Jornal Eletrônico de Atualizações em Neurologia - JEAN

31/12/2022

28/11/2022

11/09/2022

Spontaneous subarachnoid haemorrhage is the third most common type of stroke and frequently related to aneurysmal rupture. Diagnosis is made by CT scan of the head possibly followed by lumbar puncture.

Find out more in this Seminar: https://hubs.li/Q01l_K_f0

👇 Figure: Management approach for patients with aneurysmal subarachnoid haemorrhage

11/08/2022

This interactive feature about screening for atrial fibrillation in asymptomatic older adults offers a case vignette accompanied by two essays, one supporting screening and the other supporting deferral of screening. https://nej.md/3JLcjfg

10/08/2022

09/08/2022

Nature Reviews Disease Primers

21/07/2022

Orthostatic hypotension is an unusually large decrease in blood pressure on standing that increases the risk of adverse outcomes even when asymptomatic.

In this Review, Wouter Wieling and colleagues look at diagnosis and treatment of the condition 👉 https://hubs.li/Q01h9NtW0

12/07/2022

This Special Communication discusses findings from a World Health Organization consultation workshop on global disparities in Parkinson disease, including 6 workable avenues for action: disease burden; advocacy and awareness; prevention and risk reduction; diagnosis, treatment, and care; caregiver.....

23/06/2022

This randomized clinical trial showed that use of ultrahigh-dose methylcobalamin in Japanese patients in the early stages of amyotrophic lateral sclerosis with moderate progression can slow functional decline and had a good safety profile.

21/06/2022

The past 20 years have seen remarkable advances in multiple sclerosis, as evidenced by the timeline below.

In The Lancet Neurology, authors discuss breakthrough moments in our understanding of the condition and the development of therapeutic options over the past two decades.

Explore for yourself 👉 https://hubs.li/Q01d-D7w0

21/06/2022

In the Alzheimer Prevention Initiative (API) Autosomal Dominant Alzheimer Disease (ADAD) Colombia trial (NCT01998841), crenezumab (Genentech, South Sa

27/05/2022

In a recent study in Science, researchers with the consortium present the dataset, a particularly broad cell atlas that provides a molecular definition of more than 400 cell types across 24 organs. Learn more: https://fcld.ly/9oala6q

26/05/2022

A new observational study finds IV thrombolysis for acute stroke is safe for patients receiving direct oral anticoagulant therapy, prompting researchers to ask if current guidelines should be changed.

20/05/2022

A new report shows dementia deaths are disproportionate in women, with it being the leading cause of death for women.

16/05/2022

Wilson's disease is an autosomal-recessive disorder of copper metabolism with hepatic, neurological, psychiatric, ophthalmological, haematological, renal, and rheumatological manifestations. Diagnosis is challenging.

This new Review from the British Association for the Study of the Liver aims to provide a more practical guide to investigation and management: https://hubs.li/Q01bksjM0

👇 Figure: Investigation and management of Wilson's disease

11/05/2022

The authors of a new paper in the forthcoming issue of the Journal of Parkinson's Disease share a “Call to Action” with initial recommendations for engaging people with Parkinson’s disease in the design and ex*****on of clinical research. It emphasizes the value of incorporating patient perspectives in clinical Parkinson’s disease studies.

News release: http://bit.ly/JPD12-4_PR1

09/05/2022

Nature Reviews Neurology

07/04/2022

New review article covers Creutzfeldt–Jakob disease, which has advanced from detection via characteristic EEG and MRI features to lab diagnosis. https://nej.md/3LHzGWQ

27/03/2022

The rate of symptomatic hemorrhage after getting a thrombolytic is half that with tenecteplase than with alteplase.

26/03/2022

Neuromodulation is an alternative therapy to antiseizure drugs and surgery for individuals with drug-resistant epilepsy. The primary objective of neuromodulation is to lessen seizure frequency.

On —a day inviting discussion and raising awareness around epilepsy—read this Review on state-of-the-art approved therapies: https://hubs.li/Q016QVBl0

26/03/2022

Epilepsy is one of the most common brain conditions. It is characterised by a lasting predisposition to generate spontaneous epileptic seizures and has many neurobiological, cognitive, and psychosocial consequences.

Too often, people are categorised as simply having epilepsy whereas the diagnosis should be as specific and as precise as possible.

To learn more about epilepsy in adults, explore this Seminar by Roland D Thijs and colleagues ➡️ https://hubs.li/Q016QVt10

03/03/2022

Spontaneous intracranial hypotension is a debilitating medical condition caused by loss of CSF from the spinal canal.

Although not typically considered a life-threatening disorder, spontaneous intracranial hypotension can cause morbidity, result in long-term disability, and lead to decreased consciousness and coma in rare cases.

Knowledge about the condition has increased over the past decade but diagnostic criteria and optimal assessments to use remain topics for debate. In this Review in The Lancet Neurology, authors provide an update ➡️ https://hubs.li/Q015j-3K0

28/02/2022

Nature Reviews Disease Primers

24/02/2022

This post hoc secondary analysis of 4 randomized clinical trials evaluates changes in migraine frequency, medication use, and patient-reported outcomes associated with erenumab use.

16/02/2022

This multicenter cohort study uses real-world clinical data to compare the long-term safety and effectiveness of intravenous edaravone plus riluzole therapy vs propensity score–matched controls receiving riluzole therapy alone among patients with amyotrophic lateral sclerosis.

15/02/2022

ABN CONVIDA!

Participe do próximo Webinar Redone, no dia 24 de fevereiro, a partir das 19h. O tema em foco será "Compartilhamento de Dados".

Inscreva-se em: https://www.abneuro.org.br/evento/webinar-compartilhamento-de-dados/

14/02/2022

This cohort study investigates changes in dose-normalized concentrations of the antiseizure medications lamotrigine, levetiracetam, lacosamide, oxcarbazepine, and zonisamide during pregnancy among women with epilepsy.

13/02/2022

This study found large ethnic and racial, regional, and socioeconomic differences in the prevalence of risk factors, causes of stroke, and 3-month mortality among young patients with ischemic stroke worldwide. Read the full study now: bit.ly/3JeRt6d

13/02/2022

This randomized clinical trial assesses the effect of intra-arterial alteplase infusion vs placebo on functional outcomes (modified Rankin Scale scores) among patients with large vessel occlusion acute ischemic stroke and successful reperfusion following thrombectomy.

26/01/2022

This Primer published in Nature Reviews Disease Primers summarizes the epidemiology, pathophysiology, diagnosis and treatment of migraine. The Primer also discusses the quality of life issues faced by patients with migraine and future research avenues. Read the Primer: https://go.nature.com/3fSLis2

23/01/2022

Infliximab to Treat Severe Paradoxical Reaction in HIV-Negative Tuberculous Meningoencephalitis: bit.ly/3FIygrC

16/01/2022

Just published online: Class II evidence that sustained increase in overall regular physical activity levels in patients with early Parkinson disease was associated with slower decline of several clinical parameters. bit.ly/34Qx60B

13/01/2022

Post-traumatic headache is a disabling secondary headache disorder, which is often attributed to traumatic brain injury and affects millions of individuals worldwide.

A Review in The Lancet Neurology provides a comprehensive overview of the classification, clinical characteristics, and management of post-traumatic headache. Authors also propose a treatment algorithm (see below) to aid clinical decision making in the absence of robust data from controlled trials of post-traumatic headache. https://hubs.li/Q0124pD60

13/01/2022

After cannabis legalization, the prevalence of moderately injured drivers with a THC level of at least 2 ng per milliliter in participating British Columbia trauma centers more than doubled. https://nej.md/3qbk1a3

08/01/2022

Nature Reviews Neurology

05/01/2022

This genome-wide association study identifies common variants associated with risk of essential tremor.

04/01/2022

This randomized clinical trial evaluates the rate of in-stent restenosis and the risk of stroke recurrence after the placement of a drug-eluting stent vs standard bare-metal stent among patients with symptomatic high-grade intracranial atherosclerotic stenosis.

04/01/2022

Istradefylline is an A2AR antagonist that has been approved as an adjunctive PD therapy in Japan and US. Some results indicate that early use of A2AR antagonism w/ dopaminergic drug therapy may prevent drug-induced dyskinesia, however, results are mixed.
http://ow.ly/Uck250HgVbx