06/10/2021
Hyperemesis Gravidarum (HG) is associated with over 285,000 admissions/hospitalizations in the U.S. annually . Estimates of severe Nausea and Vomiting of Pregnancy (NVP) vary greatly and range from 0.3% in a Swedish registry to as high as 10.8% in a Chinese registry of pregnant women, with most authors reporting an incidence of approximately 0.5%[4-6]. HG can be associated with serious maternal and fetal morbidity such as Wernicke’s encephalopathy fetal growth restriction, and even maternal and fetal death.
IS HG REALLY THAT RARE?
Case study Results: Children exposed in utero to hyperemesis gravidarum have a 3.82-fold increase in odds of being diagnosed with a long-term health effect including allergies, chronic constipation, gastroesophageal reflux disease, growth restriction (height and weight below 20th percentile), lactose intolerance, chronic respiratory or ear infections, or sleep difficulties (p< 0.0005). Among hyperemesis gravidarum patients, women who took promethazine during pregnancy or began gaining weight later in their pregnancy (after 20 weeks) were more likely to have a child that was diagnosed with allergies for promethazine and for late weight gain). Those who took antidepressants while pregnant were more likely to have a child with aftermath issues.
The risk ?
A 3.6-fold increased risk of neurodevelopmental disorders in adults exposed to HG in utero In a more recent study we found that children exposed to HG in utero show a 3.28-fold increase in odds of having a neurodevelopmental diagnosis including attention disorders, learning delay, sensory disorders, and speech and language delay Herein, we determine the risk for non-neurodevelopmental long-term health effects in children from well-defined cases of HG compared to well-defined controls. Factors including pregnancy characteristics, treatments, and medications taken during pregnancy were also evaluated for having any association with adverse outcomes in children exposed to HG in utero.
https://www.oatext.com/Long-term-health-effects-in-children-exposed-in-utero-to-hyperemesis-gravidarum.php
CASE STUDY VIA Marlena S. Fejzo
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA
Frederic P. Schoenberg
Department of Statistics, University of California, Los Angeles, CA, USA
Kimber Macgibbon
Hyperemesis Education and Research Foundation, Damascus
Aromalyn Magtira
Department of Statistics, University of California, Los Angeles, CA, USA
Bhuvan Martin
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA
Patrick M. Mullin
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA
DOI: 10.15761/COGRM.1000138
QUESTION OF THE DAY
Does your HG baby/children has any lasting issues ?
HG Fairy 🧚♂️ Godmother
Starr Andrews Strong HGactivist
HER volunteer
Founder of Hyperemesis Gravidarum Before During And The AfterMath
https://www.oatext.com/Long-term-health-effects-in-children-exposed-in-utero-to-hyperemesis-gravidarum.php
OA Text is an independent open-access scientific publisher showcases innovative research and ideas aimed at improving health by linking research and practice to the benefit of society.
