Cell Reports Medicine

10/02/2025

Sun et al. perform a comprehensive proteomic profiling of 306 Chinese patients with prostate cancer (PCa) and develop a 16-protein panel that effectively predicts BCR for patients with PCa across different PCa stages. This study provides an effective prognosis prediction technique and potential the...

07/02/2025

By 2D and 3D in vitro models combined with 2 orthotopic xenografts, Grisendi et al. demonstrate that chemotherapy with gemcitabine in combo with an MSC-delivered TRAIL efficiently targets both pancreatic cancer cells and their fibroblasts (CAFs), inducing apoptosis, modifying CAF transcriptome, re...

06/02/2025

Tim-3 is a promising immune checkpoint in tumor immunotherapy. Chen et al. demonstrate that soluble Tim-3 (sTim-3) is a potential marker of tumor prognosis and resistance to anti-PD-1 therapy. sTim-3 exacerbates CD8+ T cell exhaustion and inhibits response to anti-PD-1 treatment, suggesting sTim-3...

05/02/2025

Vis et al. developed an approach to model combination drug effects, identifying efficacious combination benefit (ECB) responses driven by synergy, Bliss, and independent drug action. They identify biomarkers of ECB and show that ECB is better than synergy at predicting patient response. A valuable ...

03/02/2025

Zheng et al. combined genetic, real-world, and cohort evidence to show a causal protective effect of SGLT2 inhibition on the risk of prostate cancer and showed that this effect is likely through a non-glycemic pathway. This study prioritized the prescription of SGLT2 inhibitors for those with prost...

31/01/2025

Yin et al. utilizes 4D-DIA proteomics and machine learning to identify key biomarkers PF4 and AACT in serum extracellular vesicles for colorectal cancer (CRC) diagnosis. Their random forest model demonstrates superior diagnostic performance for early-stage CRC and distinguishing CRC from benign col...

30/01/2025

Tang et al. introduce a malaria protein VAR2-based platform for retrieving circulating tumor cells from patients with pancreatic cancer. The obtained high numbers of circulating tumor cells facilitated the creation of in vitro and in vivo models suitable for drug screening and identified stearoyl...

29/01/2025

Lian et al. found that, upon various risk factors of PD, SIRT1 expression in DAs was reduced, leading to an increase in PKM2 activity. As a consequence, lactate accumulates in the brain to induce glial activation and sustained neuroinflammation. These outcomes eventually induce DA degeneration and ...

27/01/2025

Ates et al. propose a machine learning approach to measure the impact of therapeutic drug monitoring (TDM) on sepsis recovery. Their framework dynamically tracks treatment efficacy and patient response, using clinical trial data comparing TDM-guided piperacillin/tazobactam therapy to fixed dosing, ...

24/01/2025

23/01/2025

Despite their role as drivers of clinical deterioration in multiple sclerosis, the molecular mechanisms driving the leading inflammatory edge of chronically inflamed lesions are poorly understood. Fagiani et al. propose an organoid platform recapitulating the diversity of central nervous system cel...

22/01/2025

Hengist et al. show that restricting free sugars or overall carbohydrates (ketogenic diet) both reduce body fat over 12 weeks in healthy adults. While sugar restriction had relatively little effect on metabolism or the gut microbiome, ketogenic carbohydrate restriction increases atherogenic lipopr...

20/01/2025

Subfertility is a significant adverse effect of chemotherapy in reproductive-age females. Feng et al. identify that Limosilactobacillus reuteri and its catabolite, β-resorcylic acid, protect against chemotherapy-induced subfertility by inhibiting granulosa cell apoptosis through the SOX7-BAX axis....

17/01/2025

Voss et al. demonstrate that hybrid immunity to SARS-CoV-2 arises from distinct immunological imprints left by infection and vaccination. Plasma antibodies maintain these initial imprints, with over 60% of the response derived from the initial exposure, but with enhanced potency and breadth, highli...

16/01/2025

Li et al. utilized transformer-based AI technology to learn the knowledge of methylome-wide features among different CpG sites from 110,000 cancer samples and then applied the learned knowledge to analyze large numbers of cfDNA methylation markers in 754 EOC patients and 1,118 healthy females and d...

15/01/2025

Nokin et al. identify two redox-related cellular states that involve an adaptive drug-tolerant stage followed by a genetic-defined resistance phase in BRAFV600E-driven lung cancer. Timely treatments with small molecules (GPX4 and HDAC inhibitors) that further enhance the resulting oxidative stress ...

13/01/2025

The utilization of non-invasive, liquid biopsy-based analysis of cfDNA has emerged as a promising approach in disease detection. By integrating features derived from whole-genome sequencing including fragmentomics profiles, copy-number variation, and nucleosome positioning, Jiao et al. develop a ro...

10/01/2025

Neurodegenerative diseases are often investigated from a postnatal perspective, ignoring the potential contribution of developmental aspects. Using a spinal cord organoid model derived from isogenic SMA iPSCs, Grass et al. uncover the role of SMN in neuronal progenitor and mesodermal specification....