It covers basic, translational, and clinical research on human diseases.
16/06/2025
An AI pipeline named DeepHeme can classify blood lineage cells in patients with bone marrow diseases, and performs well in a robust external dataset while matching the accuracy of a panel of medical experts.
Humans may be genetically programmed to produce antibodies against peanut, suggests a new study showing nonallergic people harbor convergent, germline-encoded antibodies against the allergen Ara h 2.
Don't miss the new issue of Science Translational Medicine!
An AI platform named DeepHeme accurately classifies bone marrow cells in patients, research suggests humans may be genetically programmed to produce antibodies against peanuts, and more.
A new phase 1 clinical trial shows that an intra-articular AAV gene therapy is safe in humans with osteoarthritis in the knee and increased the expression of an IL-1 receptor antagonist for as long as 1 year.
Examining longitudinal data from 100 healthy people, researchers have identified four immunotypes that translate into different immune cell behavior, offering insight into immune system variation between individuals.
The approved drug methotrexate can potentiate antitumor immune activity and shows signs of boosting the efficacy of checkpoint blockade immunotherapy in patients with solid tumors, according to a preliminary clinical trial.
A team has designed a host defense peptide–mimicking prodrug that attacks drug-resistant Gram-negative bacteria at the infection site, decreasing the odds of treatment resistance and showing potency in five mouse models of bacterial infections.
The new issue of Science Translational Medicine is out now!
A drug for rheumatoid arthritis shows signs of boosting the anticancer capabilities of immunotherapy in a clinical trial, a new Review explores the molecular hallmarks of hydrocephalus, and more.
A new study in mice suggests that fibrate medications may protect against cardiovascular disease by dampening inflammatory signaling in hepatocytes through PPAR-alpha, rather than by lowering lipids as previously thought.
Scientists identify cadherin-17 as a promising target for CAR T cells in colorectal cancer liver metastases, and find systemic delivery of anti-CDH17 cells suppresses tumors in mice while sparing healthy colon tissue.
New research untangles how gasdermin D exacerbates the systemic storm after severe trauma and hemorrhagic shock—especially in female patients—but shows that disulfiram can improve survival in both sexes in mice.
Don't miss the new issue of Science Translational Medicine!
A clinical study uncovers a female-biased driver of mortality after severe trauma, systemic CAR T cells safely target colorectal cancer metastases in the liver in mice, and more.
Be the first to know and let us send you an email when Science Translational Medicine posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.
