Journal of Nephrology & Renal Diseases (2024)

01/11/2019

The Contemporary Scope of in - Analysis of Kidney Biopsy in Single Centre
==============================================

The study included 212 diabetic patients who underwent at the kidney centre. Those who do not have complete record and eye examination were excluded. The mean age was 52.4 ± 11.96 SD. There were total 128 (60.4%) male and 84 (39.6%) female with a male to female ratio of 1.5:1. The patients with DKD were 76 (35.8%) NDKD were 91 (42.9%) and NDKD + DKD were 45 (21.2%) Among different NDKD, the frequency of different lesions found alone were FSGS 22(16.2%) which was the most frequently occurring lesion followed by chronic TIN 13 (9.6%), chronic GN10 (7.4%), Crescentic GN 8 (5.9%),

More Details @ https://www.scitechnol.com/abstract/the-contemporary-scope-of-renal-histopathology-in-diabetic-patients-analysis-of-kidney-biopsy-in-single-centre-6171.html

22/10/2019

Hantavirus Infections with Renal Involvement do not Result in Chronic Renal Disease or End-stage Renal Failure
==============================================

Rodent-borne are one of the most important causes worldwide of acute kidney injury in previously , mostly young adults, but remain still heavily underestimated as such by the global . Despite of a sometimes severe impairment of renal function, often accompanied by massive proteinuria, this acute has, after survival, an excellent renal and general prognosis on short and on long term. However, this fact remains contradicted by repeated and unproven statements of the opposite in literature. Indeed, with the advent of early in the ‘80’s, speculations rose as to the potential of this novel agent to cause , and even end-stage renal failure, since the bulk of pathogenic hantaviruses has the human kidney as main target organ.

More details @ https://www.scitechnol.com/abstract/hantavirus-infections-with-renal-involvement-do-not-result-in-chronic-renal-disease-or-endstage-renal-failure-5994.html

01/10/2019

The Dynamics of Carnitine, γ-butyrobetaine and Trimethylamine N-oxide in Diabetics and the Effects of Changes in Renal Function
==============================================

In , vascular disorders progress alongside loss of , possibly due to higher blood concentrations of , such as gamma-butyrobetaine (γBB), produced by gut that feed on carnitine in dietary red meat. Therefore, we established the hypothesis that urinary γBB excretion declines with decreasing renal function, causing a rise in blood γBB concentration, leading to aggravated .

More Details @ https://www.scitechnol.com/abstract/the-dynamics-of-carnitine-butyrobetaine-and-trimethylamine-noxide-in-diabetics-and-the-effects-of-changes-in-renal-function-6108.html

26/09/2019

Assessment of Fibroblast Growth Factor-23 ( Fgf23) as Risk Factor for Diastolic Dysfunction in Patients
=============================================

is the most common cause of death in patients with . Diastolic dysfunction is an important risk factor result in development of advanced cardiovascular disease. growth factor- 23 (FGF23) secretes in response to as a result of renal excretion of phosphate. Elevation of serum FGF23 is one of the possible causes of . The aim of the current study was to investigate association between Serum levels of FGF23 and diastolic dysfunction in hemo dialysis patients.

More Details @

30/08/2019

Soluble E-Cadherin in Prostate Cancer as a Serum Biomarker in Contrast to Prostate Specific Antigen
===============================================

His is in diagnosis of but it is a cumbersome method. On the other hand, prostate specific screening has revolutionized in detection of prostate cancer but due to PSA’s lack of sensitivity and as it is not cancer specific are needed to improve risk assessment.

More Details @ https://www.scitechnol.com/abstract/soluble-ecadherin-in-prostate-cancer-as-a-serum-biomarker-in-contrast-to-prostate-specific-antigen-9140.html

20/06/2019

Placement of Central Venous Dialysis Catheters without X-Ray: Safety and Feasibility
===============================================

After a placement of central venous x-ray is the standard procedure to exclude and . In this study we combined to obviate the routine use of x-ray. Setting: Dialysis Center of the Department of , Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. 298 consecutive adult patients undergoing placement for hemodialysis.

More Details @ https://www.scitechnol.com/abstract/placement-of-central-venous-dialysis-catheters-without-xray-safety-and-feasibility-6005.html

14/06/2019

Fish Oil Supplementation Ameliorates Long Term Cisplatin Treatment Induced Toxicity and Oxidative Damage in Rat Kidney
==============================================

(CP) is an effective widely used against various . However, CP exerts several side effects through oxidative stress by generating reactive oxygen species (ROS). The major side effect of CP chemotherapy is dose dependent that limits its clinical usage. We have previously shown that fish oil (FO) supplementation ameliorated gentamicin induced nephrotoxicity as evident by increase in the activities of brush border membrane (BBM) and free in rat .

More Details @ https://www.scitechnol.com/abstract/fish-oil-supplementation-ameliorates-long-term-cisplatin-treatment-induced-toxicity-and-oxidative-damage-in-rat-kidney-6560.html

03/05/2019

Placement of Central Venous Dialysis Catheters without X-Ray: Safety and Feasibility
============================================

After a placement of chest x-ray is the standard procedure to exclude and . In this study we combined ultrasonographic techniques to obviate the routine use of x-ray. Setting: of the Department of Nephrology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

More Details @ https://www.scitechnol.com/abstract/placement-of-central-venous-dialysis-catheters-without-xray-safety-and-feasibility-6005.html

18/04/2019

Fish Oil Supplementation Ameliorates Long Term Cisplatin Treatment Induced Toxicity and Oxidative Damage in Rat Kidney
===========================================

(CP) is an effective widely used against various . However, CP exerts several side effects through oxidative stress by generating reactive oxygen species (ROS). The major side effect of CP chemotherapy is dose dependent that limits its clinical usage. We have previously shown that fish oil (FO) supplementation ameliorated induced nephrotoxicity as evident by increase in the activities of brush border membrane (BBM) and free radical scavenging in rat . In the present study we aimed to investigate whether fish oil (FO) can prevent the long term CP-induced nephrotoxic effects.

More Details @ https://www.scitechnol.com/peer-review/fish-oil-supplementation-ameliorates-long-term-cisplatin-treatment-induced-toxicity-and-oxidative-damage-in-rat-kidney-OHlN.php?article_id=6560

08/04/2019

The Causes of Chronic Kidney Disease in Adults in a Developing Country
=========================================

(DM) and (HTN) are considered as the leading causes of CKD all around the world. But the causes of differ from region to region. In developing countries the population is heterogeneous therefore regional causes of CKD need to be evaluated.

More Details @ https://www.scitechnol.com/peer-review/the-causes-of-chronic-kidney-disease-in-adults-in-a-developing-country-rZUx.php?article_id=6044

25/03/2019

The Contemporary Scope of Renal Histopathology in Diabetic Patients- Analysis of Kidney Biopsy in Single Centre
===========================================

The study included 212 who underwent at the kidney centre. Those who do not have complete record and eye examination were excluded. The mean age was 52.4 ± 11.96 SD. There were total 128 (60.4%) male and 84 (39.6%) female with a male to female ratio of 1.5:1. The patients with DKD were 76 (35.8%) NDKD were 91 (42.9%) and NDKD + DKD were 45 (21.2%) Among different NDKD,

More Details @ https://www.scitechnol.com/abstract/the-contemporary-scope-of-renal-histopathology-in-diabetic-patients-analysis-of-kidney-biopsy-in-single-centre-6171.html

20/03/2019

Renal Osteodystrophy in End Stage Renal Failure Patients on Maintenance Haemodialysis Visiting at Tertiary Care Hospital, Karachi
============================================

A Cross sectional study was conducted at , Jinnah Postgraduate Medical Center, Karachi from April to October 2009. Fifty-six (56) patients on maintenance were included through non-probability purposive sampling. Various biochemical parameters of were included in the current study. Serum corrected calcium, phosphate, and and iPTH levels. Chi square test was used to determined frequency of renal osteodystrophy in .

More Details @ https://www.scitechnol.com/abstract/renal-osteodystrophy-in-end-stage-renal-failure-patients-on-maintenance-haemodialysis-visiting-at-tertiary-care-hospital-karachi-5664.html

25/02/2019

Assessment of Fibroblast Growth Factor-23 ( Fgf23) as Risk Factor for Diastolic Dysfunction in Hemodialysis Patients
==========================================

is the most common cause of death in patients with . Diastolic dysfunction is an important risk factor result in development of advanced cardiovascular disease. Fibroblast growth factor- 23 (FGF23) secretes in response to as a result of renal excretion of phosphate. Elevation of serum FGF23 is one of the possible causes of .

More Details @ https://www.scitechnol.com/peer-review/assessment-of-fibroblast-growth-factor23--fgf23-as-risk-factor-for-diastolic-dysfunction-in-hemodialysis-patients-UjoR.php?article_id=6386

19/02/2019

EPS in a Patient Following a Four Week Exposure to Peritoneal Dialysis
========================================

(EPS) is a rare but fatal complication in patients on long-term (PD). We report a patient who was established on peritoneal dialysis for four weeks and subsequently developed EPS. 60 year old lady with end stage renal failure (ESRF) secondary to presumed presented with 3 months history of , , and 25 kg -loss over a 3 month period.

More Details @ https://www.scitechnol.com/peer-review/eps-in-a-patient-following-a-four-week-exposure-to-peritoneal-dialysis-Woxh.php?article_id=6890

07/02/2019

The Dynamics of Carnitine, γ-butyrobetaine and Trimethylamine N-oxide in Diabetics and the Effects of Changes in Renal Function
==========================================

In , vascular disorders progress alongside loss of , possibly due to higher blood concentrations of , such as gamma-butyrobetaine (γBB), produced by gut that feed on carnitine in dietary red meat. Therefore, we established the that urinary γBB excretion declines with decreasing renal function, causing a rise in blood γBB concentration, leading to aggravated .

More Details @ https://www.scitechnol.com/peer-review/the-dynamics-of-carnitine-butyrobetaine-and-trimethylamine-noxide-in-diabetics-and-the-effects-of-changes-in-renal-function-A8EC.php?article_id=6108

22/01/2019

Urologic conditions lead to depression, sleep issues in men
==========================================

Men who have , prostate problems, or other urologic conditions are often at higher risk for depression and . Physicians need to screen for this and refer them for specialist care. This was the main conclusion that investigators at the University of California, Irvine (UCI) came to after studying 124 men aged 54, on average, who were attending a clinic specializing in men's health. The men completed detailed questionnaires about mental and , , and , such as erectile function and ease or difficulty in passing urine, which could indicate .

More Details @ https://www.scitechnol.com/nephrology-renal-diseases.php

26/11/2018

Anti-Aging Molecule' Could Improve Liver and
==========================================

Scientists have revealed that an that is present in the liver and kidneys limits the activity of a molecule that plays a role in cell metabolism and longevity. Their research suggests that blocking this enzyme could be a way to preserve the health of these organs. adenine dinucleotide (NAD+) is called the " " because research has shown that its levels fall with age and that restoring them can extend years of and even longevity itself. This molecule plays a key role in several biological processes that help cells get energy and stay healthy, such as , , gene expression, and cell signaling.

More Details @ https://www.scitechnol.com/nephrology-renal-diseases.php

22/10/2018

The Contemporary Scope of in Diabetic Patients-Analysis of Kidney Biopsy in Single Centre
=========================================

The aim of the study is to form an impression about the spectrum of and evaluate the factors which can differentiate the two. A descriptive study, conducted in unit, The kidney center Karachi, from January 1998 till December 2015. The study included 212 diabetic patients. Those who do not have complete record and eye examination were excluded.

More Details @ https://www.scitechnol.com/peer-review/the-contemporary-scope-of-renal-histopathology-in-diabetic-patients-analysis-of-kidney-biopsy-in-single-centre-U2DF.php?article_id=6171

04/10/2018

Cancer Risk After Kidney Transplantation Reduced by Switching Immunosuppressants
=========================================

In spite of the life-saving nature of , the need for transplant recipients to continue treatment with drugs that suppress the immune system to prevent rejection of the organ is associated with a number of side effects, one of which is the development of cancer.
Patients switched to sirolimus had a significantly lower rate of new . Overall, new skin cancers developed in 56 percent of patients in the sirolimus group, compared to 81 percent of those who remained on the standard . Most of the difference reflected a lower rate of one type of cancer, called .

More Details @ https://www.scitechnol.com/nephrology-renal-diseases.php

20/09/2018

An adjustment in BMP4 function represents a treatment for diabetic nephropathy and podocyte injury
============================================

Podocyte injury has been proposed to play an important role in ; however, its pathological mechanism remains unclear. Bone morphogenetic protein 4 (BMP4) signaling leads to the characteristic of this disorder. To analyze the molecular mechanism of , the effect of BMP4 was investigated using streptozotocin (STZ)-induced, Bmp4 heterozygous knockout (Bmp4+/−) and podocyte-specific Bmp4 knockout mice.

More Details @ https://www.scitechnol.com/nephrology-renal-diseases.php

23/08/2018

The Dynamics of Carnitine, γ-butyrobetaine and Trimethylamine N-oxide in Diabetics and the Effects of Changes in Renal Function
============================================

In , vascular disorders progress alongside loss of renal function, possibly due to higher blood concentrations of , such as gamma-butyrobetaine (γBB), produced by gut microbiota that feed on carnitine in dietary red meat. Therefore, we established the that urinary γBB excretion declines with decreasing renal function, causing a rise in blood γBB concentration, leading to aggravated .

More Details @ https://www.scitechnol.com/peer-review/the-dynamics-of-carnitine-butyrobetaine-and-trimethylamine-noxide-in-diabetics-and-the-effects-of-changes-in-renal-function-A8EC.php?article_id=6108

16/08/2018

Mini-Kidneys Grown in Lab Reveal Renal Disease Secrets
============================================

By creating and manipulating mini organoids that contain a realistic micro-anatomy, researchers can now track the early stages of polycystic kidney disease. The organoids are grown from .
By substituting certain physical components in the , cyst formation can be increased or decreased.

More Details @ https://www.scitechnol.com/nephrology-renal-diseases.php

10/08/2018

Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression
===========================================

(CKD) patients accumulate uremic toxins in the body, potentially require dialysis, and can eventually develop . ABCG2 mediates the physiological transport of indoxyl sulfate, a major uremic toxin, and plays a crucial role in its excretion.
Results demonstrated that ATP-binding cassette transporter subfamily G member 2 (ABCG2) is a major transporter of the uremic toxin indoxyl sulfate.

More Details @ https://www.scitechnol.com/nephrology-renal-diseases.php

06/08/2018

Administering Nitric Oxide Gas after Heart Surgery may Decrease Risk of Kidney Problems
========================================

Nitric Oxide Decreases Acute Kidney Injury and Stage 3 Chronic Kidney Disease after . Prolonged bypass causes disruption of circulating red blood cells and the release of hemoglobin, which can cause acute kidney injury, leading to kidney failure and the need for long-term . This is the first study to show that a pharmacological treatment can reduce acute and resulting from cardiac surgery.

More Details @ https://www.scitechnol.com/nephrology-renal-diseases.php

27/06/2018

Time trend of renal replacement therapy for end-stage renal disease
====================

End-stage (ESRD) continues to be a major public health priority in France due to the increasing number of patients requiring therapy (RRT). On December 31, 2015, 82,295 patients received a RRT: 54% were on dialysis and 46% were living with a functional .

More Details @ https://www.scitechnol.com/nephrology-renal-diseases.php

14/06/2018

Difference between Cortical or Trabecular Bone
=================

Bone is an exquisite example of the principle that form follows function. provides structural support for ambulation and ventilation; a tank for calcium, phosphate, amino acids and bicarbonate; protection of internal organs; transmission of sound waves; and nourishment of .

More Details @ https://www.scitechnol.com/nephrology-renal-diseases.php

09/05/2018

PLA2R is a good diagnostic method for idiopathic membranous nephropathy
=============================================
The type M phospholipase A2 receptor (PLA2R) is known as a major antigen on , which is involved in the $pathogenesis of (iMN). Many studies have shown that serum anti-PLA2R autoantibodies (sPLA2R) are prevalent in patients with iMN but are rarely detected in (SMN) or other . The anti-PLA2R is considered a promising of serum in iMN, but reports on its diagnostic value are variable and inconsistent.

For more information:
https://www.scitechnol.com/nephrology-renal-diseases.php

20/04/2018

Hepatic dysfunction doesn’t affect Serum BTP concentrations
============================================
Beta Trace Protein (BTP) is a promising marker of (GFR). Conditions to gauge GFR utilizing have been proposed. Almost nothing is thought about BTP's generation and . It has been estimated that the liver metabolizes certain BTP isoforms.

For more information:
https://www.scitechnol.com/nephrology-renal-diseases.php

10/04/2018

Prediabetes-associated single nucleotide polymorphisms associated with microalbuminuria
===========================================
Microalbuminuria, little measures of albumin spillage into , shows dysfunction of the , which isn't just the early element of a yet in addition an autonomous hazard factor of , even in nondiabetic populaces.

For more information:
https://www.scitechnol.com/nephrology-renal-diseases.php

14/03/2018

Partial Remission of Proteinuria as a Prognostic Indicator of the Outcome of the Focal Segmental Glomerulosclerosis in Children and Young Adults with Nephrotic Syndrome
===============================================
Focal segmental glomerulosclerosis (FSGS) is an important cause of and in children and young adults, accounting for 15 to 20% of the total cases of . Recent studies conducted at different centers suggest the incidence of idiopathic has been increasing in children and adults.

For more information:
https://www.scitechnol.com/peer-review/partial-remission-of-proteinuria-as-a-prognostic-indicator-of-the-outcome-of-the-focal-segmental-glomerulosclerosis-in-children-an-KLgo.pdf

See more:
https://www.scitechnol.com/nephrology-renal-diseases.php

Journal of Nephrology & Renal Diseases