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๐’๐ž๐ž๐ข๐ง๐  ๐ข๐ฌ ๐›๐ž๐ฅ๐ข๐ž๐ฏ๐ข๐ง๐ : ๐•๐ข๐ฌ๐ฎ๐š๐ฅ๐ข๐ฌ๐ข๐ง๐  ๐ญ๐ก๐ž ๐…๐จ๐ซ๐ฆ๐š๐ญ๐ข๐จ๐ง ๐จ๐Ÿ ๐Œ๐จ๐ง๐จ๐ณ๐ฒ๐ ๐จ๐ญ๐ข๐œ ๐“๐ฐ๐ข๐ง๐ฌ ๐ข๐ง ๐ˆ๐•๐…Author: Jennifer ZenkerMonozygotic (MZ) twins,...
10/31/2024

๐’๐ž๐ž๐ข๐ง๐  ๐ข๐ฌ ๐›๐ž๐ฅ๐ข๐ž๐ฏ๐ข๐ง๐ : ๐•๐ข๐ฌ๐ฎ๐š๐ฅ๐ข๐ฌ๐ข๐ง๐  ๐ญ๐ก๐ž ๐…๐จ๐ซ๐ฆ๐š๐ญ๐ข๐จ๐ง ๐จ๐Ÿ ๐Œ๐จ๐ง๐จ๐ณ๐ฒ๐ ๐จ๐ญ๐ข๐œ ๐“๐ฐ๐ข๐ง๐ฌ ๐ข๐ง ๐ˆ๐•๐…

Author: Jennifer Zenker

Monozygotic (MZ) twins, identical clones developed from a single embryo, have long been a subject of curiosity, with their formation remaining largely unexplored [1]. In In Vitro Fertilisation (IVF) clinics, MZ twinning occurs at a relatively high rate up to 5%, compared to about 0.4% in natural pregnancies [2]. MZ twinsโ€™ pregnancy pose high risks for both the mother and the fetus, including twin-to-twin transfusion syndrome and twin reversed arterial perfusion. Therefore, understanding the exact mechanisms of MZ twinning during IVF procedure is crucial for predicting and potentially preventing it before embryo transfer.

Studying MZ twins has been challenging due to the low rate of MZ twinning in natural pregnancies and the inaccessibility to observe their in vivo development. Furthermore, there has been a lack of suitable animal models to study their formation in research. However, recent rapid advancements in Assisted Reproductive Technologies (ARTs) have reduced these barriers, offering valuable insights into the formation of MZ twins. ARTs allow for the development of human embryos outside the body before implantation. Along with cutting-edge live embryo imaging techniques, it is now possible to record and monitor real-time human embryo development while maintaining optimal development conditions within the incubator [3-5]. Consequently, an increase in MZ twin cases, observed through embryo imaging, has been reported following assisted reproduction [3-12], providing a clearer view on when and how a single embryo splits into two.

๐“๐จ ๐‘๐ž๐š๐ ๐…๐ฎ๐ฅ๐ฅ ๐€๐ซ๐ญ๐ข๐œ๐ฅ๐ž:
https://www.heraldopenaccess.us/openaccess/seeing-is-believing-visualising-the-formation-of-monozygotic-twins-in-ivf
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๐…๐ซ๐จ๐ฆ ๐„๐ง๐ž๐ซ๐ ๐ฒ ๐ฐ๐ข๐ฌ๐ž ๐‘๐ž๐ ๐ฎ๐ฅ๐š๐ญ๐ข๐จ๐ง ๐ญ๐จ ๐‘๐ž๐ ๐ฎ๐ฅ๐š๐ซ๐ข๐ณ๐ž๐ ๐’๐ž๐ฅ๐Ÿ-๐•๐ข๐ญ๐š๐ฅ๐ข๐ญ๐ฒ ๐’๐ฒ๐ฌ๐ญ๐ž๐ฆ โ€“ ๐Ÿ ๐‘๐ž๐ ๐ฎ๐ฅ๐š๐ซ๐ข๐ฎ๐ฆAuthor: Edwin Chau Leung YuThe whole organ...
10/29/2024

๐…๐ซ๐จ๐ฆ ๐„๐ง๐ž๐ซ๐ ๐ฒ ๐ฐ๐ข๐ฌ๐ž ๐‘๐ž๐ ๐ฎ๐ฅ๐š๐ญ๐ข๐จ๐ง ๐ญ๐จ ๐‘๐ž๐ ๐ฎ๐ฅ๐š๐ซ๐ข๐ณ๐ž๐ ๐’๐ž๐ฅ๐Ÿ-๐•๐ข๐ญ๐š๐ฅ๐ข๐ญ๐ฒ ๐’๐ฒ๐ฌ๐ญ๐ž๐ฆ โ€“ ๐Ÿ ๐‘๐ž๐ ๐ฎ๐ฅ๐š๐ซ๐ข๐ฎ๐ฆ

Author: Edwin Chau Leung Yu

The whole organism is energy concerned, and the energy economy mode prevails from basic cell regulation to higher systems regularized along with environmental setup. Energy and resources are basic and expressed everywhere. Concerning energy, as external interactions magnify, the whole human body may be viewed as a jumbo compo of physiological cues and environmental signals acting at different sites with complex cellular, neural or humoral controls and interacting functional nodes. The classical neural and endocrinal frame often becomes insufficient to understand it. Though disorders around the metabolic syndrome now prevail medical literature, energy related disorders are far more complex and need a better understanding from the whole person organism level.

Maintenance of homeostasis starts with organ systems with their set reflexive responses in reactive mode. Over the central reflexively reactive mechanisms, particularly with saliency and its linkage mechanisms and frugal liver provisions, self-vitality systems have evolved. Activities are generally meant for being energetic productive. The organism level needs to gain advantage of both basic energetic efficiency as well as the capacity for energetic production. To reduce erratic energy costs by placing the right job at the right time, regularized patterns have to be formed to match the environment to direct a certain physiological process to take place at a specific time of the day or night. Through set patterns consciously or subconsciously in various states and levels, the set regularium of each individual could function to conserve energy or being energetic productive as life requires. As a whole coordinating myriads of scenarios for self enhancement in living, the person then functions in adaptivity and useful patterns to suit the best survival and achieve snug-fit states positively. Poorly set self-vitality systems lead to pathologies. The self-vitality system concerning energy which is basic from cells to physiological processes and up to organismic level has a much wider context, and the paper is put in smaller succinct paragraphs in pertinent areas to describe the whole, and pathologies are only briefly described.

๐“๐จ ๐‘๐ž๐š๐ ๐…๐ฎ๐ฅ๐ฅ ๐€๐ซ๐ญ๐ข๐œ๐ฅ๐ž:
https://www.heraldopenaccess.us/openaccess/from-energy-wise-regulation-to-regularized-self-vitality-system-2-regularium

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๐†๐ฅ๐ฎ๐ญ๐š๐ฆ๐ข๐œ-๐€๐œ๐ข๐ ๐†๐ซ๐š๐Ÿ๐ญ๐ž๐ ๐‡๐ฒ๐š๐ฅ๐ฎ๐ซ๐จ๐ง๐ข๐œ ๐€๐œ๐ข๐ ๐ˆ๐ง๐ก๐ข๐›๐ข๐ญ๐ฌ ๐ˆ๐ง๐Ÿ๐ฅ๐š๐ฆ๐ฆ๐š๐ญ๐จ๐ซ๐ฒ ๐…๐š๐œ๐ญ๐จ๐ซ๐ฌ ๐ฏ๐ข๐š ๐…๐ข๐›๐ซ๐จ๐›๐ฅ๐š๐ฌ๐ญ ๐š๐ง๐ ๐’๐ค๐ข๐ง ๐Œ๐จ๐๐ž๐ฅ ๐“๐ž๐ฌ๐ญ๐ฌAuthor: Zhe Liu I...
10/24/2024

๐†๐ฅ๐ฎ๐ญ๐š๐ฆ๐ข๐œ-๐€๐œ๐ข๐ ๐†๐ซ๐š๐Ÿ๐ญ๐ž๐ ๐‡๐ฒ๐š๐ฅ๐ฎ๐ซ๐จ๐ง๐ข๐œ ๐€๐œ๐ข๐ ๐ˆ๐ง๐ก๐ข๐›๐ข๐ญ๐ฌ ๐ˆ๐ง๐Ÿ๐ฅ๐š๐ฆ๐ฆ๐š๐ญ๐จ๐ซ๐ฒ ๐…๐š๐œ๐ญ๐จ๐ซ๐ฌ ๐ฏ๐ข๐š ๐…๐ข๐›๐ซ๐จ๐›๐ฅ๐š๐ฌ๐ญ ๐š๐ง๐ ๐’๐ค๐ข๐ง ๐Œ๐จ๐๐ž๐ฅ ๐“๐ž๐ฌ๐ญ๐ฌ

Author: Zhe Liu

In the pursuit of more effective cosmetic ingredients for combating skin inflammation, the recent study, โ€œGlutamic-Acid Grafted Hyaluronic Acid: A New Cosmetic Ingredient to Suppress Inflammatory Factor Expression in Cell and Skin Model Tests,โ€ presents a novel approach. By conjugating Glutamic Acid (Glu) to low-molecular-weight Hyaluronic Acid (HA), the researchers aimed to leverage the anti-inflammatory properties of both compounds for improved skin health outcomes.

The study describes how excessive inflammation can compromise the skin barrier and lead to issues like aging and various skin diseases [1-3]. Interleukins and tumor necrosis factors, specifically IL-1ฮฑ, IL-6, and TNF-ฮฑ, are reported to play pivotal roles in these processes [4-9]. HA, known for its regulatory role on inflammatory factors [10,11], was modified with Glu, an amino acid with reported influence on inflammation [12,13]. This modification aimed to combine the beneficial properties of both substances for enhanced skin care applications.

The synthesis of HA-Glu involved a two-step process adapted from previous works [14,15], leading to the production of HA-Glu with varying degrees of grafting (Figure 1). The anti-inflammatory efficacy was assayed using human dermal fibroblasts and a 3D skin model, comparing the grafted compound against native HA. The results showed that HA-Glu significantly inhibits inflammatory markers IL-1ฮฑ, IL-6, and TNF-ฮฑ more effectively than HA alone.

๐“๐จ ๐‘๐ž๐š๐ ๐…๐ฎ๐ฅ๐ฅ ๐š๐ซ๐ญ๐ข๐œ๐ฅ๐ž:

๐Ÿ‘‰ https://www.heraldopenaccess.us/openaccess/glutamic-acid-grafted-hyaluronic-acid-inhibits-inflammatory-factors-via-fibroblast-and-skin-model-tests

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๐๐ฅ๐š๐œ๐ž๐ง๐ญ๐š๐ฅ ๐Œ๐ž๐ฌ๐ž๐ง๐œ๐ก๐ฒ๐ฆ๐š๐ฅ ๐ƒ๐ฒ๐ฌ๐ฉ๐ฅ๐š๐ฌ๐ข๐š - ๐…๐ซ๐จ๐ฆ ๐ƒ๐ข๐š๐ ๐ง๐จ๐ฌ๐ข๐ฌ ๐ญ๐จ ๐ƒ๐ž๐ฅ๐ข๐ฏ๐ž๐ซ๐ฒAuthor: Petronijevic MPlacental mesenchymal dysplasia is a r...
10/23/2024

๐๐ฅ๐š๐œ๐ž๐ง๐ญ๐š๐ฅ ๐Œ๐ž๐ฌ๐ž๐ง๐œ๐ก๐ฒ๐ฆ๐š๐ฅ ๐ƒ๐ฒ๐ฌ๐ฉ๐ฅ๐š๐ฌ๐ข๐š - ๐…๐ซ๐จ๐ฆ ๐ƒ๐ข๐š๐ ๐ง๐จ๐ฌ๐ข๐ฌ ๐ญ๐จ ๐ƒ๐ž๐ฅ๐ข๐ฏ๐ž๐ซ๐ฒ

Author: Petronijevic M

Placental mesenchymal dysplasia is a rare, benign condition that shows an enlargement of the placenta with multiple vesicles that can resemble a molar pregnancy by ultrasound and gross pathologic examination. Clinical presentation is various, and fetal anomalies and fetal overgrowth can be associated with this condition.

MRI could help differentiate between a complete hydatidiform mole with coexistent fetus. We present a case of a 26-year-old patient, primiparous, with sonographically suspicious hydatidiform mole. In the 16th week of pregnancy, her ฮฒ-HCG levels were normal and alpha-fetoprotein values were elevated. TORCH, Parvo B-19, Lysteria, Brucellosis, and TPH were negative.

Amniocentesis showed normal fetal karyotype, and triploidy, e.g. molar pregnancy was excluded. Chromosomal microarray was also normal. Serial ultrasound exams were performed with normal fetal growth pattern, extremely enlarged placenta, and lower amount of amniotic fluid. MRI showed normal fetal morphology and enlarged, multicystic placenta (AP diameter 99 mm).

The delivery by emergency Caesarean section was conducted at 31 weeks of gestation due to premature rupture of fetal membranes, spontaneous onset of labour, and fetal asphyxia. An alive female fetus was born, length of 39cm, weight of 1160g, and head circumference of 28cm, Apgar score was 6/7. Placental weight was 1312g, the size was 20 ร— 19 ร— 4.5-6cm, with tumour-like formation 12 ร— 8 ร— 1cm resembling an old organised hematoma.

Placental tissue was diffusely but unevenly permeated with vesicles filled with gelatinous content 5-20mm in diameter. Seventy percent of placental parenchyma was formed from devitalised, degeneratively changed and very enlarged chorionic villi with totally attenuated trophoblast. Regarding possible complications of pregnancy, placental mesenchymal dysplasia requires a comprehensive and multidisciplinary approach.

๐‘ป๐’ ๐‘น๐’†๐’‚๐’… ๐‘ญ๐’–๐’๐’ ๐‘จ๐’“๐’•๐’Š๐’„๐’๐’† :
๐Ÿ‘‰ https://www.heraldopenaccess.us/openaccess/placental-mesenchymal-dysplasia-from-diagnosis-to-delivery

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๐‰๐จ๐ฎ๐ซ๐ง๐š๐ฅ ๐จ๐Ÿ ๐‘๐ž๐ฉ๐ซ๐จ๐๐ฎ๐œ๐ญ๐ข๐ฏ๐ž ๐Œ๐ž๐๐ข๐œ๐ข๐ง๐ž, ๐†๐ฒ๐ง๐š๐ž๐œ๐จ๐ฅ๐จ๐ ๐ฒ & ๐Ž๐›๐ฌ๐ญ๐ž๐ญ๐ซ๐ข๐œ๐ฌ ๐ฐ๐ž๐ฅ๐œ๐จ๐ฆ๐ž๐ฌ ๐๐ข๐ซ๐ž๐œ๐ญ ๐ฌ๐ฎ๐›๐ฆ๐ข๐ฌ๐ฌ๐ข๐จ๐ง๐ฌ.
Kindly send us your manuscript to the mail at [email protected]
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๐’๐ž๐ข๐ณ๐ฎ๐ซ๐ž๐ฌ ๐š๐ง๐ ๐„๐ฅ๐ž๐ฏ๐š๐ญ๐ž๐ ๐“๐ซ๐จ๐ฉ๐จ๐ง๐ข๐ง๐ฌ ๐ƒ๐ฎ๐ž ๐ญ๐จ ๐’๐ฒ๐ง๐ญ๐ก๐ž๐ญ๐ข๐œ ๐‚๐š๐ง๐ง๐š๐›๐ข๐ง๐จ๐ข๐๐ฌAuthor: Roy Kondapavuluru, University Of Texas Rio Grande V...
10/22/2024

๐’๐ž๐ข๐ณ๐ฎ๐ซ๐ž๐ฌ ๐š๐ง๐ ๐„๐ฅ๐ž๐ฏ๐š๐ญ๐ž๐ ๐“๐ซ๐จ๐ฉ๐จ๐ง๐ข๐ง๐ฌ ๐ƒ๐ฎ๐ž ๐ญ๐จ ๐’๐ฒ๐ง๐ญ๐ก๐ž๐ญ๐ข๐œ ๐‚๐š๐ง๐ง๐š๐›๐ข๐ง๐จ๐ข๐๐ฌ

Author: Roy Kondapavuluru, University Of Texas Rio Grande Valley, Texas, USA

The use of synthetic cannabinoids has been steadily rising, with an associated increase in reported adverse events. There is limited data on managing these adverse events in adults mainly due to the diagnostic challenges of detecting synthetic cannabinoids compared to traditional ma*****na. This unique case highlights not only the rare clinical presentation of seizures but also the subtle EKG changes and significantly elevated biomarkers, as would be seen in a myocardial infarction secondary to synthetic cannabinoids.

๐ˆ๐ง๐ญ๐ซ๐จ๐๐ฎ๐œ๐ญ๐ข๐จ๐ง
Ma*****na, a readily available drug, can cause long-term adverse effects on overall health, including neurological and cardiovascular events [1]. The National Institute of Drug Abuse has declared ma*****na as โ€œthe most commonly used illicit drug in the US and the third most common cause of drug-related emergency department visits between 2004-2011.โ€ Presentations can include but are not limited to stroke, myocardial infarction, and other conditions. However there have been very few reported cases of young adults and adolescents with seizures [2], and coronary vasospasms in literature, making this case of a young adult lady who presented with altered mental status and seizures, and was found to have subtle EKG changes and elevated troponins secondary to smoking synthetic cannabinoids, particularly unique and intriguing.

๐“๐จ ๐‘๐ž๐š๐ ๐…๐ฎ๐ฅ๐ฅ ๐š๐ซ๐ญ๐ข๐œ๐ฅ๐ž:
๐Ÿ‘‰ https://www.heraldopenaccess.us/openaccess/seizures-and-elevated-troponins-due-to-synthetic-cannabinoids

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๐‘ฑ๐’๐’–๐’“๐’๐’‚๐’ ๐’๐’‡ ๐‘จ๐’…๐’…๐’Š๐’„๐’•๐’Š๐’๐’ & ๐‘จ๐’…๐’…๐’Š๐’„๐’•๐’Š๐’—๐’† ๐‘ซ๐’Š๐’”๐’๐’“๐’…๐’†๐’“๐’” ๐’˜๐’†๐’๐’„๐’๐’Ž๐’†๐’” ๐’…๐’Š๐’“๐’†๐’„๐’• ๐’”๐’–๐’ƒ๐’Ž๐’Š๐’”๐’”๐’Š๐’๐’๐’”.

Kindly send us your manuscript to the mail at [email protected] (or)
[email protected] (or)
[email protected]

| | | *****na | | |

๐“๐ก๐ž ๐๐ฎ๐š๐ฅ๐ข๐ญ๐ฒ ๐‚๐ก๐š๐ซ๐š๐œ๐ญ๐ž๐ซ๐ข๐ฌ๐ญ๐ข๐œ๐ฌ ๐จ๐Ÿ ๐ƒ๐ข๐Ÿ๐Ÿ๐ž๐ซ๐ž๐ง๐ญ ๐…๐ซ๐ฎ๐ข๐ญ ๐‰๐ฎ๐ข๐œ๐ž ๐๐ซ๐š๐ง๐๐ฌ ๐‚๐จ๐ง๐ฌ๐ฎ๐ฆ๐ž๐ ๐ข๐ง ๐Ž๐ฆ๐š๐งAuthor: Mohamed Al-FarsiEvaluation of fruit ...
10/21/2024

๐“๐ก๐ž ๐๐ฎ๐š๐ฅ๐ข๐ญ๐ฒ ๐‚๐ก๐š๐ซ๐š๐œ๐ญ๐ž๐ซ๐ข๐ฌ๐ญ๐ข๐œ๐ฌ ๐จ๐Ÿ ๐ƒ๐ข๐Ÿ๐Ÿ๐ž๐ซ๐ž๐ง๐ญ ๐…๐ซ๐ฎ๐ข๐ญ ๐‰๐ฎ๐ข๐œ๐ž ๐๐ซ๐š๐ง๐๐ฌ ๐‚๐จ๐ง๐ฌ๐ฎ๐ฆ๐ž๐ ๐ข๐ง ๐Ž๐ฆ๐š๐ง

Author: Mohamed Al-Farsi

Evaluation of fruit juice quality is an important parameter in terms of consumer acceptability and international conformity standards. The objectives of this study were to evaluate the quality and sensory attributes of orange, mango, and apple juice brands consumed in Oman and to observe whether they meet the standard of compliance status and consumer satisfaction. Samples from five brands of different fruit juice products (15 samples in total) were collected to investigate the physicochemical characteristics, sensory attributes, consumer preferences, and compliance with label standards. The brands were labelled as (D, E, F, L, and J for orange juices; N, B, I, H, and O for mango juices; and M, C, K, A, and G for apple juices). Results revealed that non-compliance of Brix values in juices were as follows: mango juice brand B, 11.6 and brand O, 11.8; and apple juices brand M, 11.2 and brand K, 10.8. The overall acceptability scores for sensory assessment ranged from 2.3 to 3.7 for orange juices, 1.5 to 4.3 for mango juices, and 1.3 to 3.8 for apple juices, while average consumer preference scores ranged from 2.2 to 3.6 for orange juices, 2.5 to 3.7 for mango juices, and 2.4 to 3.4 for apple juices. All evaluated juice brands were found to be Non-Compliant (NC) with label requirements. This study may assist in improving and implementing legislation of fruit juice products, thereby contributing to the maintenance of a sustainable fruit juice industry through enhanced quality control.

๐ˆ๐ง๐ญ๐ซ๐จ๐๐ฎ๐œ๐ญ๐ข๐จ๐ง
Fruit juices are widely consumed beverages worldwide due to their refreshing taste, nutritional benefits, and convenience. They contain several important health-promoting bioactive that may reduce the risk of various non-communicable diseases. Fruit juices are rich in antioxidants, vitamins C and E, and possess pleasant taste and aroma [1]. The demand for fruit juices has increased rapidly in recent years, leading to the development of numerous commercialized fruit juice products with different formulations and flavour characteristics. The quality of fruit juices is defined by their physical properties, enzymatic, microbiological, and sensory characteristics as well as stability [2]. Evaluation of the physicochemical and sensory properties of these products is important in terms of quality, safety, and consumer acceptance [3]. The fruit juice industry has shown an increased interest in producing healthy, high-quality, minimally processed, and natural products [4], as consumers demand. Therefore, several non-thermal food processing technologies, such as sonication, pulsed electric field, and high-pressure homogenization, have gained considerable attention due to their capacities to keep original freshness and nutritional contents in foods, with minor energy utilization and high sensory acceptability, compared to the conventional heat treatments [1; 4; 5]. Heat treatments can degrade sensitive nutrients and enzymes in juices, leading to a loss of nutritional value and flavour. Non-thermal methods minimize nutrient loss by avoiding the high temperatures associated with traditional pasteurization. This retention of nutrients can result in juices with better taste, colour, and nutritional content [1].

The physicochemical evaluation of fruit juice products involves analysing chemical and physical properties, such as acidity, pH, Total Soluble Solids (TSS), colour, and viscosity. These parameters provide information about the composition, stability, and shelf-life of the products [6]. The acidity of fruit juice is a crucial parameter that determines its taste, microbial stability, and nutritional value [7]. The pH of fruit juice affects its stability and enzymatic reactions, while TSS represents the total amount of dissolved solids in the juice and influences its sweetness and texture [8]. The colour and viscosity of fruit juice products are important sensory attributes that influence consumer acceptance [9].

In addition to the physicochemical properties, the sensory evaluation of fruit juice products involves assessing their taste, aroma, appearance, texture, and overall acceptability [10]. Sensory evaluation is crucial for determining the product's marketability, consumer preference, and final quality [11]. The taste of fruit juice products is affected by their sweetness, sourness, bitterness, and astringency, while the aroma is influenced by their volatile compounds present in the juice [12]. The appearance of fruit juice products, such as colour and clarity, also affects their sensory characteristics. The texture of fruit juice products, such as viscosity and mouthfeel, is important for their sensory characteristics and consumer acceptance [13].

๐“๐จ ๐‘๐ž๐š๐ ๐…๐ฎ๐ฅ๐ฅ ๐€๐ซ๐ญ๐ข๐œ๐ฅ๐ž:

๐Ÿ‘‰https://www.heraldopenaccess.us/openaccess/the-quality-characteristics-of-different-fruit-juice-brands-consumed-in-oman

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๐“๐ก๐ž ๐„๐Ÿ๐Ÿ๐ž๐œ๐ญ๐ข๐ฏ๐ž๐ง๐ž๐ฌ๐ฌ ๐š๐ง๐ ๐’๐š๐Ÿ๐ž๐ญ๐ฒ ๐จ๐Ÿ ๐€๐œ๐ฎ๐ฉ๐จ๐ญ๐จ๐ฆ๐ฒ ๐ข๐ง ๐•๐ข๐ฌ๐ฎ๐š๐ฅ๐ข๐ณ๐š๐ญ๐ข๐จ๐ง ๐“๐ž๐œ๐ก๐ง๐ข๐ช๐ฎ๐ž ๐จ๐ง ๐Š๐ง๐ž๐ž ๐จ๐ฌ๐ญ๐ž๐จ๐š๐ซ๐ญ๐ก๐ซ๐ข๐ญ๐ข๐ฌ: ๐€ ๐’๐ฒ๐ฌ๐ญ๐ž๐ฆ๐š๐ญ๐ข๐œ ๐‘๐ž๐ฏ๐ข๐ž๐ฐ ๐š๐ง๐ ๐Œ๐ž๐ญ...
10/18/2024

๐“๐ก๐ž ๐„๐Ÿ๐Ÿ๐ž๐œ๐ญ๐ข๐ฏ๐ž๐ง๐ž๐ฌ๐ฌ ๐š๐ง๐ ๐’๐š๐Ÿ๐ž๐ญ๐ฒ ๐จ๐Ÿ ๐€๐œ๐ฎ๐ฉ๐จ๐ญ๐จ๐ฆ๐ฒ ๐ข๐ง ๐•๐ข๐ฌ๐ฎ๐š๐ฅ๐ข๐ณ๐š๐ญ๐ข๐จ๐ง ๐“๐ž๐œ๐ก๐ง๐ข๐ช๐ฎ๐ž ๐จ๐ง ๐Š๐ง๐ž๐ž ๐จ๐ฌ๐ญ๐ž๐จ๐š๐ซ๐ญ๐ก๐ซ๐ข๐ญ๐ข๐ฌ: ๐€ ๐’๐ฒ๐ฌ๐ญ๐ž๐ฆ๐š๐ญ๐ข๐œ ๐‘๐ž๐ฏ๐ข๐ž๐ฐ ๐š๐ง๐ ๐Œ๐ž๐ญ๐š-๐š๐ง๐š๐ฅ๐ฒ๐ฌ๐ข๐ฌ

Author: Zhu Xiangyu

๐Ž๐›๐ฃ๐ž๐œ๐ญ๐ข๐ฏ๐ž: This study is to assess the efficacy and safety of acupotomy visualization in Knee Osteoarthritis (KOA).

๐Œ๐ž๐ญ๐ก๐จ๐๐ฌ: We searched for relevant studies in PubMed, the Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), the Wanfang Data, and the Chinese Scientific Journal Database (VIP) from their inception to October 2023. Randomized controlled trials on the effectiveness of acupotomy visualization for the treatment of KOA were included. Two reviewers screened each literature and extracted data independently according to Cochrane Reviewsโ€™ Handbook (5.1). Meta-analysis was conducted using StataSE-64. The continuous data were presented as the mean difference (MD) with 95% confidence intervals (CI), while dichotomous data were described in terms of relative risk (RR) or odds ratio (OR) with 95% CI.

๐‘๐ž๐ฌ๐ฎ๐ฅ๐ญ๐ฌ: We identified 11 studies involving 834 patients. The result indicated significant improvement of KOA following acupotomy [clinical effectiveness: OR =5.21, 95% CI: 3.04~8.92, P < 0.001; pain score: MD =-0.67, 95% CI: -0.86~-0.48, P < 0.001; ROM: SMD = 0.99, 95% CI: 0.711.26, P < 0.001]. In addition, the acupotomy visualization groups had fewer adverse events than the control groups [RR=0.19, 95%CI: 0.06~0.57, P=0.003 < 0.05].

๐‚๐จ๐ง๐œ๐ฅ๐ฎ๐ฌ๐ข๐จ๐ง: Acupotomy visualization is a safe and effective treatment for KOA. However, due to the methodological deficiencies of the included studies, well-designed randomized controlled trials are required to further confirm the findings.

๐“๐จ ๐‘๐ž๐š๐ ๐…๐ฎ๐ฅ๐ฅ ๐€๐ซ๐ญ๐ข๐œ๐ฅ๐ž:
๐Ÿ‘‰ https://www.heraldopenaccess.us/openaccess/the-effectiveness-and-safety-of-acupotomy-in-visualization-technique-on-knee-osteoarthritis-a-systematic-review-and-meta-analysis

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๐€๐ซ๐ญ๐ข๐Ÿ๐ข๐œ๐ข๐š๐ฅ ๐ˆ๐ง๐ญ๐ž๐ฅ๐ฅ๐ข๐ ๐ž๐ง๐œ๐ž ๐€๐ฉ๐ฉ๐ฅ๐ข๐œ๐š๐ญ๐ข๐จ๐ง๐ฌ ๐Ÿ๐จ๐ซ ๐ƒ๐ข๐š๐ ๐ง๐จ๐ฌ๐ข๐ฌ ๐š๐ง๐ ๐ƒ๐ข๐Ÿ๐Ÿ๐ž๐ซ๐ž๐ง๐ญ๐ข๐š๐ญ๐ข๐จ๐ง ๐จ๐Ÿ ๐•๐ž๐ฌ๐ญ๐ข๐›๐ฎ๐ฅ๐š๐ซ ๐ƒ๐ข๐ฌ๐จ๐ซ๐๐ž๐ซ๐ฌAuthor: Ingrid Raponi๐€๐›๐ฌ๐ญ๐ซ...
10/17/2024

๐€๐ซ๐ญ๐ข๐Ÿ๐ข๐œ๐ข๐š๐ฅ ๐ˆ๐ง๐ญ๐ž๐ฅ๐ฅ๐ข๐ ๐ž๐ง๐œ๐ž ๐€๐ฉ๐ฉ๐ฅ๐ข๐œ๐š๐ญ๐ข๐จ๐ง๐ฌ ๐Ÿ๐จ๐ซ ๐ƒ๐ข๐š๐ ๐ง๐จ๐ฌ๐ข๐ฌ ๐š๐ง๐ ๐ƒ๐ข๐Ÿ๐Ÿ๐ž๐ซ๐ž๐ง๐ญ๐ข๐š๐ญ๐ข๐จ๐ง ๐จ๐Ÿ ๐•๐ž๐ฌ๐ญ๐ข๐›๐ฎ๐ฅ๐š๐ซ ๐ƒ๐ข๐ฌ๐จ๐ซ๐๐ž๐ซ๐ฌ

Author: Ingrid Raponi

๐€๐›๐ฌ๐ญ๐ซ๐š๐œ๐ญ

๐Ž๐›๐ฃ๐ž๐œ๐ญ๐ข๐ฏ๐ž: The objective of this work lies in leveraging recent advances in Artificial Intelligence to enhance the diagnosis and treatment of vestibular disorders, crucially improving patients' conditions and their overall quality of life.

๐Œ๐ž๐ญ๐ก๐จ๐๐ฌ: In this study, a Machine Learning algorithm was used to differentiate between four vestibular disorders considering an anamnestic questionnaire administered by the practitioner.

๐‘๐ž๐ฌ๐ฎ๐ฅ๐ญ๐ฌ: The high diagnosis accuracy achieved by our algorithm shows its reliability in treating patients with vestibular disorders. For instance, our algorithm could help general practitioners optimize the diagnosis and management of patients with symptoms such as vertigo.

๐‚๐จ๐ง๐œ๐ฅ๐ฎ๐ฌ๐ข๐จ๐ง: The results of this work highlight the potential of using machine learning algorithms to support the diagnosis of vestibular disorders, improving patientsโ€™ management and, eventually, their quality of life.

๐“๐จ ๐‘๐ž๐š๐ ๐…๐ฎ๐ฅ๐ฅ ๐€๐ซ๐ญ๐ข๐œ๐ฅ๐ž:
๐Ÿ”— https://www.heraldopenaccess.us/openaccess/artificial-intelligence-applications-for-diagnosis-and-differentiation-of-vestibular-disorders

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๐€ ๐๐ก๐š๐ซ๐ฆ๐š๐œ๐จ๐ฏ๐ข๐ ๐ข๐ฅ๐š๐ง๐œ๐ž ๐’๐ญ๐ฎ๐๐ฒ ๐จ๐Ÿ ๐ญ๐ก๐ž ๐€๐ฌ๐ฌ๐จ๐œ๐ข๐š๐ญ๐ข๐จ๐ง ๐›๐ž๐ญ๐ฐ๐ž๐ž๐ง ๐€๐ง๐ญ๐ข๐ง๐ž๐จ๐ฉ๐ฅ๐š๐ฌ๐ญ๐ข๐œ ๐€๐ ๐ž๐ง๐ญ๐ฌ ๐š๐ง๐ ๐๐ž๐ฎ๐ญ๐ซ๐จ๐ฉ๐ž๐ง๐ข๐š ๐€๐๐ฏ๐ž๐ซ๐ฌ๐ž ๐„๐ฏ๐ž๐ง๐ญ๐ฌ ๐๐š๐ฌ๐ž๐ ๐จ๐ง ๐…๐จ๐จ๐ ...
10/16/2024

๐€ ๐๐ก๐š๐ซ๐ฆ๐š๐œ๐จ๐ฏ๐ข๐ ๐ข๐ฅ๐š๐ง๐œ๐ž ๐’๐ญ๐ฎ๐๐ฒ ๐จ๐Ÿ ๐ญ๐ก๐ž ๐€๐ฌ๐ฌ๐จ๐œ๐ข๐š๐ญ๐ข๐จ๐ง ๐›๐ž๐ญ๐ฐ๐ž๐ž๐ง ๐€๐ง๐ญ๐ข๐ง๐ž๐จ๐ฉ๐ฅ๐š๐ฌ๐ญ๐ข๐œ ๐€๐ ๐ž๐ง๐ญ๐ฌ ๐š๐ง๐ ๐๐ž๐ฎ๐ญ๐ซ๐จ๐ฉ๐ž๐ง๐ข๐š ๐€๐๐ฏ๐ž๐ซ๐ฌ๐ž ๐„๐ฏ๐ž๐ง๐ญ๐ฌ ๐๐š๐ฌ๐ž๐ ๐จ๐ง ๐…๐จ๐จ๐ ๐š๐ง๐ ๐ƒ๐ซ๐ฎ๐  ๐€๐๐ฆ๐ข๐ง๐ข๐ฌ๐ญ๐ซ๐š๐ญ๐ข๐จ๐ง ๐€๐๐ฏ๐ž๐ซ๐ฌ๐ž ๐„๐ฏ๐ž๐ง๐ญ ๐‘๐ž๐ฉ๐จ๐ซ๐ญ๐ข๐ง๐  ๐’๐ฒ๐ฌ๐ญ๐ž๐ฆ ๐ƒ๐š๐ญ๐š

Author: Rong Chen

๐€๐›๐ฌ๐ญ๐ซ๐š๐œ๐ญ
Neutropenia is one of the most common adverse events associated with antineoplastic agents. However, comprehensive real-world studies on the relationship between antineoplastic agents and neutropenia are relatively scarce. The objective of this study was to analyze the Adverse Events (AEs) of antineoplastic agents related to neutropenia, in order to provide a reference for the safe use of antineoplastic agents in clinical practice. We applied the Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi-Item Gamma Poisson Shrinker (MGPS) models to assess the signal of antineoplastic-related adverse events due to antineoplastic agents from 2004 Q1 to 2024 Q1. The top 64 antineoplastic agents associated with neutropenia were identified. Among these, the three drugs with the highest ROR were Eribulin (ROR=45.72), Cytarabine and Daunorubicin (ROR=34.09), and Isatuximab (ROR=25.35). Excluding patients with missing s*x data (11,858 patients, 14.2%), the number of female patients (40,405, 48.6%) was higher than that of male patients (31,047, 37.2%). A total of 21,135 patients (18.1%) experienced severe clinical outcomes including death or life-threatening conditions. Weibull shape parameter analysis revealed that most antineoplastic agents that cause neutropenia were characterized by early failure. Our study indicates that neutropenia should be closely monitored in the early stage of chemotherapy, and provides a reference for the rational use of antineoplastic agents in clinical practice.

๐‘ป๐’ ๐‘น๐’†๐’‚๐’… ๐‘ญ๐’–๐’๐’ ๐‘จ๐’“๐’•๐’Š๐’„๐’๐’†:
๐Ÿ‘‰ https://www.heraldopenaccess.us/openaccess/a-pharmacovigilance-study-of-the-association-between-antineoplastic-agents-and-neutropenia-adverse-events-based-on-food-and-drug-administration-adverse-event-reporting-system-data

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Kindly send us your manuscript to the mail at ๐ญ๐จ๐ฑ๐ข๐œ๐จ๐ฅ๐จ๐ ๐ฒ@๐ก๐ž๐ซ๐š๐ฅ๐๐ฌ๐จ๐ฉ๐ž๐ง๐š๐œ๐œ๐ž๐ฌ๐ฌ.๐ฎ๐ฌ
(๐จ๐ซ)
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๐๐„๐”๐Ÿ ๐ˆ๐ง๐ก๐ข๐›๐ข๐ญ๐จ๐ซ๐ฌ ๐š๐ง๐ ๐‘๐ข๐ฌ๐ค ๐จ๐Ÿ ๐Œ๐š๐ฅ๐ข๐ ๐ง๐š๐ง๐œ๐ฒ: ๐Œ๐ž๐ง๐๐ž๐ฅ๐ข๐š๐ง ๐‘๐š๐ง๐๐จ๐ฆ๐ข๐ณ๐š๐ญ๐ข๐จ๐ง ๐ˆ๐ง๐ฌ๐ข๐ ๐ก๐ญ๐ฌ ๐ข๐ง ๐ƒ๐ซ๐ฎ๐  ๐“๐š๐ซ๐ ๐ž๐ญ๐ข๐ง๐  ๐’๐ญ๐ฎ๐๐ข๐ž๐ฌAuthor: Zhiwei ChenBac...
10/14/2024

๐๐„๐”๐Ÿ ๐ˆ๐ง๐ก๐ข๐›๐ข๐ญ๐จ๐ซ๐ฌ ๐š๐ง๐ ๐‘๐ข๐ฌ๐ค ๐จ๐Ÿ ๐Œ๐š๐ฅ๐ข๐ ๐ง๐š๐ง๐œ๐ฒ: ๐Œ๐ž๐ง๐๐ž๐ฅ๐ข๐š๐ง ๐‘๐š๐ง๐๐จ๐ฆ๐ข๐ณ๐š๐ญ๐ข๐จ๐ง ๐ˆ๐ง๐ฌ๐ข๐ ๐ก๐ญ๐ฌ ๐ข๐ง ๐ƒ๐ซ๐ฎ๐  ๐“๐š๐ซ๐ ๐ž๐ญ๐ข๐ง๐  ๐’๐ญ๐ฎ๐๐ข๐ž๐ฌ

Author: Zhiwei Chen

Background: Rheumatoid Arthritis (RA) is associated with an increased risk of cancer, and celecoxib is a commonly used drug for treating both RA and cancer. Celecoxib, a NEU1 inhibitor, exerts its anti-cancer effects by modulating NEU1 expression. This study employs Mendelian randomization to explore the therapeutic potential of NEU1 in cancer treatment.

Methods: We collected Single Nucleotide Polymorphisms (SNPs) of NEU1 from published genome-wide association study data and conducted drug-target Mendelian Randomization (MR) analysis to examine the causal relationship between NEU1 inhibitors and various malignant tumors. The main outcomes included lung cancer, Gastric Cancer (GC), Esophageal Cancer (EC), Colorectal Cancer (CRC), Breast Cancer (BC), Pancreatic Cancer (PC) and Cervical Cancer (CC). MR methods (Egger, IVW, MR-PRESSO) and colocalization analysis were employed to analyze these seven types of cancer.

Results: NEU1 inhibition significantly reduced the risk of gastric cancer (OR [95% CI] = 0.55 [0.36 to 0.84], p < 0.001) and lung cancer (OR [95% CI] = 0.90 [0.83 to 0.96], p < 0.001). Initial data showed a reduced risk of cervical cancer (OR [95% CI] = 0.61 [0.49 to 0.78], p < 0.001), while in the repeat analysis, the result was OR = 0.44 with p = 3.34. Colocalization analysis confirmed the reduction in cervical cancer risk with NEU1 inhibition.

Conclusion: The Neu1 inhibitors significantly reduced the risk of gastric cancer, lung cancer, and cervical cancer.

To Read Full Article:
๐Ÿ‘‰https://www.heraldopenaccess.us/openaccess/neu1-inhibitors-and-risk-of-malignancy-mendelian-randomization-insights-in-drug-targeting-studies

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๐„๐ฑ๐ฉ๐ฅ๐จ๐ซ๐ข๐ง๐  ๐ญ๐ก๐ž ๐ซ๐ž๐ฅ๐š๐ญ๐ข๐จ๐ง๐ฌ๐ก๐ข๐ฉ ๐›๐ž๐ญ๐ฐ๐ž๐ž๐ง ๐ฌ๐จ๐œ๐ข๐š๐ฅ ๐ง๐ž๐ญ๐ฐ๐จ๐ซ๐ค๐ข๐ง๐  ๐š๐๐๐ข๐œ๐ญ๐ข๐จ๐ง, ๐…๐ž๐š๐ซ ๐จ๐Ÿ ๐ฆ๐ข๐ฌ๐ฌ๐ข๐ง๐  ๐จ๐ฎ๐ญ, ๐ฅ๐จ๐ง๐ž๐ฅ๐ข๐ง๐ž๐ฌ๐ฌ ๐š๐ง๐ ๐“๐ข๐ค๐“๐จ๐ค ๐ฎ๐ฌ๐ž ๐š๐ฆ๐จ๐ง๐  ๐€๐๐จ...
10/02/2024

๐„๐ฑ๐ฉ๐ฅ๐จ๐ซ๐ข๐ง๐  ๐ญ๐ก๐ž ๐ซ๐ž๐ฅ๐š๐ญ๐ข๐จ๐ง๐ฌ๐ก๐ข๐ฉ ๐›๐ž๐ญ๐ฐ๐ž๐ž๐ง ๐ฌ๐จ๐œ๐ข๐š๐ฅ ๐ง๐ž๐ญ๐ฐ๐จ๐ซ๐ค๐ข๐ง๐  ๐š๐๐๐ข๐œ๐ญ๐ข๐จ๐ง, ๐…๐ž๐š๐ซ ๐จ๐Ÿ ๐ฆ๐ข๐ฌ๐ฌ๐ข๐ง๐  ๐จ๐ฎ๐ญ, ๐ฅ๐จ๐ง๐ž๐ฅ๐ข๐ง๐ž๐ฌ๐ฌ ๐š๐ง๐ ๐“๐ข๐ค๐“๐จ๐ค ๐ฎ๐ฌ๐ž ๐š๐ฆ๐จ๐ง๐  ๐€๐๐จ๐ฅ๐ž๐ฌ๐œ๐ž๐ง๐ญ๐ฌ

Author: Zinaida Adelhardt

๐€๐›๐ฌ๐ญ๐ซ๐š๐œ๐ญ
With the increasing popularity of social media among adolescents, understanding social networking addiction and its psychological predictors has become extremely important. This study explores the relationships between social networking addiction, Fear of Missing Out (FOMO), loneliness and TikTok usage among adolescents. Data were collected from 143 teenagers (M = 14.97, SD = 0.769; 58.7% female) from 16 out of 18 federal states in Germany, using the Social Networking Addiction Scale (SNAS), the Fear of Missing Out (FOMO) scale and the Revised UCLA Loneliness Scale (UCLA-LS). Regression analyses, with the overall model fit of Rยฒ = 0.259, revealed that both FOMO (ฮฒ = 0.328, p < 0.001, 95% CI: 0.384 to 1.049) and loneliness (ฮฒ = 0.223, p = 0.004, 95% CI: 0.078 to 0.399) were significant predictors of social networking addiction. TikTok use was also positively related to social networking addiction (ฮฒ = 0.187, p = 0.014, 95% CI: 0.232 to 2.044), though it showed a wider confidence interval. Gender was not a significant predictor (ฮฒ = 0.013, p = 0.859). Further analysis of SNAS dimensions revealed significant correlations with loneliness and FOMO across all dimensions - salience, mood modification, tolerance, withdrawal, conflict and relapse. TikTok was positive correlated with overall SNAS (r = 0.263, p < 0.01) and its three dimensions: salience (r = 0.270, p < 0.01), mood modification (r = 0.317, p < 0.01), and conflict (r = 0.224, p < 0.01). Additionally, TikTok use had a weak but significant correlation with FOMO (r = 0.179, p < 0.05), but no significant correlation with loneliness. These findings suggest that FOMO and loneliness are significant psychological predictors of social networking addiction, and TikTok use also contributes to addiction levels. Understanding these predictors is essential for addressing social networking addiction among adolescents and safeguarding their well-being.

๐ˆ๐ง๐ญ๐ซ๐จ๐๐ฎ๐œ๐ญ๐ข๐จ๐ง
The rise of social media has significantly changed the way adolescents interact, communicate and spend their leisure time. Platforms like TikTok have become important in many teenagersโ€™ daily lives, offering an endless stream of engaging content, diverse entertainment, and extensive social interaction opportunities. These digital innovations have significantly influenced the way how young people interact with their peers and engage with the world around them. Despite the numerous benefits of social media - such as continuous connectivity, social networking opportunities, diverse entertainment options, and opportunities for self-presentation - they also pose significant challenges. One major concern is social media addiction. This phenomenon, characterized by excessive and compulsive use of social media, can negatively impact an individual's daily functioning and both psychological and physical well-being. Andreassen et al. [1] identified key symptoms of social media addiction, including mood modification, salience, tolerance, withdrawal, conflict and relapse. While the concept of social media addiction normally refers to the compulsive use across all types of social media platforms (e.g. video-sharing platforms like YouTube, photo-sharing services like Instagram, or microblogging applications like Twitter), social networking addiction is a subset of social media addiction that specifically refers to excessive use of Social Networking Sites (SNS) designed primarily for social interaction, such as Facebook or Twitter.

Research involving over 150,000 adolescents in 29 countries indicates that problematic social media use is associated with lower well-being. Specifically, symptoms of social media addiction are linked with lower mental, academic and social well-being [2]. Adolescents due to their developmental need for peer validation and social interaction are particularly vulnerable to social media and SNS addiction. However, findings on the impact of different social media use patterns on well- and ill-being are mixed, with variations based on the nature (active vs. passive) and duration of use [3]. Addictive behaviours on SNS often revolve around the social aspect of these platforms, such as frequently checking notifications and likes, posting and reading updates, commenting on others' posts, and engaging with friends or followers. This perceived need to be constantly connected can lead to compulsive behaviors, with severe cases exhibiting symptoms and consequences similar to substance-related addictions. This compulsive engagement in online social activities is often driven by the constant need for validation, social approval, and interaction with peers. Kuss and Griffiths [4] highlight that the Fear of Missing Out (FOMO) significantly contributes to the addictive nature of SNS, with potential overlaps with smartphone addiction

๐“๐จ ๐‘๐ž๐š๐ ๐…๐ฎ๐ฅ๐ฅ ๐€๐ซ๐ญ๐ข๐œ๐ฅ๐ž:

๐Ÿ”—https://t.ly/vtK-f

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๐‰๐จ๐ฎ๐ซ๐ง๐š๐ฅ ๐จ๐Ÿ ๐€๐๐๐ข๐œ๐ญ๐ข๐จ๐ง & ๐€๐๐๐ข๐œ๐ญ๐ข๐ฏ๐ž ๐ƒ๐ข๐ฌ๐จ๐ซ๐๐ž๐ซ๐ฌ will be at the forefront to publish unparalleled knowledge on addiction that ...
09/30/2024

๐‰๐จ๐ฎ๐ซ๐ง๐š๐ฅ ๐จ๐Ÿ ๐€๐๐๐ข๐œ๐ญ๐ข๐จ๐ง & ๐€๐๐๐ข๐œ๐ญ๐ข๐ฏ๐ž ๐ƒ๐ข๐ฌ๐จ๐ซ๐๐ž๐ซ๐ฌ will be at the forefront to publish unparalleled knowledge on addiction that vanguards the treatment of trauma and addiction.

๐Ÿ‘‰https://t.ly/XN_KJ

Journal of Addiction & Addictive Disorders welcomes direct submissions. Kindly send us your to the mail at [email protected] or [email protected]

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Journal of Gerontology and Geriatric Medicine covers different aspects of Aging Demographics, Biogerontology, Aging Proc...
09/30/2024

Journal of Gerontology and Geriatric Medicine covers different aspects of Aging Demographics, Biogerontology, Aging Process, Geroscience, Dementia, Aging Population, Biological Theories of Aging, Genetics Factors, Social Geronotology, Adult Gerontology, Gerontechnology, Psychological Gerontology

https://t.ly/oq-lN

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