Cell Reports (2024)

08/06/2023

Meet with editors to discuss your research. We would be happy to tell you more about the scope of our journal and help determine if your research fits within its scope! https://hubs.li/Q01RyYbZ0

27/04/2023

Read the Cell Reports Portfolio joint special issue on artificial intelligence! https://hubs.li/Q01MTc5t0

17/03/2023

Read some of our best reports from last year in this Cell Reports Portfolio collection: https://hubs.li/Q01HhCfW0

10/03/2023

👁‍🗨 Editor's pick

Panguiarchaeum symbiosum, a potential hyperthermophilic symbiont in the TACK superphylum

Qu et al. report 10 closely related genomes from hot springs with the name Panguiarchaeum symbiosum proposed. By focusing on ecological niches and evolution, they reveal a symbiotic lifestyle of these microbes, where genes associated with nutrient acquisition and cell attachment are prone to be positively selected and highly transcribed.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00169-9

09/03/2023

👁‍🗨 Editor's pick

Single-cell transcriptomic profiling redefines the origin and specification of early adrenogonadal progenitors

Neirijnck et al. report a high-resolution single-cell atlas of early mouse adrenogonadal development. Their analysis demonstrates that gonadal and adrenal progenitors derive from the lateral, rather than the intermediate, mesoderm and are specified before Nr5a1 expression. While gonadal cells activate the canonical Wnt pathway, adrenal cells show enhanced Rho signaling.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00202-4

08/03/2023

👁‍🗨 Editor's pick

Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis

Zuo et al. show that HIF-1 stimulates PLXNB3 expression, which is required for breast cancer cell migration, invasion, and cancer stem cell specification. Hypoxia-induced PLXNB3 stimulates MET signaling to promote breast cancer tumorigenesis and lung metastasis.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00175-4

08/03/2023

👁‍🗨 Editor's pick

DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops

Marchena-Cruz et al. present a functional assay identifying 59 factors that protect against harmful R loops and are known to be involved in different cellular processes, including RNA metabolism and chromatin function. They study two of these factors, DDX47 and MeCP2, and conclude that R loops accumulate upon dysfunction of unrelated processes.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00159-6

07/03/2023

👁‍🗨 Editor's pick

Single-cell multiome sequencing clarifies enteric glial diversity and identifies an intraganglionic population poised for neurogenesis

By performing comprehensive single-cell transcriptomic and chromatin accessibility profiling of enteric glial cells both in culture and freshly isolated from mouse small intestine, Guyer et al. identify intraganglionic glia as a distinct subpopulation of enteric glial cells that are epigenetically poised for neurogenesis.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00205-X

06/03/2023

👁‍🗨 Editor's pick

NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking

Zhang et al. find that activation of a wide range of NF-κB pathways enhances STING-mediated immune responses. NF-κB activation blocks STING degradation by inhibiting microtubule-mediated STING trafficking from the Golgi apparatus to lysosomes and thus prolongs and increases STING signaling. This then augments STING-mediated interferon responses and host antiviral defenses.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00196-1

06/03/2023

👁‍🗨 Editor's pick

Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein

Hellert et al. describe the 3D structures of the membrane fusion protein from two orthobunyaviruses, La Crosse and Schmallenberg viruses, in the conformation they adopt after completing the membrane fusion reaction. Structure-based mutagenesis identifies key residues required for their fusogenic activity, and comparison with homologs across the Bunyavirales shows evolutionary relationships.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00153-5

04/03/2023

👁‍🗨 Editor's pick

SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

Cognitive impairment is frequent in post-COVID-19 syndrome patients, but its underlying mechanisms are unclear. Fontes-Dantas et al. show that Spike brain infusion in mice induces late neuroinflammation and synapse loss, leading to long-term cognitive impairment mediated by TLR4 signaling. In patients, genotype GG TLR4-2604G>A was associated with poor cognitive outcome.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00200-0

03/03/2023

👁‍🗨 Editor's pick

Dietary tryptophan deficiency promotes gut RORγt+ Treg cells at the expense of Gata3+ Treg cells and alters commensal microbiota metabolism

Rankin et al. show that dietary tryptophan deficiency reshapes the microbiota and alters intestinal gene expression profiles, resulting in a microbiota-dependent expansion of gut RORγt+ Tregs. These findings highlight the potential for harnessing dietary immune modifiers, such as tryptophan, to regulate RORγt+ Treg numbers and possibly treat intestinal inflammatory disorders.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00146-8

02/03/2023

On the cover, this month, in Cell Reports

The cover image shows a projection of serial confocal optical sections of protonemal filaments and leafy shoot of a Physcomitrium patens moss plant with nuclear YFP-PpRIC fusion protein (yellow) and chlorophyll autofluorescence in plastids (red).

Ntefidou et al. find that nuclear PpRIC maintains apical initial cell identity in protonemata, whereas flowering plant RIC homologs generally regulate cytoplasmic processes, including F-acting reorganization. Image by Sylwia Schulmeister.

Read the full issue here: https://www.cell.com/cell-reports/current #

02/03/2023

👁‍🗨 Editor's pick

METTL16 promotes translation and lung tumorigenesis by sequestering cytoplasmic eIF4E2

Wang et al. show that METTL16 facilitates selective protein synthesis by impeding the association of eIF4E2 to the mRNA 5′ cap structure. Depletion of METTL16 suppresses lung tumorigenesis by downregulating the translation of key oncogenes.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00161-4

01/03/2023

👁‍🗨 Editor's pick

Extensive de novo activity stabilizes epigenetic inheritance of CG methylation in Arabidopsis transposons

By inbreeding DNA methylation-deficient Arabidopsis thaliana plants for many generations, Lyons et al. find that epigenetic inheritance of heterochromatic CG methylation relies on multiple methyltransferases and, using mathematical modeling, demonstrate that the inheritance process is much more dynamic and flexible than previously thought.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00143-2

01/03/2023

👁‍🗨 Editor's pick

Promiscuous splicing-derived hairpins are dominant substrates of tailing-mediated defense of miRNA biogenesis in mammals

Lee et al. find hundreds of intermediate-length, structured, splicing-derived RNAs (ssdRNAs) in human cells. ssdRNAs are related to mirtrons but do not generate substantial small RNAs; still, these hairpins can associate with the miRNA factors Dicer and Argonaute. Their collective existence contaminates the canonical miRNA pathway, provoking 3′-tailing defense via TENT2/TUT4/TUT7.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00122-5

28/02/2023

👁‍🗨 Editor's pick

Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer

Wei et al. show that periostin recruits programmed death receptor 1 (PD-1+) tumor-associated macrophages (TAMs) through integrin-nuclear factor κB (NF-κB) signaling in colorectal cancer (CRC). Periostin deficiency decreases the infiltration of PD-1+ TAMs, which promote immune escape by inducing the expression of PD-L1 on colorectal tumor cells. Blocking periostin and PD-1 inhibits CRC progression.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00101-8

28/02/2023

👁‍🗨 Editor's pick

Periodontal disease is associated with increased gut colonization of pathogenic Haemophilus parainfluenzae in patients with Crohn’s disease

Sohn et al. show differential pathogenicity of H. parainfluenzae strains and its potential association with periodontal disease in patients with Crohn’s disease.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00131-6

27/02/2023

👁‍🗨 Editor's pick

A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl

Triller et al. exploit the unique immunogenicity of Trypanosoma brucei surface coats to generate an antibody elicitation platform tailored to difficult targets including small molecules. They use this platform to elicit high-affinity monoclonal antibodies to the synthetic opioid fentanyl, which could be used as overdose-preventing prophylactics.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00060-8

27/02/2023

👁‍🗨 Editor's pick

Distinct reward processing by subregions of the nucleus accumbens

Chen et al. find that diverse patterns of reward encoding in the medial and lateral shell subdivision of the nucleus accumbens (NAc). They identify two functionally distinct subpopulations, Cartpt+ neurons in the medial and Nts+ neurons in the lateral NAc, which play opposite roles in motivated behaviors.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00080-3

25/02/2023

👁‍🗨 Editor's pick - New SARS-CoV-2 paper

CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication

Programmed ribosomal frameshifting is essential for SARS-CoV-2 replication. Through genome-wide CRISPR screening, Rehfeld et al. find a requirement for ribosome recycling factors in efficient frameshifting and viral replication. The unique position of the ORF1a stop codon in SARS-CoV-2 necessitates the efficient removal of post-termination ribosomes to enable frameshifting of trailing ribosomes.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00087-6

24/02/2023

👁‍🗨 Editor's pick

The microbiota regulates hematopoietic stem and progenitor cell development by mediating inflammatory signals in the niche

Zhong et al. show that commensal microbiota regulates normal HSPC development by mediating appropriate inflammatory cytokine expression in HSPC niche. The microbiota of chd8−/− zebrafish induces enhanced cytokine expression and impairs HSPC development. An Aeromonas strain selectively suppresses excessive cytokines in HSPC niche and restores HSPC development in chd8−/− zebrafish.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00127-4

24/02/2023

We're calling for proposals for the webinar on : Fighting global challenges. Submit your proposal by April 15, 2023. https://hubs.li/Q01CSwqk0

24/02/2023

Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold

By studying Drosophila pupal intestinal stem cells, Wu et al. find that the number of stem cells is precisely determined by interlocked polarity components via control of Prospero threshold. Thus, the final number of stem cells in a developing tissue is predetermined by internal gene-regulatory networks of stem cells.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00104-3

23/02/2023

👁‍🗨 Editor's pick

Genomic profiling of HIV-1 integration in microglia cells links viral integration to the topologically associated domains

Rheinberger et al. characterize HIV-1 integration and host chromatin profiles in the unexplored microglia reservoir. The authors report that the architectural protein CTCF contributes to HIV-1 integration and latency in the microglia cellular model and that HIV-1 integrates proximally to H3K36me3-enriched boundaries of topologically associated domains.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00121-3

23/02/2023

👁‍🗨 Editor's pick

A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemia

Eldeeb et al. report an LIN28B-mediated molecular layer of protection against perinatal AML. LIN28B expression associates with attenuated MYB activity driven by positive regulation of MYBBP1A. These insights into the roles of LIN28B can be exploited for therapeutic benefits.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00110-9

22/02/2023

👁‍🗨 Editor's pick - New Resource

On the origin and evolution of RNA editing in metazoans

Zhang et al. profile the RNA editomes of 22 species that cover major groups of Holozoa. Their findings support ADAR-mediated A-to-I editing as a metazoan innovation, which might have first emerged as a safeguard mechanism against repeat-derived dsRNA and was later co-opted into other biological processes due to its mutagenic nature.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00123-7

22/02/2023

👁‍🗨 Editor's pick

Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst

Staphylococcus aureus is a major human pathogen that causes persistent lung infections. Tomlinson et al. demonstrate that S. aureus elicits a specific metabolic response from neutrophils—the primary immune cells required for eliminating S. aureus—that impairs their ability to kill the bacteria and clear the infection.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00075-X

17/02/2023

👁‍🗨 Editor's pick - New Resource

SLAMseq resolves the kinetics of maternal and zygotic gene expression during early zebrafish embryogenesis

Bhat et al. establish metabolic RNA sequencing in early zebrafish embryos to provide insights into the scope, timescales, molecular features, and regulation of gene expression during maternal-to-zygotic transition.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00081-5

17/02/2023

👁‍🗨 Editor's pick

Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress

Cancer cells must adapt their metabolism to withstand fluctuating nutrient levels in the tumor microenvironment. Here, Liu et al. show that SENP2 dampens mitochondrial respiration in response to glutamine deprivation. This stress state specifically activates SENP2, which deSUMOylates the SDHA subunit, attenuating the assembly and activity of the SDH complex.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00052-9

Cell Reports

08/06/2023

27/04/2023

17/03/2023

10/03/2023

09/03/2023

08/03/2023

08/03/2023

07/03/2023

06/03/2023

06/03/2023

04/03/2023

03/03/2023

02/03/2023

02/03/2023

01/03/2023

01/03/2023

28/02/2023

28/02/2023

27/02/2023

27/02/2023

25/02/2023

24/02/2023

24/02/2023

24/02/2023

23/02/2023

23/02/2023

22/02/2023

22/02/2023

17/02/2023

17/02/2023

Address

Website

Alerts

Shortcuts

Share