Cell Reports Medicine

14/06/2024

Bootsma et al. reveal that CMS4-subtype colorectal peritoneal metastases show a dismal prognosis despite surgery with local chemotherapy. Elesclomol was identified as a potent new compound, demonstrating selective cytotoxicity against CMS4 cells by targeting oxidative phosphorylation machinery. Ele...

13/06/2024

Roy et al. provide insight into molecular causes and mechanistic underpinning of white adipose tissue dysfunction after spinal cord injury (SCI), facilitating the development of strategies targeting sensory processing to reduce metabolic and cardiovascular complications after SCI.

12/06/2024

Adnan Awad et al. investigate the BCR::ABL1-independent resistance mechanisms in chronic myeloid leukemia (CML) with integrated ex vivo drug screening and genome-wide CRISPR screening. Discovered drugs targeting leukemia stem and progenitor cells, along with resistance mechanisms to tyrosine kinas...

10/06/2024

07/06/2024

Forrest et al. pilot a genome-first strategy for assessing individuals genetically predisposed to disease who may be missing a diagnosis in their routine healthcare. Participants carrying disease-risk variants are identified and undergo targeted phenotyping with laboratory measurements, electrophys...

06/06/2024

Yang et al. genetically engineer bacteria, with an acoustic reporter gene and the hyperthermia-responsive IFN-γ gene, and chemically modify them with DOX. These GV-containing bacteria can guide hHIFU to precisely induce the expression of the IFN-γ gene. The concurrent effects of IFN-γ and DOX ac...

05/06/2024

Here, we present 3 different perspectives on how the microbiome has impacted cancer patients, treatment, and clinical studies. We hear about the challenges of implementing microbiome analyses into the clinics, the impact these analyses might have on patients’ care, and treatment in the future, spe...

03/06/2024

Dr. Jennifer A. Wargo, Dr. Nadim J. Ajami, and Dr. Carrie R. Daniel-MacDougall describe their academic and clinical work on the role of the microbiome to determine response to immunotherapies and discuss current challenges and potential needs to integrate their findings into clinical practice.

30/05/2024

The study by Chen et al. has advanced research by developing predictive models based on circulating microbial DNA, offering potential for early cancer detection and personalized treatment. However, further validation and simplification of techniques are needed for widespread clinical application.

29/05/2024

The precise identities of bone marrow resident cells contributing to AML relapse are not fully known. Hollands et al. report early evidence to support the existence of an aberrant monocytic cell population that appears to promote LSC expansion after cytarabine treatment.

27/05/2024

PET scans provide additional clinical value but are costly and not universally accessible. Salehjahromi et al. developed an AI-based pipeline to synthesize PET images from diagnostic CT scans, demonstrating its potential clinical utility across various clinical tasks for lung cancer.

24/05/2024

Published trials sometimes report data for the overall population and selected subgroups, but not for the remaining population. Shenoy reports two methods able to extract data from the remaining subgroup using data for the overall population and a given subgroup.

23/05/2024

The gut microbiome is closely associated with cancer immunotherapy. Kang et al. explore the roles and underlying mechanisms of gut microbes and their derived metabolites (e.g., tryptophan, short-chain fatty acids) in modulating immunotherapy. Targeting the gut microbiome (e.g., f***l microbiota tra...

20/05/2024

Bagheri et al. demonstrate that the FDA-approved microtubule inhibitor eribulin, when applied in the treatment-naive setting, induces epigenetic remodeling to reverse the epithelial-to-mesenchymal transition, prevent metastasis, and sensitize breast cancer cells to other chemotherapeutics. These fi...

17/05/2024

Shen et al. interrogate the transcriptome and DNA methylome of developing human go**ds in the context of the COVID-19 pandemic. Trivial impacts but a precocious development trend occur in fetal germ cells (FGCs) following maternal infection. Extensive immune responses are activated in the gonadal m...

16/05/2024

Ingels and De C**k et al. demonstrate feasibility, safety, and immunogenicity of a dendritic cell vaccine targeting patient-individual neoantigens in patients with resected NSCLC. Vaccine-induced T cells persist long term, are polyclonal, and exhibit the near-full spectrum of differentiation state...

15/05/2024

Xu, Saunders, and Huang et al. generate a large, single-cell RNA sequencing dataset of the breast tumor microenvironment. They use this real-world data atlas to further characterize NK cells and create InteractPrint. InteractPrint is a method that accounts for tumor heterogeneity and accurately pre...

13/05/2024

How the tumor cells harboring key gene mutations affect the malignant transformation of intestinal epithelial cells (IECs) and its role in colorectal cancer progression have not been defined. We report that PIK3CA mutant tumor cells transmit oncogenic signals and trigger malignant transformation of....

10/05/2024

Ning et al. identify that the MCTC structure serves as a biomarker for poor prognosis and ICI resistance in HCC, functioning by sequestering cytotoxic T cells and establishing an immunosuppressive niche. Their strategy disrupts MCTC formation by targeting M2BP, restoring T cell infiltration and p...

08/05/2024

Zhu et al. summarize recent AI advances for prostate cancer management, including automated diagnosis, grading, patient outcome prediction, and molecular subtyping. This review highlights collaborative human-AI systems, public resources, and challenges such as model interpretability, generalization...

02/05/2024

In this article, Shenoy describes statistical analysis methods to derive the unpublished specific survival outcomes of the remainder patient cohort (“B”) of a randomized controlled trial with a high degree of accuracy, utilizing the published data of the overall (“A+B”) and favorable subgrou...

01/05/2024

Chen et al. reveal that circulating microbiome DNA can be a biomarker for lung cancer diagnosis and recurrence, establishing a paradigm of cancer liquid biopsy.