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Dermasphere Podcast Dermasphere is a podcast by dermatologists, for dermatologists, that delivers the latest dermatology research direct to your ears.

Happy Thanksgiving from the Dermasphere family to you! We hope everyone has a fun & safe holiday 🤎🍁🦃🧡
27/11/2025

Happy Thanksgiving from the Dermasphere family to you! We hope everyone has a fun & safe holiday 🤎🍁🦃🧡

Episode 170 is a good one! (at least we think so 😎) In this episode, we discuss Upcoming HS Treatments, Photodermatoses,...
17/11/2025

Episode 170 is a good one! (at least we think so 😎)
In this episode, we discuss Upcoming HS Treatments, Photodermatoses, Hydralazine-induced ANCA Vasculitis, and we feature a clip show from Episodes 160-169!

Listen wherever you get your podcasts 🎧

And now for Michelle's Top 5!• Neuropathic pruritus presents without primary lesions, with localized, dermatomal, or gen...
16/11/2025

And now for Michelle's Top 5!
• Neuropathic pruritus presents without primary lesions, with localized, dermatomal, or generalized distribution and associated burning, tingling, or pain from abnormal neural signaling.
• Standard anti-inflammatory or Th2-targeted therapies are often ineffective since the cause is neural, not immune; treatment should address the underlying neurologic source.
• The “Great Eight” neuropathic itch types: brachioradial pruritus, notalgia paresthetica, multilevel symmetric pruritus, scalp pruritus, postherpetic neuralgia, small fiber neuropathy, CNS syndromes (post-stroke, tumor, MS), and peripheral injury (post-surgical, scar-related).
• Brachioradial pruritus causes chronic itching of the lateral forearms, often in middle-aged women, linked to UV exposure and cervical spine disease. Relief with an ice pack supports a neuropathic cause.
• Multilevel symmetric pruritus appears as symmetric, well-demarcated dermatitis on the extremities or trunk, commonly tied to degenerative spine disease with multilevel nerve compression.

We also wanted to include Dr. Lam’s Top 3:
• “Sugar bug vein” refers to the transverse nasal root vein, a visible vein across the nasal bridge in fair-skinned infants that is benign and clinically insignificant.
• “Milky tongue” describes transient infantile lingual leukoplakia, a benign, previously unnamed cause of white tongue discoloration due to retained keratin.
• Tip sparing in transient infantile lingual leukoplakia likely stems from friction between the tongue tip and alveolar ridge; solid food introduction adds friction, promoting resolution.

If you haven't listened to Episode 169, here are Luke's Top Five!• Transient infantile lingual leukoplakia is a benign c...
15/11/2025

If you haven't listened to Episode 169, here are Luke's Top Five!

• Transient infantile lingual leukoplakia is a benign cause of white tongues in infants that spares the tip. It doesn’t scrape off like milk residue or spread to other mucosa like thrush, and typically resolves by age 1.
• Other causes of white oral mucosal change include white sponge nevus, pachyonychia congenita, and dyskeratosis congenita.
• The 5 A’s to address SDOH in dermatology: Awareness – Identify social needs. Adjustment – Adapt care to barriers. Assistance – Connect to resources. Alignment – Strengthen community networks. Advocacy – Support policy-level change.
• Conge***al syphilis rates are rising due to limited prenatal care, poverty, substance use, poor insurance, low sexual health literacy, and gender inequity- disproportionately impacting underserved communities.
• About two-thirds of infants with conge***al syphilis are asymptomatic; others show a copper-red morbilliform rash (often on palms/soles), “snuffles,” hepatosplenomegaly, jaundice, anemia, thrombocytopenia, bone lesions, or early neurosyphilis.

Hey listeners! We are working on a Dermasphere-powered app for users to keep themselves up-to-date about dermatology in ...
10/11/2025

Hey listeners! We are working on a Dermasphere-powered app for users to keep themselves up-to-date about dermatology in 15-25 minutes per day. 📱 We need a name! Which is your favorite? Comment the corresponding number below!

Have you listened to the newest episode yet? 🎧In Episode 169, we discuss the following topics:➡Sugar bugs and milk tongu...
04/11/2025

Have you listened to the newest episode yet? 🎧In Episode 169, we discuss the following topics:

➡Sugar bugs and milk tongues - with special guest Dr. Joseph Lam! (learn more about him her: https://www.bcchr.ca/jlam)
➡Social determinants of health
➡Neuropathic pruritus
➡Conge***al syphilis

Exciting news!!!! Dr. Tarbox was inducted into the American Dermatological Association this weekend. The ADA is the olde...
01/11/2025

Exciting news!!!! Dr. Tarbox was inducted into the American Dermatological Association this weekend. The ADA is the oldest and most prestigious, honorific society in the world of dermatology. It was established in 1876 and it spawned the AAD, the ABD, the ASDS and the ASDP. She was inducted by Dr. Bergfield. Join us in congratulating her on this amazing accomplishment! 🎉

Hello friends & colleagues! I’m inviting you to participate in a FREE small-group, online social learning experience! It...
28/10/2025

Hello friends & colleagues! I’m inviting you to participate in a FREE small-group, online social learning experience! It's about chronic spontaneous urticaria. It's free, accredited (earn 7.25 AMA CME/CE credits), brief, non-branded, valuable (current modules and patient cases), and flexible in time commitment. In addition to independently completing the short modules and cases, our cohort will meet online via Zoom for discussions to exchange insights: We meet once at the beginning and then several times throughout the year to review updates from major conferences!

Sign up here: https://aaaaicsu.gathered.com/invite/KQe1wPZbJY

And now we have Michelle's Top Five! 👩‍⚕️• Chemowraps with 5-FU can be particularly useful on AKs and SCCs of the lower ...
23/10/2025

And now we have Michelle's Top Five! 👩‍⚕️

• Chemowraps with 5-FU can be particularly useful on AKs and SCCs of the lower legs for patients who are poor surgical candidates or have comorbidities leading to poor healing.
• Traditional treatment of AKs or SCCs on the lower legs often requires excision, followed by secondary intention healing or skin grafting, particularly in patients with poor circulation or limited wound-healing capacity.
• DSAP (disseminated superficial actinic porokeratosis) has been linked to mutations in the mevalonate kinase pathway in cholesterol synthesis. Individual lesions typically arise after a second hit, such as UV damage or local trauma, and chemowraps may be helpful in these cases.
• Imiquimod is a topical immune response modifier that acts via toll-like receptor 7, and to some extent TLR8, activating NF-κB and type I interferon pathways to stimulate local innate immunity against BCC, AKs, warts, and superficial malignancies.
• Women may display stronger local skin reactions to imiquimod than men, possibly because TLR7 is encoded on the X chromosome and may escape complete X-inactivation leading to higher baseline expression in females.

It's time for Top Five's from Episode 168! First up, Luke! 👨‍⚕️ For new listeners, our Top Five segment consists of each...
23/10/2025

It's time for Top Five's from Episode 168! First up, Luke! 👨‍⚕️ For new listeners, our Top Five segment consists of each doc's clinical pearls from the articles discussed in that episode 🤓

➡Cidofovir is a deoxycytidine monophosphate analogue that inhibits viral DNA synthesis and binds 35-40 x more avidly to viral vs. human DNA polymerases.
➡Intralesional cidofovir can be given for recalcitrant warts; IV formulation is commonly diluted for IL use (often ~15 mg/mL) and injected into lesions using serial puncture or cross-hatching techniques.
➡IL or topical cidofovir demonstrates ~50% response in case reports for common, plantar, periungual, flat, and ge***al warts. Response is often seen between 1-3 months.
➡Cidofovir can be used for acyclovir-resistant HSV because it does not require viral thymidine kinase activation unlike acyclovir/valacyclovir.
➡Cidofovir may have antineoplastic and antiproliferative effects, making it a potential option for HPV-induced SCCs, BCCs, HSIL, CIN, erythroplasia of Queyrat, lentigo maligna, and EBV-related nasopharyngeal carcinoma.

A new episode dropped this week! Have you listened yet?In this episode, we were joined again by Dr. Ian Myles (who last ...
17/10/2025

A new episode dropped this week! Have you listened yet?

In this episode, we were joined again by Dr. Ian Myles (who last joined us in Episode 124!) to discuss topical steroid withdrawal. The other topics discussed were chemowraps and cidofovir in dermatology!

Listen wherever you get your podcasts (Apple Podcasts, Spotify, Amazon music, & more!) 🎧

Now for Michelle's Top Five from Episode 167!➡Scalp dysesthesia: potential causes include cervical spine disease, crania...
16/10/2025

Now for Michelle's Top Five from Episode 167!

➡Scalp dysesthesia: potential causes include cervical spine disease, cranial nerve impingement, dermatomyositis, autoimmune or inflammatory alopecia, and occasionally delusional parasitosis.
➡Lichen sclerosus (LS) is a chronic inflammatory dermatosis that primarily affects the anoge***al region in postmenopausal women and prepubertal girls. Extrage***al LS occurs in ~15% of cases, often presenting with pruritus or treatment resistance.
➡A review of extrage***al LS showed topical corticosteroids were the most effective first-line therapy: ~80% complete response.
➡Patients with extrage***al LS should receive a full-skin and ge***al exam, as asymptomatic or unrecognized ge***al disease is common and may be mistaken for menopausal changes.
➡Sites of extrage***al LS: upper back > breasts > abdominal folds. Lesions appear as porcelain-white plaques with pruritus and color change. It is important to rule out morphea and overlapping presentations.

In addition to Michelle's Top Five, we wanted to include Dr. Shreya Sreekantaswamy's Top 3!

1️⃣-methionine is an essential amino acid obtained solely through diet, vital for protein synthesis, liver function, and antioxidant activity.
2️⃣Possible mechanisms for L-methionine in wart therapy include oxidation of intracellular methionine, increasing protein susceptibility to proteolytic degradation, or altering keratin composition and its precursors.
3️⃣In a retrospective review of 29 patients treated with Versulisin verulise methionine for verrucae vulgaris, 56% achieved complete or near-complete resolution, while 44% did not respond. All patients with verrucae plana failed treatment.

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