly distinguish clinical cases of punctate inner choroidopathy from multifocal choroiditis and panuveitis, even with the aid of diagnostic criteria. Reevaluating existing criteria and considering additional characteristics could improve diagnostic accuracy. https://journals.lww.com/retinajournal/abstract/2024/11000/exploring_the_challenges_of_distinguishing.3.aspx #retina

PROGRESSION OF PERIPAPILLARY AND MACULAR CHORIORETINAL ATROPHY IN MULTIFOCAL CHOROIDITIS IS ASSOCIATED WITH PERIATROPHIC INFLAMMATORY PLUMES Ossewaarde-van Norel, Jeannette MD PhD; Spaide, Richard F. MD Retina 44(11):p 1860-1868, November 2024 In patients with multifocal choroiditis, we observed eyes that had a smoldering inflammation at the borders of peripapillary and macular chorioretinal atrophy. This inflammation appeared to be associated with the progression of atrophy, despite the use of what was typically considered adequate immunosuppression. https://journals.lww.com/retinajournal/abstract/2024/11000/progression_of_peripapillary_and_macular.2.aspx #retina

🍂 Fall is in the air, and so is the November issue of RETINA! Dive into fresh insights on eye care, innovative treatments, and emerging trends. 📖✨ We’re seeing exciting advancements that could redefine our approach to vision health. #RETINA #EyeCare #VisionHealth

Diagnostic and Therapeutic Challenges Shieh, David Drs; Paul, Samantha K.; Beckman, Madeline; Kurup, Shree K.; Dunn, James P. Editor(s): Agarwal, Anita Retina 44(10):p 1845-1850, October 2024 https://journals.lww.com/retinajournal/citation/2024/10000/diagnostic_and_therapeutic_challenges.23.aspx #retina