Turkish Journal of Gastroenterology

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Turkish Journal of Gastroenterology The Turkish Journal of Gastroenterology is the open access, international publication organ of the of the Turkish Society of Gastroenterology.

18/07/2019
Comparison of the current international guidelines on the management of HCC

HCC guidelines;

The management of hepatocellular carcinoma (HCC) has become ever more demanding. To evaluate the available evidence and to give clinicians the best guidance, all major hepatology societies have developed guidelines for HCC. Recently, updated versions have been published by the American, the Asian Pa...

09/07/2019
From the Editor’s desk…

From the Editor’s desk…

Intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) have rarely been studied separately. Mortality trends from these 2 neoplasms have been inconsistent over the last decades. Bertuccio et al. aimed to analyse trends in mortality from ICC and ECC in selected countries worl...

29/06/2019
JOURNAL OF HEPATOLOGY

JOURNAL OF HEPATOLOGY

Review | The circadian clock and liver function in health and disease

Each day, all organisms are subjected to changes in light intensity because of the Earth’s rotation around its own axis. To anticipate this geophysical variability, and to appropriately respond biochemically, most species, including mammals, have evolved an approximate 24-hour endogenous timing mechanism known as the circadian clock (CC). Herein, the authors provide an overview of the CC-dependent pathways which play critical roles in mediating several hepatic functions under physiological conditions, and whose deregulation is implicated in chronic liver diseases including non-alcoholic steatohepatitis and alcohol-related liver disease.

https://www.journal-of-hepatology.eu/article/S0168-8278(19)30191-6/fulltext

12/06/2019
JOURNAL OF HEPATOLOGY

EASL guideline

EASL Clinical Practice Guidelines: Drug-induced liver injury

Idiosyncratic (unpredictable) drug-induced liver injury is one of the most challenging liver disorders faced by hepatologists, because of the myriad of drugs used in clinical practice, available herbs and dietary supplements with hepatotoxic potential, the ability of the condition to present with a variety of clinical and pathological phenotypes and the current absence of specific biomarkers. This makes the diagnosis of drug-induced liver injury an uncertain process, requiring a high degree of awareness of the condition and the careful exclusion of alternative aetiologies of liver disease. Idiosyncratic hepatotoxicity can be severe, leading to a particularly serious variety of acute liver failure for which no effective therapy has yet been developed. These Clinical Practice Guidelines summarize the available evidence on risk factors, diagnosis, management and risk minimization strategies for drug-induced liver jury.

https://www.journal-of-hepatology.eu/article/S0168-8278(19)30129-1/fulltext

31/05/2019

New issue out now!

17/05/2019
Endoscopy

ESGE guideline

- Featured article of the month no. 3:

Endoscopic management of common bile duct stones: European Society of Gastrointestinal Endoscopy (ESGE) guideline

by Gianpiero Manes, Gregorios Paspatis, Lars Aabakken et al.

Summary:
This Guideline is an official statement from the European Society of Gastrointestinal Endoscopy (ESGE). It addresses diagnostic strategies and the various therapeutic options,
covering endoscopic retrograde cholangiopancreatography, extraction techniques, stenting, various types of lithotripsy, and the combined roles of surgery and endoscopic management for common bile duct stones.

Bibliography
DOI https://doi.org/10.1055/a-0862-0346
Published online: 2019 | Endoscopy
© Georg Thieme Verlag KG Stuttgart · New York
ISSN 0013-726X

Read more here: https://doi.org/10.1055/a-0862-0346

10/04/2019
JOURNAL OF HEPATOLOGY

JOURNAL OF HEPATOLOGY

Grand Round: Autoimmune Hepatitis

Autoimmune hepatitis is a corticosteroid-responsive autoimmune liver disease arising consequent to immunogenetic and environmental risk factors. The clinical course reflects relapsing and remitting, hepatocyte targeted, immunologic damage, which is countered by reparative responses to cell injury. In this Grand Round we appraise the evidence supporting current treatment approaches, address the impact of autoimmune liver disease ‘crossover or overlap’ presentations, explore important clinical correlates to immune-serological classifiers, and discuss the factors influencing choice of alternative therapy in difficult-to-treat situations.

https://www.journal-of-hepatology.eu/article/S0168-8278(18)32538-8/fulltext

23/03/2019
Gastroenterology

Gastroenterology

NTZ, which targets an HBV-related viral–host protein interaction, may be a promising new therapeutic agent and a step toward a functional HBV cure: https://bit.ly/2uh62Sj

07/03/2019
Clinical Gastroenterology and Hepatology

Clinical Gastroenterology and Hepatology

CGH recently published an American Gastroenterological Association (AGA) Clinical Practice Update on surgical risk assessment and perioperative management in . GI & Hep News has more on the expert review:

16/01/2019
Nature Reviews

Nature Reviews

Nature Reviews Gastroenterology and Hepatology: Alcoholic liver disease (ALD) is a leading cause of morbidity and mortality worldwide. Here, Bajaj discusses clinical studies on the gut microbiota in individuals with ALD and explores the specific alterations in the gut–liver–brain axis that might alter patient outcomes. (£)

15/01/2019
JOURNAL OF HEPATOLOGY

Statins in Liver diseases

Statins: Old drugs as new therapy for liver diseases?

In addition to lowering levels, have pleiotropic effects, particularly anti-inflammatory, antiangiogenic, and antifibrotic, that may be beneficial in some chronic inflammatory conditions. Statins have only recently been investigated as a potential treatment option in chronic liver diseases because of concerns related to their safety in patients with impaired liver function.

https://www.journal-of-hepatology.eu/article/S0168-8278(18)32275-X/fulltext

03/10/2018
Nature Reviews

Nature Reviews

Nature Reviews Gastroenterology and Hepatology: Current nutritional approaches to prevent and treat various diseases have limited effectiveness. Here, Zmora et al. review the major principles underlying effects of dietary constituents on the gut microbiota, resolving aspects of the diet–microbiota–host crosstalk, and present the promises and challenges of incorporating microbiome data into dietary planning. (£)

12/09/2018
Nature Reviews

Nature Reviews

Nature Reviews Gastroenterology and Hepatology: Inflammasome signalling has a central role in the regulation of gastrointestinal health and disease. Here, an overview of inflammasome biology in relation to the gastrointestinal tract is presented, with insights into how targeted interventions might be useful to treat inflammasome-mediated gastrointestinal diseases. (£)

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