Retina

DEEP LEARNING FOR AUTOMATIC PREDICTION OF EARLY ACTIVATION OF TREATMENT-NAIVE NONEXUDATIVE MACULAR NEOVASCULARIZATIONS IN AGE-RELATED MACULAR DEGENERATION Crincoli, Emanuele MD; Catania, Fiammetta MD; Sacconi, Riccardo PhD; Ribarich, Nicolò MD; Ferrara, Silvia MD; Parravano, Mariacristina MD; Costanzo, Eliana MD; Querques, Giuseppe PhD Retina 44(8):p 1360-1370, August 2024 Deep learning can accurately predict quiescent macular neovascularization that will develop exudation within the first 2 years of follow-up. https://journals.lww.com/retinajournal/abstract/2024/08000/deep_learning_for_automatic_prediction_of_early.11.aspx #retina @dr_manuel__ #NEMNV #OCTA #AI

ASRS 2024 Medical and Surgical Case Conferences by @mstarr1724 for Retina Roundup Team Posted on August 7, 2024 Melissa Yuan, MD The medical case conference session was moderated by Drs. Sruthi Arepalli & Srinivas Sadda & featured cases by Drs. J Fernando Arevalo, Narciso Atienza, Sreenivasa Basavanthappa, Paul Bernstein, Rachel Downes, Jaclyn Kovach, Yasha Modi, Mohamed Mohamed, Kareem Moussa, Ksh*tij Raizada, Avik Sarkar, Mohammad Siddiqui, Bradley Smith, & Scott Walter. The surgical case conference moderators were Drs. Maria Berrocal and Gaurav Shah, and the case presenters included Drs. Nishikant Borse, Jinghua Chen, Srinivas Joshi, Eric Hung, Jayant Kumar, Ananth Sastry, Vinay Shah, Veer Singh, and Jennifer Tingley. https://retinaroundup.com/2024/08/07/asrs-2024-medical-and-surgical-case-conferences/ #retina #retinaroundup #ASRS2024 @ASRS2024

ASRS 2024: Update to the Port Delivery System by Retina Roundup Team Posted on Aug 1, 2024 Lindsay Kozek MD, PhD This session, moderated by Robert A. Mittra, MD, provided both technical updates regarding the Port Delivery System as well as readouts of several ongoing studies using the device. Dr. Dante Pieramici reviewed the voluntary recall of the port delivery system (PDS) that was in effect from 2021-2022. A root cause analysis was performed, and a mechanical malfunction was identified that resulted in septum dislodgement into the body of the device, making it unrefillable in some cases. A new updated implant was designed with improved bond strength of the septum. The needle has also been updated to reduce insertion force. With this updated device, testing with over thirty years of simulated use showed no dislodgements (versus a 50% rate with the previous model). The PDS is thus now re-FDA approved and the voluntary recall has been terminated. Read: https://retinaroundup.com/2024/08/01/asrs-2024-update-to-the-port-delivery-system/ #retina #retinaroundup #ASRS2024 @ASRS2024

ASRS 2024: Pyron Award by Retina Roundup Team Posted on Aug 1, 2024 Nikhil Bommakanti, MD RETINA Editorial Board Member Dr. Anat Loewenstein, MD, MHA was awarded the Retina Research Foundation’s 29th Annual Gertrude D. Pyron Award on Friday, July 19, 2024. The Pyron Award was established by the Retina Research Foundation to recognize outstanding vision scientists whose work contributes to knowledge about vitreoretinal disease. The Retina Research Foundation was founded by the late Alice McPherson, MD. The purpose of her lecture was to present the study design of 2 parallel phase 3 trials of intravitreal vamikibart in UME due to noninfectious uveitis. IL-6 is a potential target to address the inflammatory cascade as it is upregulated during infection and inflammation, and is involved in angiogenesis, fibrosis, inflammation, and blood-retinal barrier integrity. https://retinaroundup.com/2024/08/01/asrs-2024-pyron-award/ #retina #retinaroundup #ASRS2024 @ASRS2024

ASRS 2024: Young Investigator Award by Retina Roundup Team Posted on Aug 1, 2024 Gabriel Kaufmann, MD This year, the 11th annual Presidents’ Young Investigator Award was presented to J. Peter Campbell, MD, MPH, FASRS. Dr. Campbell is the Edwin and Josephine Knowles Professor of Ophthalmology at the Casey Eye Institute, Oregon Health & Science University (OHSU), in Portland, Oregon. In recognizing Dr. Campbell with this award, the ASRS recognized the importance and promise of his translational research in the areas of OCT imaging in pediatric retina and the development of artificial intelligence algorithms for retinopathy of prematurity. Read about his work: https://retinaroundup.com/2024/08/01/asrs-2024-young-investigator-award/ #retina #retinaroundup #ASRS2024 @ASRS2024

ASRS 2024: Awards Ceremony by Retina Roundup Team Posted on Aug 1, 2024 Michael Yu, MD Several awards were presented at the ASRS Award Ceremony to honor ASRS member contributions to teaching, research, and clinical care within the field of retina. Read about the worthy recipients: https://retinaroundup.com/2024/08/01/asrs-2024-awards-ceremony/ #retina #retinaroundup #ASRS2024 @ASRS2024

ASRS 2024: Diabetic Retinopathy Symposium II by Retina Roundup Team Posted on Aug 1, 2024 Vishal Swaminathan, MD This session featured a great discussion on the use of various agents for the treatment of diabetic macular edema and featured 4 speakers: Drs. Theodore Leng, Murat Oncel, Baruch Kuppermann, & Dilsher Dhoot. Read about these new findings: https://retinaroundup.com/2024/08/01/asrs-2024-diabetic-retinopathy-symposium-ii/ #retina #retinaroundup #ASRS2024 #vitreoretinal_surgery @ASRS2024

ASRS 2024: Wet AMD Symposium I by Retina Roundup Team Posted on August 1, 2024 This exciting opening session was moderated by Drs. Barbara Blodi and Donald D’Amico and features 4 talks by Drs. Charles Wykoff, Raj Maturi, Edward Wood, & Veeral Sheth. The ensuing discussion included speculation on whether follow up for inflammatory sequelae of novel gene therapies could become somewhat burdensome especially considering that one major benefit of these therapies would include fewer visits needed. Another question related to delivery routes for these therapies which currently include subretinal, suprachoroidal, and intravitreal delivery, with discussion surround the benefits and drawbacks of these routes. Read all about it: https://retinaroundup.com/2024/08/01/asrs-2024-wet-amd-symposium-i/ #retina #retinaroundup #ASRS2024 #vitreoretinal_surgery @ASRS2024

OPEN ACCESS Article ADVANCES IN PHOTORECEPTOR AND RETINAL PIGMENT EPITHELIUM QUANTIFICATIONS IN INTERMEDIATE AGE-RELATED MACULAR DEGENERATION High-Res Versus Standard SPECTRALIS Optical Coherence Tomography Frank, Sophie MD; Reiter, Gregor Sebastian PhD, MD; Leingang, Oliver PhD; Fuchs, Philipp MD; Coulibaly, Leonard Mana MD; Mares, Virginia MD; Bogunovic, Hrvoje PhD; Schmidt-Erfurth, Ursula MD Retina 44(8):p 1351-1359, August 2024 Layer quantifications on two high-resolution optical coherence tomography devices with different axial resolutions and power were compared in patients with intermediate age-related macular degeneration. These eyes presented higher photoreceptor thickness with thinner retinal pigment epithelium on High-Res optical coherence tomography. Topographic analyses showed a thicker retinal pigment epithelium above the drusen, and photoreceptor loss was greater in the central and parafoveal regions. https://journals.lww.com/retinajournal/fulltext/2024/08000/advances_in_photoreceptor_and_retinal_pigment.10.aspx #retina #agerelatedmaculardegeneration #opticalcoherencetomography #artificialintelligence #AI

CHANGES IN SCLERAL THICKNESS IN THE ACUTE PHASE OF VOGT–KOYANAGI–HARADA DISEASE Oshiro, Ayano MD; Imanaga, Naoya MD, PhD; Terao, Nobuhiro MD, PhD; Koizumi, Hideki MD, PhD Retina 44(8):p 1344-1350, August 2024 In Vogt–Koyanagi–Harada (VKH) disease, eyes with ciliochoroidal effusion exhibited maximum thickness of the anterior sclera in the acute phase. The sclera became thinner soon after the start of corticosteroid treatment, indicating that inflammation in VKH disease may affect not only the choroid but also the sclera. https://journals.lww.com/retinajournal/abstract/2024/08000/changes_in_scleral_thickness_in_the_acute_phase_of.9.aspx #retina

OPEN ACCESS Article THREE-DIMENSIONAL RETINAL DISPLACEMENT BEFORE AND AFTER MACULAR PUCKER SURGERY Rossi, Tommaso MD; Querzoli, Giorgio PhD; Cosimi, Pamela MD; Ripandelli, Guido MD; Placentino, Luca MD; Steel, David H. MD; Romano, Mario R. MD, PhD Retina 44(8):p 1329-1336, August 2024 Retinal displacement across the sagittal is greater than across the coronal plane in epiretinal membranes. Displacement across all planes in the postoperative period exceeds that occurring before surgery was deemed necessary, and in neither plane, the retina returns to its original configuration. https://ow.ly/EM8T50SUh5C #retina

EPIRETINAL MACROPHAGE-LIKE CELLS ON OPTICAL COHERENCE TOMOGRAPHY Potential Inflammatory Imaging Biomarker of Severity in Diabetic Retinopathy Zeng, Yunkao PhD; Wen, Feng PhD; Zhuang, Xuenan MD; He, Guiqin MD; Zhang, Xiongze PhD Retina 44(8):p 1314-1322, August 2024 Increased density along with morphological changes of epiretinal macrophage-like cells was observed beginning with moderate nonproliferative diabetic retinopathy and correlated with the progression of diabetic retinopathy, including diabetic macular edema. It is a potential inflammatory imaging biomarker of severity in diabetic retinopathy. https://journals.lww.com/retinajournal/abstract/2024/08000/epiretinal_macrophage_like_cells_on_optical.5.aspx #retina

SUPERFICIAL AND DEEP VASCULAR COMPLEXES DAMAGED TO DIFFERENT EXTENTS IN ADVANCED STAGES OF DIABETIC RETINOPATHY Lee, Min-Woo MD, PhD; Jun, Ji-Ho MD; Yu, Hwa-Young MD; Kim, Jung-Tae MD; Song, Yong-Yeon MD Retina 44(8):p 1298-1304, August 2024 Although both the SVC and DVC were more severely impaired in the advanced stages of DR, damage was more extensive and pronounced in the DVC than in the SVC. https://ow.ly/21By50SPF3f #retina

RELIABILITY OF CLINICAL GRADING OF DIABETIC RETINOPATHY COMPARED WITH GRADING OF ULTRA-WIDEFIELD IMAGES Castellanos-Canales, Daniela MD; Decker, Nicole L. BS; Fukuyama, Hisashi MD, PhD; Duffy, Brandon V. BS; Fawzi, Amani A. MD Retina 44(8):p 1279-1287, August 2024 The aim of this study was to determine whether ultrawide-field imaging offers an advantage to the clinical grading of diabetic retinopathy. Studying the agreement between clinical and ultrawide-field grading, ultrawide-field was found to be a helpful adjunct to clinical grading for detecting referable eyes and those with sight-threatening diabetic retinopathy. https://journals.lww.com/retinajournal/abstract/2024/08000/reliability_of_clinical_grading_of_diabetic.1.aspx #retina

Exciting news for ophthalmologists and retina specialists! Dr. Samuel Minaker recently discussed the latest trends in complete retinal pigment epithelial and outer retinal atrophy in age-related macular degeneration on the July RETINA Journal podcast. This is a must-listen for anyone in the field. Share your thoughts with us! #Retina #MacularDegeneration #OphthalmologyTrends

Exciting new trends in ophthalmology podcasts! Just listened to Dr. Samuel Minaker's latest episode on the evaluation of prone vs supine positioning in retinal detachment treatment. Fascinating insights and observations. Let's continue the conversation - share your thoughts! #Ophthalmology #Retina #medicalpodcasts

Just listened to the latest RETINA journal podcast by Dr. Samuel Minaker on the validation of M-Charts for quantitative assessment of metamorphopsia following retinal detachment repair. The insights and observations shared are truly valuable for anyone in the field. Let's discuss! #retina #ophthalmology #medicalpodcast

DIAGNOSTIC AND THERAPEUTIC CHALLENGES Shi, Jie Drs; Cheng, Yizhe; Chen, Chunli; Peng, Xiaoyan; Aye, Jennifer; Murray, Timothy; Berrocal, Audina Editor(s): Agarwal, Anita Retina 44(7):p 1274-1278, July 2024 https://journals.lww.com/retinajournal/citation/2024/07000/diagnostic_and_therapeutic_challenges.21.aspx #retina

Inverted Internal Limiting Membrane Flap Coverage With Autologous Blood Technique After Air–Fluid Exchange and Silicone Oil Tamponade for Extensive Macular Hole Retinal Detachment in Highly Myopic Eyes Tao, Jiwei MD; Zhao, Shixin MD; She, Xiangjun MD; lv, Zhe MD; Zhang, Yun MD Editor(s): Williams, George A. Retina 44(7):p 1268-1273, July 2024 This retrospective interventional case series study reports the use of an inverted internal limiting membrane flap with autologous blood for coverage after air–fluid exchange, which may promote anatomical and functional recovery in treating extensive retinal detachment. https://journals.lww.com/retinajournal/abstract/2024/07000/inverted_internal_limiting_membrane_flap_coverage.20.aspx #retina

OUTER RETINAL MICROCAVITATIONS IN RETINITIS PIGMENTOSA A Novel Optical Coherence Tomography Finding Common in RP1-Related Retinopathy Dimopoulos, Ioannis S. MD; Huryn, Laryssa A. MD; Hufnagel, Robert B. MD, PhD; Ullah, Ehsan PhD; Agather, Aime R. MS; Blain, Delphine MS; Brooks, Brian P. MD, PhD; Cukras, Catherine A. MD, PhD; Zein, Wadih M. MD Retina 44(7):p 1260-1267, July 2024 This study describes a novel OCT finding observed in inherited retinal degenerations and in particular RP1-related retinopathy that correlates with prominent cone involvement in the macula both structurally and functionally. https://journals.lww.com/retinajournal/abstract/2024/07000/outer_retinal_microcavitations_in_retinitis.19.aspx #retina