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17/11/2021

Few have evolved elevated body temperatures compared to ambient temperatures and only in (Lampris spp) is the entire body affected. To understand the molecular basis of , we analyzed the opah genome and identified 23 genes with convergent amino acid substitutions across fish, birds, and mammals, including , which encodes the mitochondrial Na+/Ca2+ exchanger and is essential for heart function and metabolic heat production. Among endothermic fishes, 44 genes with suggestive metabolic functions were identified, such as , encoding a crucial protein for hemoglobin maturation. Numerous genes involved in the production and retention of metabolic heat were also found to be under positive selection. Analyses of opah’s unique inner -producing pectoral muscle layer, an evolutionary key-innovation, revealed that many proteins were co-opted from dorsal swimming muscles for and oxidative phosphorylation. Thus, the opah provides valuable resources and opportunities to uncover the genetic basis of thermal adaptations in fish.

Read the full story in The Innovation Journal at https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00110-7
BBC BBC News BBC Earth CGTN CNN CNN International

04/11/2021

The world's first near-real-time global map with gridded daily CO2 emissions was created by scientists from

Reading Guide:
Precise and high-resolution ( ) emission data is of great importance of achieving the carbon neutrality around the world. Here we present for the first time the near-real-time Global Gridded Daily CO2 Emissions Dataset (called GRACED) from fossil fuel and cement production with a global spatial-resolution of 0.1° by 0.1° and a temporal-resolution of 1-day. Gridded fossil emissions are computed for different sectors based on the daily national CO2 emissions from near real time dataset (Carbon Monitor), the spatial patterns of point source emission dataset Global Carbon Grid (GID), Emission Database for Global Atmospheric Research (EDGAR) and spatiotemporal patters of satellite nitrogen dioxide (NO2) retrievals. Our study on the global CO2 emissions responds to the growing and urgent need for high-quality, fine-grained near-real-time CO2 emissions estimates to support global emissions monitoring across various spatial scales. We show the spatial patterns of emission changes for power, industry, residential consumption, ground transportation, domestic and international aviation, and international shipping sectors from January 1, 2019 to December 31, 2020. This gives thorough insights into the relative contributions from each sector. Furthermore, it provides the most up-to-date and finer-grained overview of where and when fossil CO2 emissions have decreased and rebounded in response to emergencies (e.g. COVID-19) and other disturbances of human activities than any previously published dataset. As the world recovers from the pandemic and decarbonizes its energy systems, regular updates of this dataset will enable policymakers to more closely monitor the effectiveness of climate and energy policies and quickly adapt.

Read the full story published on The Innovation:
https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00107-7 #%20

22/07/2021

Shortened duration and reduced area of frozen soil in the Northern Hemisphere.
In this study, the spatiotemporal patterns and main driving factors of soil FTCs across the Northern Hemisphere (NH) during 1979-2017 were analyzed using multi-source data fusion and attribution approaches. Our results showed that the duration and the annual mean area of frozen soil in the NH decreased significantly at rates of 0.13 ± 0.04 d/y and 4.9 × 104 km2/y, respectively, over the past 40 years. These were mainly because the date of frozen soil onset was significantly delayed by 0.1 ± 0.02 d/y, while the end of freezing and onset of thawing were substantially advanced by 0.21 ± 0.02 d/y and 0.15 ± 0.03 d/y, respectively. Moreover, the interannual FTC changes were more drastic in Eurasia than in North America, especially at mid-latitudes (30-45°N) and in Arctic regions (>75°N). More importantly, our results highlighted that near-surface air temperature (Ta) and snowpack are the main driving factors of the spatiotemporal variations in soil FTCs. Furthermore, our results suggested that the long-term dynamics of soil FTCs at the hemisphere scale should be considered in terrestrial biosphere models to reduce uncertainties in future simulations.
https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00071-0

18/07/2021

Highly efficient conversion of surplus electricity to hydrogen energy via polysulfides redox.

The authors designed a high-performance device, using polysulfides as mediators and graphene-encapsulated CoNi as catalysts. It produced hydrogen with a low potential of 0.82 V at 100 mA/cm2, saving 60.2% more energy than direct water electrolysis. The capacity of H2 production reached 2.5*105 mAh/cm2, which is the highest capacity reported so far. This device exhibited excellent cyclability in 15-days recycle tests, without any decay of performance. The calculation results revealed the electronic structure of the graphene shell was modulated by the electron transfer from N-dopant and metal core, which significantly facilitated recycle of polysulfides on graphene surfaces. This study provides a promising method for constructing a smart grid by developing efficient decoupled devices. BBC CNN CGTN

https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00069-2

17/07/2021

Coronavirus ultimately not over, says Harvard Chan School's William Hanage.

17/07/2021

Topological phononic materials: Computation and data.
Considering the current volume of materials data, it is impossible to investigate each compound by trial-and-error experiments involving labor-intensive efforts. The scientists in the Shenyang National Laboratory for Materials Science developed a home-made software, HT-PHONON, selecting over 5,000 topological phononic (TP) materials out of 13,000 materials within high-throughput computational materials design combined with a big data analysis. Furthermore, an online database for TP materials has been constructed, which is now freely open to the public community through the website www.phonon.synl.ac.cn. In this perspective, we review this platform and discuss exciting consequences of TP materials that are expected from manipulating the phonons, linking fundamental research to potential applications.

https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00059-X

11/07/2021

Adsorption and desorption mechanisms on graphene oxide nanosheets: Kinetics and tuning.
Here, we present a new pathway to determine the kinetics of adsorption/desorption on SASs of graphene oxide (GO) based on total internal reflectance fluorescence microscopy. The switching on and off of the fluorescent signal of SAS lit by carbon dots (CDs) was used to trace the adsorption process and desorption process. We find that sodium pyrophosphate (PPi) could increase the adsorption equilibrium of CDs thermodynamically and promote the substrate-assisted desorption pathway kinetically. At the single turnover level, it was disclosed that the species that can promote desorption may also be an adsorption promoter. Such discovery provides significant guidance for improving the chemical reactivity of the heterogeneous catalyst.
https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00062-X

01/07/2021

😁Common vaccine for mutating virus.
These results demonstrated that the SARS-CoV-2 RBD-trimer vaccine candidate is highly immunogenic and safe, providing long-lasting, broad, and significant immunity protection in nonhuman primates, thereby offering an optimal vaccination strategy against COVID-19.。

https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00065-5

22/06/2021

Carbon neutrality: Toward a sustainable future.

At the core of the issues in the relationship between humans and nature is our consumption of fossil fuels, which causes not only global warming but also the degradation of our environment. The fifth industrial revolution could solve these core issues, and, therefore, carbon neutrality would be the first step toward a sustainable future in which humans and nature can harmoniously coexist. CGTN BBC CNN

https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00052-7

Thank you
28/05/2021

Thank you

We'd like to say thank you! As The Innovation celebrates its first anniversary, we would like to thank all who have helped shape the journal in our first year
https://hubs.li/H0PcVlY0

28/05/2021

A great Cover of the 2rd issue of The Innovation 2021 Innovation Journal. https://www.cell.com/the-innovation/issue?pii=S2666-6758(21)X0002-1 #

On the cover: Earth, home of human beings, is 70% water and 30% land which has nurtured splendid civilizations and flourishing lives. The cover story of this issue reflects the evolution of Earth by merging an unknown planet in a unified scene with different landscapes throughout the history such as glacier, desert, ocean, mountain, river and magma. The contrast between the past to reality can best illustrate our respect to our motherland. It is not only the subjects of geoscience studies, but also the common goal of all multidisciplinary research and the shared duties of mankind to understand, care and protect our planet to build a better future.

25/05/2021

The emergence of SARS-CoV-2 variants harboring mutations in the spike (S) protein has raised concern about potential immune escape. Here, we studied humoral and cellular immune responses to wild type SARS-CoV-2 and the B.1.1.7 and B.1.351 variants of concern in a cohort of 121 BNT162b2 mRNA-vaccinat...

From Prof. Dake Zhang
24/05/2021

From Prof. Dake Zhang

Hepatitis B virus (HBV), one of the well-known DNA oncogenic viruses, is the leading cause of hepatocellular carcinoma (HCC). In infected hepatocytes, HBV DNA can be integrated into the host genome through an insertional mutagenesis process inducing tumorigenesis. Dissection of the genomic features....

21/05/2021

Here, we report the first discovery of X-ray synchrotron emission from the possibly middle-aged SNR G106.3+2.7, implying that this SNR is still an energetic particle accelerator despite its age. This discovery, along with the ambient environmental information, multiwavelength observation, and theoretical arguments, supports SNR G106.3+2.7 as a likely powerful proton PeV accelerator.

https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00043-6

19/05/2021

is far more than you could ever imagine.

We show that the ice-VII-bearing diamonds formed at depths down to 800 ± 60 km but temperatures 200-500 K below average mantle temperature that matches the decomposition pressure-temperature conditions of dense hydrous mantle silicates. Our work presents strong evidence for the coupled recycling of water and carbon in the deep mantle based on natural samples. CGTN ScienceAlert Science Channel
https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00042-4

18/05/2021

These data indicate that TLR4 inhibition by ni****ne and cotinine at the concentrations tested in BV-2 cells is independent of classic neuronal nAChRs and validate that MD2 is a direct target of ni****ne and cotinine in the inhibition of innate immunity.
****ne ***co Cell Press
https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00036-9

14/05/2021

The hadal zone mostly comprising deep trenches and constituting the deepest part of the world’s oceans, represents the least explored habitat but one of the last frontiers on our planet. The present scientific understanding of the hadal environment is still relatively rudimentary, particularly in ...

03/05/2021

The evolution of the Asian monsoon from the Late Oligocene to the Early Miocene is poorly understood. Here, we first reconstruct the precipitation data of central Tibet during 26-16 Ma, applying the coexistence approach to sedimentary pollen data, and detect an intensified Asian monsoon with ∼1.35...

17/04/2021

Meet The Innovation editorial board - providing support and insight, and working with the editors-in-chief to provide a forum for research that tackles important, emerging topics and many of the world’s biggest challenges https://hubs.ly/H0KM7p60

15/04/2021

The Sichuan-Tibet railway of China starts from the western Sichuan basin and subsequently runs across the “Roof of the World”-Tibet plateau, which is dubbed “Sky-high road”. However, several challenges, including the world's most remarkable topographic relief, active tectonic movement, frequent mountain hazards and vulnerable ecological environment, exert significant effects on railway construction and operation. This epic railway project, thus, has always been the world’s toughest problem. Here, we provide an overview of the existing challenges and discuss the relevant countermeasures. We highlight that an intelligent monitoring and early warning system is the top priority for eliminating the high hazard risks threatening the railway. Also, new materials and building structures are indispensable for railway surviving from active fault dislocation and earthquakes. For protecting the ecological environment, we are head for realizing humankind-nature-railway harmonious intergrowth. Completing the Sichuan-Tibet railway will promote the scientific and technological development of China and even the world. https://bit.ly/3a9PQIc

Cell Press

15/04/2021

It's looking like spring at Harvard 🌸

Photo: Jon Chase/Harvard Staff Photographer

11/04/2021

A large number of reaction systems are composed of hydrophobic interfaces and microorganisms in natural environment. However, it is not clear how microorganisms adjust their breathing patterns and respond to hydrophobic interfaces. Here, Shewanella oneidensis MR-1 was used to reduce ferrihydrite of....

07/04/2021

In this review, the authors summarized the molecular mechanisms underlying resistance to third-generation EGFR inhibitors and the ongoing efforts to address and overcome this chemoresistance. We also discuss the current status of fourth-generation EGFR inhibitors, which are of great value in overcoming resistance to EGFR inhibitors which appear to have greater therapeutic benefits in the clinics.
https://bit.ly/3wtXQxf The Lancet Cell Press BMJ

06/04/2021

Symptomless transmission of silently drives viral spread and is key to ending the pandemic, say the authors of a new .

Read more about addressing the need to extinguish these "smokeless fires" of transmission: https://fcld.ly/xt5um1z

05/04/2021

El Niño-Southern Oscillation (ENSO) had been identified as the dominant predictor for Indian summer monsoon rainfall (ISMR) by the early 1900s, showing an apparent weakening of the ENSO–ISMR relationship since the 1970s. Here, we found a clear restoration of the ENSO–ISMR since 1999/2000. This ...

03/04/2021

The Innovation | Editor in Chief: Buxing Han

His research interest is the interdisciplinary area of physical chemistry and green chemistry, and has achieved significantly in the chemical thermodynamics of green solvent systems and the application of green solvents in chemical reactions and material synthesis
https://bit.ly/3uo4OSx

02/04/2021

1. Magnetism can offer a significant contribution to thermoelectricity. 2. A generic Seebeck effect exists in magnetic conductors as a result of transport spin entropy of delocalized d electrons. 3. The magnetocaloric effect and the Seebeck effect are thermodynamically correlated to each other.

25/03/2021

The authors provided direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster. This data could help us to determine whether the current symptom-based screening should cover asymptomatic persons.
https://bit.ly/31fINbR

Research from Prof. Yuming Guo, Editorial Board Member of The Innovation.
24/03/2021

Research from Prof. Yuming Guo, Editorial Board Member of The Innovation.

Background Both cold and hot temperature have been associated with the onset of asthma, but it remains largely unknown about the risk of asthma hospitalisation associated with short-term temperature fluctuation or temperature variability (TV). Objective To explore the association between short-term....

10/03/2021

Check out exciting 2020 highlights from The Innovation. Enjoy access to a special collection including 9 reports, 3 articles, and 7 reviews .innovation.journal
https://hubs.ly/H0G3YwG0

08/03/2021

The shots are beginning to have a societal impact, but herd immunity is a distant dream

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