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Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 kinase. ...
In the past decade, after the release of CRISPR-Cas9 as a genome-editing tool, it has revolutionized biological research. CRISPR and its applications have changed how biological research is done. A review by Nobel Laureate and CRISPR pioneer Jennifer A. Doudna of the Innovative Genomics Institute, U...
Roan et al. use Olink and single‐cell RNA sequencing (scRNA-seq) to show a dysregulated crosstalk between the cellular and humoral immune responses in individuals with long COVID 8 months postinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
If, as I believe, gene therapy is in principle ethically sound except for its possible connection with eugenics then there are two obvious ways of giving a simple and straightforward answer to a question such as this. The first is to say "yes it is, and so what?" The second is to say "no it isn't so...
https://www.sciencedirect.com/science/article/pii/S002222752043576X
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has resulted in the death of mor…
Most approved gene therapies today, including those involving CRISPR-Cas9, work their magic on cells removed from the body, after which the edited cells are returned to the patient.
Researchers connecting pieces of the massive Alzheimer's puzzle are closer to slotting the next one in place, with yet another link between our guts and brain.
The current COVID-19 pandemic is a massive source of global disruption, having led so far to two hundred and fifty million COVID-19 cases and almost five million deaths worldwide. It was recognized in the beginning that only an effective vaccine could ...
Data on rare human antibody against several related viruses might aid design of broadly protective beta-coronavirus vaccine.
The COVID-19 pandemic catalyzed the swift development and distribution of mRNA vaccines, including BNT162b2, to address the disease. Concerns have arisen about the potential neurodevelopmental implications of these vaccines, especially in susceptible groups such as pregnant women and their offspring...
Cambridge, UK-based startup CellCentric is receiving $25 million to finish ongoing clinical studies and get some extra runway in the form of a cash infusion from one of the world’s largest pharmas. Pfizer is giving CellCentric the funds as a strategic investment, CellCentric CEO Will West told End...
New findings have important implications for research into the impact of COVID-19 and the mRNA vaccination on epigenetic aging in the immune system.
Thomas Paul is Director of the Cancer Epigenetics Group in the Pfizer Oncology R&D unit in La Jolla, CA. His group focuses on therapeutic targeting of oncogenic gene expression pathways in cancer through pharmacological inhibition of epigenetic enzyme complexes. His group has progressed two compound...
In a new study from UCSF, researchers found that patients who took Paxlovid and those who did not had similar outcomes when it came to long COVID symptoms.ht...
While risks higher for the unvaccinated, study points to need for more tools against the virus
Oral nirmatrelvir/ritonavir is approved as treatment for acute COVID-19, but the effect of treatment during acute infection on risk of Long COVID is unknown. We hypothesized that nirmatrelvir treatment during acute SARS-CoV-2 infection reduces risk of developing Long COVID and rebound after treatmen...
A team of researchers from UC San Francisco has found that Paxlovid did not reduce the risk of developing long COVID for vaccinated, non-hospitalized individuals during their first COVID-19 infection. They also found that a higher proportion of individuals than previously reported experience rebound...
Human endogenous retroviruses (HERVs) are retroviruses that infected human genome millions of years ago and have persisted throughout human evolution. About 8% of our genome is composed of HERVs, most of which are nonfunctional because of epigenetic control ...
The company expects its pharmaceutical division to deliver 20 new medicines through the end of the decade, including several it believes could earn peak annual sales of more than $5 billion.
The pharma is developing Fabhalta, now cleared for paroxysmal nocturnal hemoglobinuria, for several other rare, complement-driven diseases.
Endogenous retroviruses (ERVs) originate from integrated exogenous retroviruses and become part of the host genome during evolution. It now seems that they are
The footprint of human endogenous retroviruses (HERV), specifically HERV-K, has been found in malignancies, such as melanoma, teratocarcinoma, osteosarcoma, breast cancer, lymphoma, and o***y and prostate cancers. HERV-K is characterized as the most biologically ...
A medication used to treat HIV and to prevent at-risk people from contracting the virus may improve COVID-19 outcomes for both groups, according to research from Kaiser Permanente published in Clinical Infectious Diseases.
Researchers developed an intranasal trivalent measles-mumps-SARS-CoV-2 vaccine that provides robust protection against multiple coronavirus variants. Leveraging the established measles-mumps-rubella platform, this vaccine demonstrates broad and adaptable immune responses, especially against Delta an...
Research has shown that our DNA houses the ghosts of viruses fended off by your ancestors, and some of those viruses could still be dangerous if they wake up.
The latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus is a multifunctional protein with important roles in both transcriptional regulation and episomal maintenance. LANA is also a DNA-binding protein and has been shown to specifically bind to a region within the te...
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