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Once turned on you can also triple-click your home or lock button to quickly turn on the magnifier app, which uses the c...
06/11/2020

Once turned on you can also triple-click your home or lock button to quickly turn on the magnifier app, which uses the camera to zoom in on objects.

If you’ve got one of the fancy new iPhone 12 Pro phones, there’s even more you can do with it.

Genre filmmaker Johnny Kevorkian dies aged 48Films by the writer-director included ‘The Disappeared’, starring Tom Felto...
06/11/2020

Genre filmmaker Johnny Kevorkian dies aged 48
Films by the writer-director included ‘The Disappeared’, starring Tom Felton.

06/11/2020

Since low-density lipoprotein, or LDL, cholesterol entry into the artery wall drives the development of atherosclerosis, or hardening of the arteries, and atherosclerosis leads to heart attacks and strokes, future treatments preventing the process may help decrease the occurrence of these life-threatening conditions, said Dr. Philip Shaul, senior author of the study published online today in Nature.

Cardiovascular disease is the No. 1 cause of death worldwide, and coronary artery disease (which underlies heart attacks) and strokes account for over 60% of cardiovascular deaths in the U.S., according to recent statistics from the American Heart Association (AHA).

The study reveals for the first time how a protein called SR-B1 (short for scavenger receptor class B, type 1) ferries LDL particles into and then across the endothelial cells that line arteries. The study also found that a second protein called dedicator of cytokinesis 4, or DOCK4, partners with SR-B1 and is necessary for the process.

In the early stages of atherosclerosis, LDL that has entered the artery wall attracts and is engulfed by important immune system cells called macrophages that ingest, or "eat," LDL particles. LDL-laden macrophages become foam cells that promote inflammation and further the development of atherosclerotic plaques.

For example, suppose a fifty-five-year-old purchases an FIA that includes this type of income rider. For this contract, ...
06/11/2020

For example, suppose a fifty-five-year-old purchases an FIA that includes this type of income rider. For this contract, the withdrawal percentage when purchased at fifty-five is 4.5 percent, and the deferral credit is 0.3 percent for each year that the individual delays the start of income. The individual plans to retire at age sixty-five, which would provide ten years of deferral. That would mean that the lifetime withdrawal percentage is 7.5 percent (4.5 + 0.3 x 10) of the contract value at that age. In this case, principal is protected only on a gross basis before the rider fee is applied at the end of each year. If the annual rider charge is 1 percent, then in the extremely unlikely event that the index experiences a negative return for all ten years, the rider fee would reduce the contract value on a $100,000 premium to $90,438. With a 7.5 percent withdrawal rate, this provides $6,783 of lifetime income. However, this minimum amount is extremely unlikely to be realized, as it would require ten consecutive years of negative market returns—imagine what this would do to an unprotected investment portfolio—and any upside growth and positive crediting during these ten years would contribute to a higher level of protected lifetime income.

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