27/10/2023
A lot of people demonize high fructose corn syrup, or think that honey is somehow better than other sugars.
Table sugar, high-fructose corn syrup, and honey all contain glucose and fructose in similar ratios. Studies comparing intake of sucrose, HFCS, and other similar sweeteners such as honey have found they exert similar metabolic effects, and that HFCS does not uniquely contribute to weight gain.
Both fructose and glucose go through a pathway called glycolysis (albeit fructose does enter through a slightly different pathway). That leads to the production of pyruvate, which converts to Acetyl-CoA.
Acetyl-CoA can go on to create energy (ATP) through the citric acid cycle and electron transport chain, or is can be used to create fat. Importantly, acetyl-CoA pretty much only converts to body fat when we’re in a CALORIE SURPLUS.
As you can see, high fructose corn syrup isn’t inherently evil, and it isn’t much different from regular sugar or honey.
Despite the name “high-fructose,” HFCS actually has approximately the same ratio of fructose to glucose as sucrose or honey. HFCS is only “high” in fructose compared to the corn syrup from which it’s derived.
Dan Feldman
https://www.ncbi.nlm.nih.gov/pubmed/19064539/
https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-11-55
https://www.ncbi.nlm.nih.gov/pubmed/26338891/
https://www.biolayne.com/articles/nutrition/high-fructose-corn-syrup-should-we-be-afraid/