09/08/2022
《nature cancer》2022年8月封面文章
團隊研發用來誘發內質網壓力的小分子ERX-41,可以在不影響正常細胞的情況下,殺死癌細胞。
期刊原文:
https://www.nature.com/articles/s43018-022-00389-8
Liu X, Viswanadhapalli S, Kumar S, et al. Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress. Nat Cancer. 2022;3(7):866-884. doi:10.1038/s43018-022-00389-8