In Vivo

31/07/2021

"Studies show that vaccines reduce the spread of SARS-CoV-2 by more than 80%, but the Delta variant is creating fresh uncertainty."

Studies show that vaccines reduce the spread of SARS-CoV-2 by more than 80%, but the Delta variant is creating fresh uncertainty.

23/01/2021

In a study published in the latest issue of In Vivo, Dr. Pornsuda Maraming et.al. (Khon Kaen University), examined whether a lysine/tryptophan-rich peptide (KT2) could prevent metastatic cancer in human melanoma cells. KT2 was shown to inhibit the migration and invasion of cancer cells by decreasing MMP-2 and MMP-9 expression, via altering the expression of metastasis-associated proteins in a dose and time-dependent manner.

Read the full article here:
https://iv.iiarjournals.org/content/35/1/215.full

Background/Aim: KT2 is a lysine/tryptophan-rich peptide modified from Crocodylus siamensis Leucrocin I. In this study, we examined the cell toxicity, cellular uptake, anti-migration and anti-invasion activities of KT2 in A375.S2 human melanoma cells. Materials and Methods: A375.S2 cells were treated...

10/01/2021

The new In Vivo issue is now available online, open access. A lot of interesting experimental and clinical works, and five studies on COVID-19.

http://iv.iiarjournals.org/content/current

14/12/2020

Interesting read on how our brain forms expectations.

http://sciencemission.com/data/attachment.php?id=10242 ()

07/12/2020

The Swiss cheese/protection against the pandemic paradigm!

It’s not edible, but it can save lives. The virologist Ian Mackay explains how.

26/11/2020

A way to reverse aging? The key seems to always be the telomeres..

Healthy older adults exposed to hyperbaric oxygen therapies showed signs of reversal of the normal aging process at a cellular level.

19/11/2020

"The trust of the global community is hardwon and achieved through total transparency and realism of expectation, both during and long after vaccine development and deployment."



Good read:

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30870-7/fulltext

02/11/2020

Very informative and well-presented.

https://www.nationalgeographic.com/magazine/2020/11/explore-how-coronavirus-attacks-the-body-and-how-the-body-fights-back/

Action, reaction, overreaction: Once the virus gets in, the immune system can overreact—with deadly consequences.

29/10/2020

In a study that was published in the latest issue of In Vivo, Nishikawa et al. revealed that sarcopenia and frailty in chronic liver damage have both common and different pathological characteristics, thus are not synonymous and should be separately evaluated. The full article can be found here: http://iv.iiarjournals.org/content/34/5/2549.full

Aim: To elucidate the common and different points between sarcopenia and frailty in chronic liver damage (CLD). Patients and Methods: Patients with both grip strength decline and skeletal muscle index decline were regarded as sarcopenia. Frailty was defined as a syndrome in which 3 or more of the fo...

28/10/2020

Oral methioninase seems to be a promising adjuvant treatment against aggressive breast cancer, as evidenced by Prof. Hoffman's group (San Diego, CA, USA), in a mouse model.

The whole study is freely available here:

http://iv.iiarjournals.org/content/34/5/2281.full

Background/Aim: The aim of the study was to use a triple-negative breast cancer (TNBC) patient-derived orthotopic xenograft (PDOX) model to examine the efficacy of oral recombinant methioninase (o-rMETase) against this recalcitrant disease. Materials and Methods: The TNBC tumor from a patient was im...

23/09/2020

Researchers at the University of Pittsburgh and Carnegie Mellon University College of Engineering have created a machine-learning algorithm that may detect subtle signs of osteoarthritis on an MRI scan taken years before symptoms even begin.

https://www.genengnews.com/news/early-detection-of-osteoarthritis-with-artificial-intelligence/

Artificial intelligence has been used to detect osteoarthritis years before symptoms begin. The technique may lead to new therapies rather than surgery.

02/09/2020

How do wounds heal? What drives tissue regeneration?

https://immunology.sciencemag.org/content/5/50/eaba5683

Wound healing in mammalian skin often results in fibrotic scars, and the mechanisms by which original nonfibrotic tissue architecture can be restored are not well understood. Here, Wei et al. have shown that pharmacological activation of the nociceptor TRPA1, which is found on cutaneous sensory neur...

15/08/2020

Interesting read!

https://www.quantamagazine.org/mitochondria-may-hold-keys-to-anxiety-and-mental-health-20200810/

Research hints that the energy-generating organelles of cells may play a surprisingly pivotal role in mediating anxiety and depression.

01/07/2020

The latest issue of In Vivo (July-August) is now live here:
http://iv.iiarjournals.org/content/34/4.toc

26/06/2020

Great work from researchers of the University of California! Reversal of Parkinson's in mice, by inhibiting a single gene.

https://www.nature.com/articles/s41586-020-2388-4

Depletion of the RNA-binding protein PTB (also known as PTBP1) in astrocytes reprograms these cells to become functional neurons and, in a mouse model of Parkinson’s disease, reverses the disease phenotype.

21/06/2020

https://www.labroots.com/trending/cell-and-molecular-biology/17936/antibodies-isolated-covid-19-patients-therapeutic-potential

Communities worldwide are emerging from lockdowns due to the SARS-CoV-2 pandemic virus, and cases are rising. | Cell And Molecular Biology

18/06/2020

The results of a trial that found dexamethasone reduced the risk of death in extremely ill coronavirus patients have yet to be published, but some doctors are already embracing them

12/06/2020

Promising discovery that could produce a potential drug for obesity treatment!

https://www.genengnews.com/news/protein-discovered-as-potential-treatment-for-obesity/

Scientists from the Pennington Biomedical Research Center, report they have discovered BAM15, a protein that can be used as a potential treatment for obesity and its related diseases such as diabetes, heart disease, and some forms of cancers.

11/06/2020

Really interesting work from the The University of North Carolina at Chapel Hill, published in Science Immunology today.

https://immunology.sciencemag.org/content/5/48/eabc8413?utm_campaign=SciMag&utm_source=JHubbard&utm_medium=Facebook

You can now read all articles of our COVID-19 special issue, open access, here: http://iv.iiarjournals.org/content/34/3_suppl.toc

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in late 2019 is responsible for a pandemic of severe respiratory illness. People infected with this highly contagious virus can present with clinically inapparent, mild, or severe disease. Currently, the virus infect...

05/06/2020

The IN VIVO Special Issue on SARS-Cov-2 and Covid-19 Disease is now available OPEN ACCESS on HighWire:
http://iv.iiarjournals.org/content/34/3_suppl.toc

22/05/2020

An interesting study demonstrating the benefits of HPV vaccination. When performed at a proper age, vaccination can significantly reduce development of severe cervical precancers and consequently the need for treatment, as well as their long-term related obstetrical morbidity.

http://iv.iiarjournals.org/content/34/3/1445.long

Background: In Greece the population-level impact of HPV vaccination is unknown due to lack of official registries. This study presents in a pragmatic frame the comparison of cervical pathology data between HPV-vaccinated and unvaccinated women referred for colposcopy. Patients and Methods: This is....

11/05/2020

Could the BCG vaccine be used to bridge the gap until a specific COVID-19 vaccine is developed? Luke O’Neill and Mihai Netea discuss the science behind this approach.

02/05/2020

Effect of fear during the Covid-19 pandemic in cancer treatment decision-making.

https://iiar-anticancer.org/wp-content/uploads/2020/04/4985VANNI.pdf

25/04/2020

All articles for the Covid-19 Special Issue will be uploaded on our website ahead of print as soon as they have been peer-reviewed. The issue will be formally published in June 2020 and will be accessible on In Vivo’s website through Highwire Press.

https://iiar-anticancer.org/in-vivo-special-issue/

22/04/2020

During the Covid-19 pandemic, sharing knowledge and information is crucial for both the scientific community and the broader audience. For this reason, articles for the IN VIVO Special Issue οn SARS-Cov-2 and Covid-19 Disease will be posted on the IIAR website ahead of print as soon as they have been peer-reviewed. The issue will be formally published in June 2020 and will be accessible on In Vivo's website through Highwire Press.

14/04/2020

CALL FOR PAPERS
IN VIVO Special Issue On SARS-Cov-2 and Covid-19 Disease
TOPICS: Reviews, experimental and clinical articles on all aspects of SARS-Cov-2 and Covid-19 disease.

Deadline for article submission: 18 May 2020
Publication Policy: Submitted articles should not exceed 20 typewritten pages plus figures and tables.

All submitted manuscripts will be rapidly peer-reviewed within 3-5 days, and Authors will be immediately noticed if a revision is requested. Revised manuscripts should reach our office within 24-48 hours. Prompt arrangements focus on the rapid publication of this issue online OPEN ACCESS in the Highwire-IN VIVO site on June 2, 2020.
All accepted papers will be subject to a publication fee of US$ 250.00. Color figures will be published free of charge.
Manuscripts should follow our Instructions to Authors and should be submitted electronically (www.iiar-submissions.com).
Information: Dr. George J. Delinasios, e-mail: [email protected]

http://iiar-anticancer.org/home-in-vivo/

To submit an article you should first create an account. IMPORTANT NOTE: You may submit your article only through our online submission system To create an account please click here

11/04/2020

Remdesivir, a nucleotide analogue prodrug that inhibits viral RNA polymerases, showed some promising results against Covid-19.

https://www.nejm.org/doi/full/10.1056/NEJMoa2007016

Original Article from The New England Journal of Medicine — Compassionate Use of Remdesivir for Patients with Severe Covid-19

08/04/2020

The use of powerful anti-inflammatory drugs in Covid-19 patients can slow or stop lung deterioration due to "cytokine storm" .

https://www.newscientist.com/term/cytokine-storm/

Diseases such as covid-19 and influenza can be fatal due to an overreaction of the body's immune system called a cytokine storm. Cytokines are small proteins released by many different cells in the body, including those of the immune system where they coordinate the body's response against infection...

31/03/2020

An interesting article by a Greek group led by Professor Tsiordas, highlighting the high transmissibility/low-severity profile for the current pandemic. The study may indicate the rationale behind the Greek strategy against Covid-19, giving priority in the disease mitigation, rather than its suppression.

https://www.medrxiv.org/content/10.1101/2020.03.24.20042218v1

We sought to estimate the ascertainment ratio of SARS-CoV-2 infection in Wuhan, China, using a modified Bayesian SEIR model with publicly reported case data. We estimated it at 0.465% (95%CI: 0.464-0.466%), implying that the outbreak in Wuhan was abated by depletion of susceptibles, rather than publ...

18/03/2020

New study published on Science explaining the rapid geographic spread of SARS-CoV2

https://science.sciencemag.org/content/early/2020/03/13/science.abb3221