
09/01/2025
Thanks to genetic manipulation, Korean scientists have managed to "heal" colorectal cancer cells by stimulating their differentiation into intestinal cells and suppressing processes leading to malignancy, reports the journal Advanced Science.
Researchers from the Korea Advanced Institute of Science and Technology (KAIST), working with a line of colorectal cancer cells, discovered a way to activate several genetic switches to return the cells to a normal, healthy state.
Simulations of the digital twin allowed the discovery of three main control factors responsible for cell differentiation. When these factors were applied to cancer cells, they were transformed into a state resembling healthy cells. This process was confirmed through molecular and cellular studies as well as animal models, demonstrating that regulating these genes can systematically reverse the cancerous process without destroying the cells.
Source: https://news.kaist.ac.kr/newsen/html/news/?mode=V&mng_no=42710