ABCR - Annals of Biomedical and Clinical Research

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ABCR - Annals of Biomedical and Clinical Research

Annals of Biomedical and Clinical Research (ABCR) is the official peer reviewed journal of the University of Mostar, School of Medicine.

21/05/2024

Abstract

📚 Background: Acute nasopharyngitis is a common condition usually accompanied by nasal congestion. The aim of this study was to compare efficacy and safety of a spray containing xylometazoline and lysozyme with a spray containing only xylometazoline in the treatment of acute nasopharyngitis.

👣 Methods: A prospective, comparative, post-marketing study was performed on subjects with acute nasopharyngitis divided into xylometazoline+lysozyme or xylometazoline nasal spray groups. Data collection was performed at baseline before treatment, 30 minutes after treatment and at seven-day follow-up.

🧾 Main findings: Out of 173 included subjects, 59 were in the xylometazoline+lysozyme and 114 in the xylometazoline group. In both groups nasal patency was significantly improved 30 minutes after the therapy application (p

14/05/2024

Abstract

📚 Background: To determine the influence of hypothyroidism and hyperthyroidism on the course, outcome of pregnancy, and parameters of the newborn.

👣 Methods: A cross-sectional epidemiological study was conducted. The study included 319 pregnant women of whom 257 had hypothyroidism and 62 had hyperthyroidism. The main parameter was the pathological conditions of the mother’s thyroid gland. Data were collected from the protocol, medical history, and discharge letters. The results of the statistical analysis are expressed in absolute and relative frequencies. The significance of the differences was tested using the χ2 test.

🧾 Main findings: In 2020 and 2021, 3,627 children were born. A total of 318 mothers were included in the research, of whom 257 (80.82%) had hypothyroidism and 61 (19.18%) had hyperthyroidism. Ninety-one newborns (35.4%) of mothers suffering from hypothyroidism and 20 newborns (32.79%) of mothers suffering from hyperthyroidism were transferred to the NICU. No statistically significant difference was found in relation to the influence of hypothyroidism and hypothyroidism on newborn parameters. However, a statistically significant difference was observed in the incidence of pathological conditions during pregnancy. In subjects with hypothyroidism, there was significantly more gestational diabetes (15%) and preeclampsia (3.5%).

🛎 Principal conclusion: Thyroid dysfunction in pregnant women did not significantly affect the course and outcome of pregnancy or the parameters of the newborn, including gestational age or anthropometric measurements.

🔑 Keywords: TSH Deficiency, Primary Hyperthyroidism, Neonate, Perinatal Care, Complications, Pregnancy

🔗 https://abcr-mefmo.org/index.php/abcr/article/view/30/36

07/05/2024

Abstract (full text link below)

📚 Background: The aim of this study was to compare the yields of acetylsalicylic acid synthesis based on the traditional approach and the green chemistry approach. Green chemistry is one of the most important approaches in pharmaceutical sustainability. The reagents used for acetylsalicylic acid synthesis can be environmentally harmful, so there is a need for a better and safer alternative.

👣 Methods: We conducted five syntheses based on the traditional approach and five syntheses based on the green chemistry approach. The synthesis process was identical except for one element – traditional synthesis uses sulfuric acid and green chemistry synthesis uses phosphoric acid. After synthesis, the theoretical and experimental yields were calculated. The obtained products were tested using high-performance liquid chromatography.

🧾 Main findings: The theoretical yield of acetylsalicylic acid in both reactions was determined as 3.896 g. Traditional synthesis gave us a mean yield of 3.113 g (79.8%). Green chemistry synthesis gave us a mean yield of 3.104 g (79.4%). The quality of both products was confirmed by the above-mentioned chromatography method. There was no statistically significant difference between the means of the product masses (p=0.8220).

🛎 Principal conclusions: Phosphoric acid can be used as a safe alternative to acetylsalicylic acid synthesis instead of sulfuric acid. As phosphoric acid is much safer than sulfuric acid in terms of environmental impact, these findings can be used in a pharmaceutical industry setting to obtain a better, cleaner, and safer alternative to acetylsalicylic acid synthesis.

🔑 Keywords: acetylsalicylic acid, synthesis, green chemistry, medicinal chemistry

🔗 https://abcr-mefmo.org/index.php/abcr/article/view/29/35

30/04/2024

Abstract (full text link below)

📚 Background: In addition to progression to lymphoproliferative diseases, patients with monoclonal gammopathy of undetermined significance (MGUS) appear to suffer from other types of comorbidities, although the extent to which MGUS contributes to these comorbidities is unclear. The aim of this study is to evaluate the presence of patients with MGUS who attend general practice (GP) in our healthcare area, as well as to describe the comorbidities and abnormal blood test results associated with these patients.

👣 Methods: A retrospective study was carried out whereby demographic data, comorbidities, and the results of certain analytical parameters were collected from 1201 patients, who visited their GP physician: 201 patients with a monoclonal protein and 1000 patients without the presence of monoclonal protein were identified.

🧾 Main findings: Of the 6307 proteinograms performed on patients from GP, 201 presented with an M-protein (3.2%). The presence of MGUS increased with age and was significantly higher in men than in women (55.7% vs 44.3%, p

22/04/2024

Abstract (full text link below)

📚Background: The aim of this study was to determine the type and frequency of complications during multiple pregnancies, mode of delivery and perinatal outcomes in three groups of pregnant women, categorized by gestational age of pregnancy.

👣Methods: A total of 149 pregnant women and their neonates were included and divided into three groups according to gestational age: moderately preterm birth (from 22 to 33 + 6 weeks - MPTB), late preterm birth (from 34 to 36 + 6 weeks - LPTB ) and term birth (from 37 weeks). SPSS for Windows software (version 23.0, SPSS Inc., Chicago, Illinois, USA) was used for statistical analysis.

🧾Main findings: Of the total 149 pregnancies, 64.86% were completed by Cesarian section, which was the dominant mode of delivery in all gestational groups. Hypertension, preterm premature rupture of membranes (PPROM) and gestational diabetes pregnancy were the most common complications in the term birth group, PPROM and preeclampsia in the LPTB group, and multiple maternal complications in the MPTB group (p

02/04/2024

Abstract - full text link below

Dear Readers,

Welcome to the latest issue of the Annals of Biomedical and Clinical Research. In this editorial, we take a moment to reflect on the opportunities and challenges faced by the scientific community in the Western Balkans, with a special focus on Bosnia and Herzegovina.

In recent years, local researchers have demonstrated exceptional dedication and skill to scientific research, leading to new discoveries and advancements in the field of medical sciences. The pages of our journal proudly feature the work of these scientists, showcasing the depth and breadth of talent present in the region.
..

🔗 https://abcr-mefmo.org/index.php/abcr/article/view/41

01/04/2024

In case you have missed the last volume, here we will bring you article highlights starting next tuesday!
See you soon :)

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