10/31/2022
Scientists led by groups at EPFL and the University of Tennessee Health Science Center (UTHSC) explore the elaborate interplay between genes, s*x, growth, and age and how they influence variation in longevity.
Aging, senescence, and death are given as inevitable. Some people age faster, some suffer from age-related diseases, and some die younger than others. Robert Williams points out that "Finding common molecular denominators of aging differences is critical. Lifespan and health are under some level of genetic control that varies both within and between species. Once defined we can then intervene rationally."
The problem is that lifespan—the duration of time one lives—is one of the most complicated traits that one can study and is affected by genes and the environment as well as their complex interactions.
- Genetic determinants of longevity are specific to one s*x or only make a difference past a certain age.
- Genetics and early growth affect longevity
- The hunt for aging and longevity genes is real
- The future lies in healthspan research
This study is an important step in understanding the factors behind why some people live longer than others. However, Johan Auwerx, one of the lead authors of the study comments “This particular study is focused on longevity, yet what is arguably more important is how long health is maintained. This is referred to as ’healthspan‘, the period of life that is disease-free. Studies in animal models and ultimately in humans will need to assess how the health degrades in a longitudinal manner, and then search for the underlying causes. We are in the midst of such a healthspan study in our laboratory”. A main question remains: can one postpone many diseases at once by affecting aging globally? The results of this study will be a rich resource of aging genes that will hopefully guide the design of therapies that not only extend lifespan, but also healthspan.