Scientists have harnessed fMRI techniques to visualize the cognitive control circuit in patients with depression and obesity, and find the circuit can help predict outcomes in a trial of integrated problem-solving therapy.
đź“„: https://scim.ag/8gC
By dissecting the characteristics of spitting cobra venom, researchers discover that drugs called heparinoids can mitigate tissue injury in exposed mice, hinting heparinoids could act as more accessible antidotes for snakebites.
đź“„: https://scim.ag/7Ip
In the newest issue, scientists present a soft biorobotic heart to assess the feasibility and safety of new valve designs and biomaterials to correct Tetralogy of Fallot, offering a reliable model to inform reconstructive heart surgery.
đź“„ : https://scim.ag/7FW
New 3D-printable pacing leads can adhere to heart tissue to capture heart activity in animals without the need for traumatic punctures, offering a less invasive tool for monitoring after cardiac surgery.
đź“„: https://scim.ag/7rm
A miniaturized, snake-like OCT imaging probe navigates and illuminates the labyrinth of cerebral arteries with high resolution, offering a diagnostic tool to guide endovascular interventions for stroke and other conditions.
đź“„: https://scim.ag/6YZ
A new EEG microdisplay for neurosurgery conforms to the brain surface and employs colorful light patterns to visualize brain activity in large animals, potentially providing a more reliable method for surgeons to map and avoid functional brain tissue.
đź“„: https://scim.ag/6N5
Applying machine learning to biopsies, scientists show that gene expression patterns in synovial fibroblasts and sensory neuron outgrowth may explain why pain in rheumatoid arthritis doesn’t always correlate with inflammation.
Learn more: https://scim.ag/6zQ
An antibody-drug conjugate that combines an anti-TNF antibody with a glucocorticoid receptor activator can selectively calm arthritic inflammation in mice, hinting it could overcome safety obstacles in the clinical use of glucocorticoid therapies.
đź“„: https://scim.ag/6lP
A protein “decrowding” technique for expansion microscopy allows scientists to probe and stain brain tissues with nanoscale precision, uncovering previously invisible structures and cell populations in glioma.
đź“„ : https://scim.ag/5Kd
Vaccines defend against invasive bacteria such as S. pneumoniae through the liver by engaging Kupffer and epithelial cells, shows work in mice that contradicts previous assumptions about vaccine-induced clearance of bacterial pathogens.
đź“„ : https://scim.ag/5hq
Researchers present a tension-activated nanofiber repair patch loaded with an anti-inflammatory drug that can treat damaged intervertebral discs—a leading cause of back pain—and find the patches are safe and can stabilize disc injuries in goats.
đź“„: https://scim.ag/4TN
A compound that stops the microRNA miR-206-3p from repressing CXCR4 can prevent atherosclerosis in mice and can support CXCR4 specifically in vessels without off-target effects.
Read more: https://scim.ag/4HC
It covers basic, translational, and clinical research on human diseases.
