International Journal of Cancer

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International Journal of Cancer

The world of cutting-edge scientific cancer research at your fingertips! Impact Factor 2020: 7.396
(1)

14/02/2023

NOW ONLINE

New study demonstrates the accuracy of evaluation in uterine aspirates from patients using a droplet-digital PCR assay that allows comprehensive tumor genotyping without the need for invasive procedures

🔓OPEN ACCESS
➡https://doi.org/10.1002/ijc.34435

The analysis of mismatch repair proteins in solid tumor tissue is the current standard of care for microsatellite instability (MSI) characterization in endometrial cancer. Our study demonstrates the accuracy and advantages of MSI analysis by droplet-digital PCR in uterine aspirates and plasma samples from endometrial cancer patients. The new approach allows comprehensive tumor genotyping without the need for invasive procedures and improves the rate of MSI detection. The assay also has the capacity of monitoring tumor evolution in both localized and metastatic disease by assessing MSI markers. The approach could be easily implemented into the clinic as a follow-up tool.

09/02/2023

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Study led by Florian Wegwitz and Frauke Alves presents the role of AXL receptor in of basal-like suggesting AXL as a potential therapeutic target.

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➡https://doi.org/10.1002/ijc.34429

Basal-like breast cancer (BLBC) is the most aggressive breast cancer subtype, and it often develops resistance to chemotherapy. Here, the authors used high-throughput mRNA sequencing to identify transcriptional changes that allowed the tumor cells to withstand chemotherapy. After only one round of combination chemotherapy (Cyclophosphamide, Adriamycin and 5-Fluorouracil) the tumor cells had begun a massive gene expression reprogramming, becoming more like cancer stem cells by activating Axl and its ligand Pros1. They also showed that inhibition of AXL made the cells susceptible to cytotoxic treatment in vitro, suggesting AXL may be a potential therapeutic target.

07/02/2023

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Transcriptomic profiling identified 3 molecular subgroups of , including two MCPyV-positive MCC subgroups that differed in prognosis, tumor size & expression of genes associated with epidermal structures and activities

🔓OPEN ACCESS
➡️https://doi.org/10.1002/ijc.34425

Merkel cell carcinoma (MCC), a rare and highly aggressive malignancy, differs in gene expression patterns from tumor to tumor. Deeper understanding of these patterns could offer insight into the elusive cellular origin of MCC. Here, transcriptomic profiling identified three molecular subgroups of MCC, including two Merkel cell polyomavirus (MCPyV)-positive MCC subgroups that differed in prognosis, tumor size and expression of genes associated with epidermal structures and activities. The latter potentially reflects both epidermal and nonepidermal origins of MCPyV-positive MCC. Meanwhile, MCPyV-negative MCC exhibited elevated expression of genes related to developmental processes and reduced expression of genes associated with neuroendocrine functions.

04/02/2023

| 📌Virtual issue https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0215.world-cancer-day2023

New study aims to propose a holistic and culturally adapted framework to improve services and outcomes among in Colombia

🔓FREE until 28.02!
➡https://doi.org/10.1002/ijc.34410

UICC - Union for International Cancer Control

03/02/2023

| 📌Virtual issue https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0215.world-cancer-day2023

Survival among patients in Iran tends to be lower compared to , suggesting a need for better early-detection programs & increased access to high quality care.

🔓FREE until 28.02!
➡https://doi.org/10.1002/ijc.34224

UICC - Union for International Cancer Control

02/02/2023

| 📌Virtual issue https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0215.world-cancer-day2023

Disparities found in incidence, diagnosis, treatment & mortality of between Asian Americans & other racial groups, as well as within subgroups

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➡https://doi.org/10.1002/ijc.34154

UICC - Union for International Cancer Control

01/02/2023

| 📌Virtual issue https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0215.world-cancer-day2023

Men with and/or living in deprived areas had the heaviest burdens of and incurable disease at diagnosis

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➡https://doi.org/10.1002/ijc.33993

UICC - Union for International Cancer Control

31/01/2023

| 📌Virtual Issue https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0215.world-cancer-day2023

Aggravating impact of the COVID-19 pandemic on already existing health care disparities: people with were less frequently seen in clinic during the first pandemic year

🔓➡https://doi.org/10.1002/ijc.33960

UICC - Union for International Cancer Control

30/01/2023

| 📌Virtual issue https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0215.world-cancer-day2023

Incidence rates of have increased in pointing to the need for improving ovarian cancer care in Africa

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➡https://doi.org/10.1002/ijc.34335

UICC - Union for International Cancer Control

27/01/2023

| 📌Virtual issue https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0215.world-cancer-day2023

90% of women in this study experienced pain during , however, nearly all women treated would recommend the treatment to others

🔓FREE to read until 28.02!
➡https://doi.org/10.1002/ijc.34369

UICC - Union for International Cancer Control

26/01/2023

| 📌Virtual Issue https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0215.world-cancer-day2023

Study revealed in treatment for **alcancer: women less often underwent metastatic surgery & experienced slightly impaired survival compared with men

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➡https://doi.org/10.1002/ijc.34255

UICC - Union for International Cancer Control

25/01/2023

| 📌Virtual issue https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0215.world-cancer-day2023

Disparity in survival between Black & White women is associated with lifestyle, education, diabetes, postmenopausal hormone use & tumor characteristics.

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➡https://doi.org/10.1002/ijc.34141

UICC - Union for International Cancer Control

24/01/2023

| 📌Virtual issue https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1097-0215.world-cancer-day2023

benefited from personalized care and felt less isolated after using a platform

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➡https://doi.org/10.1002/ijc.34196

UICC - Union for International Cancer Control

19/01/2023

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M. D΄Incalci and collaborators attempted to profile the entire repertoire of isoforms across the different histological subtypes that characterize Stage I epithelial

🔓OPEN ACCESS
➡https://doi.org/10.1002/ijc.34408

Little is known about the molecular characteristics that distinguish the subtypes of Stage I ovarian cancer. The expression profile of microRNA (miRNA) can be used to distinguish certain subtypes and also help predict survival. Here, the authors cataloged the array of miRNA variants, called isomiRs, expressed in a cohort of Stage I epithelial ovarian cancers and investigated their biological role in tumor growth and progression. Different tumor subtypes could be distinguished by the collection of isomiRs they expressed, and many of these isomiRs result from copy number variations and changes in transcription factor activity, suggesting a role in tumor evolution.

18/01/2023

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New study proposes a novel test that is based on a signature in cervical samples and that can identify women both with, and at risk, for .

🔓OPEN ACCESS
➡https://doi.org/10.1002/ijc.34406

The endometrial cancer incidence is rising, and imaging-based screening is often not suitably accurate for endometrial cancers. Here, the authors show that a new DNA methylation signature (Women's cancer risk IDentification-Endometrial Cancer, or WID-EC) can both detect the presence and predict the risk of endometrial cancer. Together with three other recently-reported methylation indices that detect breast, ovarian, and cervical cancers (WID-BC, WID-OC, and WID-CIN), WID-EC completes a list of signatures that can detect/predict all four women-specific cancers using a single cervical sample and the same technology platform for methylation array-based tests.

17/01/2023

📢 !

Our latest virtual issue will be launched this week.

This year's theme is celebrating progress that enables more people to seek & receive the care they need & deserve.

All papers will be FREE until the end of February!

12/01/2023

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Albin Sandelin, Stine Falsig Pedersen et al. found that cancer cells adapted to exhibit increased metabolic flexibility, peroxisome- and mitochondria content, and lipid metabolism driven, at least in part, by increased activity

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➡https://doi.org/10.1002/ijc.34404

The microenvironment of solid tumors contains highly acidic niches proposed to favor cancer aggressiveness, but the mechanisms involved are not understood. Here we show that cancer cells adapted to tumor acidosis exhibit increased metabolic flexibility, peroxisome- and mitochondria content, and lipid metabolism. We demonstrate that these changes are driven at least in part by increased PPARα activity. Importantly, this renders acid-adapted cancer cells sensitive to PPARα inhibition, pointing to a therapeutic relevance of targeting PPARα.

10/01/2023

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Anne Kuijer and collaborators suggest in their new study that early adoption to new within a multidisciplinary team results in a more reticent attitude toward treatment

🔓OPEN ACCESS
➡https://doi.org/10.1002/ijc.34400

Novel treatment insights and adjusted guidelines have propagated a de-escalating treatment approach in breast cancer. However, little is known about the factors associated with early or late adoption of less aggressive strategies. This nationwide prospective study assesses inequalities in the omission of completion axillary lymph node dissection (cALND) in sentinel lymph node-positive breast cancer patients. Besides known patient and tumor characteristics, treatment in an academic or highly innovative hospital lowers the chance of receiving cALND. The findings call for further research on the implementation of innovation in clinical practice to help reduce national inequalities in breast cancer care.

05/01/2023

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and collaborators show that methylation-based liquid biopsy can predict outcomes and facilitate patient selection in **alcancer

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➡https://doi.org/10.1002/ijc.34364

The treatment of locally advanced re**al cancer is a rapidly evolving field, involves multidisciplinary decision-making, and has no predictive biomarkers for optimal treatment selection. Here, we show that cell-free DNA from colore**al cells can be identified in patients with re**al cancer, using tissue-specific methylation markers. Furthermore, cell-free DNA levels and dynamics are correlated with individuals' outcomes in patients undergoing neoadjuvant chemoradiation for locally advanced re**al cancer.

04/01/2023

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Review by b. Koopmann et al. evaluated the impact of screening on life expectancy and found that although detrimental in general population, in high-risk populations may increase life expectancy.

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➡https://doi.org/10.1002/ijc.34379

03/01/2023

🔥📢Read the new study led by our Editor-in-Chief C. Plass German Cancer Research Center (DKFZ) & R. Scherz-Shourval Weizmann Institute of Science on the epigenetic reprogramming of and their landscape

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➡https://doi.org/10.1002/ijc.34364

, ,

In many solid cancers, tumor-associated macrophages (TAMs) congregate in the microenvironment around the tumor. These TAMs have distinct gene expression profiles and help the tumor survive and grow. Here, the authors investigated the differences between TAMs from a mouse model of triple-negative breast cancer and mammary gland macrophages as well as monocytes from healthy mice. They show for the first time that cancer cells alter DNA methylation patterns in macrophages. These alterations, they found, affected transcription factors and signaling pathways associated with breast cancer progression and prognosis.

23/12/2022

✨We wish to all of you and your families a period and we hope that 2023 will bring you health and happiness!

This year our Editorial Office will remain open during the holiday season.🎄

22/12/2022

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New shows the highly ethnic-specific nature of Asian variants, their & provides protein structure-based evidence on their deleteriousness

🔓OPEN ACCESS
➡https://doi.org/10.1002/ijc.34359

, ,

Pathogenic variation in BRCA increases the risk of breast and ovarian cancer. However, BRCA variation in the Asian population remains poorly characterized. This systematic analysis identified 7587 BRCA variants from 685 592 Asian individuals in 40 Asian regions, including 1762 clinically actionable pathogenic variants, and revealed the highly ethnic-specific nature of Asian BRCA variation. Moreover, the authors provide archeological evidence for the evolutionary origin and arising time of Asian BRCA variation and protein structure-based evidence for the enrichment of deleterious variants in the abundant unclassified BRCA variants. The data provide a rich resource to guide clinical applications in the Asian population.

20/12/2022

✨NOW ONLINE🔝

Study led by T. Bund, E.-M. de Villiers and H. zur Hausen identified vesicular structures of a novel group of infectious pathogens of bovine origin in colore**al, lung and pancreatic cancer.

🔓OPEN ACCESS
➡️https://doi.org/10.1002/ijc.34374

BMMF isolates constitute a novel group of infectious pathogens of which the detailed structure had not yet been identified. Expression of a BMMF Rep protein was previously demonstrated in peritumour mucosa of colore**al cancer (CRC) using immunohistochemistry. In this study, the authors identified structurally dense, vesicular targets (size of approximately 50-200 nm) labeled with gold particles attached to Rep-antibody both in pre-embedding and cryo immuno electron microscopy. The pleomorphic, vesicular structures were identified in CRC, lung and pancreatic cancer and open new avenues for diagnosis, preventive and therapeutic intervention.

15/12/2022

NOW ONLINE

Albin Sandelin, Stine F. Pedersen & collaborators suggest that interplay between , composition and driver mutations strongly influences

🔓OPEN ACCESS
➡https://doi.https://doi. /10.1002/ijc.34367

, ,

Pancreatic ductal adenocarcinoma (PDAC) is characterized by specific driver mutations and by the presence of extracellular acidosis within a dense, fibrotic, extracellular matrix (ECM). While these features are independently linked to increased PDAC invasiveness, whether genotype impacts the pancreatic tumor microenvironment remains unclear. Our study shows that three-dimensional and anchorage-independent PDAC cell growth and PDAC progression are enhanced by acid adaptation, specifically when normal ECM pH is reestablished, as occurs during vascularization and metastasis. The findings suggest that interplay between acidosis, ECM composition and driver mutations strongly influences PDAC aggressiveness, with possible relevance for the development of novel therapeutic strategies.

14/12/2022

🔥NOW ONLINE🔥

New study evaluated visual inspection with acetic acid (VIA) performance as triage of HPV-positive women: VIA detected most precancerous cervical lesions present, particularly in women younger than 50 years

🔓OPEN ACCESS
➡https://doi.org/10.1002/ijc.34384

International Agency for Research on Cancer (IARC/WHO)

WHO guidelines for cervical cancer screening include partial HPV genotyping, cytology, visual inspection with acetic acid (VIA), and colposcopy to triage HPV-positive women. Here, the authors report on the performance of VIA to triage HPV-positive women. Data from 5 sites across Latin America showed that VIA detected about 85% of high-grade cervical lesions in HPV-positive women, particularly those under age 50. The method also correctly identified almost 60% of women without lesions, reducing referral or treatment to nearly 50% of HPV-positive women. However, the performance varied depending on the skill of the examiner.

13/12/2022

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New on the interconnection between and cancer onset and progression summarizes the current evidence focusing on and **alcancer, analyzes lifestyle interventions and discusses current targets and drugs.

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➡https://doi.org/10.1002/ijc.34355

12/12/2022

Today is !

In the first year of the pandemic, people with were seeking cancer care significantly less frequently than before. Countermeasures are needed!

OPEN ACCESS
https://doi.org/10.1002/ijc.33960

, UICC - Union for International Cancer Control , World Health Organization (WHO)

The COVID-19 pandemic caused disruptions to cancer care all over the world. But has it also worsened existing healthcare disparities for patients with low socioeconomic status? Here, using data from a European welfare state where patients have easy access to cancer treatment regardless of their employment or insurance status, the authors compared the socioeconomic status of cancer outpatients who received treatment before and during the pandemic. In the first year of the pandemic, people with low socioeconomic status were seeking cancer care significantly less frequently than before the pandemic. Countermeasures to reach this underserved patient group are needed.

06/12/2022

NOW ONLINE

New study in Denmark by Susanne Kjaer and colleagues highlights the positive impact of implementation of in children and in catch-up cohorts on women´s health

,

🔓OPEN ACCESS
➡️https://doi.org/10.1002/ijc.34328

Vaccination against human papillomavirus (HPV) is an effective preventive tool against cervical precancerous lesions and cancer. This study examined the population impact of HPV vaccines in Denmark by comparing incidence of cervical precancerous lesions and cervical cancer before and after implementation of HPV vaccination in a multi-cohort vaccination program. Analyses show that prior to the HPV vaccination program, incidence of cervical precancerous lesions was increasing. Following implementation of HPV vaccination in children and in catch-up cohorts, however, a reduction in incidence of cervical precancerous lesions and squamous cell carcinoma occurred, highlighting the positive impact of HPV vaccination on women's health.

01/12/2022

Today is !

Sengayi-Muchengeti et al. studied the association between and among South African cancer patients and found that 13 cancers were associate with HIV infection

🔓OPEN ACCESS until 7/12!
➡https://doi.org/10.1002/ijc.34236

In South Africa, the changing shape of the HIV epidemic has also shifted patterns of cancer. Here, the authors studied the association between HIV infection and cancer incidence over a 22-year period. More than 20,000 black cancer patients participated, contributing information about HIV infection status, lifestyle and behavior, and other risk factors. The researchers found that 13 cancers were associated with HIV infection. As antiretroviral treatments become more available and the population living with HIV ages, odds ratios of HPV-related cancers and conjunctival cancer have risen, suggesting a need for education and surveillance among people living with HIV.

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