Open Access Journal of Pharmaceutical Research

06/05/2024

Galenic Laboratory: State of the Art-A Scientific and Technological Discipline, Innovation and Management

https://medwinpublishers.com/OAJPR/galenic-laboratory-state-of-the-art-a-scientific-and-technological-discipline-innovation-and-management.pdf

Author: Luisetto M*, Naserr A, Khaled E, Mashori GR, Benzi CR, Fiazza C, Cabianca L and Yurevich OL

DOI: 10.23880/oajpr-16000316

Abstract:

The term galenic imply a scientific and technical matter but also an art. Related the hospital practice the future of pharmacy pass though the innovation of the galenic lab. Observing the today hospital practice HP in many countries and the international literature involved it is clear how clinical pharmacy is linked to the galenic lab practice LP. Today more than recent past due to the various kinds of magistral formula requested by the clinicians It is necessary that the clinical pharmacist CP perspective must to be added to the classic galenic lab competencies: this make possible to complete the profile of efficacy and safety of this fundamental and crucial Drugs like the magistral formula and officinal and their use. Aim of this ancient discipline and art is today to provide efficacy and safe drugs for the need of single patient when it is not possible to use the industrial product. The clinical galenic activity can be divided into sterile and non-sterile. (Total parenteral nutrition TPN bags, Pain therapy, oncological parenteral drugs lab UFA, radio drugs and diagnostics and non-sterile galenics).Aim of this work is to deeply investigate this relevant link (Clinical Pharmacy CP with Lab Practice LP) in order to get the really best clinical results for the patients and healthcare org need. Clinical pharmacy CP principle, Pharmaceutical care PC, the managerial competencies and personalized pharmacy added to the best knowledge and competencies in the galenic lab. Make the difference in order to obtain the right final clinical results. The same in this work are submitted to the international pharmacy practitioner, directors, researcher or students the Normative rules operating in an advanced country like Italy: the simplified NBP (NORME DI BUONA PREPARAZIONE), example that can be applied also in the non-advanced nations. In Italy pharmacist can follow or the full NBP (NORME DI BUONA PREPARAZIONE) rules of the official pharmacopeia or the simplified according DM Salute 18.nov.2003. (Related the kind of galenic formula prepared if sterile or not). The NBP (NORME DI BUONA PREPARAZIONE) (good manufacturing rules) introduce a QUALITY CQ SYSTEM MANAGEMENT. The full NBP (NORME DI BUONA PREPARAZIONE) are more used in more complex labs in ex. involved in specialist products (Like oncologic or radio drugs, sterile colliria and other). These rules guarantee the quality, security and the efficacy of a drug prepared in galenic lab. These are based on the responsibility principles, plan, and documentation of all activity. (QUALITY SYSTEM OF INSURANCE CQ). All the phases of the preparation are under the responsibility of the pharmacist. The final quality of the products depends on the correct use of API and excipients, on the right calculations operation, right volume measure or weight operation and the Check on the final products: -following of the procedure, aspects, packaging and closing system and other request by ITALIAN FU related the specific pharmaceutical form. According NBP (NORME DI BUONA PREPARAZIONE) the lab. Must to be separated (or it must to be separable) form the rest of pharmacy and a second pharmacist (that is different form the pharmacist that prepare) must to check the final preparation. The locals must to be according strictly environmental condition required normative rules by to make possible to prepare in safety way drugs. And it is mandatory to follow the written procedure: instrument verify, training of the pharmacists Cleaning procedure, significations. For Raw materials: it is needed to have certifications, technical sheet, safety sheet, data of the first use, expiry data Working sheet is mandatory to testify the operations. The pharmacist can follow this 2 option related the kind of drugs produced and the characteristic of the lab. It is not the main focus of this work to produce a literal translation of the DM 18/nov /2003 only to submit its general meanings. This can be considered for the authors useful to be added also to the normative rules in force in other non-advanced countries. In order to make more interesting this book some useful concepts of physiology of the stomach and GI tract are reported. The same relevant pharmaceutical concepts and technique with a focus on the capsules CPS as pharmaceutical form (gastro resistance, delayed release), some oral suspension, gels and other few preparation. This work is produced whit a non-conventional approach: it is not a book of pharmaceutical technique. Innovation and management of the system make possible to increase the power of the galenic laboratories In the hospital or in private pharmacy. This work is produced only for international purpose.

Keywords: Physiology; Galenic Lab; Magistral Formula; Clinical Pharmacy; Pharmaceutical Care; Personalized Pharmacy; Drug Shortage; NBP; Simplified Rules; Official Pharmacopeia; Control Process; Quality Management System; Rare Disease; 3D Printing Systems; Management

05/29/2024

Review on Tropical Carriers of Antifungal Drug Therapy

https://medwinpublishers.com/OAJPR/review-on-tropical-carriers-of-antifungal-drug-therapy.pdf

Author: Mayuri B*, Ritesh A, Deepak S, Yogesh S and Dhananajay P

DOI: 10.23880/oajpr-16000315

Abstract:

Among the most prevalent conditions affecting the skin are fungus infections. OTC and oral antifungal medications are used in treatment regimens. Considering the potential negative effects of oral treatment, the topical method is usually favoured. Soon, traditional products like gels, ointments, and creams may become obsolete due to advancements made in formulation. When used to treat cutaneous fungal infections, a number of carrier systems that are packed with antifungal medications have shown encouraging outcomes. These more recent carriers include liposomes, ethosomes, liposomes, Microemulsion, and lipid systems such solid lipid nanoparticles and nanostructured lipid carriers. Pe*******on enhancer vesicles are another example of these newer carriers. Compared to cream and ointment, gel and composition have superior stability and application qualities. Among the most prevalent dermatology issues are skin interactions resulting from fungal infections. The most effective treatment for cutaneous infections is topical medication.

Keywords: Antifungal; Topical Formulation; Mycoses; Nanosponge; Microemulsion; Amphiphilic Gel has context menu

05/08/2024

The Role of Medicinal Plants in the Development of Afghanistan's Economy and Trade

https://medwinpublishers.com/OAJPR/the-role-of-medicinal-plants-in-the-development-of-afghanistans-economy-and-trade.pdf

Author: Ayoubi R, Zhakfar AM* and Sediqi MN

DOI: 10.23880/oajpr-16000313

Abstract: Securing a favorable place in the global trade market and achieving sustainable economic growth are among the objectives of developing countries. A country's commercial status has significantly improved as a result of increased exports and improved economic conditions brought about by the growth of its domestic output. Medicinal plants (MPs) are a significant and productive part of the economies of the majority of countries, including Afghanistan. Afghanistan has an exceptional capacity for the production and export of MPs and herbal medications because of its unique geopolitical situation and climate. Because of their varied temperatures and geographic locations, the many provinces in the country offer considerable possibilities for the investment, commerce, and cultivation of these species. In addition to receiving basic healthcare, they may create jobs, stop the loss of the green flora so that certain significant wild species can be domesticated, and protect the environment with careful planning in this area. This article's goal is to review the contribution that MPs have made to the country's commerce and economic growth. Based on the results, it can be said that MPs have a multifaceted function in the expansion and growth of the Afghanistan's economy and commerce, and taking this into account, it is possible to understand the significance of these products on the list of significant exports from the Country. MPs are viewed as a potential link between biodiversity preservation, accessible healthcare, and sustainable economic growth.

Keywords: Medicinal Plants; Economic Growth and Development; Domestication of Wild Plants

05/01/2024

A Review on: Formulation and Evaluation of Herbal Medicated Chewing Gum
# SuvarnaT
https://medwinpublishers.com/OAJPR/a-review-on-formulation-and-evaluation-of-herbal-medicated-chewing-gum.pdf

Author: Suvarna T*

DOI: 10.23880/oajpr-16000312

Abstract: One portable method of medicine delivery is chewing gum. It may be used to provide medications orally, either systemically or locally. In recent years, significant progress has been made in research and technology related to the oral medication administration route. Medicated chewing gum has gained international attention throughout the year due to its ability to promote patient compliance in both pediatric and geriatric patients as well as the general population. The Mayan Indians used to clean their teeth and refresh their breath by chewing tree resin from the sapodilla tree a thousand years ago. Over the course of the year, herbal chewing gum has been more widely accepted as a medication delivery method. Herbal chewing gum today contains a number of substances. A variety of characteristics, including color, stickiness, hardness, and in vitro drug release, are assessed for the prepared product. Chewing gum can be utilized as a portable medication delivery mechanism for oral drug administration, both systemic and local. The majority of people find chewing gum to be enjoyable. Medicated gum preparations frequently require organic solvents to solubilize the active ingredients, and it can be challenging to remove these organic solvents from the finished product.

Keywords: Chewing Gum; Drug Delivery System; Medicated Chewing Gum; Oral Health; Gum Base; Agent

09/05/2019

Open Access Journal of Pharmaceutical Research By
https://medwinpublishers.com/OAJPR/

09/04/2019