The program recreates unusual supposed deaths and debunked urban legends and includes interviews with experts who describe the science behind each death. Up until the end of season one, the final story of each episode showed actual footage of dangerous situations that almost ended in death, along with interviews with people involved in the situations. A portion of these deaths have been nominated
for or have received a Darwin Award. Stylization
1000 Ways to Die takes a tongue-in-cheek approach to death through its presentation of stories derived from myths and science, and the show makes liberal use of artistic license to significantly embellish or change the circumstances of real-life incidents that resulted in death for greater entertainment value. A frequently recurring motif is that of unsympathetic individuals' choices backfiring on them, resulting in death. The show is filled with black humor (particularly in the narration) which tempers the otherwise somber theme of death. It portrays the deaths using live-action recreations of the events along with expert and sometimes witness testimony, also using graphic CGI animations, similar to those used in the popular TV show CSI, to illustrate the ways people have died. A narration provides background information within each death-story, which all end with titles that are puns on popular figures of speech.