Genomics Proteomics Bioinformatics

03/06/2023

Omics Views of Mechanisms for Cell Fate Determination in Early Mammalian Development
Lin-Fang Ju, Heng-Ji Xu, Yun-Gui Yang, Ying Yang

During mammalian preimplantation development, a totipotent zygote undergoes several cell cleavages and two rounds of cell fate determination, ultimate…

31/05/2023

Research article
Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons
Liang Wang, Xiaojie Wang, Chunqi Liu, Wei Xu, ... Xiaobo Cen

The expression of linear DNA sequence is precisely regulated by the three-dimensional (3D) architecture of chromatin. Morphine-induced aberrant gene n…

12/05/2023

Research article
NetGO 3.0: Protein Language Model Improves Large-scale Functional Annotations
Shaojun Wang, Ronghui You, Yunjia Liu, Yi Xiong, Shanfeng Zhu

As one of the state-of-the-art automated function prediction (AFP) methods, NetGO 2.0 integrates multi-source information to improve the performance. …

11/05/2023

Research article
Novel Time-dependent Multi-omics Integration in Sepsis-associated Liver Dysfunction
Ann-Yae Na, Hyojin Lee, Eun Ki Min, Sanjita Paudel, ... Sangkyu Lee

The recently developed technologies that allow the analysis of each single omics have provided an unbiased insight into ongoing disease processes. How…

06/05/2023

ORIGINAL RESEARCH
Gut Microbiome Variation Along A Lifestyle Gradient Reveals Threats Faced by Asian Elephants
Chengbo Zhang , Zhenghan Lian , Bo Xu , Qingzhong Shen , Mingwei Bao , Zunxi Huang ,Hongchen Jiang , Wenjun Li

The gut microbiome is closely related to host nutrition and health. However, the relationships between gut microorganisms and host lifestyle are not w…

06/05/2023

Review
Recent Advances in Assembly of Plant Complex Genomes
Weilong Kong, Yibin Wang, Shengcheng Zhang, Jiaxin Yu, Xingtan Zhang

Over the past 20 years, tremendous advances in sequencing technologies and computational algorithms have spurred plant genomic research into a thrivin…

04/05/2023

Letter
The Proteome Landscape of Human Placentas for Monochorionic Twins with Selective Intrauterine Growth Restriction

In perinatal medicine, intrauterine growth restriction (IUGR) is one of the greatest challenges. The etiology of IUGR is multifactorial, but most case…

14/04/2023

Review
Protein Structure Prediction: Challenges, Advances, and the Shift of Research Paradigms

Protein structure prediction is an interdisciplinary research topic that has attracted researchers from multiple fields, including biochemistry, medic…

28/03/2023

ORIGINAL RESEARCH
RNA Methylome Reveals the m6A-mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-withering

The epitranscriptomic mark N6-methyladenosine (m6A), which is the predominant internal modification in RNAs, is important for plant responses to diver…

24/03/2023

Database
VIS Atlas: A Database of Virus Integration Sites in Human Genome from NGS Data to Explore Integration Patterns

Integration of oncogenic DNA viruses into the human genome is a key step in most virus-induced carcinogenesis. Here, we constructed virus integration …

23/03/2023

ORIGINAL RESEARCH
Multi-omics of Circular RNAs and Their Responses to Hormones in Moso Bamboo (Phyllostachys edulis)

Circular RNAs (circRNAs) are endogenous non-coding RNAs with covalently closed structures, which have important functions in plants. However, their bi…

21/01/2023

Cell Evolution, a coming new journal ……

21/01/2023

Wish you a healthy and prosperous year of the rabbit!

21/01/2023

ORIGINAL RESEARCH
stAPAminer: Mining Spatial Patterns of Alternative Polyadenylation for Spatially Resolved Transcriptomic Studies

Alternative polyadenylation (APA) contributes to transcriptome complexity and gene expression regulation and has been implicated in various cellular p…

13/01/2023

Database
Organs-on-a-chip Database (OOCDB): A Comprehensive, Systematic, and Real-time Organs-on-a-chip Database

Organs-on-a-chip is a microfluidic microphysiological system that uses microfluidic technology to analyze the structure and function of living human c…

13/01/2023

Editorial:
Artificial Intelligence in Omics

Genomics, Proteomics & BioinformaticsAvailable online 12 January 2023In Press, Journal Pre-proofWhat are Journal Pre-proof articles?EditorialArtificial Intelligence in OmicsAuthor links open overlay panelFengGaoabKunHuangcdeYiXingfghShow moreShareCitehttps://doi.org/10.1016/j.gpb.2023.01.002Get righ...

04/01/2023

DeepNoise: Signal and Noise Disentanglement Based on Classifying Fluorescent Microscopy Images via Deep Learning

The high-content image-based assay is commonly leveraged for identifying the phenotypic impact of genetic perturbations in biology field. However, a p…

04/01/2023

scEMAIL: Universal and Source-free Annotation Method for scRNA-seq Data with Novel Cell-type Perception

Current cell-type annotation tools of single-cell RNA sequencing (scRNA-seq) data mainly utilize well-annotated source data to help identify cell type…